{"id":5038,"date":"2019-03-19T10:21:12","date_gmt":"2019-03-19T03:21:12","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=5038"},"modified":"2019-03-19T10:21:12","modified_gmt":"2019-03-19T03:21:12","slug":"medsafe-khuyen-cao-than-trong-su-dung-natri-valproat-o-tre-em-gai-va-phu-nu","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/medsafe-khuyen-cao-than-trong-su-dung-natri-valproat-o-tre-em-gai-va-phu-nu\/","title":{"rendered":"Medsafe: Khuy\u1ebfn c\u00e1o th\u1eadn tr\u1ecdng s\u1eed d\u1ee5ng natri valproat \u1edf tr\u1ebb em g\u00e1i v\u00e0 ph\u1ee5 n\u1eef"},"content":{"rendered":"<p><strong>S\u1eed d\u1ee5ng natri valproat trong thai k\u1ef3 c\u00f3 nguy c\u01a1 cao g\u00e2y d\u1ecb t\u1eadt b\u1ea9m sinh cho thai nhi.<\/strong> Do \u0111\u00f3, t\u1ea1i New Zealand, ch\u1ec9 \u0111\u1ecbnh c\u1ee7a thu\u1ed1c n\u00e0y khi s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c \u0111\u00e3 \u0111\u01b0\u1ee3c thay \u0111\u1ed5i. Natri valproat hi\u1ec7n ch\u1ec9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf nh\u1eefng ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng sinh con khi t\u1ea5t c\u1ea3 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c \u0111\u1ec1u kh\u00f4ng mang l\u1ea1i hi\u1ec7u qu\u1ea3. Ngo\u00e0i ra, ph\u1ee5 n\u1eef c\u1ea7n s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 trong khi d\u00f9ng natri valproat.<\/p>\n<h2>Theo Medsafe, natri valproat kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c t\u00ecnh hu\u1ed1ng sau \u0111\u00e2y do nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn thai nhi:<\/h2>\n<p>ph\u1ee5 n\u1eef c\u00f3 kh\u1ea3 n\u0103ng sinh con (tr\u1eeb khi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng hi\u1ec7u qu\u1ea3 ho\u1eb7c kh\u00f4ng dung n\u1ea1p \u0111\u01b0\u1ee3c).<br \/>\n\u0111i\u1ec1u tr\u1ecb \u0111\u1ed9ng kinh trong th\u1eddi k\u1ef3 mang thai (tr\u1eeb khi kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb thay th\u1ebf ph\u00f9 h\u1ee3p).<br \/>\n\u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c trong th\u1eddi k\u1ef3 mang thai.<br \/>\n\u0110i\u1ec1u quan tr\u1ecdng l\u00e0 tr\u1ebb em g\u00e1i (v\u00e0 cha m\u1eb9\/ng\u01b0\u1eddi ch\u0103m s\u00f3c) v\u00e0 ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh n\u1edf d\u00f9ng natri valproat \u0111\u1ec1u c\u1ea7n nh\u1eadn th\u1ee9c v\u00e0 hi\u1ec3u \u0111\u01b0\u1ee3c c\u00e1c r\u1ee7i ro khi d\u00f9ng thu\u1ed1c.<\/p>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1eb1ng natri valproat \u1edf tr\u1ebb em g\u00e1i v\u00e0 ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh n\u1edf ph\u1ea3i \u0111\u01b0\u1ee3c gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd b\u1edfi chuy\u00ean gia y t\u1ebf. C\u1ea7n th\u1ea3o lu\u1eadn v\u1edbi b\u00e1c s\u1ef9 n\u1ebfu b\u1ec7nh nh\u00e2n c\u00f3 \u00fd \u0111\u1ecbnh ng\u1eebng d\u00f9ng natri valproat.<\/p>\n<h2>Khuy\u1ebfn c\u00e1o cho b\u1ec7nh nh\u00e2n (tr\u1ebb em g\u00e1i\/ph\u1ee5 n\u1eef):<\/h2>\n<p>Natri valproat c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i nghi\u00eam tr\u1ecdng cho thai nhi khi s\u1eed d\u1ee5ng trong th\u1eddi k\u1ef3 mang thai.<br \/>\nTrao \u0111\u1ed5i v\u1edbi b\u00e1c s\u0129 n\u1ebfu c\u00f3 b\u1ea5t k\u1ef3 th\u1eafc m\u1eafc n\u00e0o v\u1ec1 l\u1ee3i \u00edch \u2013 nguy c\u01a1 khi d\u00f9ng thu\u1ed1c.<br \/>\nB\u00e1c s\u0129 ch\u1ec9 k\u00ea \u0111\u01a1n natri valproat n\u1ebfu c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c kh\u00f4ng hi\u1ec7u qu\u1ea3 ho\u1eb7c b\u1ec7nh nh\u00e2n kh\u00f4ng dung n\u1ea1p \u0111\u01b0\u1ee3c thu\u1ed1c.<br \/>\nC\u1ea7n l\u00e0m x\u00e9t nghi\u1ec7m tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng natri valproat v\u00e0 trong khi \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o b\u1ec7nh nh\u00e2n kh\u00f4ng mang thai.<br \/>\nLu\u00f4n s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 khi d\u00f9ng natri valproat.<br \/>\nLi\u00ean h\u1ec7 v\u1edbi b\u00e1c s\u0129 c\u1ee7a b\u1ea1n ngay l\u1eadp t\u1ee9c n\u1ebfu b\u1ea1n ngh\u0129 r\u1eb1ng b\u1ea1n c\u00f3 th\u1ec3 mang thai. Th\u1ea3o lu\u1eadn v\u1edbi b\u00e1c s\u1ef9 tr\u01b0\u1edbc khi ng\u1eebng d\u00f9ng natri valproat.<br \/>\nKh\u00e1m s\u1ee9c kh\u1ecfe \u0111\u1ecbnh k\u1ef3 (\u00edt nh\u1ea5t 1 l\u1ea7n\/n\u0103m)<\/p>\n<h2>Th\u00f4ng tin cho ng\u01b0\u1eddi k\u00ea \u0111\u01a1n:<\/h2>\n<p>\u0110i\u1ec1u tr\u1ecb b\u1eb1ng natri valproat ph\u1ea3i \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u v\u00e0 gi\u00e1m s\u00e1t b\u1edfi chuy\u00ean gia y t\u1ebf.<br \/>\nKh\u00f4ng k\u00ea \u0111\u01a1n natri valproat \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh \u1edf ph\u1ee5 n\u1eef mang thai tr\u1eeb khi kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb thay th\u1ebf ph\u00f9 h\u1ee3p.<br \/>\nKh\u00f4ng k\u00ea \u0111\u01a1n natri valproat \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c ho\u1eb7c b\u1ea5t k\u1ef3 t\u00ecnh tr\u1ea1ng n\u00e0o kh\u00e1c \u1edf ph\u1ee5 n\u1eef mang thai.<br \/>\nKhuy\u1ebfn kh\u00edch b\u1ec7nh nh\u00e2n tham gia th\u1ea3o lu\u1eadn v\u00e0 ki\u1ec3m tra xem b\u1ec7nh nh\u00e2n c\u00f3 hi\u1ec3u v\u1ec1 c\u00e1c nguy c\u01a1 v\u00e0 bi\u1ec7n ph\u00e1p c\u1ea7n thi\u1ebft \u0111\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 hay kh\u00f4ng.<br \/>\nC\u00e2n nh\u1eafc th\u00eam cho ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh n\u1edf:<\/p>\n<p>\u0110\u00e1nh gi\u00e1 v\u00e0 th\u1ea3o lu\u1eadn v\u1ec1 l\u1ee3i \u00edch \u2013 nguy c\u01a1 khi \u0111i\u1ec1u tr\u1ecb b\u1eb1ng natri valproat tr\u00ean t\u1eebng b\u1ec7nh nh\u00e2n tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng.<br \/>\nTh\u1ea3o lu\u1eadn v\u1ec1 nguy c\u01a1 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn thai nhi do ph\u01a1i nhi\u1ec5m natri valproat trong thai k\u1ef3. Nh\u1eefng r\u1ee7i ro n\u00e0y bao g\u1ed3m d\u1ecb t\u1eadt b\u1ea9m sinh (VD: t\u1eadt n\u1ee9t \u0111\u1ed1t s\u1ed1ng, h\u1edf h\u00e0m \u1ebfch, d\u1ecb t\u1eadt tim) v\u00e0 r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh (VD: ch\u1eadm ph\u00e1t tri\u1ec3n, v\u1ea5n \u0111\u1ec1 h\u1ecdc t\u1eadp, IQ th\u1ea5p h\u01a1n, t\u1ef1 k\u1ef7).<br \/>\nTh\u1ea3o lu\u1eadn v\u1ec1 s\u1ef1 c\u1ea7n thi\u1ebft ph\u1ea3i s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<br \/>\nTh\u1ea3o lu\u1eadn v\u1ec1 s\u1ef1 c\u1ea7n thi\u1ebft ph\u1ea3i x\u00e9t nghi\u1ec7m m\u00e1u tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 trong khi \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o b\u1ec7nh nh\u00e2n kh\u00f4ng mang thai.<br \/>\nC\u00e1c chuy\u00ean gia y t\u1ebf v\u1ec1 \u0111\u1ed9ng kinh ho\u1eb7c r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c c\u1ea7n xem x\u00e9t \u0111\u1ecbnh k\u1ef3 qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb (\u00edt nh\u1ea5t 1 l\u1ea7n\/n\u0103m).<br \/>\nKhuy\u1ebfn c\u00e1o b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u01b0\u1ee3c t\u1ef1 \u00fd ng\u1eebng natri valproat v\u00e0 li\u00ean h\u1ec7 v\u1edbi b\u00e1c s\u0129 ngay l\u1eadp t\u1ee9c trong tr\u01b0\u1eddng h\u1ee3p nghi ng\u1edd c\u00f3 thai.<br \/>\nC\u00e2n nh\u1eafc th\u00eam cho tr\u1ebb em g\u00e1i:<\/p>\n<p>\u0110\u1ea3m b\u1ea3o cha m\u1eb9\/ng\u01b0\u1eddi ch\u0103m s\u00f3c hi\u1ec3u s\u1ef1 c\u1ea7n thi\u1ebft ph\u1ea3i li\u00ean h\u1ec7 v\u1edbi chuy\u00ean gia y t\u1ebf khi s\u1eed d\u1ee5ng natri valproat cho con \u1edf \u0111\u1ed9 tu\u1ed5i d\u1eady th\u00ec.<br \/>\n\u0110\u1ea3m b\u1ea3o cha m\u1eb9\/ ng\u01b0\u1eddi ch\u0103m s\u00f3c tr\u1ebb em g\u00e1i trong \u0111\u1ed9 tu\u1ed5i d\u1eady th\u00ec \u0111\u01b0\u1ee3c cung c\u1ea5p th\u00f4ng tin ch\u00ednh x\u00e1c v\u1ec1 c\u00e1c nguy c\u01a1 d\u1ecb t\u1eadt thai nhi v\u00e0 r\u1ed1i lo\u1ea1n ph\u00e1t tri\u1ec3n th\u1ea7n kinh.<br \/>\nC\u00e1c chuy\u00ean gia y t\u1ebf c\u1ea7n \u0111\u00e1nh gi\u00e1 l\u1ea1i s\u1ef1 c\u1ea7n thi\u1ebft ph\u1ea3i \u0111i\u1ec1u tr\u1ecb b\u1eb1ng natri valproat v\u00e0 xem x\u00e9t c\u00e1c l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb thay th\u1ebf cho nh\u1eefng b\u1ec7nh nh\u00e2n \u1edf \u0111\u1ed9 tu\u1ed5i d\u1eady th\u00ec, th\u1ea3o lu\u1eadn v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 n\u1ebfu d\u00f9ng natri valproat.<\/p>\n<h2>Th\u00f4ng tin cho d\u01b0\u1ee3c s\u1ef9:<\/h2>\n<p>Ph\u00e2n ph\u1ed1i natri valproat trong bao b\u00ec g\u1ed1c \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o ng\u01b0\u1eddi d\u00f9ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 ph\u1ee5 n\u1eef v\u00e0 tr\u1ebb em g\u00e1i c\u00f3 th\u1ec3 ti\u1ebfp c\u1eadn v\u1edbi c\u1ea3nh b\u00e1o c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t.<br \/>\n\u0110\u1ea3m b\u1ea3o vi\u1ec7c s\u1eed d\u1ee5ng bi\u1ec7n ph\u00e1p tr\u00e1nh thai hi\u1ec7u qu\u1ea3 li\u00ean t\u1ee5c trong su\u1ed1t qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb.<br \/>\nNh\u1eafc nh\u1edf b\u1ec7nh nh\u00e2n kh\u00f4ng t\u1ef1 \u00fd ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng natri valproat v\u00e0 li\u00ean h\u1ec7 ngay v\u1edbi b\u00e1c s\u0129 trong tr\u01b0\u1eddng h\u1ee3p nghi ng\u1edd c\u00f3 thai.<br \/>\nNgu\u1ed3n: <a href=\"https:\/\/www.medsafe.govt.nz\/safety\/Alerts\/Epilim.asp\" rel=\"noopener\">https:\/\/www.medsafe.govt.nz\/safety\/Alerts\/Epilim.asp<\/a><\/p>\n<p>Ng\u01b0\u1eddi t\u1ed5ng h\u1ee3p: V\u00f5 Th\u1ecb Th\u00f9y \u2013 Nguy\u1ec5n Ph\u01b0\u01a1ng Th\u00fa &#8211; Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u1eed d\u1ee5ng natri valproat trong thai k\u1ef3 c\u00f3 nguy c\u01a1 cao g\u00e2y d\u1ecb t\u1eadt b\u1ea9m sinh cho thai nhi. Do \u0111\u00f3, t\u1ea1i New Zealand, ch\u1ec9 \u0111\u1ecbnh c\u1ee7a thu\u1ed1c n\u00e0y khi s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c \u0111\u00e3 \u0111\u01b0\u1ee3c thay \u0111\u1ed5i. Natri valproat hi\u1ec7n ch\u1ec9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf nh\u1eefng ph\u1ee5 n\u1eef c\u00f3 [&#8230;]\n","protected":false},"author":1,"featured_media":5040,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5038","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=5038"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/5038\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/5040"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=5038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=5038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=5038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}