{"id":4764,"date":"2019-03-17T14:20:13","date_gmt":"2019-03-17T07:20:13","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=4764"},"modified":"2019-03-17T14:20:13","modified_gmt":"2019-03-17T07:20:13","slug":"cac-tuong-tac-thuoc-nghiem-trong-can-luu-y","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/cac-tuong-tac-thuoc-nghiem-trong-can-luu-y\/","title":{"rendered":"C\u00e1c t\u01b0\u01a1ng t\u00e1c thu\u1ed1c nghi\u00eam tr\u1ecdng c\u1ea7n l\u01b0u \u00fd"},"content":{"rendered":"

T\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e0 g\u00ec?<\/h2>\n

T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/strong> (Drug-drug interaction \u2013 DDI) l\u00e0 v\u1ea5n \u0111\u1ec1 th\u01b0\u1eddng g\u1eb7p trong l\u00e2m s\u00e0ng c\u0169ng nh\u01b0 trong vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c, \u0111\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n g\u00e2y ra bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c, bao g\u1ed3m xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh, gia t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5, g\u00e2y ra c\u00e1c ph\u1ea3n \u1ee9ng \u0111\u1ed9c h\u1ea1i trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb, th\u1ea5t b\u1ea1i trong \u0111i\u1ec1u tr\u1ecb ho\u1eb7c c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong cho b\u1ec7nh nh\u00e2n.<\/p>\n

Nguy\u00ean nh\u00e2n g\u00f3p ph\u1ea7n v\u00e0o DDI bao g\u1ed3m kho\u1ea3ng li\u1ec1u \u0111i\u1ec1u tr\u1ecb h\u1eb9p li\u00ean quan \u0111\u1ebfn m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c v\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh c\u1ee7a b\u1ec7nh nh\u00e2n. R\u00f5 r\u00e0ng, \u0111i\u1ec1u quan tr\u1ecdng l\u00e0 d\u01b0\u1ee3c s\u0129 ph\u1ea3i l\u01b0u \u00fd v\u00e0 hi\u1ec3u \u0111\u01b0\u1ee3c nh\u1eefng DDI c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u00e1c h\u1ea1i \u0111\u00e1ng k\u1ec3 cho b\u1ec7nh nh\u00e2n. B\u00e0i vi\u1ebft n\u00e0y t\u1eadp trung gi\u1edbi thi\u1ec7u m\u1ed9t s\u1ed1 DDI nghi\u00eam tr\u1ecdng, \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf B\u1ea3ng A. [1]\n

Methotrexate v\u00e0 Probenecid<\/h2>\n

Khi d\u00f9ng Probenecid v\u1edbi li\u1ec1u Methotrexate ch\u1ed1ng ung th\u01b0, k\u1ebft qu\u1ea3 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng g\u1ea5p 2 \u0111\u1ebfn 3 l\u1ea7n n\u1ed3ng \u0111\u1ed9 Methotrexate. Probenecid ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf b\u00e0i ti\u1ebft Methotrexate \u1edf th\u1eadn, do \u0111\u00f3 c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y \u0111\u1ed9c. C\u00e1c tri\u1ec7u ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c Methotrexate nghi\u00eam tr\u1ecdng bao g\u1ed3m ti\u00eau ch\u1ea3y, n\u00f4n m\u1eeda, vi\u00eam m\u00e0ng ph\u1ed5i v\u00e0 suy th\u1eadn v\u00e0 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1eed vong. T\u01b0\u01a1ng t\u00e1c n\u00e0y v\u1edbi Methotrexate c\u0169ng x\u1ea3y ra v\u1edbi nh\u00f3m Penicillin (v\u00ed d\u1ee5, Amoxicillin, Carbenicillin) v\u00e0 Salicylat. Nguy c\u01a1 v\u1edbi Methotrexate li\u1ec1u th\u1ea5p (th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho vi\u00eam kh\u1edbp) l\u00e0 th\u1ea5p h\u01a1n. Celecoxib kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc Methotrexate v\u00e0 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn thay th\u1ebf. [1]\n

Gliclazid v\u00e0 Fluconazol\/ Miconazol<\/h2>\n

Fluconazol g\u00e2y \u1ee9c ch\u1ebf enzym gan, \u0111\u1ed3ng th\u1eddi l\u00e0m t\u0103ng th\u1eddi gian b\u00e1n th\u1ea3i sulfamide t\u1eeb \u0111\u00f3 gi\u1ea3m chuy\u1ec3n h\u00f3a Gliclazid, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Glicazid trong guy\u1ebft t\u01b0\u01a1ng, g\u00e2y nguy c\u01a1 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, h\u00f4n m\u00ea. Khi \u0111i\u1ec1u tr\u1ecb c\u1ea7n l\u01b0u \u00fd tr\u00e1nh ph\u1ed1i h\u1ee3p hai thu\u1ed1c n\u00e0y. [2]\n

Bromocriptine v\u00e0 Pseudoephedrine<\/h2>\n

T\u01b0\u01a1ng t\u00e1c c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn co m\u1ea1ch ngo\u1ea1i bi\u00ean nghi\u00eam tr\u1ecdng, nh\u1ecbp nhanh th\u1ea5t, co gi\u1eadt v\u00e0 c\u00f3 th\u1ec3 t\u1eed vong. T\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u00e1ng ch\u00fa \u00fd c\u1ee7a Bromocriptine bao g\u1ed3m l\u00e0m d\u00e0y d\u1ecbch ti\u1ebft ph\u1ebf qu\u1ea3n v\u00e0 ngh\u1eb9t m\u0169i. \u0110i\u1ec1u n\u00e0y r\u1ea5t c\u00f3 \u00fd ngh\u0129a v\u00ec b\u1ec7nh nh\u00e2n d\u00f9ng Bromocriptine r\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng t\u1ef1 d\u00f9ng thu\u1ed1c th\u00f4ng m\u0169i OTC ch\u1ee9a Pseudoephedrine g\u00e2y n\u00ean c\u00e1c c\u1eb7p t\u01b0\u01a1ng t\u00e1c tr\u00ean. B\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng Bromocriptine n\u00ean \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o \u0111\u1ec3 tr\u00e1nh c\u00e1c tr\u01b0\u1eddng h\u1ee3p ph\u1ed1i h\u1ee3p thu\u1ed1c tr\u00ean. [1]\n

Clarithromycin v\u00e0 Simvastatin<\/h2>\n

Clarithromycin \u1ee9c ch\u1ebf enzym chuy\u1ec3n h\u00f3a Simvastatin, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c v\u00e0 t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a Simvastatin. C\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a DDI l\u00e0 g\u00e2y ti\u00eau c\u01a1 v\u00e2n, m\u1eafc c\u00e1c b\u1ec7nh c\u01a1 (\u0111au c\u01a1, y\u1ebfu c\u01a1\u2026), suy gan. N\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p, thay th\u1ebf Clarithromycin b\u1eb1ng Azithromycin (kh\u00f4ng \u1ee9c ch\u1ebf enzym gan) ho\u1eb7c thay Simvastatin b\u1eb1ng Rosuvastatin (\u00edt \u0111\u1ed9c t\u00ednh h\u01a1n). [2]\n

Sildenafil v\u00e0 Isosorbide Mononitrate<\/h2>\n

Sildenafil c\u00f3 th\u1ec3 l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a Isosorbide Mononitrate, l\u00e0m t\u0103ng nguy c\u01a1 d\u1eabn \u0111\u1ebfn t\u1eed vong. B\u1ec7nh nh\u00e2n d\u00f9ng Isosorbide Mononitrate ho\u1eb7c b\u1ea5t k\u1ef3 nitrate n\u00e0o, k\u1ec3 c\u1ea3 nitroglycerin, kh\u00f4ng n\u00ean d\u00f9ng Sildenafil. [1]\n

Erythromycin v\u00e0 Theophyllin<\/h2>\n

Erythromycin g\u00e2y \u1ee9c ch\u1ebf enzym gan l\u00e0m cho nhi\u1ec1u thu\u1ed1c kh\u00f3 chuy\u1ec3n h\u00f3a qua gan trong \u0111\u00f3 c\u00f3 Theophyllin, l\u00e0m k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng, g\u00e2y t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a Theophyllin (bi\u1ec3u hi\u1ec7n: n\u00f4n, bu\u1ed3n n\u00f4n, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, co gi\u1eadt). Khi k\u1ebft h\u1ee3p thu\u1ed1c n\u00ean gi\u1ea3m li\u1ec1u Theophyllin v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e1c bi\u1ec3u hi\u1ec7n ng\u1ed9 \u0111\u1ed9c. Trong nh\u00f3m Macrolid c\u00f3 Erythromycin v\u00e0 Clarithromycin g\u00e2y \u1ee9c ch\u1ebf men gan kh\u00e1 m\u1ea1nh. Tr\u01b0\u1eddng h\u1ee3p ph\u1ea3i d\u00f9ng Macrolid c\u00f9ng m\u1ed9t s\u1ed1 thu\u1ed1c chuy\u1ec3n h\u00f3a qua gan nhi\u1ec1u v\u00e0 c\u00f3 \u0111\u1ed9c t\u00ednh cao n\u00ean d\u00f9ng Azithromycin. [2]\n

Atropin v\u00e0 Kali clorid (d\u1ea1ng u\u1ed1ng)<\/h2>\n

Atropin l\u00e0m l\u01b0u gi\u1eef ho\u1eb7c ch\u1eadm qu\u00e1 tr\u00ecnh chuy\u1ec3n Kali clorid \u0111i qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. N\u1ed3ng \u0111\u1ed9 Kali clorid t\u0103ng g\u00e2y k\u00edch \u1ee9ng m\u1ea1nh \u0111\u01b0\u1eddng ti\u00eau h\u00f3a g\u00e2y t\u1ed5n th\u01b0\u01a1ng lo\u00e9t \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.N\u00ean d\u00f9ng Kali d\u1ea1ng ti\u00eam, \u0111\u1eb7c bi\u1ec7t ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho c\u00e1c b\u1ec7nh nh\u00e2n li\u1ec7t gi\u01b0\u1eddng. [2][4]\n

Nh\u00f3m Opioid v\u00e0 nh\u00f3m Benzodiazepin<\/h2>\n

Nh\u00f3m Benzodiazepin l\u00e0 thu\u1ed1c an th\u1ea7n \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh v\u1ec1 th\u1ec3 ch\u1ea5t (bao g\u1ed3m: \u0111au l\u01b0ng m\u00e3n t\u00ednh, vi\u00eam kh\u1edbp, \u0111au \u0111\u1ea7u g\u1ed1i t\u00e1i ph\u00e1t, ch\u1ee9ng \u0111au n\u1eeda \u0111\u1ea7u,\u2026). Thu\u1ed1c cho ph\u00e9p b\u1ec7nh nh\u00e2n qu\u00ean \u0111i nh\u1eefng lo l\u1eafng v\u1ec1 c\u01a1n \u0111au c\u1ee7a h\u1ecd, v\u00ec v\u1eady c\u00f3 \u0111\u01b0\u1ee3c gi\u1ea5c ng\u1ee7 ngon h\u01a1n. B\u1ec7nh nh\u00e2n c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00ea c\u00e1c lo\u1ea1i thu\u1ed1c gi\u1ea3m \u0111au c\u00f3 ch\u1ee9a Opioid v\u00e0 n\u1ebfu c\u00f3, vi\u1ec7c ph\u1ed1i h\u1ee3p hai lo\u1ea1i thu\u1ed1c n\u00e0y v\u1edbi nhau c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nh\u1eefng nguy hi\u1ec3m th\u1ef1c s\u1ef1. Nh\u00f3m Opioid c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng an th\u1ea7n, ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 c\u1ea3m th\u1ea5y bu\u1ed3n ng\u1ee7 qu\u00e1 m\u1ee9c ch\u1ec9 trong ch\u1ed1c l\u00e1t sau khi u\u1ed1ng c\u1ea3 hai thu\u1ed1c n\u00e0y. D\u00f9ng v\u1edbi li\u1ec1u cao g\u00e2y \u0111\u00f3ng c\u1eeda c\u00e1c trung t\u00e2m quan tr\u1ecdng c\u1ee7a n\u00e3o, r\u01a1i v\u00e0o tr\u1ea1ng th\u00e1i h\u00f4n m\u00ea v\u00e0 kh\u00f4ng bao gi\u1edd t\u1ec9nh d\u1eady. Khuy\u1ebfn c\u00e1o kh\u00f4ng n\u00ean k\u1ebft h\u1ee3p hai lo\u1ea1i thu\u1ed1c tr\u00ean. [3]\n

B\u1ea2NG A \u2013 C\u00c1C T\u01af\u01a0NG T\u00c1C THU\u1ed0C NGHI\u00caM TR\u1eccNG<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
C\u00e1c t\u01b0\u01a1ng t\u00e1c thu\u1ed1c nghi\u00eam tr\u1ecdng<\/td>\n<\/tr>\n
Thu\u1ed1c 1<\/td>\nThu\u1ed1c 2<\/td>\nC\u01a1 ch\u1ebf<\/td>\nH\u1eadu qu\u1ea3<\/td>\nGi\u1ea3i ph\u00e1p<\/td>\n<\/tr>\n
Methotrexate<\/td>\nProbenecid<\/td>\nProbenecid\u00a0g\u00e2y \u1ee9c ch\u1ebf b\u00e0i ti\u1ebft\u00a0Methotrexate\u00a0\u1edf th\u1eadn \u00a0l\u00e0m t\u0103ng g\u1ea5p 2 \u0111\u1ebfn 3 l\u1ea7n n\u1ed3ng \u0111\u1ed9 ch\u1ea5t n\u00e0y, do \u0111\u00f3 c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y \u0111\u1ed9c. T\u01b0\u01a1ng t\u00e1c n\u00e0y c\u0169ng x\u1ea3y ra v\u1edbi nh\u00f3m\u00a0Penicillin\u00a0v\u00e0\u00a0Salicylat.<\/td>\nC\u00e1c tri\u1ec7u ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c\u00a0Methotrexatenghi\u00eam tr\u1ecdng bao g\u1ed3m ti\u00eau ch\u1ea3y, n\u00f4n m\u1eeda, vi\u00eam m\u00e0ng ph\u1ed5i v\u00e0 suy th\u1eadn v\u00e0 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1eed vong.<\/td>\nCelecoxibkh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc\u00a0Methotrexatev\u00e0 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn thay th\u1ebf. <\/td>\n<\/tr>\n
Gliclazid<\/td>\nFluconazol\/ Miconazol<\/td>\nFluconazol\u00a0g\u00e2y \u1ee9c ch\u1ebf enzym gan, \u0111\u1ed3ng th\u1eddi l\u00e0m\u00a0 t\u0103ng th\u1eddi gian b\u00e1n th\u1ea3i sulfamide t\u1eeb \u0111\u00f3 gi\u1ea3m chuy\u1ec3n h\u00f3a\u00a0Gliclazid.<\/td>\nT\u0103ng n\u1ed3ng \u0111\u1ed9\u00a0Glicazid\u00a0trong guy\u1ebft t\u01b0\u01a1ng, g\u00e2y nguy c\u01a1 t\u1ee5t \u0111\u01b0\u1eddng huy\u1ebft, h\u00f4n m\u00ea.<\/td>\nL\u01b0u \u00fd tr\u00e1nh k\u1ebft h\u1ee3p.<\/td>\n<\/tr>\n
Bromocriptine<\/td>\nPseudoephe-drine<\/td>\nBromocriptine\u00a0c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 l\u00e0m d\u00e0y d\u1ecbch ti\u1ebft ph\u1ebf qu\u1ea3n v\u00e0 ngh\u1eb9t m\u0169i, b\u1ec7nh nh\u00e2n d\u00f9ng\u00a0Bromocriptine\u00a0r\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng t\u1ef1 d\u00f9ng thu\u1ed1c th\u00f4ng m\u0169i OTC ch\u1ee9a\u00a0Pseudoephedrineg\u00e2y t\u01b0\u01a1ng t\u00e1c thu\u1ed1c.<\/td>\nD\u1eabn \u0111\u1ebfn co m\u1ea1ch ngo\u1ea1i bi\u00ean nghi\u00eam tr\u1ecdng, nh\u1ecbp nhanh th\u1ea5t, co gi\u1eadt v\u00e0 c\u00f3 th\u1ec3 t\u1eed vong.<\/td>\nB\u1ec7nh nh\u00e2n \u0111ang d\u00f9ng\u00a0Bromocriptinen\u00ean \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o \u0111\u1ec3 tr\u00e1nh tr\u01b0\u1eddng h\u1ee3p ph\u1ed1i h\u1ee3p thu\u1ed1c. <\/td>\n<\/tr>\n
Clarithromycin<\/td>\nSimvastatin<\/td>\nClarithromycin\u00a0\u1ee9c ch\u1ebf enzym chuy\u1ec3n h\u00f3a\u00a0Simvastatin, t\u0103ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c v\u00e0 t\u0103ng \u0111\u1ed9c t\u00ednh c\u1ee7a\u00a0Simvastatin.<\/td>\nG\u00e2y ti\u00eau c\u01a1 v\u00e2n, m\u1eafc c\u00e1c b\u1ec7nh c\u01a1 (\u0111au c\u01a1, y\u1ebfu c\u01a1\u2026), suy gan.<\/td>\nN\u00ean thay\u00a0Clarithromycinb\u1eb1ng\u00a0Azithromycinho\u1eb7c thay\u00a0Simvastatinb\u1eb1ng\u00a0Rosuvastatin.<\/td>\n<\/tr>\n
Sildenafil<\/td>\nIsosorbide Mononitrate<\/td>\nSildenafil\u00a0l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p c\u1ee7a\u00a0IsosorbideMononitrate.<\/td>\nG\u00e2y gi\u1ea3m huy\u1ebft \u00e1p \u0111\u1ed9t ng\u1ed9t, tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng g\u00e2y t\u1eed vong.<\/td>\nB\u1ec7nh nh\u00e2n d\u00f9ng\u00a0IsosorbideMono\u2013nitrateho\u1eb7c b\u1ea5t k\u1ef3 nitrate n\u00e0o kh\u00f4ng n\u00ean d\u00f9ng\u00a0Sildenafil.<\/td>\n<\/tr>\n
Erythromycin<\/td>\nTheophyllin<\/td>\nErythromycin\u00a0g\u00e2y \u1ee9c ch\u1ebf enzym gan l\u00e0m cho nhi\u1ec1u thu\u1ed1c kh\u00f3 chuy\u1ec3n h\u00f3a qua gan trong \u0111\u00f3 c\u00f3\u00a0Theophyllin. <\/td>\nK\u00e9o d\u00e0i t\u00e1c d\u1ee5ng l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 \u0111\u1ed9c t\u00ednh c\u1ee7a\u00a0Theophyllin(n\u00f4n, bu\u1ed3n n\u00f4n, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, co gi\u1eadt). <\/td>\nGi\u1ea3m li\u1ec1u\u00a0Theophyllin\u00a0 v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd c\u00e1c bi\u1ec3u hi\u1ec7n ng\u1ed9 \u0111\u1ed9c. N\u00ean xem x\u00e9t d\u00f9ng\u00a0Azithromycinnh\u01b0 bi\u1ec7n ph\u00e1p thay th\u1ebf.<\/td>\n<\/tr>\n
Atropin<\/td>\nKali clorid (d\u1ea1ng u\u1ed1ng)<\/td>\nAtropin\u00a0l\u00e0m l\u01b0u gi\u1eef ho\u1eb7c ch\u1eadm qu\u00e1 tr\u00ecnh chuy\u1ec3n\u00a0Kali\u00a0clorid\u00a0\u0111i qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a<\/td>\nKali\u00a0cloridg\u00e2y k\u00edch \u1ee9ng m\u1ea1nh \u0111\u01b0\u1eddng ti\u00eau h\u00f3a l\u00e0m t\u1ed5n th\u01b0\u01a1ng, lo\u00e9t \u0111\u01b0\u1eddng ti\u00eau h\u00f3a.<\/td>\n\u0110\u1eb7c bi\u1ec7t ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh cho c\u00e1c b\u1ec7nh nh\u00e2n li\u1ec7t gi\u01b0\u1eddng. N\u00ean d\u00f9ng Kali d\u1ea1ng ti\u00eam.<\/td>\n<\/tr>\n
Nh\u00f3m Opioid<\/td>\nNh\u00f3m Benzo-diazepin<\/td>\nNh\u00f3m\u00a0Benzodiazepin\u00a0v\u00e0 nh\u00f3m\u00a0Opioid\u00a0\u0111\u1ec1u c\u00f3 t\u00e1c d\u1ee5ng an th\u1ea7n, nh\u01b0ng hai lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 c\u1ee7ng c\u1ed1 v\u00e0 t\u0103ng c\u01b0\u1eddng l\u1eabn nhau g\u00e2y qu\u00e1 li\u1ec1u.<\/td>\nD\u00f9ng v\u1edbi li\u1ec1u cao g\u00e2y \u0111\u00f3ng c\u1eeda c\u00e1c trung t\u00e2m quan tr\u1ecdng c\u1ee7a n\u00e3o, r\u01a1i v\u00e0o tr\u1ea1ng th\u00e1i h\u00f4n m\u00ea v\u00e0 kh\u00f4ng bao gi\u1edd t\u1ec9nh d\u1eady.<\/td>\nL\u01b0u \u00fd tr\u00e1nh k\u1ebft h\u1ee3p.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/h2>\n
    \n
  1. Shauna B. Burns and William N. Kelly (2002). 10 Drug Interactions Every Pharmacist Should Know. Pharmacy Times. Link:<\/li>\n<\/ol>\n

    https:\/\/www.pharmacytimes.com\/publications\/issue\/2002\/2002-11\/2002-11-7010<\/em><\/a><\/p>\n

      \n
    1. DS. Ninh Mai H\u01b0\u1eddng (2017). T\u01b0\u01a1ng t\u00e1c thu\u1ed1c. B\u1ec7nh vi\u1ec7n Trung \u01af\u01a1ng Th\u00e1i Nguy\u00ean \u2013 Khoa D\u01b0\u1ee3c. Link:<\/li>\n<\/ol>\n

      http:\/\/www.bvdktuthainguyen.gov.vn\/uploads\/media\/duoc\/T%C6%B0%C6%A1ng%20t%C3%A1c%20thu%E1%BB%91c%20trong%20th%E1%BB%B1c%20h%C3%A0nh%20l%C3%A2m%20s%C3%A0ng.pdf<\/em><\/a><\/p>\n

        \n
      1. Foundation Recovery Network (2013).\u00a0Dangerous Drug Combinations. Dual Diagnosis.Org. Link:<\/li>\n<\/ol>\n

        https:\/\/www.dualdiagnosis.org\/drug-addiction\/dangerous-combinations\/#combo<\/em><\/a><\/p>\n

          \n
        1. Amber Erickson Gabbey and Rachel Nall (2016). Hypokalemia. Healthline. Link:<\/li>\n<\/ol>\n

          https:\/\/www.healthline.com\/health\/hypokalemia<\/a><\/u><\/em><\/p>\n

          T\u00e1c gi\u1ea3: Sinh vi\u00ean D\u01b0\u1ee3c Phan Ng\u1ecdc \u00c1nh, L\u00e2m H\u1ed3ng Ch\u00e2u Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Y Khoa Ph\u1ea1m Ng\u1ecdc Th\u1ea1ch – Nh\u1ecbp c\u1ea7u D\u01b0\u1ee3c L\u00e2m S\u00e0ng.
          \n<\/em><\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          T\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e0 g\u00ec? T\u01b0\u01a1ng t\u00e1c thu\u1ed1c (Drug-drug interaction \u2013 DDI) l\u00e0 v\u1ea5n \u0111\u1ec1 th\u01b0\u1eddng g\u1eb7p trong l\u00e2m s\u00e0ng c\u0169ng nh\u01b0 trong vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c, \u0111\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n g\u00e2y ra bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c, bao g\u1ed3m xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh, gia t\u0103ng t\u00e1c d\u1ee5ng ph\u1ee5, g\u00e2y ra […]\n","protected":false},"author":1,"featured_media":3811,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4764","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4764","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=4764"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4764\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/3811"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=4764"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=4764"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=4764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}