{"id":32538,"date":"2022-05-09T17:29:53","date_gmt":"2022-05-09T10:29:53","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=32538"},"modified":"2022-05-10T10:05:12","modified_gmt":"2022-05-10T03:05:12","slug":"thuoc-doc-mui-ten","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/thuoc-doc-mui-ten\/","title":{"rendered":"M\u0169i t\u00ean t\u1ea9m \u0111\u1ed9c l\u00e0 g\u00ec? N\u00f3 c\u00f3 ph\u1ed5 bi\u1ebfn kh\u00f4ng?"},"content":{"rendered":"

Nh\u00e0 thu\u1ed1c L\u01b0u V\u0103n Ho\u00e0ng<\/a> \u2013 Ch\u1ee7 \u0111\u1ec1: Thu\u1ed1c \u0111\u1ed9c m\u0169i t\u00ean<\/a><\/strong><\/p>\n

Ngu\u1ed3n: Ngu\u1ed3n: Ngu\u1ed3n: B\u1ed9 m\u00f4n d\u01b0\u1ee3c li\u1ec7u \u2013 \u0110\u1ea1i h\u1ecdc Y D\u01b0\u1ee3c TP HCM<\/strong><\/p>\n

T\u1eeb l\u00e2u, m\u0169i t\u00ean t\u1ea9m \u0111\u1ed9c \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi m\u1ee5c \u0111\u00edch s\u0103n b\u1eaft \u0111\u1ed9ng v\u1eadt v\u00e0 sau \u0111\u00f3 trong chi\u1ebfn tranh. Theo m\u1ed9t c\u00e2u chuy\u1ec7n h\u01b0 c\u1ea5u trong th\u1ea7n tho\u1ea1i Hy L\u1ea1p, Heracles (t\u1ee9c Hercules) \u0111\u00e3 h\u1ea1 nh\u00e2n m\u00e3 Nessus b\u1eb1ng m\u0169i t\u00ean t\u1ea9m m\u00e1u c\u1ee7a qu\u00e1i v\u1eadt Hydra.<\/p>\n

Huy\u1ec1n s\u1eed<\/h2>\n
$\"h\u00ecnh$
h\u00ecnh \u1ea3nh t\u00ean t\u1ea9m \u0111\u1ed9c<\/figcaption><\/figure>\n
Trong quy\u1ec3n s\u1eed thi c\u00f9ng t\u00ean c\u1ee7a Homer, ng\u01b0\u1eddi anh h\u00f9ng Odysseus \u0111\u00e3 d\u00f9ng ch\u1ea5t \u0111\u1ed9c trong c\u00e2y hellebore \u0111\u1ec3 t\u1ea9m v\u00e0o m\u0169i t\u00ean c\u1ee7a m\u00ecnh. Thu\u1eadt ng\u1eef ch\u1ec9 ch\u1ea5t \u0111\u1ed9c th\u1eddi hi\u1ec7n \u0111\u1ea1i \u201ctoxin\u201d c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ti\u1ebfng Hy L\u1ea1p c\u1ed5 \u201ctoxon\u201d ngh\u0129a l\u00e0 c\u00e2y cung v\u00e0 \u201ctaxa\u201d trong ti\u1ebfng Ba T\u01b0 c\u1ed5 ngh\u0129a l\u00e0 m\u0169i t\u00ean.<\/p>\n
Hellebore, Ch\u00e2u \u00c2u<\/h2>\n
Hellebore l\u00e0 t\u00ean g\u1ecdi nh\u1eefng c\u00e2y thu\u1ed9c chi Helleborus, c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ti\u1ebfng Hy L\u1ea1p g\u1ed3m “Elein” l\u00e0m t\u1ed5n th\u01b0\u01a1ng v\u00e0 “bora” th\u1ef1c ph\u1ea9m, c\u00f2n g\u1ecdi l\u00e0 thi\u1ebft kho\u00e1i t\u1eed, c\u00e2y tr\u1ecb \u0111i\u00ean, c\u00e2y l\u00ea l\u01b0, hoa h\u1ed3ng tuy\u1ebft, hoa h\u1ed3ng gi\u00e1ng sinh (nh\u01b0ng kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean h\u1ec7 v\u1edbi hoa h\u1ed3ng),… T\u00ean c\u00e2y tr\u1ecb \u0111i\u00ean l\u1ea1i xu\u1ea5t ph\u00e1t t\u1eeb m\u1ed9t huy\u1ec1n tho\u1ea1i Hy L\u1ea1p kh\u00e1c r\u1eb1ng Melampus \u2013 anh ch\u00e0ng c\u00f3 th\u1ec3 hi\u1ec3u ti\u1ebfng \u0111\u1ed9ng v\u1eadt – \u0111\u00e3 c\u1ee9u c\u00e1c c\u00f4 con g\u00e1i vua Proetus x\u1ee9 Argos kh\u1ecfi c\u01a1n \u0111i\u00ean lo\u1ea1n b\u1eb1ng hellebore. Hoa h\u1ed3ng gi\u00e1ng sinh l\u00e0 c\u00e1i t\u00ean d\u1ef1a tr\u00ean m\u1ed9t c\u00e2u chuy\u1ec7n c\u1ea3m \u0111\u1ed9ng r\u1eb1ng m\u1ed9t ng\u01b0\u1eddi ph\u1ee5 n\u1eef kh\u00f3c v\u00ec kh\u00f4ng c\u00f3 qu\u00e0 t\u1eb7ng cho Th\u01b0\u1ee3ng \u0111\u1ebf v\u00e0o d\u1ecbp Gi\u00e1ng sinh, ch\u1ed7 n\u01b0\u1edbc m\u1eaft trong tuy\u1ebft \u1ea5y m\u1ecdc l\u00ean lo\u00e0i c\u00e2y n\u00e0y.<\/p>\n
Curare, Nam M\u1ef9<\/h2>\n
$\"C\u00f4ng$
C\u00f4ng th\u1ee9c h\u00f3a h\u1ecdc<\/figcaption><\/figure>\n
Khi ng\u01b0\u1eddi T\u00e2y Ban Nha \u0111\u1eb7t ch\u00e2n \u0111\u1ebfn Nam M\u1ef9, h\u1ecd th\u1ea5y d\u00e2n b\u1ea3n \u0111\u1ecba s\u1eed d\u1ee5ng ch\u1ea5t \u0111\u1ed9c m\u0169i t\u00ean \u201cwurari\u201d \u0111\u1ec3 s\u0103n b\u1eaft \u0111\u1ed9ng v\u1eadt. \u0110i\u1ec1u th\u00fa v\u1ecb l\u00e0 sau \u0111\u00f3, nh\u1eefng ng\u01b0\u1eddi kia v\u1eabn c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng \u0103n th\u1ecbt ch\u00fang m\u00e0 kh\u00f4ng b\u1ecb nhi\u1ec5m \u0111\u1ed9c. Wurari c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ph\u01b0\u01a1ng ng\u1eef \u201cMawa cure\u201d ch\u1ec9 m\u1ed9t lo\u1ea1i d\u00e2y leo \u1edf Mawa, lo\u00e0i Strychnos toxifera. V\u1ec1 sau, ng\u01b0\u1eddi ph\u01b0\u01a1ng T\u00e2y \u0111\u00e3 chuy\u1ec3n ng\u1eef t\u1eeb n\u00e0y th\u00e0nh \u201ccurare\u201d. M\u1ed9t s\u1ed1 ph\u01b0\u01a1ng ng\u1eef kh\u00e1c t\u1ea1i Nam M\u1ef9 bao g\u1ed3m: ampi, woorari, woorara, woorali, wourali, wouralia, ourare, ourari, urare, urari, and uirary.<\/p>\n
Tuy nhi\u00ean, \u201ccurare\u201d \u0111\u1ea7u ti\u00ean m\u00e0 ng\u01b0\u1eddi ch\u00e2u u bi\u1ebft \u0111\u1ebfn kh\u00f4ng ph\u1ea3i t\u1eeb Strychnos toxifera (alkaloid ch\u00ednh toxiferine) m\u00e0 t\u1eeb v\u1ecf th\u00e2n c\u1ee7a Chondrodendron tomentosum. V\u1ec1 sau, c\u00e1c nh\u00e0 h\u00f3a th\u1ef1c v\u1eadt h\u1ecdc \u0111\u00e3 ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c tubocurarin t\u1eeb lo\u00e0i n\u00e0y v\u1edbi t\u1eeb tubo \u00e1m ch\u1ec9 ch\u1ea5t \u0111\u1ed9c curare \u0111\u01b0\u1ee3c \u0111\u1ef1ng trong c\u00e1c \u1ed1ng tre khi mang v\u1ec1 ch\u00e2u u nghi\u00ean c\u1ee9u. T\u01b0\u01a1ng t\u1ef1, c\u00f3 nh\u1eefng thu\u1eadt ng\u1eef nh\u01b0 calabash curare hay pot curare d\u1ef1a v\u00e0o v\u1eadt \u0111\u1ef1ng ch\u00fang. M\u1eb7c d\u00f9 nh\u01b0 th\u1ebf, c\u00e1c nh\u1eadn \u0111\u1ecbnh sau n\u00e0y cho r\u1eb1ng, th\u1ef1c t\u1ebf curare l\u00e0 m\u1ed9t h\u1ed7n h\u1ee3p c\u1ee7a nhi\u1ec1u ch\u1ea5t, do \u0111i\u1ec1u ki\u1ec7n khoa h\u1ecdc k\u1ef9 thu\u1eadt v\u00e0o th\u1eddi \u0111\u00f3, c\u0169ng kh\u00f4ng lo\u1ea1i tr\u1eeb vi\u1ec7c s\u1eed d\u1ee5ng nhi\u1ec1u c\u00e2y. (Chondros: s\u1ea1n\/s\u1ea7n, dendron: c\u00e2y; tomentosum: bao b\u1ecdc b\u1edfi l\u00f4ng x\u00f9; \u00e1m ch\u1ec9 th\u00e2n c\u00e2y th\u00f4, l\u1edbn)<\/p>\n
C\u01b0 d\u00e2n b\u1ea3n \u0111\u1ecba Nam M\u1ef9 ch\u1ee7 y\u1ebfu s\u1eed d\u1ee5ng curare trong s\u0103n b\u1eafn. Con m\u1ed3i b\u1ecb b\u1eafn b\u1edfi nh\u1eefng m\u0169i t\u00ean ho\u1eb7c phi ti\u00eau d\u1ea1ng s\u00fang ng\u1eafn nh\u00fang trong curare, d\u1eabn \u0111\u1ebfn ng\u1ea1t th\u1edf do c\u01a1 h\u00f4 h\u1ea5p kh\u00f4ng th\u1ec3 co l\u1ea1i (t\u1ee9c l\u00e0 b\u1ecb d\u00e3n c\u01a1). \u0110i\u1ec1u n\u00e0y g\u1ee3i \u00fd cho c\u00e1c nh\u00e0 khoa h\u1ecdc s\u1eed d\u1ee5ng trong l\u00e2m s\u00e0ng \u0111\u1ec3 h\u1ed7 tr\u1ee3 g\u00e2y m\u00ea.<\/p>\n
Tubocurarin \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 c\u1ea5u tr\u00fac l\u1ea7n \u0111\u1ea7u v\u00e0o n\u0103m 1948, v\u1edbi m\u1ed9t ch\u00fat nh\u1ea7m l\u1eabn, l\u00e0 alkaloid c\u00f3 2 Nit\u01a1 b\u1eadc 4 (c\u1ea3 hai Nit\u01a1 \u0111\u1ec1u b\u1ecb methyl h\u00f3a). \u0110\u1ebfn 1970, c\u1ea5u tr\u00fac ch\u00ednh x\u00e1c c\u1ee7a tubocurarin \u0111\u01b0\u1ee3c x\u00e1c nh\u1eadn l\u1ea1i ch\u1ec9 ch\u1ee9a 1 Nit\u01a1 b\u1eadc 4, Nit\u01a1 kia b\u1eadc 3 (ch\u1ec9 c\u00f3 1 Nit\u01a1 b\u1ecb methyl h\u00f3a). C\u1ea5u tr\u00fac n\u00e0y gi\u1ea3i th\u00edch t\u1ea1i sao c\u01b0 d\u00e2n Nam M\u1ef9 kh\u00f4ng b\u1ecb nhi\u1ec5m \u0111\u1ed9c khi \u0103n th\u00fa s\u0103n, v\u00ec tubocurarin kh\u00f4ng qua \u0111\u01b0\u1ee3c l\u1edbp m\u00e0ng nh\u1ea7y ti\u00eau h\u00f3a. Trong y t\u1ebf, tubocurarin \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng duy nh\u1ea5t qua \u0111\u01b0\u1eddng ti\u00eam \u1edf d\u1ea1ng mu\u1ed1i clorid. V\u00e0o gi\u1eefa th\u1ebf k\u1ef7 20, tubocurarin \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng c\u00f9ng v\u1edbi thu\u1ed1c g\u00e2y m\u00ea \u0111\u1ec3 l\u00e0m gi\u00e3n c\u01a1 x\u01b0\u01a1ng trong khi ph\u1eabu thu\u1eadt ho\u1eb7c th\u1edf m\u00e1y, h\u1ea1n ch\u1ebf vi\u1ec7c ph\u1ea3i g\u00e2y m\u00ea s\u00e2u. Hi\u1ec7n nay, n\u00f3 hi\u1ebfm \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t ch\u1ea5t h\u1ed7 tr\u1ee3 g\u00e2y m\u00ea l\u00e2m s\u00e0ng v\u00ec c\u00f3 nhi\u1ec1u l\u1ef1a ch\u1ecdn an to\u00e0n h\u01a1n.<\/p>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/h2>\n
Vasiliki Vasileiou, Georgios K. Markantes, Anastasia K. Armeni,
\nKonstantina Barouti, Angeliki Georgopoulou, Neoklis A. Georgopoulos (2017), “Melampus and the cure of Proetus\u2019 daughters”, HORMONES, 16(2), 212-216.<\/p>\n
King H (1948), “64. Curare alkaloids. Part VII. Constitution of dextrotubocurarine chloride”, J Chem Soc, 265.<\/p>\n","protected":false},"excerpt":{"rendered":"
Nh\u00e0 thu\u1ed1c L\u01b0u V\u0103n Ho\u00e0ng \u2013 Ch\u1ee7 \u0111\u1ec1: Thu\u1ed1c \u0111\u1ed9c m\u0169i t\u00ean Ngu\u1ed3n: Ngu\u1ed3n: Ngu\u1ed3n: B\u1ed9 m\u00f4n d\u01b0\u1ee3c li\u1ec7u \u2013 \u0110\u1ea1i h\u1ecdc Y D\u01b0\u1ee3c TP HCM T\u1eeb l\u00e2u, m\u0169i t\u00ean t\u1ea9m \u0111\u1ed9c \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi m\u1ee5c \u0111\u00edch s\u0103n b\u1eaft \u0111\u1ed9ng v\u1eadt v\u00e0 sau \u0111\u00f3 trong chi\u1ebfn tranh. Theo m\u1ed9t c\u00e2u chuy\u1ec7n h\u01b0 c\u1ea5u […]\n","protected":false},"author":1,"featured_media":32539,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-32538","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/32538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=32538"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/32538\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/32539"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=32538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=32538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=32538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}