{"id":5242,"date":"2019-03-21T11:54:18","date_gmt":"2019-03-21T04:54:18","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=5242"},"modified":"2019-03-21T11:54:18","modified_gmt":"2019-03-21T04:54:18","slug":"ansm-yeu-cau-tuan-thu-lieu-xeljanz-tofacitinib-trong-dieu-tri-viem-khop-dang-thap","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/ansm-yeu-cau-tuan-thu-lieu-xeljanz-tofacitinib-trong-dieu-tri-viem-khop-dang-thap\/","title":{"rendered":"ANSM y\u00eau c\u1ea7u tu\u00e2n th\u1ee7 li\u1ec1u Xeljanz (tofacitinib) trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p"},"content":{"rendered":"<p><strong>ANSM \u0111\u00e3 \u0111\u01b0\u1ee3c C\u01a1 quan y t\u1ebf ch\u00e2u \u00c2u (EMA) th\u00f4ng b\u00e1o v\u1ec1 vi\u1ec7c t\u0103ng nguy c\u01a1 thuy\u00ean t\u1eafc \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i v\u00e0 t\u1eed vong tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Xeljanz (tofacitinib)<\/strong> v\u1edbi li\u1ec1u cao (10mg, d\u00f9ng 2 l\u1ea7n m\u1ed9t ng\u00e0y) \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh trong m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. Do \u0111\u00f3, ANSM y\u00eau c\u1ea7u c\u00e1c chuy\u00ean gia y t\u1ebf v\u00e0 b\u1ec7nh nh\u00e2n tu\u00e2n th\u1ee7 li\u1ec1u \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh khi s\u1eed d\u1ee5ng thu\u1ed1c Xeljanz (ho\u1ea1t ch\u1ea5t Tofacitinib) trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p (li\u1ec1u 5mg, d\u00f9ng 2 l\u1ea7n m\u1ed9t ng\u00e0y).<\/p>\n<p>ANSM y\u00eau c\u1ea7u c\u00e1c chuy\u00ean gia y t\u1ebf v\u00e0 b\u1ec7nh nh\u00e2n tu\u00e2n th\u1ee7 li\u1ec1u \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh khi s\u1eed d\u1ee5ng thu\u1ed1c Xeljanz (ho\u1ea1t ch\u1ea5t Tofacitinib) trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p (li\u1ec1u 5mg, d\u00f9ng 2 l\u1ea7n m\u1ed9t ng\u00e0y). ANSM \u0111\u00e3 \u0111\u01b0\u1ee3c C\u01a1 quan y t\u1ebf ch\u00e2u \u00c2u (EMA) th\u00f4ng b\u00e1o v\u1ec1 vi\u1ec7c t\u0103ng nguy c\u01a1 thuy\u00ean t\u1eafc \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i v\u00e0 t\u1eed vong tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Xeljanz (tofacitinib) v\u1edbi li\u1ec1u cao (10mg, d\u00f9ng 2 l\u1ea7n m\u1ed9t ng\u00e0y) \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh trong m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n<p>Xeljanz (tofacitinib), \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh b\u1edfi Pfizer, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh khi k\u1ebft h\u1ee3p v\u1edbi methotrexate (vi\u1ebft t\u1eaft MTX) trong \u0111i\u1ec1u tr\u1ecb vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p ho\u1ea1t \u0111\u1ed9ng m\u1ee9c \u0111\u1ed9 trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng \u1edf b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh c\u00f3 \u0111\u00e1p \u1ee9ng ho\u1eb7c kh\u00f4ng dung n\u1ea1p c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u1ed1ng th\u1ea5p kh\u1edbp. Trong tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n kh\u00f4ng dung nap v\u1edbi methotrexat ho\u1eb7c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng methotrexat kh\u00f4ng ph\u00f9 h\u1ee3p, c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng tofacitinib d\u01b0\u1edbi d\u1ea1ng \u0111\u01a1n tr\u1ecb li\u1ec7u.<\/p>\n<p>Theo y\u00eau c\u1ea7u c\u1ee7a c\u01a1 quan y t\u1ebf Hoa K\u1ef3, Pfizer \u0111\u00e3 ti\u1ebfn h\u00e0nh m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u00e1nh gi\u00e1 \u0111\u1ed9an to\u00e0n c\u1ee7a tofacitinib \u0111\u00e3 cho th\u1ea5y s\u1ef1 gia t\u0103ng nguy c\u01a1 thuy\u00ean t\u1eafc \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i \u1edf b\u1ec7nh nh\u00e2n tr\u00ean 50 tu\u1ed5i, c\u00f3 \u00edt nh\u1ea5t m\u1ed9t nguy c\u01a1 tim m\u1ea1ch v\u00e0 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Xeljanz (tofacitinib) v\u1edbi li\u1ec1u cao (10mg, d\u00f9ng 2 l\u1ea7n m\u1ed9t ng\u00e0y).<\/p>\n<p>B\u00ean c\u1ea1nh \u0111\u00f3, m\u1ed9t ph\u00e2n t\u00edch chuy\u00ean s\u00e2u c\u1ee7a th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 nh\u1eefng d\u1eef li\u1ec7u c\u00f3 s\u1eb5n v\u1ec1 c\u00e1c nguy c\u01a1 tr\u00ean tim m\u1ea1ch \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u1edf ch\u00e2u \u00c2u \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 l\u1ea1i nguy c\u01a1.<\/p>\n<p>Trong khi ch\u1edd \u0111\u1ee3i k\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u, ANSM y\u00eau c\u1ea7u chuy\u00ean gia y t\u1ebf v\u00e0 b\u1ec7nh nh\u00e2n tu\u00e2n th\u1ee7 li\u1ec1u \u0111\u00e3 \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o l\u00e0 5mg , d\u00f9ng 2 l\u1ea7n m\u1ed9t ng\u00e0y. Theo \u0111\u00f3, c\u00e1c chuy\u00ean gia y t\u1ebf c\u00f3 k\u00ea toa Xeljanz (tofacitinib) s\u1ebd nh\u1eadn \u0111\u01b0\u1ee3c th\u00f4ng b\u00e1o li\u00ean quan \u0111\u1ebfn n\u1ed9i dung n\u00e0y.<\/p>\n<p>Ngu\u1ed3n: <a href=\"https:\/\/ansm.sante.fr\/S-informer\/Actualite\/Xeljanz-tofacitinib-l-ANSM-demande-aux-professionnels-de-sante-et-aux-patients-de-bien-respecter-la-dose-autorisee-dans-le-traitement-de-la-polyarthrite-rhumatoide-Point-d-Information\" rel=\"noopener\">https:\/\/ansm.sante.fr\/S-informer\/Actualite\/Xeljanz-tofacitinib-l-ANSM-demande-aux-professionnels-de-sante-et-aux-patients-de-bien-respecter-la-dose-autorisee-dans-le-traitement-de-la-polyarthrite-rhumatoide-Point-d-Information<\/a><\/p>\n<p>Ng\u01b0\u1eddi t\u1ed5ng h\u1ee3p: V\u0169 \u0110\u1ee9c Ho\u00e0n \u2013 Nguy\u1ec5n Ph\u01b0\u01a1ng Th\u00fay &#8211; Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ANSM \u0111\u00e3 \u0111\u01b0\u1ee3c C\u01a1 quan y t\u1ebf ch\u00e2u \u00c2u (EMA) th\u00f4ng b\u00e1o v\u1ec1 vi\u1ec7c t\u0103ng nguy c\u01a1 thuy\u00ean t\u1eafc \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i v\u00e0 t\u1eed vong tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Xeljanz (tofacitinib) v\u1edbi li\u1ec1u cao (10mg, d\u00f9ng 2 l\u1ea7n m\u1ed9t ng\u00e0y) \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh trong m\u1ed9t th\u1eed nghi\u1ec7m [&#8230;]\n","protected":false},"author":1,"featured_media":5243,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5242","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5242"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5242\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5243"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}