Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c \u0111\u0103ng t\u1ea3i tr\u00ean t\u1ea1p ch\u00ed New England Journal of Medecine, cho th\u1ea5y t\u1ec9 l\u1ec7 khuy\u1ebft t\u1eadt v\u1ec1 ph\u00e1t tri\u1ec3n th\u1ea7n kinh sau 2 n\u0103m \u1edf c\u00e1c tr\u1ebb sinh c\u1ef1c non c\u00f2n s\u1ed1ng \u0111\u01b0\u1ee3c kh\u00f4ng kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea gi\u1eefa nh\u00f3m tr\u1ebb d\u00f9ng budesonide d\u1ea1ng h\u00edt \u0111\u1ec3 d\u1ef1 ph\u00f2ng lo\u1ea1n s\u1ea3n ph\u1ebf qu\u1ea3n \u2013 ph\u1ed5i v\u00e0 nh\u00f3m s\u1eed d\u1ee5ng gi\u1ea3 d\u01b0\u1ee3c, nh\u01b0ng t\u1ec9 l\u1ec7 t\u1eed vong l\u1ea1i cao h\u01a1n \u1edf nh\u00f3m tr\u1ebb d\u00f9ng budesonide.
\nC\u00e1c t\u00e1c gi\u1ea3 \u0111\u00e3 ph\u00e2n b\u1ed1 ng\u1eabu nhi\u00ean 863 tr\u1ebb (tu\u1ed5i thai t\u1eeb 23 tu\u1ea7n 0 ng\u00e0y \u0111\u1ebfn 27 tu\u1ea7n 6 ng\u00e0y) v\u00e0o nh\u00f3m s\u1eed d\u1ee5ng budesonide d\u1ea1ng h\u00edt s\u1edbm sau sinh (trong v\u00f2ng 24 gi\u1edd) ho\u1eb7c s\u1eed d\u1ee5ng gi\u1ea3 d\u01b0\u1ee3c. Ch\u1ec9 s\u1ed1 \u0111\u1ea7u ra ph\u1ee5 d\u00e0i h\u1ea1n l\u00e0 khuy\u1ebft t\u1eadt th\u1ea7n kinh trong s\u1ed1 c\u00e1c tr\u1ebb c\u00f2n s\u1ed1ng, \u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a l\u00e0 ch\u1ec9 s\u1ed1 ph\u1ee9c h\u1ee3p b\u1ea1i n\u00e3o, ch\u1eadm ph\u00e1t tri\u1ec3n nh\u1eadn th\u1ee9c (\u0111i\u1ec3m Ch\u1ec9 s\u1ed1 ph\u00e1t tri\u1ec3n t\u00e2m th\u1ea7n <85 (-1 \u0111\u1ed9 l\u1ec7ch chu\u1ea9n so v\u1edbi \u0111i\u1ec3m trung b\u00ecnh l\u00e0 100) theo thang \u0111i\u1ec3m Bayley v\u1ec1 Ph\u00e1t tri\u1ec3n tr\u1ebb em, Phi\u00ean b\u1ea3n 2, \u0111i\u1ec3m s\u1ed1 n\u00e0y c\u00e0ng cao g\u1ee3i \u00fd r\u1eb1ng tr\u1ebb bi\u1ec3u hi\u1ec7n t\u1ed1t h\u01a1n), \u0111i\u1ebfc ho\u1eb7c m\u00f9 v\u1edbi tu\u1ed5i hi\u1ec7u ch\u1ec9nh t\u1eeb 18 \u0111\u1ebfn 22 th\u00e1ng.<\/p>\n
K\u1ebft qu\u1ea3 cho th\u1ea5y trong s\u1ed1 629 tr\u1ebb c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u th\u00edch h\u1ee3p v\u1ec1 ch\u1ec9 s\u1ed1 \u0111\u1ea7u ra ph\u1ee5 ph\u1ee9c h\u1ee3p d\u00e0i h\u1ea1n, c\u00f3 148 tr\u1ebb (48,1%) \u1edf nh\u00f3m 308 tr\u1ebb d\u00f9ng budesonide xu\u1ea5t hi\u1ec7n khuy\u1ebft t\u1eadt v\u1ec1 ph\u00e1t tri\u1ec3n th\u1ea7n kinh, so v\u1edbi 165 tr\u1ebb (51,4%) \u1edf nh\u00f3m 321 tr\u1ebb d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c (nguy c\u01a1 t\u01b0\u01a1ng \u0111\u1ed1i \u0111i\u1ec1u ch\u1ec9nh theo tu\u1ed5i thai l\u00e0 0,93; kho\u1ea3ng tin c\u1eady 95% l\u00e0 0,80 \u0111\u1ebfn 1,09; P=0,40). Kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea n\u00e0o v\u1ec1 t\u1eebng th\u00e0nh ph\u1ea7n ri\u00eang r\u1ebd trong ch\u1ec9 s\u1ed1 ph\u1ee9c h\u1ee3p. T\u1ec9 l\u1ec7 t\u1eed vong \u1edf nh\u00f3m d\u00f9ng budesonide cao h\u01a1n \u1edf nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c (82 [19,9%] trong s\u1ed1 413 tr\u1ebb so v\u1edbi 58 [14,5%] trong s\u1ed1 400 tr\u1ebb c\u00f3 th\u00f4ng tin v\u1ec1 t\u00ecnh tr\u1ea1ng s\u1ed1ng s\u00f3t; nguy c\u01a1 t\u01b0\u01a1ng \u0111\u1ed1i l\u00e0 1,37; kho\u1ea3ng tin c\u1eady 95% l\u00e0 1,01 \u0111\u1ebfn 1,86; P=0,04).<\/p>\n
Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c \u0111\u0103ng t\u1ea3i tr\u00ean NEJM ng\u00e0y 11\/01\/2018.<\/p>\n