{"id":4593,"date":"2019-03-11T13:08:50","date_gmt":"2019-03-11T06:08:50","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=4593"},"modified":"2019-04-13T09:43:51","modified_gmt":"2019-04-13T02:43:51","slug":"tien-hanh-thu-hoi-tu-nguyen-nhieu-lo-thuoc-chua-losartan-do-nghi-ngo-co-chua-tap-chat-nitrosamin","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/tien-hanh-thu-hoi-tu-nguyen-nhieu-lo-thuoc-chua-losartan-do-nghi-ngo-co-chua-tap-chat-nitrosamin\/","title":{"rendered":"Thu h\u1ed3i t\u1ef1 nguy\u1ec7n nhi\u1ec1u l\u00f4 thu\u1ed1c ch\u1ee9a Losartan"},"content":{"rendered":"<h2>Ti\u1ebfn h\u00e0nh thu h\u1ed3i t\u1ef1 nguy\u1ec7n nhi\u1ec1u l\u00f4 thu\u1ed1c ch\u1ee9a Losartan do nghi ng\u1edd c\u00f3 ch\u1ee9a t\u1ea1p ch\u1ea5t nitrosamin<\/h2>\n<p>B\u1ed9 Y t\u1ebf Canada ti\u1ebfp t\u1ee5c c\u1eadp nh\u1eadt th\u00f4ng tin cho ng\u01b0\u1eddi d\u00e2n v\u1ec1 nhi\u1ec1u lo\u1ea1i <strong>thu\u1ed1c c\u00f3 ch\u1ee9a Losartan<\/strong> \u0111ang \u0111\u01b0\u1ee3c c\u00e1c c\u00f4ng ty Teva Canada, Apotex Inc., Pharmascience Inc., v\u00e0 Pro Doc Limit\u00e9e thu h\u1ed3i t\u1ef1 nguy\u1ec7n do nghi ng\u1edd c\u00f3 ch\u1ee9a t\u1ea1p ch\u1ea5t nitrosamine, N-Nitroso-N-methyl-4-aminobutyric acid (NMBA).<\/p>\n<figure id=\"attachment_4610\" aria-describedby=\"caption-attachment-4610\" style=\"width: 450px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-4610\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/03\/Losartan_teva.jpg\" alt=\"Losartan teva\" width=\"450\" height=\"450\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/03\/Losartan_teva.jpg 450w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/03\/Losartan_teva-350x350.jpg 350w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/03\/Losartan_teva-150x150.jpg 150w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/03\/Losartan_teva-300x300.jpg 300w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/03\/Losartan_teva-100x100.jpg 100w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-4610\" class=\"wp-caption-text\">H\u00ecnh \u1ea3nh: S\u1ea3n ph\u1ea9m Losartan Teva<\/figcaption><\/figure>\n<p>NMBA l\u00e0 m\u1ed9t ch\u1ea5t g\u00e2y ung th\u01b0 \u1edf ng\u01b0\u1eddi, \u0111i\u1ec1u \u0111\u00f3 c\u00f3 ngh\u0129a l\u00e0 vi\u1ec7c ti\u1ebfp x\u00fac l\u00e2u d\u00e0i c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 ung th\u01b0.<\/p>\n<p>Teva Canada \u0111ang t\u1ef1 nguy\u1ec7n thu h\u1ed3i hai l\u00f4 vi\u00ean Losartan\/hydrochlorothiazide (HCTZ) sau khi th\u1eed nghi\u1ec7m ph\u00e1t hi\u1ec7n m\u1ed9t l\u01b0\u1ee3ng NMBA \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u1edf tr\u00ean m\u1ee9c \u0111\u01b0\u1ee3c coi l\u00e0 an to\u00e0n h\u1ee3p l\u00fd n\u1ebfu thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong su\u1ed1t \u0111\u1eddi. Apotex Inc., Pharmascience Inc. v\u00e0 Pro Doc Limit\u00e9e \u0111ang t\u1ef1 nguy\u1ec7n thu h\u1ed3i nhi\u1ec1u l\u00f4 s\u1ea3n ph\u1ea9m c\u00f3 ch\u1ee9a Losartan \u0111\u1ec3 \u0111\u1ec1 ph\u00f2ng.<\/p>\n<p>Th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t losartan (API) trong t\u1ea5t c\u1ea3 c\u00e1c s\u1ea3n ph\u1ea9m b\u1ecb thu h\u1ed3i \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t b\u1edfi Hetero Labs Ltd. \u1ea4n \u0110\u1ed9. Nh\u1eefng \u0111\u1ee3t thu h\u1ed3i n\u00e0y bao g\u1ed3m t\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c ph\u00e2n ph\u1ed1i t\u1ea1i Canada c\u00f3 ch\u1ee9a Losartan \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1ea1i Hetero Labs Ltd.<\/p>\n<p>Losartan thu\u1ed9c nh\u00f3m thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin (ARB), c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 sartan.Sartans l\u00e0 m\u1ed9t nh\u00f3m thu\u1ed1c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p \u0111\u1ec3 gi\u00fap ng\u0103n ng\u1eeba c\u00e1c c\u01a1n \u0111au tim v\u00e0 \u0111\u1ed9t qu\u1ef5. Ch\u00fang c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb suy tim ho\u1eb7c \u0111au tim. \u0110\u00e3 c\u00f3 nhi\u1ec1u \u0111\u1ee3t thu h\u1ed3i c\u00e1c s\u1ea3n ph\u1ea9m c\u00f3 ch\u1ee9a m\u1ed9t sartan kh\u00e1c c\u00f9ng nh\u00f3m l\u00e0 valsartan, \u1edf Canada v\u00e0 tr\u00ean to\u00e0n th\u1ebf gi\u1edbi k\u1ec3 t\u1eeb th\u00e1ng 7 n\u0103m 2018 v\u00ec nghi ng\u1edd nhi\u1ec5m t\u1ea1p ch\u1ea5t nitrosamine<\/p>\n<p>C\u0169ng nh\u01b0 c\u00e1c v\u1ee5 thu h\u1ed3i tr\u01b0\u1edbc \u0111\u00e2y li\u00ean quan \u0111\u1ebfn t\u1ea1p ch\u1ea5t nitrosamine, B\u1ed9 Y t\u1ebf Canada khuy\u00ean r\u1eb1ng kh\u00f4ng c\u00f3 r\u1ee7i ro x\u1ea3y ra ngay l\u1eadp t\u1ee9c \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n d\u00f9ng c\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y, v\u00ec nguy c\u01a1 ung th\u01b0 ti\u1ec1m \u1ea9n l\u00e0 do ti\u1ebfp x\u00fac l\u00e2u d\u00e0i v\u1edbi t\u1ea1p ch\u1ea5t. B\u1ec7nh nh\u00e2n kh\u00f4ng n\u00ean ng\u1eebng d\u00f9ng thu\u1ed1c n\u1ebfu kh\u00f4ng tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129.<\/p>\n<p>Tr\u00ean th\u1ecb tr\u01b0\u1eddng Canada c\u00f3 nhi\u1ec1u s\u1ea3n ph\u1ea9m thay th\u1ebf cho thu\u1ed1c n\u00e0y. B\u1ed9 Y t\u1ebf Canada ti\u1ebfp t\u1ee5c theo d\u00f5i t\u00ecnh h\u00ecnh thu h\u1ed3i t\u1eeb c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t. B\u1ed9 Y t\u1ebf Canada khuy\u1ebfn kh\u00edch ng\u01b0\u1eddi d\u00e2n tham kh\u1ea3o trang web drugshortagescanada.ca \u0111\u1ec3 bi\u1ebft th\u00f4ng tin v\u1ec1 t\u00ecnh tr\u1ea1ng thi\u1ebfu thu\u1ed1c v\u00e0 ng\u1eebng thu\u1ed1c. B\u1ec7nh nh\u00e2n h\u00e3y tham kh\u1ea3o \u00fd ki\u1ebfn c\u00e1n b\u1ed9 y t\u1ebf v\u1ec1 c\u00e1c lo\u1ea1i thu\u1ed1c h\u1ecd \u0111ang d\u00f9ng, bao g\u1ed3m c\u1ea3 gi\u1ea3i ph\u00e1p c\u1ea7n th\u1ef1c hi\u1ec7n khi thi\u1ebfu thu\u1ed1c.<\/p>\n<p>B\u1ed9 Y t\u1ebf Canada khuy\u1ebfn kh\u00edch ng\u01b0\u1eddi ti\u00eau d\u00f9ng b\u00e1o c\u00e1o b\u1ea5t k\u1ef3 t\u00e1c d\u1ee5ng ph\u1ee5 ho\u1eb7c khi\u1ebfu n\u1ea1i li\u00ean quan \u0111\u1ebfn thu\u1ed1c.<\/p>\n<h2>S\u1ea3n ph\u1ea9m b\u1ecb \u1ea3nh h\u01b0\u1edfng<\/h2>\n<p>C\u00e1c s\u1ea3n ph\u1ea9m c\u00f3 ch\u1ee9a Losartan do Hetero Labs Ltd. s\u1ea3n xu\u1ea5t \u0111ang b\u1ecb thu h\u1ed3i. B\u1ed9 Y t\u1ebf Canada \u0111\u00e3 \u0111\u0103ng t\u1ea3i m\u1ed9t danh s\u00e1ch \u0111\u1ea7y \u0111\u1ee7 c\u00e1c lo\u1ea1i thu\u1ed1c sartan \u0111\u00e3 b\u1ecb thu h\u1ed3i v\u00ec t\u1ea1p ch\u1ea5t nitrosamine tr\u00ean trang web .<\/p>\n<p>Th\u00f4ng tin v\u1ec1 T\u00ean thu\u1ed1c (Th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t), h\u00e0m l\u01b0\u1ee3ng, s\u1ed1 l\u00f4 v\u00e0 h\u1ea1n s\u1eed d\u1ee5ng xin tham kh\u1ea3o chi ti\u1ebft trong ngu\u1ed3n d\u1eabn.<\/p>\n<h2>C\u00e1c \u0111\u00e1nh gi\u00e1 \u0111ang ti\u1ebfn h\u00e0nh<\/h2>\n<p>B\u1ed9 Y t\u1ebf Canada ti\u1ebfp t\u1ee5c h\u1ee3p t\u00e1c v\u1edbi c\u00e1c c\u00f4ng ty v\u00e0 c\u00e1c \u0111\u1ed1i t\u00e1c ph\u00e1p l\u00fd qu\u1ed1c t\u1ebf, bao g\u1ed3m FDA vad EMA, \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 v\u1ea5n \u0111\u1ec1 t\u1ea1p ch\u1ea5t nitrosamine trong m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c sartan, nguy\u00ean nh\u00e2n g\u1ed1c r\u1ec5 v\u00e0 c\u00e1c bi\u1ec7n ph\u00e1p gi\u1ea3m thi\u1ec3u. \u0110\u00e1nh gi\u00e1 c\u1ee7a Health Canada cho th\u1ea5y r\u1eb1ng nitrosamine c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u1ea1o ra trong quy tr\u00ecnh s\u1ea3n xu\u1ea5t thu\u1ed1c,t\u1eeb c\u00e1c lo\u1ea1i h\u00f3a ch\u1ea5t trong nh\u1eefng \u0111i\u1ec1u ki\u1ec7n ph\u1ea3n \u1ee9ng nh\u1ea5t \u0111\u1ecbnh. Ch\u00fang c\u0169ng c\u00f3 th\u1ec3 l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a vi\u1ec7c t\u00e1i s\u1eed d\u1ee5ng c\u00e1c v\u1eadt li\u1ec7u, nh\u01b0 dung m\u00f4i ho\u1eb7c nguy\u00ean li\u1ec7u ban \u0111\u1ea7u, b\u1ecb nhi\u1ec5m t\u1ea1p ch\u1ea5t.<\/p>\n<p>API (active pharmaceutical ingredients) l\u00e0 th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t trong m\u1ed9t lo\u1ea1i thu\u1ed1c t\u1ea1o ra c\u00e1c t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb trong c\u01a1 th\u1ec3. API \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong s\u1ea3n xu\u1ea5t c\u00e1c thu\u1ed1c th\u00e0nh ph\u1ea9m v\u1edbi li\u1ec1u l\u01b0\u1ee3ng nh\u1ea5t \u0111\u1ecbnh d\u01b0\u1edbi nhi\u1ec1u d\u1ea1ng d\u01b0\u1ee3c d\u1ee5ng (nh\u01b0 thu\u1ed1c vi\u00ean, vi\u00ean nang ho\u1eb7c vi\u00ean n\u00e9n).<\/p>\n<p>V\u00e0o th\u00e1ng 12 n\u0103m 2018, B\u1ed9 Y t\u1ebf Canada \u0111\u00e3 y\u00eau c\u1ea7u t\u1ea5t c\u1ea3 c\u00e1c c\u00f4ng ty l\u01b0u h\u00e0nh c\u00e1c thu\u1ed1c sartans \u1edf Canada th\u1eed nghi\u1ec7m c\u00e1c t\u1ea1p ch\u1ea5t N-nitrosodimethylamine (NDMA) v\u00e0 N-nitrosodiethylamine (NDEA) trong c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e3 c\u00f3 tr\u00ean th\u1ecb tr\u01b0\u1eddng Canada. B\u1ed9 Y t\u1ebf Canada c\u0169ng khuy\u1ebfn ngh\u1ecb c\u00e1c c\u00f4ng ty n\u00ean c\u00e2n nh\u1eafc s\u1eed d\u1ee5ng c\u00e1c bi\u1ec7n ph\u00e1p s\u1ea3n xu\u1ea5t \u0111\u1ec3 tr\u00e1nh s\u1ef1 ph\u00e1t sinh v\u00e0 xu\u1ea5t di\u1ec7n c\u1ee7a t\u1ea5t c\u1ea3 c\u00e1c t\u1ea1p ch\u1ea5t nitrosamine. B\u1ed9 Y t\u1ebf Canada \u0111\u00e3 th\u1eed nghi\u1ec7m h\u01a1n 50 m\u1eabu thu\u1ed1c sartan v\u00e0 s\u1ebd ti\u1ebfp t\u1ee5c \u0111\u0103ng t\u1ea3i k\u1ebft qu\u1ea3 c\u1ee7a b\u1ea5t k\u1ef3 m\u1eabu m\u1edbi n\u00e0o m\u00e0 h\u1ecd th\u1eed nghi\u1ec7m tr\u00ean trang web c\u1ee7a B\u1ed9.<\/p>\n<p>B\u1ed9 Y t\u1ebf Canada ti\u1ebfp t\u1ee5c y\u00eau c\u1ea7u c\u00e1c c\u00f4ng ty ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1ec1 s\u1ef1 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh t\u1ea1i Canada v\u00e0 hy v\u1ecdng c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t s\u1ebd th\u1ef1c hi\u1ec7n b\u1ea5t k\u1ef3 h\u00e0nh \u0111\u1ed9ng c\u1ea7n thi\u1ebft n\u00e0o \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t sinh c\u1ee7a t\u1ea1p ch\u1ea5t nitrosamine. B\u1ed9 s\u1ebd th\u1ef1c hi\u1ec7n c\u00e1c \u0111\u1ed9ng th\u00e1i th\u00edch h\u1ee3p v\u00e0 k\u1ecbp th\u1eddi \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 b\u1ea3o v\u1ec7 s\u1ee9c kh\u1ecfe v\u00e0 s\u1ef1 an to\u00e0n c\u1ee7a ng\u01b0\u1eddi Canada.<\/p>\n<h2>Th\u00f4ng tin v\u1ec1 c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t c\u00e1c thu\u1ed1c sartans<\/h2>\n<p>D\u1ef1a tr\u00ean vi\u1ec7c xem x\u00e9t th\u00f4ng tin t\u1eeb m\u1ed9t cu\u1ed9c ki\u1ec3m tra c\u1ee7a FDA, B\u1ed9 Y t\u1ebf Canada \u0111\u00e3 ph\u00e1t hi\u1ec7n \u0110\u01a1n v\u1ecb 1 c\u1ee7a Hetero Labs Ltd. kh\u00f4ng tu\u00e2n th\u1ee7 c\u00e1c y\u00eau c\u1ea7u \u0111\u1ed1i v\u1edbi Th\u1ef1c h\u00e0nh S\u1ea3n xu\u1ea5t T\u1ed1t (GMP). X\u1ebfp h\u1ea1ng kh\u00f4ng tu\u00e2n th\u1ee7 c\u00f3 ngh\u0129a l\u00e0 c\u00e1c c\u00f4ng ty \u1edf Canada kh\u00f4ng c\u00f2n \u0111\u01b0\u1ee3c ph\u00e9p nh\u1eadp kh\u1ea9u c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 ch\u1ee9a API t\u1eeb \u0111\u01a1n v\u1ecb s\u1ea3n xu\u1ea5t n\u00e0y trong tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng th\u1ef1c s\u1ef1 c\u1ea7n thi\u1ebft.<\/p>\n<p>Nh\u01b0 \u0111\u00e3 th\u00f4ng b\u00e1o tr\u01b0\u1edbc \u0111\u00f3, B\u1ed9 Y t\u1ebf Canada c\u0169ng \u0111\u00e3 ph\u00e1t hi\u1ec7n trang c\u01a1 s\u1edf s\u1ea3n xu\u1ea5t Chuannan c\u1ee7a Zhejiang Huahai Pharmaceuticals (ZHP) t\u1ea1i Trung Qu\u1ed1c kh\u00f4ng tu\u00e2n th\u1ee7 c\u00e1c y\u00eau c\u1ea7u c\u1ee7a GMP. C\u00e1c thu\u1ed1c valsartan \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t t\u1ea1i \u0111\u00e2y b\u1ecb ph\u00e1t hi\u1ec7n c\u00f3 ch\u1ee9a t\u1ea1p ch\u1ea5t nitrosamin. T\u1ea5t c\u1ea3 c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 ch\u1ee9a valsartan do ZHP s\u1ea3n xu\u1ea5t \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh \u1edf Canada\u0111\u00e3 b\u1ecb thu h\u1ed3i.<\/p>\n<p>GMP l\u00e0 c\u00e1c ti\u00eau chu\u1ea9n \u0111\u01b0\u1ee3c qu\u1ed1c t\u1ebf ch\u1ea5p nh\u1eadn, gi\u00fap \u0111\u1ea3m b\u1ea3o r\u1eb1ng c\u00e1c lo\u1ea1i thu\u1ed1c lu\u00f4n \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t, th\u1eed nghi\u1ec7m, l\u01b0u tr\u1eef v\u00e0 ph\u00e2n ph\u1ed1i theo c\u00e1c ti\u00eau chu\u1ea9n v\u1ec1 ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 \u0111\u1ed9 an to\u00e0n cao c\u1ee7a Canada. \u0110\u00e1nh gi\u00e1 kh\u00f4ng tu\u00e2n th\u1ee7 cho th\u1ea5y B\u1ed9 Y t\u1ebf \u0111\u00e3 ph\u00e1t hi\u1ec7n ra nh\u1eefng sai ph\u1ea1m trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t thu\u1ed1c v\u00e0 l\u01b0u h\u00e0nh thu\u1ed1c c\u1ee7a c\u00e1c c\u00f4ng ty. B\u1ed9 Y t\u1ebf Canada th\u01b0\u1eddng xuy\u00ean ki\u1ec3m tra c\u00e1c c\u01a1 s\u1edf ho\u1eb7c \u0111\u00e1nh gi\u00e1 k\u1ebft qu\u1ea3 ki\u1ec3m tra t\u1eeb c\u00e1c \u0111\u1ed1i t\u00e1c qu\u1ea3n l\u00fd qu\u1ed1c t\u1ebf \u0111\u00e1ng tin c\u1eady \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o h\u1ecd \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau chu\u1ea9n n\u00e0y v\u00e0 duy tr\u00ec c\u01a1 s\u1edf d\u1eef li\u1ec7u v\u1edbi k\u1ebft qu\u1ea3 ki\u1ec3m tra.<\/p>\n<p>B\u1ed9 Y t\u1ebf Canada ti\u1ebfp t\u1ee5c h\u1ee3p t\u00e1c v\u1edbi c\u00e1c c\u01a1 quan qu\u1ea3n l\u00fd qu\u1ed1c t\u1ebf v\u1ec1 vi\u1ec7c ki\u1ec3m tra c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t sartans ngo\u1ea1i nh\u1eadp \u0111\u1ec3 \u0111\u01b0a ra c\u00e1c \u0111\u1ed9ng th\u00e1i ph\u00f9 h\u1ee3p v\u00e0 c\u1eadp nh\u1eadt th\u00eam th\u00f4ng tin v\u1edbi ng\u01b0\u1eddi d\u00e2n khi c\u1ea7n thi\u1ebft.<\/p>\n<h2>T\u00e0i li\u1ec7u:<\/h2>\n<p><a href=\"https:\/\/healthycanadians.gc.ca\/recall-alert-rappel-avis\/hc-sc\/2019\/69272a-eng.php\" rel=\"noopener\">https:\/\/healthycanadians.gc.ca\/recall-alert-rappel-avis\/hc-sc\/2019\/69272a-eng.php<\/a><\/p>\n<p>Ng\u01b0\u1eddi t\u1ed5ng h\u1ee3p: \u0110\u1ed7 Thu Thanh \u2013 Nguy\u1ec5n Ph\u01b0\u01a1ng Th\u00fay &#8211; Trung T\u00e2m C\u1ea3nh Gi\u00e1c D\u01b0\u1ee3c Qu\u1ed1c Gia.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ti\u1ebfn h\u00e0nh thu h\u1ed3i t\u1ef1 nguy\u1ec7n nhi\u1ec1u l\u00f4 thu\u1ed1c ch\u1ee9a Losartan do nghi ng\u1edd c\u00f3 ch\u1ee9a t\u1ea1p ch\u1ea5t nitrosamin B\u1ed9 Y t\u1ebf Canada ti\u1ebfp t\u1ee5c c\u1eadp nh\u1eadt th\u00f4ng tin cho ng\u01b0\u1eddi d\u00e2n v\u1ec1 nhi\u1ec1u lo\u1ea1i thu\u1ed1c c\u00f3 ch\u1ee9a Losartan \u0111ang \u0111\u01b0\u1ee3c c\u00e1c c\u00f4ng ty Teva Canada, Apotex Inc., Pharmascience Inc., v\u00e0 Pro Doc Limit\u00e9e thu [&#8230;]\n","protected":false},"author":1,"featured_media":4610,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4593","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4593","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=4593"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4593\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/4610"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=4593"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=4593"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=4593"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}