{"id":4757,"date":"2019-03-17T11:41:18","date_gmt":"2019-03-17T04:41:18","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=4757"},"modified":"2019-03-17T11:57:33","modified_gmt":"2019-03-17T04:57:33","slug":"phan-ung-co-hai-cua-thuoc-adverse-drug-reaction-adr","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/phan-ung-co-hai-cua-thuoc-adverse-drug-reaction-adr\/","title":{"rendered":"Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c (Adverse Drug Reaction \u2013 ADR)"},"content":{"rendered":"<h2>GI\u1edaI THI\u1ec6U<\/h2>\n<p>Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c (Adverse Drug Reaction-ADR) x\u1ea3y ra g\u1ea7n nh\u01b0 h\u00e0ng ng\u00e0y trong c\u00e1c c\u01a1 s\u1edf ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe v\u00e0 c\u00f3 th\u1ec3 g\u00e2y \u1ea3nh h\u01b0\u1edfng x\u1ea5u \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n, d\u1eabn \u0111\u1ebfn b\u1ec7nh t\u1eadt v\u00e0 t\u1eed vong. Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c cho l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y t\u1eed vong \u0111\u1ee9ng h\u00e0ng th\u1ee9 t\u01b0, cao h\u01a1n b\u1ec7nh ph\u1ed5i, AIDS v\u00e0 tai n\u1ea1n giao th\u00f4ng.<\/p>\n<p>C\u1ea3nh gi\u00e1c d\u01b0\u1ee3c l\u00e0 c\u00f4ng t\u00e1c nghi\u00ean c\u1ee9u c\u00e1c th\u01b0\u01a1ng t\u1ed5n li\u00ean quan \u0111\u1ebfn thu\u1ed1c v\u00e0 \u0111\u01b0a ra c\u00e1c khuy\u1ebfn c\u00e1o, bao g\u1ed3m vi\u1ec7c ph\u00e1t hi\u1ec7n, \u0111\u00e1nh gi\u00e1 v\u00e0 ph\u00f2ng ng\u1eeba ADR. D\u01b0\u1ee3c s\u0129 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong m\u1ed7i b\u01b0\u1edbc c\u1ee7a quy tr\u00ecnh c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c, gi\u00fap ng\u0103n ng\u1eeba b\u1ec7nh nh\u00e2n tr\u1ea3i qua c\u00e1c th\u1ee7 t\u1ee5c kh\u00f4ng c\u1ea7n thi\u1ebft ho\u1eb7c d\u00f9ng thu\u1ed1c kh\u00f4ng ch\u00ednh \u0111\u00e1ng. Ngo\u00e0i vi\u1ec7c gi\u1eef g\u00ecn s\u1ef1 an to\u00e0n v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng, c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c c\u00f2n ti\u1ebft ki\u1ec7m chi ph\u00ed cho b\u1ec7nh nh\u00e2n v\u00e0 c\u00e1c t\u1ed5 ch\u1ee9c ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe. [1]\n<h2>\u0110\u1ecaNH NGH\u0128A<\/h2>\n<p>Ch\u01b0\u01a1ng tr\u00ecnh gi\u00e1m s\u00e1t thu\u1ed1c c\u1ee7a t\u1ed5 ch\u1ee9c y t\u1ebf th\u1ebf gi\u1edbi \u0111\u01b0a ra m\u1ed9t \u0111\u1ecbnh ngh\u0129a v\u1ec1 ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c nh\u01b0 sau (WHO, 1972):<\/p>\n<p>\u201c Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c l\u00e0 ph\u1ea3n \u1ee9ng \u0111\u1ed9c h\u1ea1i, kh\u00f4ng \u0111\u01b0\u1ee3c \u0111\u1ecbnh tr\u01b0\u1edbc, xu\u1ea5t hi\u1ec7n \u1edf li\u1ec1u th\u01b0\u1eddng d\u00f9ng cho ng\u01b0\u1eddi \u0111\u1ec3 ph\u00f2ng b\u1ec7nh, ch\u1ea9n \u0111o\u00e1n hay ch\u1eefa b\u1ec7nh ho\u1eb7c nh\u1eb1m thay \u0111\u1ed5i m\u1ed9t ch\u1ee9c n\u0103ng sinh l\u00fd. \u0110\u1ecbnh ngh\u0129a n\u00e0y kh\u00f4ng bao g\u1ed3m c\u00e1c tr\u01b0\u1eddng h\u1ee3p th\u1ea5t b\u1ea1i tr\u1ecb li\u1ec7u, qu\u00e1 li\u1ec1u, l\u1ea1m d\u1ee5ng thu\u1ed1c, kh\u00f4ng tu\u00e2n th\u1ee7 v\u00e0 sai s\u00f3t trong tr\u1ecb li\u1ec7u\u201d<\/p>\n<p>Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c l\u00e0 m\u1ed9t trong nh\u1eefng nguy\u00ean nh\u00e2n l\u00e0m t\u0103ng ty\u0309 l\u1ec7 m\u1eafc b\u1ec7nh , ty\u0309 l\u1ec7 t\u01b0\u0309 vong , ke\u0301o d\u00e0i th\u1eddi gian n\u0103\u0300m vi\u1ec7n , gi\u1ea3m tu\u00e2n th\u1ee7 \u0111i\u1ec1u tr\u1ecb v\u00e0 t\u0103ng chi ph\u00ed \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n. V\u00ec v\u1eady, vi\u1ec7c gi\u00e1m s\u00e1t ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng nh\u0103\u0300m gi\u1ea3m thi\u1ec3u nh\u1eefng nguy c\u01a1 li\u00ean quan \u0111\u1ebfn thu\u1ed1c trong qu\u00e1 tr\u00ecnh s\u01b0\u0309 d\u1ee5ng thu\u1ed1c c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh.<br \/>\nPh\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c (ngh\u0129a l\u00e0 c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t, c\u00f3 th\u1ec3 tr\u00e1nh \u0111\u01b0\u1ee3c ho\u1eb7c kh\u00f4ng) ho\u1eb7c kh\u00f4ng th\u1ec3 d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c; n\u00f3 c\u00f3 th\u1ec3 x\u1ea3y ra th\u01b0\u1eddng xuy\u00ean ho\u1eb7c kh\u00f4ng th\u01b0\u1eddng xuy\u00ean \u0111\u1ed1i v\u1edbi m\u1ed9t thu\u1ed1c hay nhi\u1ec1u thu\u1ed1c m\u00e0 h\u1eadu qu\u1ea3 c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 nghi\u00eam tr\u1ecdng ho\u1eb7c kh\u00f4ng nghi\u00eam tr\u1ecdng. Vi\u1ec7c ph\u00e1t hi\u1ec7n nhanh nh\u1eefng ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i ph\u1ee5 thu\u1ed9c v\u00e0o th\u1eddi gian x\u1eed tr\u00ed v\u00e0 c\u00f4ng t\u00e1c t\u1ed5 ch\u1ee9c h\u1ec7 th\u1ed1ng C\u1ea3nh gi\u00e1c D\u01b0\u1ee3c. [2]\n<h2>PH\u00c2N LO\u1ea0I<\/h2>\n<p>Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c ban \u0111\u1ea7u \u0111\u01b0\u1ee3c ph\u00e2n th\u00e0nh hai lo\u1ea1i: A v\u00e0 B. ADR lo\u1ea1i A ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng s\u1eed d\u1ee5ng v\u00e0 c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c; ch\u00fang l\u00e0 s\u1ef1 gia t\u0103ng c\u1ee7a c\u00e1c t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd \u0111\u00e3 bi\u1ebft c\u1ee7a thu\u1ed1c. ADR lo\u1ea1i B kh\u00f4ng ph\u1ed5 bi\u1ebfn v\u00e0 kh\u00f4ng th\u1ec3 \u0111o\u00e1n tr\u01b0\u1edbc, n\u00f3 kh\u00f4ng ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng v\u00e0 ch\u1ec9 \u1ea3nh h\u01b0\u1edfng m\u1ed9t s\u1ed1 \u00edt ng\u01b0\u1eddi. Ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn v\u1edbi thu\u1ed1c l\u00e0 m\u1ed9t v\u00ed d\u1ee5 c\u1ee7a ADR lo\u1ea1i B. Ph\u1ea3n \u1ee9ng lo\u1ea1i A \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 ph\u1ea3n \u1ee9ng t\u0103ng c\u01b0\u1eddng v\u00e0 ph\u1ea3n \u1ee9ng lo\u1ea1i B \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 ph\u1ea3n \u1ee9ng b\u1ea5t th\u01b0\u1eddng. C\u00f3 th\u00eam b\u1ed1n lo\u1ea1i ph\u1ea3n \u1ee9ng \u0111\u01b0\u1ee3c b\u1ed5 sung v\u00e0o sau n\u00e0y, bao g\u1ed3m: ph\u1ea3n \u1ee9ng m\u00e3n t\u00ednh, li\u00ean quan \u0111\u1ebfn c\u1ea3 li\u1ec1u l\u01b0\u1ee3ng v\u00e0 th\u1eddi gian (lo\u1ea1i C), ph\u1ea3n \u1ee9ng ch\u1eadm (lo\u1ea1i D), h\u1ed9i ch\u1ee9ng ng\u1eebng thu\u1ed1c (lo\u1ea1i E) v\u00e0 g\u1ea7n \u0111\u00e2y nh\u1ea5t, thu\u1ed1c m\u1ea5t hi\u1ec7u l\u1ef1c \u0111\u00e3 tr\u1edf th\u00e0nh lo\u1ea1i th\u1ee9 s\u00e1u (lo\u1ea1i F)<\/p>\n<p>Kho\u1ea3ng 80% ADR trong b\u1ec7nh vi\u1ec7n thu\u1ed9c lo\u1ea1i A. C\u00e1c nh\u00f3m thu\u1ed1c th\u01b0\u1eddng g\u00e2y ra ADR \u1edf ng\u01b0\u1eddi l\u1edbn l\u00e0 corticosteroid tuy\u1ebfn th\u01b0\u1ee3ng th\u1eadn, kh\u00e1ng sinh, thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u, thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch, thu\u1ed1c tim m\u1ea1ch, thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid v\u00e0 thu\u1ed1c gi\u1ea3m \u0111au nh\u00f3m opioid. \u0110\u1ed1i v\u1edbi tr\u1ebb em, nh\u00f3m thu\u1ed1c ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0 thu\u1ed1c ch\u1ed1ng nhi\u1ec5m tr\u00f9ng, thu\u1ed1c h\u00f4 h\u1ea5p v\u00e0 v\u1eafc-xin.<\/p>\n<p style=\"text-align: center;\">B\u1ea3ng 1 : Ph\u00e2n lo\u1ea1i ADR theo t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd m\u1edf r\u1ed9ng [1]\n<table width=\"792\">\n<thead>\n<tr>\n<td colspan=\"4\" width=\"640\">PH\u00c2N LO\u1ea0I ADR THEO T\u00c1C D\u1ee4NG D\u01af\u1ee2C L\u00dd M\u1ede R\u1ed8NG<\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"130\">Lo\u1ea1i ph\u1ea3n \u1ee9ng<\/td>\n<td width=\"180\">\u0110\u1eb7c \u0111i\u1ec3m<\/td>\n<td width=\"180\">V\u00ed d\u1ee5<\/td>\n<td width=\"151\">C\u00e1ch x\u1eed l\u00fd<\/td>\n<\/tr>\n<tr>\n<td width=\"130\">A: Li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng (T\u0103ng c\u01b0\u1eddng)<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Ph\u1ed5 bi\u1ebfn\u2022\u00a0\u00a0\u00a0 Li\u00ean quan t\u1edbi t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd c\u1ee7a thu\u1ed1c-Ph\u00f3ng \u0111\u1ea1i \u0111\u00e1p \u1ee9ng thu\u1ed1c.<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 D\u1ec5 d\u1ef1 \u0111o\u00e1n<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 T\u1ef7 l\u1ec7 t\u1eed vong th\u1ea5p<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Kh\u00f4 mi\u1ec7ng v\u1edbi thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m ba v\u00f2ng, \u1ee9c ch\u1ebf h\u00f4 h\u1ea5p v\u1edbi opioids, ch\u1ea3y m\u00e1u v\u1edbi warfarin, h\u1ed9i ch\u1ee9ng serotonin v\u1edbi SSRI, \u0111\u1ed9c t\u00ednh digoxin<\/td>\n<td width=\"151\">\u2022\u00a0\u00a0\u00a0 Gi\u1ea3m li\u1ec1u ho\u1eb7c t\u1ea1m ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c.\u2022\u00a0\u00a0\u00a0 Xem x\u00e9t t\u00e1c \u0111\u1ed9ng c\u1ee7a c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi.<\/td>\n<\/tr>\n<tr>\n<td width=\"130\">B: Kh\u00f4ng li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng (B\u1ea5t th\u01b0\u1eddng)<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Kh\u00f4ng ph\u1ed5 bi\u1ebfn\u2022\u00a0\u00a0\u00a0 Kh\u00f4ng li\u00ean quan t\u1edbi t\u00e1c d\u1ee5ng d\u01b0\u1ee3c l\u00fd c\u1ee7a thu\u1ed1c<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 Kh\u00f4ng d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 T\u1ef7 l\u1ec7 t\u1eed vong cao<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch: s\u1ed1c ph\u1ea3n v\u1ec7 v\u1edbi penicillin\u2022\u00a0\u00a0\u00a0 Ph\u1ea3n \u1ee9ng do c\u01a1 \u0111\u1ecba t\u1eebng ng\u01b0\u1eddi: t\u0103ng th\u00e2n nhi\u1ec7t \u00e1c t\u00ednh v\u1edbi thu\u1ed1c g\u00e2y m\u00ea n\u00f3i chung<\/td>\n<td width=\"151\">\u2022\u00a0\u00a0\u00a0 Ng\u1eebng ngay thu\u1ed1c v\u00e0 tr\u00e1nh d\u00f9ng trong t\u01b0\u01a1ng lai.<\/td>\n<\/tr>\n<tr>\n<td width=\"130\">C: Li\u00ean quan \u0111\u1ebfn li\u1ec1u l\u01b0\u1ee3ng v\u00e0 th\u1eddi gian s\u1eed d\u1ee5ng (M\u1ea1n t\u00ednh)<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Kh\u00f4ng ph\u1ed5 bi\u1ebfn\u2022\u00a0\u00a0\u00a0 Li\u00ean quan \u0111\u1ebfn li\u1ec1u l\u01b0\u1ee3ng t\u00edch lu\u1ef9.<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 \u1ee8c ch\u1ebf tr\u1ee5c h\u1ea1 \u0111\u1ed3i-tuy\u1ebfn y\u00ean-th\u01b0\u1ee3ng th\u1eadn b\u1eb1ng corticosteroid, tho\u00e1i h\u00f3a x\u01b0\u01a1ng h\u00e0m v\u1edbi bisphosphonates<\/td>\n<td width=\"151\">\u2022\u00a0\u00a0\u00a0 Gi\u1ea3m li\u1ec1u ho\u1eb7c t\u1ea1m ng\u1eebng thu\u1ed1c.\u2022\u00a0\u00a0\u00a0 Ng\u1eebng thu\u1ed1c ho\u00e0n to\u00e0n c\u1ea7n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1eeb t\u1eeb.<\/td>\n<\/tr>\n<tr>\n<td width=\"130\">D: Li\u00ean quan \u0111\u1ebfn th\u1eddi gian (Ch\u1eadm)<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Kh\u00f4ng ph\u1ed5 bi\u1ebfn\u2022\u00a0\u00a0\u00a0 Th\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 X\u1ea3y ra ho\u1eb7c tr\u1edf n\u00ean r\u00f5 r\u00e0ng sau khi s\u1eed d\u1ee5ng thu\u1ed1c<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Y\u1ebfu t\u1ed1 g\u00e2y ung th\u01b0\u2022\u00a0\u00a0\u00a0 R\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng mu\u1ed9n<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 Khuy\u1ebft t\u1eadt b\u1ea9m sinh<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 Gi\u1ea3m b\u1ea1ch c\u1ea7u v\u1edbi lomustine<\/td>\n<td width=\"151\">\u2022\u00a0\u00a0\u00a0 Th\u01b0\u1eddng kh\u00f3 ch\u1eefa<\/td>\n<\/tr>\n<tr>\n<td width=\"130\">E: Ng\u1eebng thu\u1ed1c (Ng\u01b0ng s\u1eed d\u1ee5ng)<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Kh\u00f4ng ph\u1ed5 bi\u1ebfn\u2022\u00a0\u00a0\u00a0 X\u1ea3y ra ngay sau khi ng\u1eebng thu\u1ed1c<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 H\u1ed9i ch\u1ee9ng cai thu\u1ed1c v\u1edbi thu\u1ed1c phi\u1ec7n ho\u1eb7c thu\u1ed1c benzodiazepin (v\u00ed d\u1ee5, m\u1ea5t ng\u1ee7, lo l\u1eafng)<\/td>\n<td width=\"151\">\u2022\u00a0\u00a0\u00a0 Th\u1eed th\u00e1ch d\u00f9ng l\u1ea1i thu\u1ed1c, ng\u1eebng thu\u1ed1c t\u1eeb t\u1eeb<\/td>\n<\/tr>\n<tr>\n<td width=\"130\">F: Thu\u1ed1c m\u1ea5t hi\u1ec7u l\u1ef1c<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 Ph\u1ed5 bi\u1ebfn\u2022\u00a0\u00a0\u00a0 Li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 C\u00f3 th\u1ec3 do t\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/td>\n<td width=\"180\">\u2022\u00a0\u00a0\u00a0 D\u00f9ng kh\u00f4ng \u0111\u1ee7 li\u1ec1u thu\u1ed1c tr\u00e1nh thai khi s\u1eed d\u1ee5ng v\u1edbi ch\u1ea5t g\u00e2y c\u1ea3m \u1ee9ng enzyme\u2022\u00a0\u00a0\u00a0 Kh\u00e1ng kh\u00e1ng sinh<\/td>\n<td width=\"151\">\u2022\u00a0\u00a0\u00a0 T\u0103ng li\u1ec1u\u2022\u00a0\u00a0\u00a0 Xem x\u00e9t t\u00e1c \u0111\u1ed9ng c\u1ee7a c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1ed3ng th\u1eddi.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>(SSRI\u2013<\/em>\u00a0<em>selective serotonin reuptake inhibitors:\u00a0<\/em><em>thu\u1ed1c \u1ee9c ch\u1ebf t\u00e1i h\u1ea5p thu ch\u1ecdn l\u1ecdc tr\u00ean Serotonin)<\/em><\/p>\n<p>B\u1ea3ng 2 : Ph\u00e2n lo\u1ea1i ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn thu\u1ed1n theo Gell v\u00e0 Comb\u00a0[3]\n<table width=\"624\">\n<thead>\n<tr>\n<td colspan=\"2\" width=\"624\">PH\u00c2N LO\u1ea0I PH\u1ea2N \u1ee8NG QU\u00c1 M\u1eaaN THU\u1ed0C THEO GELL V\u00c0 COMB<\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"191\">PH\u1ea2N \u1ee8NG QU\u00c1 M\u1eaaN<\/td>\n<td width=\"432\">C\u01a0 CH\u1ebe<\/td>\n<\/tr>\n<tr>\n<td width=\"191\">I<\/td>\n<td width=\"432\">Qua trung gian kh\u00e1ng th\u1ec3 (IgE)<\/td>\n<\/tr>\n<tr>\n<td width=\"191\">II<\/td>\n<td width=\"432\">G\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o<\/td>\n<\/tr>\n<tr>\n<td width=\"191\">III<\/td>\n<td width=\"432\">Ph\u1ee9c h\u1ee3p kh\u00e1ng th\u1ec3-thu\u1ed1c l\u1eafng \u0111\u1ecdng trong m\u00f4<\/td>\n<\/tr>\n<tr>\n<td width=\"191\">IV<\/td>\n<td width=\"432\">M\u1ed9t ph\u1ea3n \u1ee9ng ch\u1eadm x\u1ea3y ra khi c\u00e1c ph\u00e2n t\u1eed thu\u1ed1c \u0111\u01b0\u1ee3c tr\u00ecnh di\u1ec7n cho c\u00e1c t\u1ebf b\u00e0o \u0111\u1eb7c bi\u1ec7t g\u1ecdi l\u00e0 lympho b\u00e0o T, ch\u1ecbu tr\u00e1ch nhi\u1ec7m trung gian cho ph\u1ea3n \u1ee9ng vi\u00eam.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Y\u1ebeU T\u1ed0 NGUY C\u01a0<\/h2>\n<p>Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c ph\u1ed5 bi\u1ebfn h\u01a1n \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i v\u00e0 n\u1eef gi\u1edbi. G\u1ea7n \u0111\u00e2y, m\u1ed9t y\u1ebfu t\u1ed1 quan tr\u1ecdng kh\u00e1c \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u2013 C\u00e1c kh\u00e1ng nguy\u00ean b\u1ea1ch c\u1ea7u c\u1ee7a ng\u01b0\u1eddi (Human Leucocyte Antigen-HLA) c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n. HLA l\u00e0 m\u1ed9t nh\u00f3m c\u00e1c gen m\u00e3 h\u00f3a m\u1ed9t nh\u00f3m protein c\u00f3 tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o. HLA c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean cho h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch. Nh\u1eefng ng\u01b0\u1eddi s\u1edf h\u1eefu m\u1ed9t s\u1ed1 HLA nh\u1ea5t \u0111\u1ecbnh c\u00f3 nguy c\u01a1 m\u1eafc ADR cao h\u01a1n v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c c\u1ee5 th\u1ec3. [3]\n<p>B\u1ea3ng 3 : C\u00e1c y\u1ebfu t\u1ed1 c\u00f3 li\u00ean quan t\u1edbi ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c<\/p>\n<table width=\"624\">\n<thead>\n<tr>\n<td colspan=\"3\" width=\"624\">C\u00c1C Y\u1ebeU T\u1ed0 C\u00d3 LI\u00caN QUAN T\u1edaI PH\u1ea2N \u1ee8NG C\u00d3 H\u1ea0I C\u1ee6A THU\u1ed0C<\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"208\">Y\u1ebeU T\u1ed0<\/td>\n<td width=\"208\">NH\u00d3M NGUY C\u01a0<\/td>\n<td width=\"208\">THU\u1ed0C<\/td>\n<\/tr>\n<tr>\n<td width=\"208\">Tu\u1ed5i<\/td>\n<td width=\"208\">\u2022\u00a0\u00a0\u00a0 Ng\u01b0\u1eddi gi\u00e0 t\u1eeb 60 tu\u1ed5i tr\u1edf l\u00ean<\/td>\n<td width=\"208\">\u2022\u00a0\u00a0\u00a0 Nhi\u1ec1u lo\u1ea1i<\/td>\n<\/tr>\n<tr>\n<td width=\"208\">Gi\u1edbi t\u00ednh<\/td>\n<td width=\"208\">\u2022\u00a0\u00a0\u00a0 N\u1eef gi\u1edbi<\/td>\n<td width=\"208\">\u2022\u00a0\u00a0\u00a0 Nhi\u1ec1u lo\u1ea1i<\/td>\n<\/tr>\n<tr>\n<td width=\"208\">HLA<\/td>\n<td width=\"208\">\u2022\u00a0\u00a0\u00a0 HLA-DQw2\u2022\u00a0\u00a0\u00a0 HLA-B7,D22,D23<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 HLA-B*5701<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 HLA-B*1502<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 HLA-B*5802<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 HLA-DR9<\/td>\n<td width=\"208\">\u2022\u00a0\u00a0\u00a0 Aspirin\u2022\u00a0\u00a0\u00a0 Insulin<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 Abacavir<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 Carbamazepine<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 Allopurinol<\/p>\n<p>\u2022\u00a0\u00a0\u00a0 Penicillin<\/td>\n<\/tr>\n<tr>\n<td width=\"208\">T\u00ecnh tr\u1ea1ng nhi\u1ec5m tr\u00f9ng<\/td>\n<td width=\"208\">\u2022\u00a0\u00a0\u00a0 HIV\u2022\u00a0\u00a0\u00a0 EBV<\/td>\n<td width=\"208\">\u2022\u00a0\u00a0\u00a0 Cotrimoxazole\u2022\u00a0\u00a0\u00a0 Ampicillin<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>(HLA\u2013 human leukocyte antigen: kh\u00e1ng nguy\u00ean b\u1ea1ch c\u1ea7u ng\u01b0\u1eddi;\u00a0HIV-human immunodeficiency virus: virus suy gi\u1ea3m mi\u1ec5n d\u1ecbch ng\u01b0\u1eddi;\u00a0EBV\u2013 Epstein-Barr virus)<\/em><\/p>\n<h2>BI\u1ec2U HI\u1ec6N L\u00c2M S\u00c0NG<\/h2>\n<p>B\u1ea3ng 4 :\u00a030 ADR ph\u1ed5 bi\u1ebfn nh\u1ea5t li\u00ean quan \u0111\u1ebfn 200 lo\u1ea1i thu\u1ed1c h\u00e0ng \u0111\u1ea7u: [4]\n<table width=\"326\">\n<tbody>\n<tr>\n<td width=\"100\">Ch\u00f3ng m\u1eb7t<\/td>\n<td width=\"113\">Gi\u1ea3m ti\u1ec3u c\u1ea7u<\/td>\n<td width=\"114\">Lo l\u1eafng<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Bu\u1ed3n n\u00f4n<\/td>\n<td width=\"113\">\u0110au b\u1ee5ng<\/td>\n<td width=\"114\">Tim \u0111\u1eadp nhanh<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Nh\u1ee9c \u0111\u1ea7u<\/td>\n<td width=\"113\">Bu\u1ed3n ng\u1ee7<\/td>\n<td width=\"114\">Run r\u1ea9y<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">N\u00f4n<\/td>\n<td width=\"113\">D\u1ecb \u1ee9ng<\/td>\n<td width=\"114\">\u0110au kh\u1edbp<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Ti\u00eau ch\u1ea3y<\/td>\n<td width=\"113\">Kh\u00f3 ti\u00eau<\/td>\n<td width=\"114\">Ch\u00e1n \u0103n<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Ph\u00e1t ban<\/td>\n<td width=\"113\">N\u1ed5i m\u1ec1 \u0111ay<\/td>\n<td width=\"114\">K\u00edch \u0111\u1ed9ng<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">T\u00e1o b\u00f3n<\/td>\n<td width=\"113\">Kh\u00f3 th\u1edf<\/td>\n<td width=\"114\">S\u1ed1c ph\u1ea3n v\u1ec7<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">M\u1ec7t m\u1ecfi<\/td>\n<td width=\"113\">H\u1ea1 huy\u1ebft \u00e1p<\/td>\n<td width=\"114\">Kh\u00f4 mi\u1ec7ng<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">M\u1ea5t ng\u1ee7<\/td>\n<td width=\"113\">Tr\u1ea7m c\u1ea3m<\/td>\n<td width=\"114\">S\u1ed1t<\/td>\n<\/tr>\n<tr>\n<td width=\"100\">Ng\u1ee9a<\/td>\n<td width=\"113\">D\u1ecb c\u1ea3m<\/td>\n<td width=\"114\">R\u1ed1i lo\u1ea1n v\u1ecb gi\u00e1c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Quy\u1ebft \u0111\u1ecbnh quan tr\u1ecdng nh\u1ea5t \u0111\u1ed1i v\u1edbi t\u1ea5t c\u1ea3 c\u00e1c nghi ng\u1edd ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c l\u00e0 ng\u1eebng s\u1eed d\u1ee5ng thu\u1ed1c nghi ng\u1edd. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng nhi\u1ec1u lo\u1ea1i thu\u1ed1c, quy\u1ebft \u0111\u1ecbnh ng\u1eebng thu\u1ed1c ph\u1ea3i \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc gi\u1eefa nhu c\u1ea7u s\u1eed d\u1ee5ng thu\u1ed1c v\u00e0 kh\u1ea3 n\u0103ng g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 quan s\u00e1t \u0111\u01b0\u1ee3c. Trong c\u00e1c ph\u1ea3n \u1ee9ng qu\u00e1 m\u1eabn lo\u1ea1i I ho\u1eb7c ph\u1ea3n \u1ee9ng to\u00e0n th\u00e2n, thu\u1ed1c \u0111\u01b0\u1ee3c l\u1ef1a ch\u1ecdn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ADR l\u00e0 adrenaline, ti\u00eam thu\u1ed1c v\u00e0o c\u01a1 nhanh nh\u1ea5t c\u00f3 th\u1ec3. M\u1ed9t c\u00e1ch kh\u00e1c \u0111\u1ec3 \u0111\u01b0a adrenaline v\u00e0o c\u01a1 th\u1ec3 l\u00e0 ti\u00eam t\u0129nh m\u1ea1ch, nh\u01b0ng \u0111i\u1ec1u n\u00e0y ch\u1ec9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p nguy c\u1ea5p, \u0111e d\u1ecda \u0111\u1ebfn t\u00ednh m\u1ea1ng m\u00e0 kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi ph\u01b0\u01a1ng ph\u00e1p ti\u00eam v\u00e0o c\u01a1. Thu\u1ed1c gi\u00e3n ph\u1ebf qu\u1ea3n v\u00e0 corticosteroid to\u00e0n th\u00e2n c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng khi \u0111i\u1ec1u tr\u1ecb c\u00e1c ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, nh\u01b0ng kh\u00f4ng n\u00ean tr\u00ec ho\u00e3n vi\u1ec7c s\u1eed d\u1ee5ng adrenaline n\u1ebfu c\u1ea7n thi\u1ebft. C\u1ea7n th\u1eadn tr\u1ecdng v\u1edbi IV Phenergen (m\u1ed9t lo\u1ea1i thu\u1ed1c kh\u00e1ng histamine) v\u00ec c\u00f3 th\u1ec3 l\u00e0m k\u00edch th\u00edch t\u0129nh m\u1ea1ch.[3]\n<h2>M\u1ed8T S\u1ed0 ADR NGHI\u00caM TR\u1eccNG<\/h2>\n<p>B\u1ea3ng 5 : M\u1ed9t s\u1ed1 ADR nghi\u00eam tr\u1ecdng\u00a0[5]\n<table width=\"624\">\n<thead>\n<tr>\n<td width=\"208\">PH\u1ea2N \u1ee8NG C\u00d3 H\u1ea0I C\u1ee6A THU\u1ed0C<\/td>\n<td width=\"222\">LO\u1ea0I THU\u1ed0C<\/td>\n<td width=\"194\">V\u00cd D\u1ee4<\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td rowspan=\"2\" width=\"208\">Thi\u1ebfu m\u00e1u (Do gi\u1ea3m s\u1ea3n xu\u1ea5t ho\u1eb7c t\u0103ng ph\u00e1 hu\u1ef7 h\u1ed3ng c\u1ea7u)<\/td>\n<td width=\"222\">M\u1ed9t s\u1ed1 lo\u1ea1i kh\u00e1ng sinh<\/td>\n<td width=\"194\">Chloramphenicol<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Thu\u1ed1c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb s\u1ed1t r\u00e9t ho\u1eb7c b\u1ec7nh lao \u1edf nh\u1eefng ng\u01b0\u1eddi thi\u1ebfu men G6PD<\/td>\n<td width=\"194\">ChloroquineIsoniazid<\/p>\n<p>Primaquine<\/td>\n<\/tr>\n<tr>\n<td width=\"208\">Ph\u00f9 m\u1ea1ch (s\u01b0ng m\u00f4i, l\u01b0\u1ee1i v\u00e0 c\u1ed5 h\u1ecdng g\u00e2y kh\u00f3 th\u1edf)<\/td>\n<td width=\"222\">Thu\u1ed1c \u1ee9c ch\u1ebf men chuy\u1ec3n angiotensin<\/td>\n<td width=\"194\">CaptoprilEnalapril<\/p>\n<p>Lisinopril<\/td>\n<\/tr>\n<tr>\n<td width=\"208\">G\u00e3y x\u01b0\u01a1ng<\/td>\n<td width=\"222\">Thu\u1ed1c \u1ee9c ch\u1ebf b\u01a1m proton<\/td>\n<td width=\"194\">EsomeprazoleLansoprazole<\/p>\n<p>Omeprazole<\/td>\n<\/tr>\n<tr>\n<td width=\"208\">H\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng<\/td>\n<td width=\"222\">Thu\u1ed1c tr\u00e1nh thai (t\u1ea5t c\u1ea3 c\u00e1c d\u1ea1ng bao g\u1ed3m mi\u1ebfng d\u00e1n v\u00e0 vi\u00ean n\u00e9n)<\/td>\n<td width=\"194\">Drospirenone\/ethinyl estradiolNorelgestromin\/ethinyl estradiol<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" width=\"208\">Hay nh\u1ea7m l\u1eabn v\u00e0 u\u1ec3 o\u1ea3i<\/td>\n<td width=\"222\">Thu\u1ed1c an th\u1ea7n, bao g\u1ed3m nhi\u1ec1u thu\u1ed1c kh\u00e1ng histamine<\/td>\n<td width=\"194\">Diphenhydramine<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m (\u0111\u1eb7c bi\u1ec7t \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i)<\/td>\n<td width=\"194\">AmitriptylineImipramine<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\" width=\"208\">Gi\u1ea3m s\u1ea3n xu\u1ea5t t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u, t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng<\/td>\n<td width=\"222\">M\u1ed9t s\u1ed1 thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n<\/td>\n<td width=\"194\">Clozapine<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Thu\u1ed1c ho\u00e1 tr\u1ecb<\/td>\n<td width=\"194\">CyclophosphamideMercaptopurine<\/p>\n<p>Methotrexate<\/p>\n<p>Vinblastine<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n tuy\u1ebfn gi\u00e1p<\/td>\n<td width=\"194\">Propylthiouracil<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"5\" width=\"208\">G\u00e2y t\u1ed5n th\u01b0\u01a1ng th\u1eadn<\/td>\n<td width=\"222\">NSAIDs (s\u1eed d\u1ee5ng qu\u00e1 li\u1ec1u nhi\u1ec1u l\u1ea7n)<\/td>\n<td width=\"194\">IbuprofenNaproxen<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Kh\u00e1ng sinh nh\u00f3m Aminoglycoside<\/td>\n<td width=\"194\">GentamicinTobramycin<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">M\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c ho\u00e1 tr\u1ecb<\/td>\n<td width=\"194\">CisplatinMethotrexate<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Thu\u1ed1c tr\u1ecb n\u1ea5m<\/td>\n<td width=\"194\">Amphotericin B<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">M\u1ed9t s\u1ed1 lo\u1ea1i kh\u00e1ng sinh<\/td>\n<td width=\"194\">GentamicinTetracycline<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"5\" width=\"208\">G\u00e2y t\u1ed5n th\u01b0\u01a1ng gan<\/td>\n<td width=\"222\">M\u1ed9t s\u1ed1 thu\u1ed1c gi\u1ea3m \u0111au<\/td>\n<td width=\"194\">Acetaminophen (d\u00f9ng qu\u00e1 li\u1ec1u)<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">M\u1ed9t s\u1ed1 thu\u1ed1c \u0111i\u1ec1u tr\u1ecb lao<\/td>\n<td width=\"194\">Isoniazid<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Thu\u1ed1c b\u1ed5 sung s\u1eaft (s\u1ed1 l\u01b0\u1ee3ng nhi\u1ec1u)<\/td>\n<td width=\"194\"><\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m<\/td>\n<td width=\"194\">Duloxetine<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Kh\u00e1ng sinh<\/td>\n<td width=\"194\">Tetracycline<\/td>\n<\/tr>\n<tr>\n<td width=\"208\">Ph\u00e1 hu\u1ef7 m\u00f4 c\u01a1 (Ti\u00eau c\u01a1 v\u00e2n)<\/td>\n<td width=\"222\">Statins<\/td>\n<td width=\"194\">AtorvastatinSimvastatin<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" width=\"208\">Lo\u00e9t d\u1ea1 d\u00e0y ho\u1eb7c ru\u1ed9t (c\u00f3 ho\u1eb7c kh\u00f4ng ch\u1ea3y m\u00e1u)<\/td>\n<td width=\"222\">Thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u<\/td>\n<td width=\"194\">HeparinWarfarin<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Biphosphonate<\/td>\n<td width=\"194\">AlendronateRisedronate<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" width=\"208\">Ho\u1ea1i t\u1eed th\u01b0\u1ee3ng b\u00ec nhi\u1ec5m \u0111\u1ed9c<\/td>\n<td width=\"222\">M\u1ed9t s\u1ed1 lo\u1ea1i kh\u00e1ng sinh<\/td>\n<td width=\"194\">PenicillinsQuinolones<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Thu\u1ed1c ch\u1ed1ng co gi\u1eadt<\/td>\n<td width=\"194\">PhenytoinValproic acid<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" width=\"208\">R\u1ed1i lo\u1ea1n nh\u1ecbp tim<\/td>\n<td width=\"222\">Thu\u1ed1c ch\u1ed1ng lo\u1ea1n nh\u1ecbp<\/td>\n<td width=\"194\">AmiodaroneProcainamide<\/p>\n<p>Sotalol<\/td>\n<\/tr>\n<tr>\n<td width=\"222\">Thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n<\/td>\n<td width=\"194\">ChlorpromazineHaloperidol<\/p>\n<p>Lithium<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>(G6PD\u2013<\/em><em>Glucose-6-phosphat dehydrogenase;\u00a0NSAIDs\u2013<\/em><em>\u00a0non-steroidal anti-inflammatory drugs: \u00a0Thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid)<\/em><\/p>\n<h2>PH\u00d2NG NG\u1eeaA PH\u1ea2N \u1ee8NG C\u00d3 H\u1ea0I C\u1ee6A THU\u1ed0C<\/h2>\n<p>Trong khi m\u1ed9t s\u1ed1 ADR kh\u00f4ng th\u1ec3 d\u1ef1 \u0111o\u00e1n tr\u01b0\u1edbc \u0111\u01b0\u1ee3c (nh\u01b0 s\u1ed1c ph\u1ea3n v\u1ec7 \u1edf b\u1ec7nh nh\u00e2n sau m\u1ed9t l\u1ea7n ti\u1ebfp x\u00fac v\u1edbi kh\u00e1ng sinh c\u00f3 ch\u1ee9a penicillin), \u0111a s\u1ed1 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ng\u0103n ng\u1eeba n\u1ebfu c\u00f3 t\u1ea7m nh\u00ecn xa v\u00e0 s\u1ef1 theo d\u00f5i k\u1ef9 l\u01b0\u1ee1ng.<\/p>\n<p>Nhi\u1ec1u ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c c\u00f3 th\u1ec3 ng\u1eeba \u0111\u01b0\u1ee3c, n\u1ebfu tu\u00e2n th\u1ee7 nh\u1eefng nguy\u00ean t\u1eafc sau \u0111\u00e2y:<\/p>\n<p>Kh\u00f4ng bao gi\u1edd k\u00ea \u0111\u01a1n b\u1ea5t k\u1ef3 thu\u1ed1c n\u00e0o m\u00e0 kh\u00f4ng c\u00f3 ch\u1ee9ng c\u1ee9 ph\u00f9 h\u1ee3p v\u1edbi t\u00ecnh tr\u1ea1ng b\u1ec7nh l\u00fd c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh.<br \/>\nN\u1ebfu ng\u01b0\u1eddi b\u1ec7nh mang thai, c\u1ea7n r\u1ea5t h\u1ea1n ch\u1ebf d\u00f9ng thu\u1ed1c.<br \/>\nH\u1ecfi ng\u01b0\u1eddi b\u1ec7nh v\u1ec1 ti\u1ec1n s\u1eed d\u1ecb \u1ee9ng v\u00e0 c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i kh\u00e1c. D\u1ecb \u1ee9ng m\u1eafc tr\u01b0\u1edbc \u0111\u00f3 l\u00e0 m\u1ed9t y\u1ebfu t\u1ed1 d\u1ef1 \u0111o\u00e1n tin c\u1eady v\u1ec1 nguy c\u01a1 d\u1ecb \u1ee9ng v\u1edbi thu\u1ed1c.<br \/>\nH\u1ecfi ng\u01b0\u1eddi b\u1ec7nh xem tr\u01b0\u1edbc \u0111\u00f3 \u0111\u00e3 d\u00f9ng thu\u1ed1c n\u00e0o ch\u01b0a, k\u1ec3 c\u1ea3 nh\u1eefng thu\u1ed1c t\u1ef1 d\u00f9 C\u00e1c thu\u1ed1c s\u1eed d\u1ee5ng tr\u01b0\u1edbc \u0111\u00f3 c\u0169ng c\u00f3 th\u1ec3 g\u00e2y t\u01b0\u01a1ng t\u00e1c thu\u1ed1c nghi\u00eam tr\u1ecdng v\u00e0 b\u1ea5t ng\u1edd.<br \/>\nTr\u00e1nh ph\u1ed1i h\u1ee3p thu\u1ed1c kh\u00f4ng c\u1ea7n thi\u1ebft. H\u00e3y d\u00f9ng c\u00e0ng \u00edt thu\u1ed1c n\u1ebfu c\u00f3 th\u1ec3.<br \/>\nTu\u1ed5i t\u00e1c, c\u00e1c b\u1ec7nh gan ho\u1eb7c th\u1eadn c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn chuy\u1ec3n h\u00f3a v\u00e0 kh\u1ea3 n\u0103ng \u0111\u00e0o th\u1ea3i thu\u1ed1c. \u1ede nh\u1eefng ng\u01b0\u1eddi b\u1ec7nh n\u00e0y, c\u1ea7n ph\u1ea3i d\u00f9ng li\u1ec1u th\u1ea5p h\u01a1n b\u00ecnh th\u01b0\u1eddng.<br \/>\nCung c\u1ea5p nh\u1eefng ch\u1ec9 d\u1eabn th\u1eadt r\u00f5 r\u00e0ng c\u1ea3 v\u1ec1 b\u1ec7nh v\u00e0 v\u1ec1 c\u00e1ch s\u1eed d\u1ee5ng \u0111\u00fang thu\u1ed1c \u0111\u00e3 k\u00ea cho ng\u01b0\u1eddi b\u1ec7nh, nh\u1ea5t l\u00e0 \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi cao tu\u1ed5<br \/>\nKhi c\u00f3 nguy c\u01a1 l\u00e0 c\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n c\u00f3 th\u1ec3 g\u00e2y ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i, ph\u1ea3i ch\u1ec9 d\u1eabn cho ng\u01b0\u1eddi b\u1ec7nh v\u1ec1 c\u00e1ch nh\u1eadn bi\u1ebft c\u00e1c tri\u1ec7u ch\u1ee9ng s\u1edbm, nh\u01b0 v\u1eady v\u1ea5n \u0111\u1ec1 ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb s\u1edbm \u1edf m\u1ee9c c\u00f3 th\u1ec3.[6]\n<h2>\u0110I\u1ec0U TR\u1eca<\/h2>\n<p>\u0110\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a ADR \u0111\u1ec3 quy\u1ebft \u0111\u1ecbnh h\u01b0\u1edbng x\u01b0\u0309 tr\u00ed l\u00e2m s\u00e0ng ph\u00f9 h\u1ee3p.<br \/>\nGi\u1ea3m li\u1ec1u ho\u1eb7c ng\u1eebng thu\u1ed1c nghi ng\u1edd g\u00e2y ADR trong \u0111i\u1ec1u ki\u1ec7n l\u00e2m s\u00e0ng cho ph\u00e9<br \/>\nK\u1ecbp th\u1eddi th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p \u0111i\u1ec1u tr\u1ecb tri\u1ec7u ch\u1ee9ng, \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3, \u0111\u1ea3m b\u1ea3o ch\u1ee9c n\u0103ng s\u1ed1ng c\u00f2n cho ng\u01b0\u1eddi b\u1ec7nh.<br \/>\nTh\u1ef1c hi\u1ec7n theo c\u00e1c h\u01b0\u1edbng d\u1eabn chuy\u00ean m\u00f4n c\u1ee7a B\u1ed9 Y t\u1ebf c\u00f3 li\u00ean quan n\u1ebfu vi\u1ec7c x\u01b0\u0309 tr\u00ed ADR thu\u1ed9c ph\u1ea1m vi c\u00e1c h\u01b0\u1edbng d\u1eabn \u0111\u00f3.<br \/>\nTrong tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft, trao \u0111\u1ed5i h\u01b0\u1edbng x\u01b0\u0309 tr\u00ed v\u1edbi \u0111\u1ed3ng nghi\u1ec7p, t\u1ed5 ch\u1ee9c h\u1ed9i ch\u1ea9n chuy\u00ean m\u00f4n, tham kh\u1ea3o th\u00eam th\u00f4ng tin v\u1ec1 ADR t\u1eeb D\u01b0\u1ee3c s\u0129, \u0110\u01a1n v\u1ecb th\u00f4ng tin thu\u1ed1c b\u1ec7nh vi\u1ec7n ho\u1eb7c c\u00e1c Trung t\u00e2m v\u1ec1 Th\u00f4ng tin thu\u1ed1c v\u00e0 Theo d\u00f5i ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c.<br \/>\nGi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd ng\u01b0\u1eddi b\u1ec7nh trong tr\u01b0\u1eddng h\u1ee3p b\u1eaft bu\u1ed9c s\u01b0\u0309 d\u1ee5ng l\u1ea1i thu\u1ed1c nghi ng\u1edd g\u00e2y ADR khi kh\u00f4ng c\u00f3 thu\u1ed1c thay th\u1ebf ho\u1eb7c khi l\u1ee3i \u00edch c\u1ee7a thu\u1ed1c v\u01b0\u1ee3t tr\u1ed9i h\u01a1n nguy c\u01a1. [7]\n<h2>M\u1eaaU B\u00c1O C\u00c1O ADR<\/h2>\n<p>T\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 li\u00ean quan \u0111\u1ebfn s\u1eed d\u1ee5ng thu\u1ed1c:<\/p>\n<p>Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi m\u1ed9t thu\u1ed1c tr\u01b0\u1edbc khi \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng ch\u1ec9 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u00ean m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n r\u1ea5t \u00edt so v\u1edbi l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n s\u1ebd s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u00f3 trong th\u1ef1c t\u1ebf. M\u1eb7t kh\u00e1c c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng th\u01b0\u1eddng kh\u00f4ng \u0111\u00e1nh gi\u00e1 tr\u00ean c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n \u0111\u1eb7c bi\u1ec7t nh\u01b0 ng\u01b0\u1eddi gi\u00e0, tr\u1ebb em, ph\u1ee5 n\u1eef c\u00f3 thai, b\u1ec7nh nh\u00e2n suy gan, suy th\u1eadn\u2026\u0110i\u1ec1u \u0111\u00f3 cho th\u1ea5y nh\u1eefng th\u00f4ng tin v\u1ec1 \u0111\u1ed9 an to\u00e0n c\u1ee7a m\u1ed9t thu\u1ed1c thu \u0111\u01b0\u1ee3c t\u1eeb c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng l\u00e0 r\u1ea5t h\u1ea1n ch\u1ebf, \u0111\u1eb7c bi\u1ec7t l\u00e0 th\u00f4ng tin v\u1ec1 c\u00e1c ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng nh\u01b0ng t\u1ea7n su\u1ea5t x\u1ea3y ra th\u1ea5p. Do v\u1eady, th\u00f4ng tin do c\u00e1c c\u00e1n b\u1ed9 y t\u1ebf cung c\u1ea5p v\u1ec1 c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c s\u1ebd v\u00f4 c\u00f9ng h\u1eefu \u00edch \u0111\u1ec3 ti\u1ebfp t\u1ee5c \u0111\u00e1nh gi\u00e1 m\u1ed9t c\u00e1ch to\u00e0n di\u1ec7n h\u01a1n v\u1ec1 c\u00e1c nguy c\u01a1 ti\u1ec1m \u1ea9n c\u1ee7a thu\u1ed1c khi l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng.<\/p>\n<p>Sau \u0111\u00e2y l\u00e0 m\u1eabu b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i theo quy \u0111\u1ecbnh c\u1ee7a B\u1ed9 Y t\u1ebf d\u00e0nh cho c\u00e1c c\u01a1 s\u1edf kh\u00e1m, ch\u1eefa b\u1ec7nh [8]:<\/p>\n<p>&nbsp;<\/p>\n<table width=\"756\">\n<tbody>\n<tr>\n<td width=\"66\"><\/td>\n<td width=\"414\"><u>\u00a0<\/u><\/td>\n<td width=\"18\"><\/td>\n<td width=\"258\"><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\" width=\"66\"><\/td>\n<td rowspan=\"3\" width=\"414\"><u>B\u00c1O C\u00c1O PH\u1ea2N \u1ee8NG C\u00d3 H\u1ea0I C\u1ee6A THU\u1ed0C<\/u><em>TH\u00d4NG TIN V\u1ec0 NG\u01af\u1edcI B\u00c1O C\u00c1O, B\u1ec6NH NH\u00c2N V\u00c0 \u0110\u01a0N V\u1eca B\u00c1O C\u00c1O<\/em><\/p>\n<p><em>S\u1ebc \u0110\u01af\u1ee2C B\u1ea2O M\u1eacT<\/em><\/td>\n<td rowspan=\"3\" width=\"18\"><\/td>\n<td width=\"258\">N\u01a1i b\u00e1o c\u00e1o:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/td>\n<\/tr>\n<tr>\n<td width=\"258\">M\u00e3 s\u1ed1 b\u00e1o c\u00e1o c\u1ee7a \u0111\u01a1n v\u1ecb:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/td>\n<\/tr>\n<tr>\n<td width=\"258\">M\u00e3 s\u1ed1 b\u00e1o c\u00e1o (do Trung t\u00e2m qu\u1ed1c gia qu\u1ea3n l\u00fd):\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026..<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><em>Xin anh\/ch\u1ecb h\u00e3y b\u00e1o c\u00e1o k\u1ec3 c\u1ea3 khi kh\u00f4ng ch\u1eafc ch\u1eafn v\u1ec1 s\u1ea3n ph\u1ea9m \u0111\u00e3 g\u00e2y ra ph\u1ea3n \u1ee9ng v\u00e0\/ho\u1eb7c kh\u00f4ng c\u00f3 \u0111\u1ea7y \u0111\u1ee7 c\u00e1c th\u00f4ng tin<\/em><\/p>\n<table width=\"815\">\n<tbody>\n<tr>\n<td colspan=\"14\" width=\"295\">A.\u00a0\u00a0\u00a0TH\u00d4NG TIN V\u1ec0 B\u1ec6NH NH\u00c2N<\/td>\n<td colspan=\"21\" width=\"456\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"17\" width=\"361\">1. H\u1ecd v\u00e0 t\u00ean:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026.<\/td>\n<td colspan=\"11\" width=\"186\">2. Ng\u00e0y sinh:\u2026\u2026\/\u2026\u2026\/\u2026\u2026\u2026\u2026Ho\u1eb7c tu\u1ed5i:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/td>\n<td colspan=\"6\" width=\"120\">3. Gi\u1edbi t\u00ednhNam\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0N\u1eef<\/td>\n<td width=\"84\">4. C\u00e2n n\u1eb7ng:\u2026\u2026\u2026\u2026.kg<\/td>\n<\/tr>\n<tr>\n<td colspan=\"14\" width=\"295\">B.\u00a0\u00a0TH\u00d4NG TIN V\u1ec0 PH\u1ea2N \u1ee8NG C\u00d3 H\u1ea0I (ADR)<\/td>\n<td colspan=\"21\" width=\"456\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"17\" width=\"361\">5. Ng\u00e0y xu\u1ea5t hi\u1ec7n ph\u1ea3n \u1ee9ng:\u2026\u2026\u2026.\/\u2026\u2026\u2026\/\u2026\u2026\u2026\u2026\u2026\u2026.\u2026.<\/td>\n<td colspan=\"18\" width=\"390\">6. Ph\u1ea3n \u1ee9ng xu\u1ea5t hi\u1ec7n sau bao l\u00e2u (t\u00ednh t\u1eeb l\u1ea7n d\u00f9ng cu\u1ed1i c\u00f9ng c\u1ee7a thu\u1ed1c nghi ng\u1edd):\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/td>\n<\/tr>\n<tr>\n<td colspan=\"17\" rowspan=\"3\" width=\"361\">7. M\u00f4 t\u1ea3 bi\u1ec3u hi\u1ec7n ADR<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td colspan=\"18\" width=\"390\">8. C\u00e1c x\u00e9t nghi\u1ec7m li\u00ean quan \u0111\u1ebfn ph\u1ea3n \u1ee9ng<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<tr>\n<td colspan=\"18\" width=\"390\">9. Ti\u1ec1n s\u1eed (<em>d\u1ecb \u1ee9ng, thai ngh\u00e9n, nghi\u1ec7n thu\u1ed1c l\u00e1, nghi\u1ec7n r\u01b0\u1ee3u, b\u1ec7nh gan, b\u1ec7nh th\u1eadn\u2026<\/em>)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<tr>\n<td colspan=\"18\" width=\"390\">10. C\u00e1ch x\u1eed tr\u00ed ph\u1ea3n \u1ee9ng<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<tr>\n<td colspan=\"35\" width=\"751\">11. M\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a ph\u1ea3n \u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td colspan=\"12\" width=\"250\">\u00a0\u00a0\u00a0 T\u1eed vong\u0110e d\u1ecda t\u00ednh m\u1ea1ng<\/td>\n<td colspan=\"15\" width=\"273\">\u00a0\u00a0\u00a0 Nh\u1eadp vi\u1ec7n\/K\u00e9o d\u00e0i th\u1eddi gian n\u1eb1m vi\u1ec7nT\u00e0n t\u1eadt v\u0129nh vi\u1ec5n\/n\u1eb7ng n\u1ec1<\/td>\n<td colspan=\"8\" width=\"228\">\u00a0\u00a0 D\u1ecb t\u1eadt thai nhiKh\u00f4ng nghi\u00eam tr\u1ecdng<\/td>\n<\/tr>\n<tr>\n<td colspan=\"12\" width=\"250\">12. K\u1ebft qu\u1ea3 sau khi x\u1eed tr\u00ed ph\u1ea3n \u1ee9ng<\/td>\n<td colspan=\"15\" width=\"273\"><\/td>\n<td colspan=\"8\" width=\"228\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"11\" width=\"241\">\u00a0\u00a0\u00a0 T\u1eed vong do ADRT\u1eed vong kh\u00f4ng li\u00ean quan \u0111\u1ebfn thu\u1ed1c<\/td>\n<td colspan=\"10\" width=\"180\">\u00a0\u00a0 Ch\u01b0a h\u1ed3i ph\u1ee5c\u0110ang h\u1ed3i ph\u1ee5c<\/td>\n<td colspan=\"10\" width=\"192\">\u00a0\u00a0 H\u1ed3i ph\u1ee5c c\u00f3 di ch\u1ee9ngH\u1ed3i ph\u1ee5c kh\u00f4ng c\u00f3 di ch\u1ee9ng<\/td>\n<td colspan=\"4\" width=\"138\">\u00a0\u00a0\u00a0\u00a0\u00a0 Kh\u00f4ng r\u00f5<\/td>\n<\/tr>\n<tr>\n<td colspan=\"15\" width=\"298\">C.\u00a0\u00a0TH\u00d4NG TIN V\u1ec0 THU\u1ed0C NGHI NG\u1edc G\u00c2Y ADR<\/td>\n<td colspan=\"20\" width=\"453\"><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\" width=\"25\">STT<\/td>\n<td colspan=\"5\" rowspan=\"2\" width=\"138\">13.Thu\u1ed1c (t\u00ean g\u1ed1c v\u00e0 t\u00ean th\u01b0\u01a1ng m\u1ea1i)<\/td>\n<td colspan=\"3\" rowspan=\"2\" width=\"66\">D\u1ea1ng b\u00e0o ch\u1ebf, h\u00e0m l\u01b0\u1ee3ng<\/td>\n<td colspan=\"4\" rowspan=\"2\" width=\"60\">Nh\u00e0s\u1ea3n xu\u1ea5t<\/td>\n<td colspan=\"3\" rowspan=\"2\" width=\"60\">S\u1ed1 l\u00f4<\/td>\n<td colspan=\"4\" rowspan=\"2\" width=\"60\">Li\u1ec1u d\u00f9ng m\u1ed9t l\u1ea7n<\/td>\n<td colspan=\"3\" rowspan=\"2\" width=\"48\">S\u1ed1 l\u1ea7n d\u00f9ng trong\u00a0<em>ng\u00e0y\/ tu\u1ea7n\/ th\u00e1ng<\/em>.<\/td>\n<td colspan=\"2\" rowspan=\"2\" width=\"54\">\u0110\u01b0\u1eddng d\u00f9ng<\/td>\n<td colspan=\"7\" width=\"120\">Ng\u00e0y \u0111i\u1ec1u tr\u1ecb(<em>Ng\u00e0y\/th\u00e1ng\/n\u0103m<\/em>)<\/td>\n<td colspan=\"3\" rowspan=\"2\" width=\"120\">L\u00fd do d\u00f9ng thu\u1ed1c<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"60\">B\u1eaft \u0111\u1ea7u<\/td>\n<td colspan=\"3\" width=\"60\">K\u1ebft th\u00fac<\/td>\n<\/tr>\n<tr>\n<td width=\"25\">i<\/td>\n<td colspan=\"5\" width=\"138\">&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td colspan=\"3\" width=\"66\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"60\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"48\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"120\"><\/td>\n<\/tr>\n<tr>\n<td width=\"25\">ii<\/td>\n<td colspan=\"5\" width=\"138\">&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td colspan=\"3\" width=\"66\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"60\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"48\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"120\"><\/td>\n<\/tr>\n<tr>\n<td width=\"25\">iii<\/td>\n<td colspan=\"5\" width=\"138\">&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<td colspan=\"3\" width=\"66\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"60\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"48\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"120\"><\/td>\n<\/tr>\n<tr>\n<td width=\"25\">iv<\/td>\n<td colspan=\"5\" width=\"138\"><\/td>\n<td colspan=\"3\" width=\"66\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"60\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"48\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"4\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"60\"><\/td>\n<td colspan=\"3\" width=\"120\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" rowspan=\"2\" width=\"55\">STT(T\u01b0\u01a1ng \u1ee9ng 13.)<\/td>\n<td colspan=\"18\" width=\"354\">14.Sau khi ng\u1eebng\/gi\u1ea3m li\u1ec1u c\u1ee7a thu\u1ed1c b\u1ecb nghi ng\u1edd, ph\u1ea3n \u1ee9ng c\u00f3 \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n kh\u00f4ng?<\/td>\n<td colspan=\"15\" width=\"342\">15.T\u00e1i s\u1eed d\u1ee5ng thu\u1ed1c b\u1ecb nghi ng\u1edd c\u00f3 xu\u1ea5t hi\u1ec7n l\u1ea1i ph\u1ea3n \u1ee9ng kh\u00f4ng?<\/td>\n<\/tr>\n<tr>\n<td width=\"36\">C\u00f3<\/td>\n<td colspan=\"2\" width=\"54\">Kh\u00f4ng<\/td>\n<td colspan=\"8\" width=\"144\">Kh\u00f4ng ng\u1eebng\/gi\u1ea3m li\u1ec1u<\/td>\n<td colspan=\"7\" width=\"120\">Kh\u00f4ng c\u00f3 th\u00f4ng tin<\/td>\n<td colspan=\"3\" width=\"48\">C\u00f3<\/td>\n<td colspan=\"2\" width=\"54\">Kh\u00f4ng<\/td>\n<td colspan=\"7\" width=\"120\">Kh\u00f4ng t\u00e1i s\u1eed d\u1ee5ng<\/td>\n<td colspan=\"3\" width=\"120\">Kh\u00f4ng c\u00f3 th\u00f4ng tin<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"55\">i<\/td>\n<td width=\"36\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"8\" width=\"144\"><\/td>\n<td colspan=\"7\" width=\"120\"><\/td>\n<td colspan=\"3\" width=\"48\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"7\" width=\"120\"><\/td>\n<td colspan=\"3\" width=\"120\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"55\">ii<\/td>\n<td width=\"36\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"8\" width=\"144\"><\/td>\n<td colspan=\"7\" width=\"120\"><\/td>\n<td colspan=\"3\" width=\"48\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"7\" width=\"120\"><\/td>\n<td colspan=\"3\" width=\"120\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"55\">iii<\/td>\n<td width=\"36\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"8\" width=\"144\"><\/td>\n<td colspan=\"7\" width=\"120\"><\/td>\n<td colspan=\"3\" width=\"48\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"7\" width=\"120\"><\/td>\n<td colspan=\"3\" width=\"120\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"55\">iv<\/td>\n<td width=\"36\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"8\" width=\"144\"><\/td>\n<td colspan=\"7\" width=\"120\"><\/td>\n<td colspan=\"3\" width=\"48\"><\/td>\n<td colspan=\"2\" width=\"54\"><\/td>\n<td colspan=\"7\" width=\"120\"><\/td>\n<td colspan=\"3\" width=\"120\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"35\" width=\"751\">16. C\u00e1c thu\u1ed1c d\u00f9ng \u0111\u1ed3ng th\u1eddi (<em>Ngo\u1ea1i tr\u1eeb c\u00e1c thu\u1ed1c d\u00f9ng \u0111i\u1ec1u tr\u1ecb\/ kh\u1eafc ph\u1ee5c h\u1eadu qu\u1ea3 c\u1ee7a ADR<\/em>)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" rowspan=\"2\" width=\"127\">T\u00ean thu\u1ed1c<\/td>\n<td colspan=\"4\" rowspan=\"2\" width=\"84\">D\u1ea1ng b\u00e0o ch\u1ebf, h\u00e0m l\u01b0\u1ee3ng<\/td>\n<td colspan=\"11\" width=\"164\">Ng\u00e0y \u0111i\u1ec1u tr\u1ecb (ng\u00e0y\/th\u00e1ng\/n\u0103m)<\/td>\n<td colspan=\"5\" rowspan=\"2\" width=\"124\">T\u00ean thu\u1ed1c<\/td>\n<td colspan=\"6\" rowspan=\"2\" width=\"84\">D\u1ea1ng b\u00e0o ch\u1ebf, h\u00e0m l\u01b0\u1ee3ng<\/td>\n<td colspan=\"5\" width=\"168\">Ng\u00e0y \u0111i\u1ec1u tr\u1ecb (ng\u00e0y\/th\u00e1ng\/n\u0103m)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" width=\"78\">B\u1eaft \u0111\u1ea7u<\/td>\n<td colspan=\"6\" width=\"86\">K\u1ebft th\u00fac<\/td>\n<td colspan=\"3\" width=\"78\">B\u1eaft \u0111\u1ea7u<\/td>\n<td colspan=\"2\" width=\"90\">K\u1ebft th\u00fac<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"127\"><\/td>\n<td colspan=\"4\" width=\"84\"><\/td>\n<td colspan=\"5\" width=\"78\"><\/td>\n<td colspan=\"6\" width=\"86\"><\/td>\n<td colspan=\"5\" width=\"124\"><\/td>\n<td colspan=\"6\" width=\"84\"><\/td>\n<td colspan=\"3\" width=\"78\"><\/td>\n<td colspan=\"2\" width=\"90\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"127\"><\/td>\n<td colspan=\"4\" width=\"84\"><\/td>\n<td colspan=\"5\" width=\"78\"><\/td>\n<td colspan=\"6\" width=\"86\"><\/td>\n<td colspan=\"5\" width=\"124\"><\/td>\n<td colspan=\"6\" width=\"84\"><\/td>\n<td colspan=\"3\" width=\"78\"><\/td>\n<td colspan=\"2\" width=\"90\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"127\"><\/td>\n<td colspan=\"4\" width=\"84\"><\/td>\n<td colspan=\"5\" width=\"78\"><\/td>\n<td colspan=\"6\" width=\"86\"><\/td>\n<td colspan=\"5\" width=\"124\"><\/td>\n<td colspan=\"6\" width=\"84\"><\/td>\n<td colspan=\"3\" width=\"78\"><\/td>\n<td colspan=\"2\" width=\"90\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"127\"><\/td>\n<td colspan=\"4\" width=\"84\"><\/td>\n<td colspan=\"5\" width=\"78\"><\/td>\n<td colspan=\"6\" width=\"86\"><\/td>\n<td colspan=\"5\" width=\"124\"><\/td>\n<td colspan=\"6\" width=\"84\"><\/td>\n<td colspan=\"3\" width=\"78\"><\/td>\n<td colspan=\"2\" width=\"90\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"127\"><\/td>\n<td colspan=\"4\" width=\"84\"><\/td>\n<td colspan=\"5\" width=\"78\"><\/td>\n<td colspan=\"6\" width=\"86\"><\/td>\n<td colspan=\"5\" width=\"124\"><\/td>\n<td colspan=\"6\" width=\"84\"><\/td>\n<td colspan=\"3\" width=\"78\"><\/td>\n<td colspan=\"2\" width=\"90\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"14\" width=\"295\">D.PH\u1ea6N TH\u1ea8M \u0110\u1ecaNH ADR C\u1ee6A \u0110\u01a0N V\u1eca<\/td>\n<td colspan=\"21\" width=\"456\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"35\" width=\"751\">17. \u0110\u00e1nh gi\u00e1 m\u1ed1i li\u00ean quan gi\u1eefa thu\u1ed1c v\u00e0 ADR<\/td>\n<\/tr>\n<tr>\n<td colspan=\"7\" width=\"205\">Ch\u1eafc ch\u1eafnC\u00f3 kh\u1ea3 n\u0103ng<\/p>\n<p>C\u00f3 th\u1ec3<\/td>\n<td colspan=\"15\" width=\"240\">Kh\u00f4ng ch\u1eafc ch\u1eafnCh\u01b0a ph\u00e2n lo\u1ea1i<\/p>\n<p>Kh\u00f4ng th\u1ec3 ph\u00e2n lo\u1ea1i<\/td>\n<td colspan=\"13\" width=\"306\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kh\u00e1c :\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026.\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026..<\/p>\n<p>\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026..<\/td>\n<\/tr>\n<tr>\n<td colspan=\"35\" width=\"751\">18. \u0110\u01a1n v\u1ecb th\u1ea9m \u0111\u1ecbnh ADR theo thang n\u00e0o?<\/td>\n<\/tr>\n<tr>\n<td colspan=\"7\" width=\"205\">Thang WHO<\/td>\n<td colspan=\"11\" width=\"168\">Thang Naranjo<\/td>\n<td colspan=\"17\" width=\"378\">Thang kh\u00e1c:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/td>\n<\/tr>\n<tr>\n<td colspan=\"35\" width=\"751\">19. Ph\u1ea7n b\u00ecnh lu\u1eadn c\u1ee7a c\u00e1n b\u1ed9 y t\u1ebf (n\u1ebfu c\u00f3)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<tr>\n<td colspan=\"14\" width=\"295\">E.\u00a0\u00a0\u00a0TH\u00d4NG TIN V\u1ec0 NG\u01af\u1edcI B\u00c1O C\u00c1O<\/td>\n<td colspan=\"21\" width=\"456\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"35\" width=\"751\">20. H\u1ecd v\u00e0 t\u00ean:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ngh\u1ec1 nghi\u1ec7p\/Ch\u1ee9c v\u1ee5:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u0110i\u1ec7n tho\u1ea1i li\u00ean l\u1ea1c:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0Email:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026.<\/td>\n<\/tr>\n<tr>\n<td colspan=\"10\" width=\"235\">21. Ch\u1eef k\u00fd<\/td>\n<td colspan=\"16\" width=\"282\">22. D\u1ea1ng b\u00e1o c\u00e1o:\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 L\u1ea7n \u0111\u1ea7u\/\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 B\u1ed5 sung<\/td>\n<td colspan=\"9\" width=\"234\">23. Ng\u00e0y b\u00e1o c\u00e1o:\u2026\u2026\u2026\/\u2026..\u2026\/\u2026\u2026\u2026\u2026<\/td>\n<\/tr>\n<tr>\n<td width=\"36\"><\/td>\n<td width=\"30\"><\/td>\n<td width=\"36\"><\/td>\n<td width=\"36\"><\/td>\n<td width=\"18\"><\/td>\n<td width=\"18\"><\/td>\n<td width=\"40\"><\/td>\n<td width=\"6\"><\/td>\n<td width=\"18\"><\/td>\n<td width=\"6\"><\/td>\n<td width=\"6\"><\/td>\n<td width=\"9\"><\/td>\n<td width=\"37\"><\/td>\n<td width=\"6\"><\/td>\n<td width=\"3\"><\/td>\n<td width=\"48\"><\/td>\n<td width=\"12\"><\/td>\n<td width=\"12\"><\/td>\n<td width=\"2\"><\/td>\n<td width=\"34\"><\/td>\n<td width=\"12\"><\/td>\n<td width=\"24\"><\/td>\n<td width=\"12\"><\/td>\n<td width=\"42\"><\/td>\n<td width=\"12\"><\/td>\n<td width=\"6\"><\/td>\n<td width=\"6\"><\/td>\n<td width=\"24\"><\/td>\n<td width=\"24\"><\/td>\n<td width=\"12\"><\/td>\n<td width=\"29\"><\/td>\n<td width=\"18\"><\/td>\n<td width=\"28\"><\/td>\n<td width=\"6\"><\/td>\n<td width=\"83\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Xin ch\u00e2n th\u00e0nh c\u1ea3m \u01a1n!<\/p>\n<p>H\u01af\u1edaNG D\u1eaaN L\u00c0M B\u00c1O C\u00c1O<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"283\">Xin h\u00e3y b\u00e1o c\u00e1o t\u1ea5t c\u1ea3 c\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i m\u00e0 anh\/ch\u1ecb nghi ng\u1edd, \u0111\u1eb7c bi\u1ec7t khi:\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C\u00e1c ph\u1ea3n \u1ee9ng li\u00ean quan t\u1edbi thu\u1ed1c m\u1edbi<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C\u00e1c ph\u1ea3n \u1ee9ng kh\u00f4ng mong mu\u1ed1n ho\u1eb7c ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C\u00e1c ph\u1ea3n \u1ee9ng nghi\u00eam tr\u1ecdng<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Th\u1ea5t b\u1ea1i trong \u0111i\u1ec1u tr\u1ecb<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng thu\u1ed1c<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C\u00e1c sai s\u00f3t trong qu\u00e1 tr\u00ecnh s\u1eed d\u1ee5ng thu\u1ed1c.<\/p>\n<p>M\u1eabu b\u00e1o c\u00e1o n\u00e0y \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho c\u00e1c ph\u1ea3n \u1ee9ng g\u00e2y ra b\u1edfi:<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Thu\u1ed1c v\u00e0 c\u00e1c ch\u1ebf ph\u1ea9m sinh h\u1ecdc<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 V\u1eafc xin<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C\u00e1c thu\u1ed1c c\u1ed5 truy\u1ec1n ho\u1eb7c thu\u1ed1c c\u00f3 ngu\u1ed3n g\u1ed1c d\u01b0\u1ee3c li\u1ec7u<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng.<\/p>\n<p>Ng\u01b0\u1eddi b\u00e1o c\u00e1o c\u00f3 th\u1ec3 l\u00e0:<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 B\u00e1c s\u0129<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 D\u01b0\u1ee3c s\u0129<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Nha s\u0129<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Y t\u00e1\/ \u0111i\u1ec1u d\u01b0\u1ee1ng\/n\u1eef h\u1ed9 sinh<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C\u00e1c nh\u00e0 cung c\u1ea5p d\u1ecbch v\u1ee5 ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe kh\u00e1c.<\/td>\n<td width=\"467\">C\u00e1ch b\u00e1o c\u00e1o:\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u0110i\u1ec1n th\u00f4ng tin v\u00e0o m\u1eabu b\u00e1o c\u00e1o<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ch\u1ec9 c\u1ea7n \u0111i\u1ec1n nh\u1eefng ph\u1ea7n anh\/ch\u1ecb c\u00f3 th\u00f4ng tin<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 C\u00f3 th\u1ec3 \u0111\u00ednh k\u00e8m th\u00eam m\u1ed9t v\u00e0i trang (n\u1ebfu m\u1eabu b\u00e1o c\u00e1o kh\u00f4ng \u0111\u1ee7 kho\u1ea3ng tr\u1ed1ng \u0111\u1ec3 \u0111i\u1ec1n th\u00f4ng tin hay c\u00f3 nh\u1eefng x\u00e9t nghi\u1ec7m li\u00ean quan).<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Xin h\u00e3y g\u1eedi b\u00e1o c\u00e1o v\u1ec1 Trung t\u00e2m Qu\u1ed1c gia v\u1ec1 Th\u00f4ng tin thu\u1ed1c v\u00e0 Theo d\u00f5i ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c theo c\u00e1c \u0111\u1ecba ch\u1ec9 sau:<\/p>\n<table width=\"482\">\n<tbody>\n<tr>\n<td width=\"77\"><\/td>\n<td width=\"405\">Th\u01b0:\u00a0Trung t\u00e2m Qu\u1ed1c gia v\u1ec1 Th\u00f4ng tin thu\u1ed1c v\u00e0 Theo d\u00f5i ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1cTr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc D\u01b0\u1ee3c H\u00e0 N\u1ed9i<\/p>\n<p>13-15 L\u00ea Th\u00e1nh T\u00f4ng, Qu\u1eadn Ho\u00e0n Ki\u1ebfm, H\u00e0 N\u1ed9i<\/td>\n<\/tr>\n<tr>\n<td width=\"77\"><\/td>\n<td width=\"405\">Fax: 024 3933.5642<\/td>\n<\/tr>\n<tr>\n<td width=\"77\"><\/td>\n<td width=\"405\">\u0110i\u1ec7n tho\u1ea1i: 024 3933.5618<\/td>\n<\/tr>\n<tr>\n<td width=\"77\"><\/td>\n<td width=\"405\">Website:\u00a0<a href=\"http:\/\/canhgiacduoc.org.vn\/\" rel=\"noopener\">http:\/\/canhgiacduoc.org.vn<\/a>Email:\u00a0<u>di.pvcenter@gmail.com<\/u><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Anh\/ch\u1ecb c\u00f3 th\u1ec3 l\u1ea5y m\u1eabu b\u00e1o c\u00e1o n\u00e0y t\u1ea1i khoa D\u01b0\u1ee3c, ph\u00f2ng K\u1ebf ho\u1ea1ch t\u1ed5ng h\u1ee3p c\u1ee7a b\u1ec7nh vi\u1ec7n ho\u1eb7c t\u1ea3i t\u1eeb trang web\u00a0http:\/\/canhgiacduoc.org.vn. N\u1ebfu c\u00f3 b\u1ea5t k\u1ef3 th\u1eafc m\u1eafc n\u00e0o, anh\/ch\u1ecb c\u00f3 th\u1ec3 li\u00ean h\u1ec7 v\u1edbi Trung t\u00e2m Qu\u1ed1c gia v\u1ec1 Th\u00f4ng tin thu\u1ed1c v\u00e0 Theo d\u00f5i ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c theo s\u1ed1 \u0111i\u1ec7n tho\u1ea1i 024 3933 5618 ho\u1eb7c theo \u0111\u1ecba ch\u1ec9 email\u00a0<u>di.pvcenter@gmail.com<\/u>.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table>\n<tbody>\n<tr>\n<td colspan=\"15\" width=\"751\">Ph\u1ea7n d\u00e0nh cho Trung t\u00e2m DI &amp; ADR Qu\u1ed1c gia<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"307\">1.\u00a0\u00a0\u00a0\u00a0 G\u1eedi x\u00e1c nh\u1eadn t\u1edbi \u0111\u01a1n v\u1ecb b\u00e1o c\u00e1o<\/td>\n<td colspan=\"2\" width=\"48\"><\/td>\n<td colspan=\"8\" width=\"336\">3.\u00a0\u00a0\u00a0\u00a0 Ph\u1ea3n \u1ee9ng \u0111\u00e3 c\u00f3 trong y v\u0103n\/ SPC\/ CSDL<\/td>\n<td width=\"59\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" rowspan=\"2\" width=\"307\">2.\u00a0\u00a0\u00a0\u00a0 Ph\u00e2n lo\u1ea1i ph\u1ea3n \u1ee9ng\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0Thu\u1ed1c m\u1edbi\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0Thu\u1ed1c c\u0169<\/p>\n<p>\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0Nghi\u00eam tr\u1ecdng\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0Kh\u00f4ng nghi\u00eam tr\u1ecdng<\/td>\n<td colspan=\"2\" rowspan=\"2\" width=\"48\"><\/td>\n<td colspan=\"8\" width=\"336\">4.\u00a0\u00a0\u00a0\u00a0 Nh\u1eadp d\u1eef li\u1ec7u v\u00e0o h\u1ec7 c\u01a1 s\u1edf d\u1eef li\u1ec7u qu\u1ed1c gia<\/td>\n<td width=\"59\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" width=\"336\">5.\u00a0\u00a0\u00a0\u00a0 Nh\u1eadp d\u1eef li\u1ec7u v\u00e0o ph\u1ea7n m\u1ec1m Vigiflow<\/td>\n<td width=\"59\"><\/td>\n<\/tr>\n<tr>\n<td colspan=\"15\" width=\"751\">6.\u00a0\u00a0\u00a0\u00a0 M\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a ph\u1ea3n \u1ee9ng<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" width=\"193\">\u00a0\u00a0\u00a0\u00a0\u00a0 \u0110e d\u1ecda t\u00ednh m\u1ea1ng\/ g\u00e2y t\u1eed vong<\/td>\n<td colspan=\"6\" width=\"210\">\u00a0\u00a0\u00a0\u00a0 Nh\u1eadp vi\u1ec7n\/ k\u00e9o d\u00e0i th\u1eddi gian n\u1eb1m vi\u1ec7n<\/td>\n<td colspan=\"2\" width=\"120\">\u00a0\u00a0\u00a0\u00a0\u00a0 G\u00e2y d\u1ecb t\u1eadt\/ t\u00e0n t\u1eadt<\/td>\n<td colspan=\"5\" width=\"227\">\u00a0\u00a0\u00a0\u00a0\u00a0 Li\u00ean quan t\u1edbi l\u1ea1m d\u1ee5ng\/ ph\u1ee5 thu\u1ed9c thu\u1ed1c<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" width=\"277\">7.\u00a0\u00a0\u00a0\u00a0 G\u1eedi b\u00e1o c\u00e1o t\u1edbi h\u1ed9i \u0111\u1ed3ng th\u1ea9m \u0111\u1ecbnh<\/td>\n<td colspan=\"2\" width=\"42\"><\/td>\n<td colspan=\"4\" width=\"114\">Ng\u00e0y g\u1eedi.\u2026\u2026\/.\u2026..\/\u2026\u2026\u2026.<\/td>\n<td colspan=\"3\" width=\"174\">8.\u00a0\u00a0\u00a0\u00a0 G\u1eedi b\u00e1o c\u00e1o cho UMC<\/td>\n<td width=\"36\"><\/td>\n<td colspan=\"2\" width=\"107\">Ng\u00e0y g\u1eedi\u2026\u2026..\/\u2026\u2026\/\u2026\u2026\u2026<\/td>\n<\/tr>\n<tr>\n<td colspan=\"15\" width=\"751\">9.\u00a0\u00a0\u00a0\u00a0 K\u1ebft qu\u1ea3 th\u1ea9m \u0111\u1ecbnh<\/td>\n<\/tr>\n<tr>\n<td width=\"187\">Ch\u1eafc ch\u1eafnC\u00f3 kh\u1ea3 n\u0103ng<\/p>\n<p>C\u00f3 th\u1ec3<\/td>\n<td colspan=\"6\" width=\"187\">Kh\u00f4ng ch\u1eafc ch\u1eafnCh\u01b0a ph\u00e2n lo\u1ea1i<\/p>\n<p>Kh\u00f4ng th\u1ec3 ph\u00e2n lo\u1ea1i<\/td>\n<td colspan=\"8\" width=\"377\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kh\u00e1c:\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/p>\n<p>\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/td>\n<\/tr>\n<tr>\n<td colspan=\"7\" width=\"373\">10.\u00a0\u00a0 Ng\u01b0\u1eddi qu\u1ea3n l\u00fd b\u00e1o c\u00e1o\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026<\/td>\n<td colspan=\"4\" width=\"180\">11.\u00a0\u00a0 Ng\u00e0y:\u2026.\u2026.\/\u2026..\u2026\/\u2026\u2026\u2026..<\/td>\n<td colspan=\"4\" width=\"197\">12.\u00a0\u00a0 Ch\u1eef k\u00fd<\/td>\n<\/tr>\n<tr>\n<td width=\"187\"><\/td>\n<td width=\"7\"><\/td>\n<td width=\"83\"><\/td>\n<td width=\"30\"><\/td>\n<td width=\"12\"><\/td>\n<td width=\"36\"><\/td>\n<td width=\"18\"><\/td>\n<td width=\"30\"><\/td>\n<td width=\"30\"><\/td>\n<td width=\"90\"><\/td>\n<td width=\"30\"><\/td>\n<td width=\"53\"><\/td>\n<td width=\"36\"><\/td>\n<td width=\"48\"><\/td>\n<td width=\"59\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>K\u1ebeT LU\u1eacN<\/h2>\n<p>L\u00e0 chuy\u00ean gia v\u1ec1 thu\u1ed1c, d\u01b0\u1ee3c s\u0129 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong nh\u00f3m \u0111i\u1ec1u tr\u1ecb, \u0111\u1eb7c bi\u1ec7t l\u00e0 khi x\u1ea3y ra ADR. \u0110i\u1ec1u tr\u1ecb ADR bao g\u1ed3m ch\u1ee7 y\u1ebfu l\u00e0 tr\u1ecb li\u1ec7u h\u1ed7 tr\u1ee3 v\u1edbi qu\u1ea3n l\u00fd tri\u1ec7u ch\u1ee9ng. Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c s\u1ebd kh\u00f4ng bao gi\u1edd \u0111\u01b0\u1ee3c lo\u1ea1i b\u1ecf ho\u00e0n to\u00e0n, ngay c\u1ea3 v\u1edbi c\u00e1c h\u1ec7 th\u1ed1ng c\u1ea3nh gi\u00e1c d\u01b0\u1ee3c tinh vi nh\u1ea5t. Nhi\u1ec7m v\u1ee5 c\u1ee7a ng\u01b0\u1eddi h\u00e0nh ngh\u1ec1 ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe l\u00e0 gi\u1ea3m thi\u1ec3u s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a ADR. Vi\u1ec7c b\u00e1o c\u00e1o ADR cho c\u00e1c c\u01a1 quan b\u00e1o c\u00e1o qu\u1ed1c gia v\u00e0 to\u00e0n c\u1ea7u, cho c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t thu\u1ed1c v\u00e0 trong c\u00e1c t\u00e0i li\u1ec7u ch\u00ednh th\u1ee9c \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n gi\u00fap DS trang b\u1ecb ki\u1ebfn th\u1ee9c th\u1ee9c cho b\u1ea3n th\u00e2n c\u0169ng nh\u01b0 c\u00e1c chuy\u00ean gia y t\u1ebf kh\u00e1c trong c\u00f4ng t\u00e1c ph\u00f2ng ng\u1eeba ADR. Ng\u01b0\u1eddi DS c\u1ea7n hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf c\u1ee7a ADR \u0111\u1ec3 \u1ee9ng d\u1ee5ng trong vi\u1ec7c ph\u00e1t tri\u1ec3n thu\u1ed1c v\u00e0 ch\u0103m s\u00f3c b\u1ec7nh nh\u00e2n. Ngo\u00e0i ra c\u00e1c y\u1ebfu t\u1ed1 ch\u1ee7 quan c\u1ee7a b\u1ec7nh nh\u00e2n nh\u01b0 tu\u1ed5i t\u00e1c, gi\u1edbi t\u00ednh, lo\u1ea1i HLA, ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 gan c\u0169ng l\u00e0 nh\u1eefng y\u1ebfu t\u1ed1 quan tr\u1ecdng c\u1ea7n \u0111\u01b0\u1ee3c c\u00e2n nh\u1eafc trong vi\u1ec7c l\u1ef1a ch\u1ecdn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1eb1ng thu\u1ed1c v\u00e0 li\u1ec1u l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/h2>\n<p>Stephanie N. Schatz, Robert J. Weber (2015). Adverse Drug Reactions. American College of Clinical Pharmacy. Link: <a href=\"https:\/\/bit.ly\/2J12M7W\" rel=\"noopener\">https:\/\/bit.ly\/2J12M7W<\/a><\/p>\n<p>B\u1ed9 Y T\u1ebf. Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c. Trung t\u00e2m DI &amp; ADR qu\u1ed1c gia. Link: <a href=\"http:\/\/canhgiacduoc.org.vn\/CanhGiacDuoc\/phanungcohai.aspx\" rel=\"noopener\">http:\/\/canhgiacduoc.org.vn\/CanhGiacDuoc\/phanungcohai.aspx<\/a><\/p>\n<p>John W Quin; Gary A Unglick (2010). Adverse Drug Reactions. Virtual Medical Centre. Link: https:\/\/bit.ly\/2UtzkJd<br \/>\nKristin A. Williams, M. Louay Taifour. Adverse Drug Reactions \u2013 Part I Clinical Manifestations of ADRs. Dentalcare. Link : <a href=\"https:\/\/www.dentalcare.com\/en-us\/professional-education\/ce-courses\/ce536\/clinical-manifestations-of-adrs\" rel=\"noopener\">https:\/\/www.dentalcare.com\/en-us\/professional-education\/ce-courses\/ce536\/clinical-manifestations-of-adrs<\/a><\/p>\n<p>Daphne E. Smith Marsh (2018). Overview of Adverse Drug Reactions. MSDMANUALS. Link: https:\/\/msdmnls.co\/2UuaLeU<br \/>\nPh\u1ea1m V\u0103n Voi (2017). Ph\u00f2ng ng\u1eeba v\u00e0 x\u1eed tr\u00ed ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c. B\u1ec7nh vi\u1ec7n \u0111a khoa C\u00e1i N\u01b0\u1edbc. Link: <a href=\"https:\/\/bit.ly\/2SVXRoC\" rel=\"noopener\">https:\/\/bit.ly\/2SVXRoC<\/a><\/p>\n<p>B\u1ed9 Y T\u1ebf (2013). Quy\u1ebft \u0111\u1ecbnh v\u1ec1 vi\u1ec7c ban h\u00e0nh h\u01b0\u1edbng d\u1eabn ho\u1ea1t \u0111\u1ed9ng gi\u00e1m s\u00e1t ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c (ADR) t\u1ea1i c\u00e1c c\u01a1 s\u1edf kh\u00e1m, ch\u1eefa b\u1ec7nh. Trung t\u00e2m DI &amp; ADR qu\u1ed1c gia. Link: <a href=\"http:\/\/canhgiacduoc.org.vn\/SiteData\/3\/UserFiles\/VanBanPhapQuy\/Guidline%20ADR_2013.04.04.pdf\" rel=\"noopener\">http:\/\/canhgiacduoc.org.vn\/SiteData\/3\/UserFiles\/VanBanPhapQuy\/Guidline%20ADR_2013.04.04.pdf<\/a><\/p>\n<p>B\u1ed9 Y T\u1ebf. M\u1eabu b\u00e1o c\u00e1o ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i theo quy \u0111\u1ecbnh c\u1ee7a B\u1ed9 Y t\u1ebf d\u00e0nh cho c\u00e1c c\u01a1 s\u1edf kh\u00e1m, ch\u1eefa b\u1ec7nh. Trung t\u00e2m DI &amp; ADR qu\u1ed1c gia. Link: <a href=\"http:\/\/canhgiacduoc.org.vn\/CanhGiacDuoc\/ADROnline.aspx\" rel=\"noopener\">http:\/\/canhgiacduoc.org.vn\/CanhGiacDuoc\/ADROnline.aspx<\/a><\/p>\n<p style=\"text-align: right;\">T\u00e1c gi\u1ea3: Sinh vi\u00ean D\u01b0\u1ee3c\u00a0T\u0103ng V\u00e2n H\u1ea3i, Phan D\u01b0\u01a1ng Li\u00ean Ph\u01b0\u01a1ng, Hu\u1ef3nh Xu\u00e2n Th\u1ea3o, Nguy\u1ec5n \u0110\u00ecnh \u0110\u1ea1m, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Y khoa Ph\u1ea1m Ng\u1ecdc Th\u1ea1ch<\/p>\n<p style=\"text-align: right;\">Nh\u1ecbp c\u1ea7u D\u01b0\u1ee3c L\u00e2m S\u00e0ng.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>GI\u1edaI THI\u1ec6U Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c (Adverse Drug Reaction-ADR) x\u1ea3y ra g\u1ea7n nh\u01b0 h\u00e0ng ng\u00e0y trong c\u00e1c c\u01a1 s\u1edf ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe v\u00e0 c\u00f3 th\u1ec3 g\u00e2y \u1ea3nh h\u01b0\u1edfng x\u1ea5u \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n, d\u1eabn \u0111\u1ebfn b\u1ec7nh t\u1eadt v\u00e0 t\u1eed vong. Ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c cho [&#8230;]\n","protected":false},"author":1,"featured_media":4759,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4757","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=4757"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4757\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/4759"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=4757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=4757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=4757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}