{"id":22301,"date":"2019-10-02T16:36:24","date_gmt":"2019-10-02T09:36:24","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=22301"},"modified":"2019-10-02T16:37:16","modified_gmt":"2019-10-02T09:37:16","slug":"oseltamivir","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/oseltamivir\/","title":{"rendered":"Oseltamivir"},"content":{"rendered":"

Oseltamivir<\/a><\/strong> l\u00e0 ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00fam A v\u00e0 c\u00fam B v\u1edbi bi\u1ec7t d\u01b0\u1ee3c n\u1ed5i ti\u1ebfng Tamiflu.\u00a0Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang t\u00f4i xin g\u1eedi \u0111\u1ebfn \u0111\u1ed9c gi\u1ea3 nh\u1eefng th\u00f4ng tin chi ti\u1ebft v\u00e0 quan tr\u1ecdng nh\u1ea5t v\u1ec1 ho\u1ea1t ch\u1ea5t Oseltamivir<\/strong>: Oseltamivir l\u00e0 thu\u1ed1c g\u00ec<\/strong>?\u00a0T\u00e1c d\u1ee5ng v\u00e0 C\u00f4ng d\u1ee5ng c\u1ee7a Oseltamivir<\/strong>? Li\u1ec1u d\u00f9ng v\u00e0 nh\u1eefng l\u01b0u \u00fd th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng thu\u1ed1c n\u00e0y.<\/p>\n

Oseltamivir l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\n
Oseltamivir<\/strong>, \u0111\u01b0\u1ee3c b\u00e1n d\u01b0\u1edbi t\u00ean Tamiflu, l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf neurominidase \u0111\u1ea7u ti\u00ean s\u1eed d\u1ee5ng b\u1eb1ng \u0111\u01b0\u1eddng u\u1ed1ng, d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb, d\u1ef1 ph\u00f2ng c\u00e1c tr\u01b0\u1eddng h\u1ee3p m\u1eafc c\u00fam A v\u00e0 c\u00fam B. Thu\u1ed1c \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng trong v\u00f2ng 48 gi\u1edd k\u1ec3 t\u1eeb khi xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng \u0111\u1ea7u ti\u00ean, d\u00f9ng c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t.<\/p>\n
Oseltamivir \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng t\u1ea1i Hoa K\u1ef3 v\u00e0o n\u0103m 1999. \u0110\u1ebfn n\u0103m 2016, \u0111\u00e2y l\u00e0 lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n nhi\u1ec1u th\u1ee9 249 t\u1ea1i Hoa K\u1ef3 v\u1edbi h\u01a1n m\u1ed9t tri\u1ec7u \u0111\u01a1n thu\u1ed1c.<\/p>\n
$\"Tamiflu$ Bi\u1ec7t d\u01b0\u1ee3c Tamiflu 75mg<\/figcaption><\/figure>\n
T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Oseltamivir<\/h2>\n
Sau khi v\u00e0o c\u01a1 th\u1ec3, Oseltamivir<\/strong> l\u00e0 ti\u1ec1n thu\u1ed1c \u0111\u01b0\u1ee3c chuy\u1ec3n ho\u00e1 th\u00e0nh Oseltamivir carboxylat. Oseltamivir carboxylat l\u00e0 ch\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf ch\u1ecdn l\u1ecdc enzym neurominidase c\u1ee7a virus l\u00e0 enzym c\u00f3 vai tr\u00f2 gi\u1ea3i ph\u00f3ng c\u00e1c h\u1ea1t virus m\u1edbi \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh trong t\u1ebf b\u00e0o ch\u1ee7 v\u00e0 lan truy\u1ec1n kh\u1eafp c\u01a1 th\u1ec3, do \u0111\u00f3 ng\u0103n c\u1ea3n \u0111\u01b0\u1ee3c virus m\u1edbi x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o l\u00e0nh. Do chu k\u1ef3 nh\u00e2n l\u00ean c\u1ee7a virus l\u00e0 24 – 72 ti\u1ebfng sau khi xu\u1ea5t hi\u1ec7n tri\u1ec7u ch\u1ee9ng n\u00ean Oseltamivir ph\u1ea3i \u0111\u01b0\u1ee3c d\u00f9ng c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t.<\/p>\n
S\u1ef1 kh\u00e1ng thu\u1ed1c x\u1ea3y ra v\u1edbi m\u1ed9t t\u1ef7 l\u1ec7 th\u1ea5p \u1edf virus c\u00fam A nh\u01b0ng ch\u01b0a th\u1ea5y xu\u1ea5t hi\u1ec7n \u1edf virus c\u00fam B.<\/p>\n
D\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc<\/h2>\n
H\u1ea5p thu: Oseltamivir \u0111\u01b0\u1ee3c h\u1ea5p thu m\u1ea1nh \u1edf \u1ed1ng ti\u00eau ho\u00e1 v\u00e0 chuy\u1ec3n ho\u00e1 \u1edf gan th\u00e0nh Oseltamivir carboxylat, th\u1ee9c \u0103n kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u1ea5p thu thu\u1ed1c. Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a thu\u1ed1c d\u00f9ng \u0111\u01b0\u1eddng u\u1ed1ng v\u1edbi li\u1ec1u l\u01b0\u1ee3ng 75mg l\u00e0 > 75%.<\/p>\n
Ph\u00e2n b\u1ed1: 3% l\u01b0\u1ee3ng Oseltamivir carboxylat v\u00e0 42% d\u1ea1ng thu\u1ed1c nguy\u00ean v\u1eb9n g\u1eafn v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng. Th\u1ec3 t\u00edch ph\u00e2n b\u1ed1 c\u1ee7a Oseltamivir carboxylat v\u00e0o kho\u1ea3ng 23-26 l\u00edt<\/p>\n
Chuy\u1ec3n ho\u00e1 v\u00e0 th\u1ea3i tr\u1eeb: Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Oseltamivir l\u00e0 1-3 gi\u1edd trong khi ch\u1ea5t chuy\u1ec3n ho\u00e1 Oseltamivir carboxylat c\u00f3 th\u1eddi gian b\u00e1n th\u1ea3i 6-10 gi\u1edd, kh\u00f4ng b\u1ecb chuy\u1ec3n ho\u00e1 v\u00e0 \u0111\u00e0o th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u \u0111\u1ebfn 99%.<\/p>\n
N\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u t\u0103ng l\u00ean \u1edf ng\u01b0\u1eddi cao tu\u1ed5i, b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng gan, th\u1eadn do \u0111\u00f3 khi s\u1eed d\u1ee5ng trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p n\u00e0y c\u1ea7n ph\u1ea3i hi\u1ec7u ch\u1ec9nh li\u1ec1u.<\/p>\n
C\u00f4ng d\u1ee5ng v\u00e0 ch\u1ec9 \u0111\u1ecbnh<\/h2>\n
– C\u00fam typ A (bao g\u1ed3m c\u00fam H_{5<\/sub>N_{1<\/sub> truy\u1ec1n t\u1eeb gia c\u1ea7m sang ng\u01b0\u1eddi) v\u00e0 C\u00fam typ B c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng \u0111i\u1ec3n h\u00ecnh kh\u00f4ng qu\u00e1 48 gi\u1edd.<\/p>\n}}
– D\u1ef1 ph\u00f2ng c\u00fam cho ng\u01b0\u1eddi tr\u00ean 13 tu\u1ed5i ti\u1ebfp x\u00fac v\u1edbi ngu\u1ed3n b\u1ec7nh<\/p>\n
$\"Oseltamivir$
Oseltamivir \u0111i\u1ec1u tr\u1ecb c\u00fam A H5N1<\/figcaption><\/figure>\n
Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng<\/h2>\n
– \u0110i\u1ec1u tr\u1ecb c\u00fam typ A v\u00e0 c\u00fam typ B: Ph\u1ea3i u\u1ed1ng thu\u1ed1c v\u1edbi nhi\u1ec1u n\u01b0\u1edbc, \u0111\u1ee7 li\u1ec1u v\u00e0 \u0111\u00fang th\u1eddi gian quy \u0111\u1ecbnh.<\/p>\n
Li\u1ec1u d\u00f9ng cho ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 12 tu\u1ed5i: M\u1ed7i l\u1ea7n 75mg, 12 gi\u1edd m\u1ed9t l\u1ea7n trong 5 ng\u00e0y<\/p>\n
Li\u1ec1u d\u00f9ng cho tr\u1ebb t\u1eeb 1-12 tu\u1ed5i: c\u00e2n n\u1eb7ng d\u01b0\u1edbi 15kg: 30mg\/l\u1ea7n\/12 gi\u1edd; c\u00e2n n\u1eb7ng t\u1eeb 16-23 kg: 45mg\/l\u1ea7n\/12 gi\u1edd; c\u00e2n n\u1eb7ng t\u1eeb 24-40kg: 60mg\/l\u1ea7n\/12 gi\u1edd; tr\u00ean 40kg t\u00ednh theo li\u1ec1u ng\u01b0\u1eddi l\u1edbn<\/p>\n
Li\u1ec1u d\u00f9ng cho tr\u1ebb d\u01b0\u1edbi 12 th\u00e1ng tu\u1ed5i: D\u00f9ng 2 l\u1ea7n trong 5 ng\u00e0y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb v\u00e0 1 l\u1ea7n trong 10 ng\u00e0y \u0111\u1ec3 d\u1ef1 ph\u00f2ng: Tr\u1ebb d\u01b0\u1edbi 1 th\u00e1ng tu\u1ed5i: 2mg\/kg; 1-3 th\u00e1ng tu\u1ed5i: 2.5mg\/kg; 3-12 th\u00e1ng tu\u1ed5i: 3mg\/kg.<\/p>\n
– D\u1ef1 ph\u00f2ng c\u00fam cho ng\u01b0\u1eddi tr\u00ean 13 tu\u1ed5i ti\u1ebfp x\u00fac v\u1edbi ngu\u1ed3n b\u1ec7nh: U\u1ed1ng 75mg ng\u00e0y 1 l\u1ea7n \u00edt nh\u1ea5t trong 7 ng\u00e0y. N\u1ebfu trong v\u00f9ng d\u1ecbch u\u1ed1ng trong v\u00f2ng 6 tu\u1ea7n.<\/p>\n
– \u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn c\u1ea7n gi\u1ea3m li\u1ec1u theo Cl_{Cr.<\/sub><\/p>\n}
– Ng\u01b0\u1eddi cao tu\u1ed5i kh\u00f4ng c\u1ea7n gi\u1ea3m li\u1ec1u.<\/p>\n
$\"D\u1ecbch$
D\u1ecbch c\u00fam A H5N1<\/figcaption><\/figure>\n
T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a Oseltamivir<\/h2>\n
T\u1ef7 l\u1ec7 g\u1eb7p ph\u1ea3i c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c th\u01b0\u1eddng ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u d\u00f9ng<\/p>\n
R\u1ea5t hay g\u1eb7p:<\/p>\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean h\u1ec7 ti\u00eau ho\u00e1: n\u00f4n<\/p>\n
Hay g\u1eb7p:<\/p>\n
\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean ti\u00eau ho\u00e1: n\u00f4n nao, \u0111au b\u1ee5ng, \u1ec9a ch\u1ea3y;<\/li>\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean m\u1eaft: vi\u00eam k\u1ebft m\u1ea1c;<\/li>\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean h\u00f4 h\u1ea5p: ch\u1ea3y m\u00e1u cam, ho, vi\u00eam ph\u1ebf qu\u1ea3n, hen, vi\u00eam xoang, vi\u00eam ph\u1ed5i;<\/li>\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean tai: vi\u00eam tai gi\u1eefa.<\/li>\n<\/ul>\n
\u00cdt g\u1eb7p:<\/p>\n
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T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean gan: vi\u00eam gan c\u1ea5p;<\/li>\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean ti\u00eau ho\u00e1: ch\u1ea3y m\u00e1u \u0111\u01b0\u1eddng ti\u00eau ho\u00e1;<\/li>\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean mi\u1ec5n d\u1ecbch: d\u1ecb \u1ee9ng, m\u1eabn c\u1ea3m, shock ph\u1ea3n v\u1ec7;<\/li>\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean m\u00e1u: gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u;<\/li>\n
T\u00e1c d\u1ee5ng ph\u1ee5 tr\u00ean th\u1eadn: vi\u00eam th\u1eadn c\u1ea5p\u2026<\/li>\n<\/ul>\n
Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/h2>\n
Ng\u01b0\u1eddi b\u1ec7nh d\u1ecb \u1ee9ng v\u1edbi Oseltamivir ho\u1eb7c v\u1edbi b\u1ea5t k\u00ec th\u00e0nh ph\u1ea7n n\u00e0o kh\u00e1c c\u00f3 trong ch\u1ebf ph\u1ea9m<\/p>\n
Ng\u01b0\u1eddi b\u1ec7nh suy th\u1eadn n\u1eb7ng (Cl\u00ad_{Cr <\/sub>< 10 mL\/ ph\u00fat) ho\u1eb7c \u0111ang ph\u1ea3i ch\u1ea1y th\u1eadn nh\u00e2n t\u1ea1o.<\/p>\n}
Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng Oseltamivir<\/h2>\n
Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng tr\u00ean b\u1ec7nh nh\u00e2n suy gan<\/p>\n
Th\u1eadn tr\u1ecdng tr\u00ean b\u1ec7nh nh\u00e2n suy th\u1eadn v\u1eeba ho\u1eb7c n\u1eb7ng: gi\u1ea3m li\u1ec1u v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd<\/p>\n
Th\u1eadn tr\u1ecdng tr\u00ean b\u1ec7nh nh\u00e2n c\u00f3 ti\u1ec1n s\u1eed kh\u00f3 dung n\u1ea1p fructose ho\u1eb7c b\u1ea9m sinh kh\u00f4ng dung n\u1ea1p fructose<\/p>\n
Theo d\u00f5i bi\u1ec3u hi\u1ec7n v\u1ec1 th\u1ea7n kinh \u2013 t\u00e2m th\u1ea7n.<\/p>\n
Th\u1eddi k\u1ef3 mang thai: ch\u01b0a r\u00f5 v\u1ec1 nguy c\u01a1, ch\u1ec9 d\u00f9ng cho PNCT trong tr\u01b0\u1eddng h\u1ee3p th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft<\/p>\n
Th\u1eddi k\u1ef3 cho con b\u00fa: Ch\u01b0a r\u00f5 v\u1ec1 kh\u1ea3 n\u0103ng b\u00e0i ti\u1ebft v\u00e0o s\u1eefa m\u1eb9 c\u1ee7a thu\u1ed1c, ch\u1ec9 d\u00f9ng trong tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft.<\/p>\n
T\u01b0\u01a1ng t\u00e1c thu\u1ed1c<\/h2>\n
Oseltamivir c\u00f3 t\u1ef7 l\u1ec7 li\u00ean k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng th\u1ea5p v\u00e0 \u00edt chuy\u1ec3n ho\u00e1 qua CytochromP450 n\u00ean \u00edt x\u1ea3y ra t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf hay c\u1ea3m \u1ee9ng enzym chuy\u1ec3n ho\u00e1 thu\u1ed1c c\u1ee7a CYP450. D\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi probenecid l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 Oseltamivir carboxylat do c\u1ea1nh tranh b\u00e0i ti\u1ebft \u1edf \u1ed1ng th\u1eadn tuy nhi\u00ean ch\u01b0a c\u00f3 \u00fd ngh\u0129a trong l\u00e2m s\u00e0ng. Oseltamivir c\u00f3 th\u1ec3 d\u00f9ng \u0111\u1ed3ng th\u1eddi v\u1edbi c\u00e1c vaccin b\u1ea5t ho\u1ea1t \u0111\u1ec3 ph\u00f2ng c\u00fam.<\/p>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed qu\u00e1 li\u1ec1u<\/h2>\n
C\u00f2n ch\u01b0a c\u00f3 kinh nghi\u1ec7m v\u1ec1 qu\u00e1 li\u1ec1u, n\u1ebfu g\u1eb7p c\u00e1c ph\u1ea3n \u1ee9ng nh\u01b0 bu\u1ed3n n\u00f4n, n\u00f4n nghi li\u00ean quan \u0111\u1ebfn li\u1ec1u d\u00f9ng c\u1ea7n ng\u1eebng thu\u1ed1c ngay. Hi\u1ec7n ch\u01b0a c\u00f3 thu\u1ed1c gi\u1ea3i \u0111\u1ed9c \u0111\u1eb7c hi\u1ec7u.<\/p>\n
Gi\u00e1 b\u00e1n m\u1ed9t s\u1ed1 thu\u1ed1c c\u00f3 ch\u1ee9a Oseltamivir<\/p>\n
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Thu\u1ed1c Tamiflu 75 mg<\/a> gi\u00e1\u00a01.450.000 \u0111\u1ed3ng 1 h\u1ed9p<\/li>\n<\/ul>\n
Ngu\u1ed3n tham kh\u1ea3o:<\/p>\n
https:\/\/en.wikipedia.org\/wiki\/Oseltamivir<\/a><\/p>\n
https:\/\/www.drugbank.ca\/drugs\/DB00198<\/a><\/p>\n
Copy ghi ngu\u1ed3n: Nh\u00e0 thu\u1ed1c L\u01b0u V\u0103n Ho\u00e0ng<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
Oseltamivir l\u00e0 ho\u1ea1t ch\u1ea5t \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb c\u00fam A v\u00e0 c\u00fam B v\u1edbi bi\u1ec7t d\u01b0\u1ee3c n\u1ed5i ti\u1ebfng Tamiflu.\u00a0Trong b\u00e0i vi\u1ebft n\u00e0y, ch\u00fang t\u00f4i xin g\u1eedi \u0111\u1ebfn \u0111\u1ed9c gi\u1ea3 nh\u1eefng th\u00f4ng tin chi ti\u1ebft v\u00e0 quan tr\u1ecdng nh\u1ea5t v\u1ec1 ho\u1ea1t ch\u1ea5t Oseltamivir: Oseltamivir l\u00e0 thu\u1ed1c g\u00ec?\u00a0T\u00e1c d\u1ee5ng v\u00e0 C\u00f4ng d\u1ee5ng c\u1ee7a Oseltamivir? Li\u1ec1u […]\n","protected":false},"author":1,"featured_media":22308,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-22301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/22301","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=22301"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/22301\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/22308"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=22301"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=22301"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=22301"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}