{"id":4181,"date":"2019-03-09T23:52:22","date_gmt":"2019-03-09T16:52:22","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=4181"},"modified":"2019-03-09T23:54:26","modified_gmt":"2019-03-09T16:54:26","slug":"ema-khuyen-cao-thay-doi-thong-tin-nhan-thuoc-cua-khang-sinh-vancomycin","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/ema-khuyen-cao-thay-doi-thong-tin-nhan-thuoc-cua-khang-sinh-vancomycin\/","title":{"rendered":"EMA: khuy\u1ebfn c\u00e1o thay \u0111\u1ed5i th\u00f4ng tin nh\u00e3n thu\u1ed1c c\u1ee7a kh\u00e1ng sinh vancomycin"},"content":{"rendered":"<p>C\u00e1c thay \u0111\u01b0\u1ee3c \u0111\u01b0a ra nh\u1eb1m m\u1ee5c \u0111\u00edch \u0111\u1ea3m b\u1ea3o vi\u1ec7c s\u1eed d\u1ee5ng vancomycin th\u00edch h\u1ee3p trong b\u1ed1i c\u1ea3nh cu\u1ed9c chi\u1ebfn ch\u1ed1ng l\u1ea1i s\u1ef1 kh\u00e1ng kh\u00e1ng sinh.<\/p>\n<p>V\u00e0o ng\u00e0y 19\/5\/2017, C\u01a1 quan qu\u1ea3n l\u00fd d\u01b0\u1ee3c ch\u00e2u \u00c2u (EMA) \u0111\u00e3 \u0111\u01b0a ra khuy\u1ebfn c\u00e1o thay \u0111\u1ed5i th\u00f4ng tin nh\u00e3n thu\u1ed1c c\u1ee7a kh\u00e1ng sinh vancomycin nh\u1eb1m \u0111\u1ea3m b\u1ea3o vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c h\u1ee3p l\u00fd trong \u0111i\u1ec1u tr\u1ecb c\u00e1c nhi\u1ec5m khu\u1ea9n n\u1eb7ng do vi khu\u1ea9n Gram d\u01b0\u01a1ng.<br \/>\nVancomycin \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng k\u1ec3 t\u1eeb nh\u1eefng n\u0103m 1950 v\u00e0 cho t\u1edbi nay v\u1eabn l\u00e0 l\u1ef1a ch\u1ecdn quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n n\u1eb7ng. \u1ee6y ban v\u1ec1 c\u00e1c ch\u1ebf ph\u1ea9m y t\u1ebf s\u1eed d\u1ee5ng cho ng\u01b0\u1eddi (CHMP) c\u1ee7a EMA \u0111\u00e3 r\u00e0 so\u00e1t c\u00e1c d\u1eef li\u1ec7u hi\u1ec7n c\u00f3 v\u1ec1 vancomycin d\u00f9ng \u0111\u01b0\u1eddng truy\u1ec1n (nh\u1ecf gi\u1ecdt) v\u00e0 ti\u00eam c\u0169ng nh\u01b0 \u0111\u01b0\u1eddng u\u1ed1ng, \u0111\u00e2y l\u00e0 m\u1ed9t ph\u1ea7n trong chi\u1ebfn l\u01b0\u1ee3c c\u1ee7a EMA nh\u1eb1m c\u1eadp nh\u1eadt th\u00f4ng tin s\u1ea3n ph\u1ea9m c\u1ee7a c\u00e1c thu\u1ed1c kh\u00e1ng khu\u1ea9n c\u0169 trong b\u1ed1i c\u1ea3nh cu\u1ed9c chi\u1ebfn ch\u1ed1ng l\u1ea1i s\u1ef1 kh\u00e1ng kh\u00e1ng sinh.<\/p>\n<p>CHMP k\u1ebft lu\u1eadn r\u1eb1ng vi\u1ec7c truy\u1ec1n vancomycin c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n n\u1eb7ng do m\u1ed9t s\u1ed1 ch\u1ee7ng vi khu\u1ea9n trong \u0111\u00f3 c\u00f3 MRSA (t\u1ee5 c\u1ea7u v\u00e0ng kh\u00e1ng meticillin) \u1edf c\u00e1c b\u1ec7nh nh\u00e2n \u1edf m\u1ecdi l\u1ee9a tu\u1ed5i. Vancomycin c\u0169ng c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ec3 d\u1ef1 ph\u00f2ng vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c nhi\u1ec5m khu\u1ea9n \u1edf b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ph\u1eabu thu\u1eadt v\u00e0 \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n \u1edf b\u1ec7nh nh\u00e2n l\u1ecdc m\u00e0ng b\u1ee5ng.<\/p>\n<p>Khi s\u1eed d\u1ee5ng \u0111\u01b0\u1eddng u\u1ed1ng, ch\u1ec9 n\u00ean gi\u1edbi h\u1ea1n \u1edf vi\u1ec7c \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m Clostridium difficle.<\/p>\n<p>V\u00ec c\u00e1c d\u1eef li\u1ec7u hi\u1ec7n c\u00f3 kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 \u1ee7ng h\u1ed9 vi\u1ec7c s\u1eed d\u1ee5ng vancomycin trong \u0111i\u1ec1u tr\u1ecb vi\u00eam ru\u1ed9t do t\u1ee5 c\u1ea7u (nhi\u1ec5m khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t do t\u1ee5 c\u1ea7u v\u00e0ng) v\u00e0 di\u1ec7t khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t \u1edf b\u1ec7nh nh\u00e2n suy gi\u1ea3m mi\u1ec5n d\u1ecbch, CHMP k\u1ebft lu\u1eadn r\u1eb1ng vancomycin s\u1ebd kh\u00f4ng c\u00f2n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho c\u00e1c ch\u1ec9 \u0111\u1ecbnh n\u00f3i tr\u00ean n\u1eefa.<\/p>\n<p>Th\u00eam v\u00e0o \u0111\u00f3, \u1ee6y ban n\u00e0y c\u0169ng r\u00e0 so\u00e1t li\u1ec1u d\u00f9ng khuy\u1ebfn c\u00e1o c\u1ee7a vancomycin trong nhi\u1ec1u ch\u1ec9 \u0111\u1ecbnh v\u00e0 tr\u00ean nhi\u1ec1u nh\u00f3m b\u1ec7nh nh\u00e2n, v\u00e0 k\u1ebft lu\u1eadn r\u1eb1ng li\u1ec1u truy\u1ec1n vancomycin kh\u1edfi \u0111\u1ea7u n\u00ean \u0111\u01b0\u1ee3c t\u00ednh to\u00e1n d\u1ef1a theo tu\u1ed5i v\u00e0 c\u00e2n n\u1eb7ng c\u1ee7a b\u1ec7nh nh\u00e2n. C\u00e1c khuy\u1ebfn c\u00e1o c\u1eadp nh\u1eadt n\u00e0y d\u1ef1a tr\u00ean c\u00e1c c\u01a1 s\u1edf d\u1eef li\u1ec7u cho th\u1ea5y li\u1ec1u khuy\u1ebfn c\u00e1o tr\u01b0\u1edbc \u0111\u00e2y th\u01b0\u1eddng cho th\u1ea5y n\u1ed3ng \u0111\u1ed9 vancomycin trong m\u00e1u th\u1ea5p h\u01a1n so v\u1edbi n\u1ed3ng \u0111\u1ed9 t\u1ed1i \u01b0u, do \u0111\u00f3 l\u00e0m gi\u1ea3m hi\u1ec7u qu\u1ea3 c\u1ee7a kh\u00e1ng sinh n\u00e0y.<br \/>\nKhuy\u1ebfn c\u00e1o \u0111\u01b0\u1ee3c EMA c\u1eadp nh\u1eadt v\u00e0o ng\u00e0y 17\/11\/2017.<\/p>\n<p>Ngu\u1ed3n:\u00a0<a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/vancomycin-containing-medicines\" rel=\"noopener\">https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/vancomycin-containing-medicines<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1c thay \u0111\u01b0\u1ee3c \u0111\u01b0a ra nh\u1eb1m m\u1ee5c \u0111\u00edch \u0111\u1ea3m b\u1ea3o vi\u1ec7c s\u1eed d\u1ee5ng vancomycin th\u00edch h\u1ee3p trong b\u1ed1i c\u1ea3nh cu\u1ed9c chi\u1ebfn ch\u1ed1ng l\u1ea1i s\u1ef1 kh\u00e1ng kh\u00e1ng sinh. V\u00e0o ng\u00e0y 19\/5\/2017, C\u01a1 quan qu\u1ea3n l\u00fd d\u01b0\u1ee3c ch\u00e2u \u00c2u (EMA) \u0111\u00e3 \u0111\u01b0a ra khuy\u1ebfn c\u00e1o thay \u0111\u1ed5i th\u00f4ng tin nh\u00e3n thu\u1ed1c c\u1ee7a kh\u00e1ng sinh vancomycin nh\u1eb1m \u0111\u1ea3m [&#8230;]\n","protected":false},"author":1,"featured_media":4182,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4181","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=4181"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/4181\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/4182"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=4181"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=4181"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=4181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}