{"id":32561,"date":"2022-05-09T18:15:42","date_gmt":"2022-05-09T11:15:42","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=32561"},"modified":"2022-05-11T09:32:08","modified_gmt":"2022-05-11T02:32:08","slug":"cao-kho-bach-duong-dieu-tri-ly-thuong-bi-bong-nuoc","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/cao-kho-bach-duong-dieu-tri-ly-thuong-bi-bong-nuoc\/","title":{"rendered":"Cao kh\u00f4 b\u1ea1ch d\u01b0\u01a1ng \u0111i\u1ec1u tr\u1ecb Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc"},"content":{"rendered":"

Nh\u00e0 thu\u1ed1c L\u01b0u V\u0103n Ho\u00e0ng<\/a> \u2013 ch\u1ee7 \u0111\u1ec1: Cao kh\u00f4 b\u1ea1ch d\u01b0\u01a1ng \u0111i\u1ec1u tr\u1ecb Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc<\/a><\/strong><\/p>\n

Ngu\u1ed3n: Ngu\u1ed3n: Ngu\u1ed3n: B\u1ed9 m\u00f4n d\u01b0\u1ee3c li\u1ec7u \u2013 \u0110\u1ea1i h\u1ecdc Y D\u01b0\u1ee3c TP HCM<\/strong><\/p>\n

Gi\u1edbi thi\u1ec7u chung<\/h2>\n
V\u00e0o ng\u00e0y 22 th\u00e1ng 4 v\u1eeba qua, \u1ee6y ban S\u1ea3n ph\u1ea9m Y t\u1ebf d\u00e0nh cho Ng\u01b0\u1eddi (Committee for Medicinal Products for Human Use, CHMP) c\u1ee7a ch\u00e2u \u00c2u \u0111\u00e3 \u0111\u01b0a ra quan \u0111i\u1ec3m t\u00edch c\u1ef1c v\u1ec1 d\u01b0\u1ee3c ph\u1ea9m ch\u1eefa c\u0103n b\u1ec7nh hi\u1ebfm Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc c\u00f3 ngu\u1ed3n g\u1ed1c d\u01b0\u1ee3c li\u1ec7u.<\/p>\n
D\u1ea1ng b\u00e0o ch\u1ebf \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0 gel d\u00f9ng ngo\u00e0i v\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh cao kh\u00f4 B\u1ea1ch d\u01b0\u01a1ng, l\u1ea5y t\u1eeb v\u1ecf th\u00e2n 2 lo\u00e0i Betula pendula Roth ho\u1eb7c Betula pubescens Ehrh, v\u1edbi m\u1ee9c quy \u0111\u1ecbnh h\u00e0m l\u01b0\u1ee3ng triterpen t\u00ednh theo t\u1ed5ng betulin, acid betulinic, erythrodiol, lupeol v\u00e0 acid oleanolic l\u00e0 84 \u2013 95 mg (t\u1eeb 0,5 \u2013 1,0 g d\u01b0\u1ee3c li\u1ec7u).<\/p>\n
Cao kh\u00f4 B\u1ea1ch d\u01b0\u01a1ng \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng \u0111i\u1ec1u h\u00f2a ch\u1ea5t trung gian h\u00f3a h\u1ecdc g\u00e2y vi\u00eam v\u00e0 k\u00edch th\u00edch qu\u00e1 tr\u00ecnh bi\u1ec7t h\u00f3a, di chuy\u1ec3n c\u1ee7a c\u00e1c t\u1ebf b\u00e0o s\u1eebng, do \u0111\u00f3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh l\u00e0m l\u00e0nh v\u00e0 \u0111\u00f3ng mi\u1ec7ng v\u1ebft th\u01b0\u01a1ng.<\/p>\n
Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a d\u01b0\u1ee3c ph\u1ea9m \u0111\u01b0\u1ee3c \u0111\u1ec1 ngh\u1ecb c\u1ea5p ph\u00e9p t\u1ea1i ch\u00e2u \u00c2u:
\n\u201cTreatment of partial thickness wounds associated with dystrophic and junctional epidermolysis bullosa (EB) in patients 6 months and older.\u201d (Qua \u0111\u00f3 c\u00f3 th\u1ec3 th\u1ea5y quan \u0111i\u1ec3m \u1ee7ng h\u1ed9 s\u1eed d\u1ee5ng s\u1ea3n ph\u1ea9m tr\u00ean c\u1ea3 hai th\u1ec3 lo\u1ea1n d\u01b0\u1ee1ng v\u00e0 th\u1ec3 ti\u1ebfp n\u1ed1i \u1edf tr\u1ebb tr\u00ean 6 th\u00e1ng tu\u1ed5i).<\/p>\n
C\u0103n b\u1ec7nh Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc l\u00e0 g\u00ec?<\/h2>\n
D\u01b0\u1ee3c ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c thi\u00ean nhi\u00ean n\u00f3i tr\u00ean n\u1eb1m trong ch\u01b0\u01a1ng tr\u00ecnh ph\u00e1t tri\u1ec3n thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh hi\u1ebfm (orphan drug).<\/p>\n
Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc l\u00e0 m\u1ed9t b\u1ec7nh di truy\u1ec1n v\u1ec1 da ch\u1ee7 y\u1ebfu \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u1ebb s\u01a1 sinh v\u00e0 tr\u1ebb em, trong \u0111\u00f3 l\u1edbp ngo\u00e0i c\u1ee7a da, l\u1edbp bi\u1ec3u b\u00ec, ng\u0103n c\u00e1ch v\u1edbi l\u1edbp b\u00ean trong l\u00e0 l\u1edbp h\u1ea1 b\u00ec. \u0110i\u1ec1u n\u00e0y l\u00e0m cho da r\u1ea5t m\u1ecfng manh v\u00e0 g\u00e2y ph\u1ed3ng r\u1ed9p nghi\u00eam tr\u1ecdng v\u00e0 s\u1eb9o. C\u0103n b\u1ec7nh n\u00e0y g\u00e2y ra b\u1edfi s\u1ef1 b\u1ea5t th\u01b0\u1eddng trong c\u00e1c gen ch\u1ecbu tr\u00e1ch nhi\u1ec7m s\u1ea3n xu\u1ea5t c\u00e1c protein gi\u00fap da ch\u1eafc kh\u1ecfe v\u00e0 \u0111\u00e0n h\u1ed3i, ch\u1eb3ng h\u1ea1n nh\u01b0 collagen.<\/p>\n
B\u1ec7nh g\u00e2y suy nh\u01b0\u1ee3c v\u1ec1 l\u00e2u d\u00e0i c\u00f3 th\u1ec3 \u0111e d\u1ecda \u0111\u1ebfn t\u00ednh m\u1ea1ng, nguy\u00ean nh\u00e2n ch\u1ee7 y\u1ebfu l\u00e0 do t\u00ecnh tr\u1ea1ng ph\u1ed3ng r\u1ed9p n\u1eb7ng khi\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng k\u00e9m, tu\u1ed5i th\u1ecd gi\u1ea3m s\u00fat. \u0110\u00e2y th\u1ef1c s\u1ef1 l\u00e0 m\u1ed9t n\u1ed7i \u00e1m \u1ea3nh \u0111\u00e1ng s\u1ee3 c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh v\u00e0 c\u00e1c \u00f4ng b\u1ed1 b\u00e0 m\u1eb9 c\u00f3 con m\u1eafc ph\u1ea3i.<\/p>\n
V\u00e0o th\u1eddi \u0111i\u1ec3m tham gia ch\u01b0\u01a1ng tr\u00ecnh n\u0103m 2010, Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc c\u00f3 t\u1ea7n s\u1ed1 m\u1eafc trong d\u00e2n s\u1ed1 t\u1ea1i ch\u00e2u \u00c2u kho\u1ea3ng 0,5:10.000 ng\u01b0\u1eddi (\u00edt h\u01a1n 25.000 tr\u00ean 506.500.000 ng\u01b0\u1eddi) th\u1ea5p h\u01a1n nhi\u1ec1u con s\u1ed1 \u0111\u1ecbnh ngh\u0129a 5:10.000 \u0111\u1ed1i v\u1edbi b\u1ec7nh hi\u1ebfm. Ch\u01b0\u01a1ng tr\u00ecnh ph\u00e1t tri\u1ec3n thu\u1ed1c hi\u1ebfm l\u00e0 n\u1ed7 l\u1ef1c c\u1ee7a c\u00e1c ch\u00ednh ph\u1ee7 nh\u1eb1m khuy\u1ebfn kh\u00edch c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t nghi\u00ean c\u1ee9u \u2013 ph\u00e1t tri\u1ec3n d\u01b0\u1ee3c ph\u1ea9m \u0111i\u1ec1u tr\u1ecb b\u1ec7nh hi\u1ebfm, \u0111\u1ed1i t\u01b0\u1ee3ng th\u01b0\u1eddng kh\u00f4ng c\u00f3 l\u1ee3i v\u1ec1 m\u1eb7t s\u1ea3n xu\u1ea5t. N\u1ebfu kh\u00f4ng c\u00f3 s\u1ef1 tr\u1ee3 gi\u00fap t\u1eeb ph\u00eda c\u00e1c ch\u00ednh ph\u1ee7, c\u00e1c doanh nghi\u1ec7p th\u01b0\u1eddng kh\u00f4ng c\u00f3 \u0111\u1ed9ng l\u1ef1c \u0111\u1ec3 ph\u00e1t tri\u1ec3n nh\u1eefng thu\u1ed1c nh\u01b0 v\u1eady.<\/p>\n
V\u00e0o th\u1eddi \u0111i\u1ec3m lo\u1ea1i thu\u1ed1c \u0111\u1ec1 c\u1eadp \u1edf tr\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng, kh\u00f4ng c\u00f3 m\u1ed9t d\u01b0\u1ee3c ph\u1ea9m \u0111i\u1ec1u tr\u1ecb ch\u00ednh th\u1ee9c cho c\u0103n b\u1ec7nh Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc. Ph\u01b0\u01a1ng ph\u00e1p ch\u0103m s\u00f3c ti\u00eau chu\u1ea9n th\u01b0\u1eddng l\u00e0 gi\u1eef v\u1ec7 sinh c\u1ea9n th\u1eadn, th\u01b0\u1eddng xuy\u00ean ch\u0103m s\u00f3c da, b\u1ea3o v\u1ec7 kh\u1ecfi c\u00e1c t\u00e1c nh\u00e2n g\u00e2y t\u1ed5n th\u01b0\u01a1ng. \u0110\u00f4i khi thu\u1ed1c gi\u1ea3m \u0111au c\u0169ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ho\u1eb7c ph\u1ea3i ph\u1eabu thu\u1eadt n\u1ebfu c\u00f3 c\u00e1c bi\u1ebfn ch\u1ee9ng bi\u1ebfn d\u1ea1ng b\u00e0n tay ho\u1eb7c ung th\u01b0 da.<\/p>\n
C\u00f4ng d\u1ee5ng c\u1ee7a B\u1ea1ch d\u01b0\u01a1ng<\/h2>\n
H\u1ed3i n\u0103m 2016, C\u01a1 quan Y t\u1ebf ch\u00e2u \u00c2u c\u0169ng t\u1eebng ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng m\u1ed9t gel d\u00f9ng ngo\u00e0i chi\u1ebft xu\u1ea5t t\u1eeb v\u1ecf th\u00e2n b\u1ea1ch d\u01b0\u01a1ng \u0111\u1ec3 ch\u1eefa v\u1ebft th\u01b0\u01a1ng d\u00e0y m\u1ed9t ph\u1ea7n (partial-thickness skin wounds). Nh\u1eefng v\u1ebft th\u01b0\u01a1ng n\u00e0y t\u1ea1i n\u01a1i b\u1ecb m\u1ea5t l\u1edbp th\u01b0\u1ee3ng b\u00ec do b\u1ecfng ho\u1eb7c trong qu\u00e1 tr\u00ecnh ch\u1edd l\u00e0nh sau ph\u1eabu thu\u1eadt gh\u00e9p da. Ch\u1ebf ph\u1ea9m c\u00f3 kh\u1ea3 n\u0103ng th\u00fac \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh l\u00e0m l\u00e0nh.<\/p>\n
\u0110i\u1ec1u n\u00e0y l\u00e0 kh\u00e1 \u00fd ngh\u0129a v\u1ec1 m\u1eb7t h\u00ecnh t\u01b0\u1ee3ng: s\u1eed d\u1ee5ng da ngo\u00e0i c\u1ee7a th\u1ef1c v\u1eadt \u0111\u1ec3 l\u00e0m l\u00e0nh v\u1ebft th\u01b0\u01a1ng m\u1ea5t da \u1edf ng\u01b0\u1eddi. 1 gam gel ch\u1ee9a 100 mg cao kh\u00f4 B\u1ea1ch d\u01b0\u01a1ng, chi\u1ebft t\u1eeb 0,5 \u0111\u1ebfn 1,0 gam nguy\u00ean li\u1ec7u b\u1eb1ng dung m\u00f4i n-heptan. \u0110i\u1ec1u \u0111\u00e1ng n\u00f3i l\u00e0 100 mg cao kh\u00f4 n\u00e0y ch\u1ee9a 72 \u0111\u1ebfn 88 mg betulin.<\/p>\n
C\u00e1c lo\u00e0i b\u1ea1ch d\u01b0\u01a1ng: Betula pendula (\u0111\u1ed3ng danh: B. verrucosa) th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 silver birch v\u00e0 Betula pubescens (\u0111\u1ed3ng danh: B. alba) l\u00e0 white birch, thu\u1ed9c h\u1ecd Betulaceae.<\/p>\n
T\u1eeb l\u00e2u, v\u1ecf th\u00e2n B\u1ea1ch d\u01b0\u01a1ng \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 thu\u1ed9c da. L\u1edbp v\u1ecf n\u00e0y c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng l\u1ed9t ra m\u00e0 kh\u00f4ng g\u00e2y ch\u1ebft c\u00e2y. Ch\u00fang c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong th\u1ef1c ph\u1ea9m nh\u01b0 l\u1ea5y l\u1edbp m\u00e0u \u0111\u1ecf b\u00ean d\u01b0\u1edbi v\u1ecf ngo\u00e0i l\u00e0m b\u00e1nh m\u00ec, hay s\u1eed d\u1ee5ng ph\u1ea7n v\u1ee5n tr\u1ed9n v\u1edbi nh\u1ef1a t\u1ea1o th\u00e0nh r\u01b0\u1ee3u m\u00f9i, hay th\u1eadm ch\u00ed g\u00f5 v\u00e0o th\u00e2n c\u00e2y v\u00e0o m\u00f9a xu\u00e2n \u0111\u1ec3 thu \u0111\u01b0\u1ee3c ch\u1ea5t l\u1ecfng ng\u1ecdt, d\u00f9ng t\u01b0\u01a1i ho\u1eb7c c\u00f4 \u0111\u1eb7c th\u00e0nh sir\u00f4.<\/p>\n
$\"V\u1ecf$
V\u1ecf th\u00e2n c\u00e2y b\u1ea1ch d\u01b0\u01a1ng<\/figcaption><\/figure>\n
C\u00e2y c\u0169ng \u0111\u01b0\u1ee3c d\u00f9ng l\u00e0m c\u1ee7i nh\u01b0ng nhanh ch\u00e1y h\u1ebft ho\u1eb7c s\u1eed d\u1ee5ng ph\u1ea7n l\u00f5i th\u00e2n trong n\u1ed9i th\u1ea5t. C\u00f3 m\u1ed9t th\u1eddi \u0111i\u1ec3m, s\u1ef1 khai kh\u00e1c v\u1ecf th\u00e2n qu\u00e1 nhi\u1ec1u \u0111\u1ebfn m\u1ee9c Carl Linnaeus b\u00e0y t\u1ecf quan ng\u1ea1i.<\/p>\n
Trong v\u1ecf th\u00e2n c\u1ee7a B\u1ea1ch d\u01b0\u01a1ng ch\u1ee9a m\u1ed9t l\u01b0\u1ee3ng l\u1edbn betulin, c\u00f3 th\u1ec3 l\u00ean \u0111\u1ebfn 30% (10% \u2013 45%), t\u00ednh tr\u00ean kh\u1ed1i l\u01b0\u1ee3ng kh\u00f4. \u0110\u00e2y l\u00e0 m\u1ed9t triterpen 5 v\u00f2ng khung lupan, c\u00f3 l\u1ecbch s\u1eed ph\u00e2n l\u1eadp t\u1eeb n\u0103m 1788, c\u00f3 l\u1ebd do h\u00e0m l\u01b0\u1ee3ng qu\u00e1 l\u1edbn trong nguy\u00ean li\u1ec7u.<\/p>\n
D\u01b0\u1ee3c li\u1ec7u ch\u1ee9a ho\u1ea1t ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 B\u1ea1ch d\u01b0\u01a1ng<\/h2>\n
Ng\u01b0\u1eddi d\u00e2n b\u1ea3n \u0111\u1ecba Ch\u00e2u M\u1ef9 \u0111\u00e3 s\u1eed d\u1ee5ng v\u1ecf th\u00e2n c\u00e2y Tr\u0103n \u0111\u1ecf (red alder), Alnus rubra, m\u1ed9t lo\u00e0i c\u00e2y c\u0169ng thu\u1ed9c h\u1ecd Betulaceae \u0111\u1ec3 ch\u1eefa c\u00f4n tr\u00f9ng c\u1eafn, k\u00edch \u1ee9ng da hay poison oak. Poison oak kh\u00f4ng ph\u1ea3i l\u00e0 s\u1ed3i, \u0111\u00f3 l\u00e0 m\u1ed9t lo\u1ea1i c\u00e2y b\u1ee5i leo B\u1eafc M\u1ef9 thu\u1ed9c h\u1ecd \u0110\u00e0o l\u1ed9n h\u1ed9t, c\u00f3 quan h\u1ec7 h\u1ecd h\u00e0ng g\u1ea7n v\u1edbi c\u00e2y th\u01b0\u1eddng xu\u00e2n \u0111\u1ed9c v\u00e0 c\u00f3 c\u00e1c \u0111\u1eb7c t\u00ednh t\u01b0\u01a1ng t\u1ef1.<\/p>\n
$\"D\u01b0\u1ee3c$
D\u01b0\u1ee3c li\u1ec7u tr\u0103n \u0111\u1ecf ch\u1eefa c\u00f4n tr\u00f9ng c\u1eafn<\/figcaption><\/figure>\n
Nh\u1eefng ng\u01b0\u1eddi Blackfeet Indian \u0111\u00e3 s\u1eed d\u1ee5ng Tr\u0103n \u0111\u1ecf \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb r\u1ed1i lo\u1ea1n b\u1ea1ch huy\u1ebft v\u00e0 lao. V\u1ec1 sau, ng\u01b0\u1eddi ta bi\u1ebft r\u1eb1ng, trong Tr\u0103n \u0111\u1ecf ch\u1ee9a c\u00e1c triterpin nh\u01b0 betulin v\u00e0 lupeol. Lo\u00e0i c\u00e2y n\u00e0y h\u1ea7u nh\u01b0 ch\u1ec9 ph\u00e2n b\u1ed1 \u1edf b\u1edd T\u00e2y Hoa K\u1ef3.<\/p>\n
Betulin c\u00f3 m\u1ed9t ch\u1ee9c alcol trong c\u1ea5u tr\u00fac, n\u1ebfu chuy\u1ec3n th\u00e0nh ch\u1ee9c acid carboxylic s\u1ebd l\u00e0 acid betulinic. C\u00e1c triterpen \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng vi\u00eam c\u0169ng nh\u01b0 g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o.<\/p>\n
K\u1ebft lu\u1eadn<\/h2>\n
Trong ch\u1ebf ph\u1ea9m gel \u0111i\u1ec1u tr\u1ecb Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc, cao kh\u00f4 \u0111\u01b0\u1ee3c chi\u1ebft xu\u1ea5t \u1edf t\u1ec9 l\u1ec7 1:5 \u0111\u1ebfn 1:10 trong n-heptan 95%. S\u1ea3n ph\u1ea9m d\u0129 nhi\u00ean c\u0169ng c\u00f3 m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n \u0111\u01b0\u1ee3c ghi nh\u1eadn nh\u01b0: qu\u00e1 m\u1eabn, nhi\u1ec5m tr\u00f9ng v\u1ebft th\u01b0\u01a1ng hay g\u00e2y ng\u1ee9a.<\/p>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n
Hordyjewska, A., Ostapiuk, A., Horecka, A. et al (2019). Betulin and betulinic acid: triterpenoids derivatives with a powerful<\/a> biological potential. Phytochem Rev 18, 929\u2013951<\/p>\n
Ebeling, S., Naumann, K., Pollok, S., Wardecki, T., Vidal-Y-Sy, S., Nascimento, J. M., Boerries, M., Schmidt, G., Brandner, J. M., & Merfort, I. (2014). From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract. PloS one, 9(1), e86147.<\/p>\n","protected":false},"excerpt":{"rendered":"
Nh\u00e0 thu\u1ed1c L\u01b0u V\u0103n Ho\u00e0ng \u2013 ch\u1ee7 \u0111\u1ec1: Cao kh\u00f4 b\u1ea1ch d\u01b0\u01a1ng \u0111i\u1ec1u tr\u1ecb Ly th\u01b0\u1ee3ng b\u00ec b\u1ecdng n\u01b0\u1edbc Ngu\u1ed3n: Ngu\u1ed3n: Ngu\u1ed3n: B\u1ed9 m\u00f4n d\u01b0\u1ee3c li\u1ec7u \u2013 \u0110\u1ea1i h\u1ecdc Y D\u01b0\u1ee3c TP HCM Gi\u1edbi thi\u1ec7u chung V\u00e0o ng\u00e0y 22 th\u00e1ng 4 v\u1eeba qua, \u1ee6y ban S\u1ea3n ph\u1ea9m Y t\u1ebf d\u00e0nh cho Ng\u01b0\u1eddi (Committee for Medicinal […]\n","protected":false},"author":1,"featured_media":32646,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-32561","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/32561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=32561"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/32561\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/32646"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=32561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=32561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=32561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}