{"id":4411,"date":"2019-03-13T15:14:58","date_gmt":"2019-03-13T08:14:58","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=4411"},"modified":"2019-03-13T15:14:58","modified_gmt":"2019-03-13T08:14:58","slug":"hsa-da-va-dang-tich-cuc-phat-hien-tap-chat-nitrosamine-trong-thuoc-uc-che-thu-the-angiotensin-ii-arbs","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/hsa-da-va-dang-tich-cuc-phat-hien-tap-chat-nitrosamine-trong-thuoc-uc-che-thu-the-angiotensin-ii-arbs\/","title":{"rendered":"HSA \u0111\u00e3 v\u00e0 \u0111ang t\u00edch c\u1ef1c ph\u00e1t hi\u1ec7n t\u1ea1p ch\u1ea5t nitrosamine trong thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin II (ARBs)"},"content":{"rendered":"<p><strong>C\u01a1 quan qu\u1ea3n l\u00fd Khoa h\u1ecdc Y t\u1ebf Singapore (HSA) \u0111\u00e3 v\u00e0 \u0111ang t\u00edch c\u1ef1c ph\u00e1t hi\u1ec7n t\u1ea1p ch\u1ea5t nitrosamine trong thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin II (ARBs) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong ki\u1ec3m so\u00e1t t\u0103ng huy\u1ebft \u00e1p \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng \u1edf Singapore.<\/strong><\/p>\n<p>C\u00e1c t\u1ea1p ch\u1ea5t nitrosamine l\u00e0 c\u00e1c ph\u1ee5 ph\u1ea9m \u0111\u01b0\u1ee3c sinh ra v\u1edbi s\u1ed1 l\u01b0\u1ee3ng \u00edt trong qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t c\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y. Sau khi ph\u00e1t hi\u1ec7n c\u00e1c t\u1ea1p ch\u1ea5t Nitrosodimethylamine (NDMA) v\u00e0 N-Nitrosodiethylamine (NDEA) trong m\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m ngo\u1ea1i nh\u1eadp v\u00e0o n\u0103m ngo\u00e1i, HSA \u0111\u00e3 ti\u1ebfn h\u00e0nh ki\u1ec3m nghi\u1ec7m t\u1ea5t c\u1ea3 c\u00e1c thu\u1ed1c li\u00ean quan \u1edf Singapore \u0111\u1ec3 ph\u00e1t hi\u1ec7n ra c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 ch\u1ee9a t\u1ea1p ch\u1ea5t n\u00e0y. HSA c\u0169ng \u0111\u00e3 l\u00e0m vi\u1ec7c v\u1edbi c\u00e1c c\u00f4ng ty \u0111\u1ec3 xem x\u00e9t l\u1ea1i c\u00e1c quy tr\u00ecnh s\u1ea3n xu\u1ea5t c\u1ee7a h\u1ecd v\u00e0 ti\u1ebfn h\u00e0nh ki\u1ec3m nghi\u1ec7m tr\u00ean c\u00e1c s\u1ea3n ph\u1ea9m c\u1ee7a h\u1ecd tr\u01b0\u1edbc khi cung c\u1ea5p ra th\u1ecb tr\u01b0\u1eddng Singapore. \u0110\u1ebfn nay, ch\u01b0a c\u00f3 s\u1ea3n ph\u1ea9m thu\u1ed1c trong n\u01b0\u1edbc n\u00e0o \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n ch\u1ee9a h\u00e0m l\u01b0\u1ee3ng c\u00e1c t\u1ea1p ch\u1ea5t n\u00e0y v\u01b0\u1ee3t qu\u00e1 m\u1ee9c cho ph\u00e9p.<\/p>\n<p>M\u1ed9t l\u01b0\u1ee3ng nh\u1ecf c\u1ee7a t\u1ea1p ch\u1ea5t nitrosamine kh\u00e1c, N-Nitroso-N-methyl-4-axit aminobutyric (NMBA) g\u1ea7n \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00e1c c\u01a1 quan qu\u1ea3n l\u00fd n\u01b0\u1edbc ngo\u00e0i ph\u00e1t hi\u1ec7n trong th\u00e0nh ph\u1ea7n thu\u1ed1c losartan do Hetero Labs s\u1ea3n xu\u1ea5t. HSA \u0111ang l\u00e0m vi\u1ec7c v\u1edbi c\u00e1c c\u00f4ng ty ki\u1ec3m \u0111\u1ecbnh xem c\u00e1c l\u00f4 thu\u1ed1c l\u01b0u h\u00e0nh trong n\u01b0\u1edbc c\u00f3 b\u1ecb \u1ea3nh h\u01b0\u1edfng hay kh\u00f4ng v\u00e0 \u0111\u00e3 b\u1eaft \u0111\u1ea7u th\u1eed nghi\u1ec7m t\u1ea1p ch\u1ea5t m\u1edbi n\u00e0y tr\u00ean t\u1ea5t c\u1ea3 thu\u1ed1c losartan. C\u00e1c s\u1ea3n ph\u1ea9m s\u1ebd \u0111\u01b0\u1ee3c thu h\u1ed3i n\u1ebfu b\u1ecb ph\u00e1t hi\u1ec7n ch\u1ee9a h\u00e0m l\u01b0\u1ee3ng t\u1ea1p ch\u1ea5t v\u01b0\u1ee3t m\u1ee9c cho ph\u00e9p. HSA s\u1ebd ti\u1ebfp t\u1ee5c theo d\u00f5i c\u00e1c th\u00f4ng b\u00e1o t\u1eeb ng\u01b0\u1eddi d\u00e2n v\u1ec1 b\u1ea5t k\u1ef3 ph\u00e1t hi\u1ec7n quan tr\u1ecdng.<\/p>\n<p>Khuy\u1ebfn c\u00e1o d\u00e0nh cho b\u1ec7nh nh\u00e2n<\/p>\n<p>B\u1ec7nh nh\u00e2n n\u00ean ti\u1ebfp t\u1ee5c d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 Angiotensin II (ARB) theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a b\u00e1c s\u0129. Do c\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ki\u1ec3m so\u00e1t huy\u1ebft \u00e1p cao, n\u00ean d\u1eebng thu\u1ed1c m\u00e0 kh\u00f4ng tham kh\u1ea3o \u00fd ki\u1ebfn \u200b\u200bb\u00e1c s\u0129 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn \u0111au tim v\u00e0 \u0111\u1ed9t qu\u1ef5.<\/p>\n<p>Nh\u00f3m thu\u1ed1c ARB \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ki\u1ec3m so\u00e1t t\u0103ng huy\u1ebft \u00e1p v\u00e0 bao g\u1ed3m valsartan, losartan, candesartan, fimasartan, irbesartan v\u00e0 olmesartan. Vi\u1ec7c thu h\u1ed3i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c nhi\u1ec1u qu\u1ed1c gia th\u1ef1c hi\u1ec7n v\u00ec thu\u1ed1c ARB c\u00f3 ch\u1ee9a h\u00e0m l\u01b0\u1ee3ng c\u00e1c t\u1ea1p ch\u1ea5t \u0111\u00e3 n\u00eau v\u01b0\u1ee3t m\u1ee9c cho ph\u00e9p.<\/p>\n<p>Ngu\u1ed3n\u00a0<a href=\"https:\/\/www.hsa.gov.sg\/content\/hsa\/en\/News_Events\/HSA_Updates\/2019\/overseasrecallangiotensin.html?fbclid=IwAR3P_8mWjazpTmJi7Ap02014AULIjsiBcQj50J5uG1GQWBY-59IvodgV52M\" rel=\"noopener\">https:\/\/www.hsa.gov.sg\/content\/hsa\/en\/News_Events\/HSA_Updates\/2019\/overseasrecallangiotensin.html<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>C\u01a1 quan qu\u1ea3n l\u00fd Khoa h\u1ecdc Y t\u1ebf Singapore (HSA) \u0111\u00e3 v\u00e0 \u0111ang t\u00edch c\u1ef1c ph\u00e1t hi\u1ec7n t\u1ea1p ch\u1ea5t nitrosamine trong thu\u1ed1c \u1ee9c ch\u1ebf th\u1ee5 th\u1ec3 angiotensin II (ARBs) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong ki\u1ec3m so\u00e1t t\u0103ng huy\u1ebft \u00e1p \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh tr\u00ean th\u1ecb tr\u01b0\u1eddng \u1edf Singapore. C\u00e1c t\u1ea1p ch\u1ea5t nitrosamine l\u00e0 c\u00e1c ph\u1ee5 ph\u1ea9m \u0111\u01b0\u1ee3c [&#8230;]\n","protected":false},"author":1,"featured_media":4412,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4411","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=4411"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4411\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/4412"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=4411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=4411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=4411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}