{"id":4743,"date":"2019-03-12T10:23:32","date_gmt":"2019-03-12T03:23:32","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=4743"},"modified":"2019-04-13T09:43:15","modified_gmt":"2019-04-13T02:43:15","slug":"medsafe-khuyen-cao-su-dung-paracetamol-dang-giai-phong-bien-doi","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/medsafe-khuyen-cao-su-dung-paracetamol-dang-giai-phong-bien-doi\/","title":{"rendered":"Medsafe: Khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i"},"content":{"rendered":"<p>Do xu\u1ea5t hi\u1ec7n m\u1ed9t s\u1ed1 b\u00e1o c\u00e1o case v\u1ec1 bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i li\u00ean quan \u0111\u1ebfn<strong> paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/strong>, MEDSAFE (C\u01a1 quan qu\u1ea3n l\u00fd an to\u00e0n ch\u1ebf ph\u1ea9m y t\u1ebf NewZealand) \u0111\u00e3 c\u00f3 khuy\u1ebfn c\u00e1o \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng vi\u1ec7c s\u1eed d\u1ee5ng h\u1ee3p l\u00fd, an to\u00e0n lo\u1ea1i ch\u1ebf ph\u1ea9m n\u00e0y.<\/p>\n<h2>Th\u00e0nh ph\u1ea7n c\u1ee7a c\u00e1c ch\u1ebf ph\u1ea9m paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i<\/h2>\n<p>Vi\u00ean paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i c\u00f3 m\u1eb7t tr\u00ean th\u1ecb tr\u01b0\u1eddng New Zealand ch\u1ee9a 665mg paracetamol, li\u1ec1u d\u00f9ng 3 l\u1ea7n\/ng\u00e0y.<\/p>\n<p>Vi\u00ean thu\u1ed1c n\u00e0y ch\u1ee9a 31% paracetamol gi\u1ea3i ph\u00f3ng t\u1ed1c \u0111\u1ed9 trung b\u00ecnh v\u00e0 69% paracetamol gi\u1ea3i ph\u00f3ng ch\u1eadm.<\/p>\n<h2>Qu\u00e1 li\u1ec1u paracetamol<\/h2>\n<p>C\u00e1c s\u1ea3n ph\u1ea9m paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i c\u00f3 ch\u1ea5t l\u01b0\u1ee3ng, \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c khi d\u00f9ng \u1edf li\u1ec1u khuy\u1ebfn c\u00e1o.<\/p>\n<p>Qu\u00e1 li\u1ec1u paracetamol d\u1ea1ng th\u01b0\u1eddng c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y suy gan. \u0110i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi b\u1eb1ng N-acetyl cysteine c\u00f3 th\u1ec3 ng\u0103n ng\u1eeba t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y. Tuy nhi\u00ean, \u0111i\u1ec1u tr\u1ecb qu\u00e1 li\u1ec1u paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i th\u01b0\u1eddng kh\u00f3 kh\u0103n h\u01a1n.<\/p>\n<p>Qu\u00e1 li\u1ec1u paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i d\u1eabn \u0111\u1ebfn vi\u1ec7c h\u1ea5p thu paracetamol k\u00e9o d\u00e0i v\u00e0 kh\u00f4ng th\u1ec3 \u0111o\u00e1n tr\u01b0\u1edbc. N\u1ed3ng \u0111\u1ed9 paracetamol trong huy\u1ebft thanh c\u00f3 th\u1ec3 \u0111\u1ea1t c\u1ef1c \u0111\u1ea1i mu\u1ed9n nh\u1ea5t l\u00e0 24 gi\u1edd sau khi u\u1ed1ng paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i. Khi qu\u00e1 li\u1ec1u n\u1eb7ng, c\u00e1c vi\u00ean n\u00e9n gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i c\u00f3 th\u1ec3 t\u1ea1o th\u00e0nh m\u1ed9t kh\u1ed1i (\u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 s\u1ecfi) trong ru\u1ed9t, d\u1eabn \u0111\u1ebfn l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh h\u1ea5p thu do thay \u0111\u1ed5i t\u00ednh ch\u1ea5t ph\u00e2n r\u00e3 v\u00e0 h\u00f2a tan c\u1ee7a c\u00e1c vi\u00ean n\u00e9n. B\u00ean c\u1ea1nh \u0111\u00f3, s\u1ef1 h\u1ea5p thu ch\u1eadm v\u00e0 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc kh\u00f3 d\u1ef1 \u0111o\u00e1n c\u1ee7a paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm s\u1ef1 xu\u1ea5t hi\u1ec7n m\u1ed9t c\u1ef1c \u0111\u1ea1i c\u1ee7a n\u1ed3ng \u0111\u1ed9 paracetamol trong huy\u1ebft thanh.<\/p>\n<p>MARC l\u01b0u \u00fd r\u1eb1ng c\u00e1c h\u01b0\u1edbng d\u1eabn x\u1eed tr\u00ed ng\u1ed9 \u0111\u1ed9c paracetamol s\u1ebd \u0111\u01b0\u1ee3c b\u1ed5 sung \u0111\u1ec3 gi\u1ea3i quy\u1ebft tr\u01b0\u1eddng h\u1ee3p qu\u00e1 li\u1ec1u c\u1ee7a paracetamol gi\u1ea3i ph\u00f3ng bi\u1ebfn \u0111\u1ed5i.<\/p>\n<h2>Medsafe khuy\u1ebfn c\u00e1o h\u1ea1n ch\u1ebf k\u00ea \u0111\u01a1n paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/h2>\n<p>Paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i hi\u1ec7n \u0111ang \u0111\u01b0\u1ee3c h\u1ea1n ch\u1ebf k\u00ea \u0111\u01a1n (ch\u1ec9 b\u00e1n thu\u1ed1c theo \u0111\u01a1n, \u0111\u01a1n \u0111\u01b0\u1ee3c k\u00ea b\u1edfi c\u00e1n b\u1ed9 y t\u1ebf, kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e9p mua d\u01b0\u1edbi d\u1ea1ng thuocs OTC).<\/p>\n<p>MEDSAFE v\u00e0 c\u00e1c c\u00e1n b\u1ed9 y t\u1ebf c\u1ea7n \u0111\u1ea3m b\u1ea3o r\u1eb1ng ng\u01b0\u1eddi ti\u00eau d\u00f9ng nh\u1eadn \u0111\u01b0\u1ee3c th\u00f4ng tin v\u1ec1 c\u00e1ch d\u00f9ng thu\u1ed1c \u0111\u00fang c\u00e1ch v\u00e0 kh\u00f4ng d\u00f9ng \u0111\u1ed3ng th\u1eddi c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1cc\u00f3 ch\u1ee9a paracetamol.<\/p>\n<p>Ngu\u1ed3n: <a href=\"https:\/\/www.medsafe.govt.nz\/profs\/PUArticles\/March2019\/Modified-release%20paracetamol%20%E2%80%93%20Unpredictable%20in%20overdose.htm\" rel=\"noopener\">https:\/\/www.medsafe.govt.nz\/profs\/PUArticles\/March2019\/Modified-release%20paracetamol%20%E2%80%93%20Unpredictable%20in%20overdose.htm<\/a><\/p>\n<p>Ng\u01b0\u1eddi t\u1ed5ng h\u1ee3p: V\u00f5 Th\u1ecb Th\u00f9y &#8211; Nguy\u1ec5n Ph\u01b0\u01a1ng Th\u00fay &#8211; Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Do xu\u1ea5t hi\u1ec7n m\u1ed9t s\u1ed1 b\u00e1o c\u00e1o case v\u1ec1 bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i li\u00ean quan \u0111\u1ebfn paracetamol d\u1ea1ng gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i, MEDSAFE (C\u01a1 quan qu\u1ea3n l\u00fd an to\u00e0n ch\u1ebf ph\u1ea9m y t\u1ebf NewZealand) \u0111\u00e3 c\u00f3 khuy\u1ebfn c\u00e1o \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng vi\u1ec7c s\u1eed d\u1ee5ng h\u1ee3p l\u00fd, an to\u00e0n lo\u1ea1i ch\u1ebf ph\u1ea9m n\u00e0y. Th\u00e0nh ph\u1ea7n c\u1ee7a [&#8230;]\n","protected":false},"author":1,"featured_media":4744,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4743","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4743","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=4743"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4743\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/4744"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=4743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=4743"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=4743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}