{"id":11162,"date":"2019-06-17T15:38:35","date_gmt":"2019-06-17T08:38:35","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=11162"},"modified":"2019-06-19T16:07:49","modified_gmt":"2019-06-19T09:07:49","slug":"thuc-hu-thuc-pham-chuc-nang-chua-cac-chat-flavonoid-chua-ung-thu","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/thuc-hu-thuc-pham-chuc-nang-chua-cac-chat-flavonoid-chua-ung-thu\/","title":{"rendered":"Th\u1ef1c h\u01b0 th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng ch\u1ee9a c\u00e1c ch\u1ea5t Flavonoid ch\u1eefa ung th\u01b0?"},"content":{"rendered":"<h2>Gi\u1edbi thi\u1ec7u<\/h2>\n<p>Tr\u00ean th\u1ecb tr\u01b0\u1eddng hi\u1ec7n nay c\u00f3 nhi\u1ec1u s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c qu\u1ea3ng c\u00e1o v\u1edbi nh\u1eefng c\u00f4ng d\u1ee5ng th\u1ea7n k\u00ec trong ph\u00f2ng ng\u1eeba ung th\u01b0, h\u1ed7 tr\u1ee3 v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0, k\u1ec3 c\u1ea3 ung th\u01b0 giai \u0111o\u1ea1n cu\u1ed1i v\u00e0 c\u00f3 th\u1ec3 \u00e1p d\u1ee5ng cho r\u1ea5t nhi\u1ec1u lo\u1ea1i ung th\u01b0 nh\u01b0 ung th\u01b0 ph\u1ed5i, gan, v\u00fa, \u0111\u1ea1i tr\u00e0ng, d\u1ea1 d\u00e0y, tuy\u1ebfn tuy\u1ec1n li\u1ec7t, th\u1eadn, m\u00e1u, v\u00f2m h\u1ecdng, tuy\u1ebfn gi\u00e1p, tuy\u1ebfn t\u1ee5y, x\u01b0\u01a1ng, c\u1ed5 t\u1eed cung.<\/p>\n<p>V\u1edbi th\u00e0nh ph\u1ea7n ch\u00ednh ch\u1ee9a c\u00e1c flavonoid thu nh\u1eadn t\u1eeb hoa, qu\u1ea3, h\u1ea1t, th\u1ea3o d\u01b0\u1ee3c, c\u00e2y gia v\u1ecb, c\u00e1c s\u1ea3n ph\u1ea9m n\u00e0y cho t\u00e1c d\u1ee5ng hi\u1ec7u qu\u1ea3 trong h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n ung th\u01b0?<\/p>\n<p>V\u1eady \u0111\u00e2y l\u00e0 s\u1ef1 th\u1eadt \u0111\u00e1ng l\u01b0u t\u00e2m hay th\u1ed5i ph\u1ed3ng nh\u1eb1m tr\u1ee5c l\u1ee3i?<\/p>\n<p>B\u00e0i vi\u1ebft s\u1ebd cung c\u1ea5p nh\u1eefng th\u00f4ng tin cho bi\u1ebft Flavonoid l\u00e0 g\u00ec v\u00e0 c\u00f4ng d\u1ee5ng c\u1ee7a n\u00f3 th\u1ebf n\u00e0o trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0!<\/p>\n<h2>Flavonoid l\u00e0 g\u00ec?<\/h2>\n<p>Flavonoid l\u00e0 nh\u00f3m c\u00e1c h\u1ee3p ch\u1ea5t th\u1ee9 c\u1ea5p t\u1eeb th\u1ef1c v\u1eadt c\u00f3 trong nhi\u1ec1u lo\u1ea1i tr\u00e1i c\u00e2y, rau v\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i h\u1ea1t. Hi\u1ec7n nay c\u00f3 h\u01a1n 6000 h\u1ee3p ch\u1ea5t flavonoid \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh.<\/p>\n<p>C\u1ea5u tr\u00fac h\u00f3a h\u1ecdc, flavonoid l\u00e0 nh\u1eefng h\u1ee3p ch\u1ea5t polyphenol, ch\u1ee9a khung 15 nguy\u00ean t\u1eed Carbon t\u1ea1o th\u00e0nh 2 v\u00f2ng benzen li\u00ean k\u1ebft b\u1edfi carbon s\u1ed1 3[1]\n<p>V\u00ec l\u00e0 nh\u1eefng h\u1ee3p ch\u1ea5t ch\u1ed1ng oxy h\u00f3a ti\u1ec1m n\u0103ng n\u00ean flavonoid \u0111\u01b0\u1ee3c ch\u00fa \u00fd nhi\u1ec1u trong nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng trong ph\u00f2ng ng\u1eeba b\u1ec7nh t\u1eadt.<\/p>\n<h2>Ph\u00e2n lo\u1ea1i:<\/h2>\n<p>D\u1ef1a v\u00e0o c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc, flavonoid \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i th\u00e0nh 6 nh\u00f3m flavones, isoflavones, flavonol, flavanones, anthocyanidins v\u00e0 flavan-3-ols<\/p>\n<p>H\u00ecnh 1. C\u1ea5u tr\u00fac h\u00f3a h\u1ecdc c\u1ee7a c\u00e1c ph\u00e2n l\u1edbp ch\u00ednh c\u1ee7a flavonoid<\/p>\n<p>(Ngu\u1ed3n: Kyselova Z, Interdiscip Toxicol. 2011 Dec;4(4):173-83)<\/p>\n<p>C\u00e1c ph\u00e2n l\u1edbp v\u00e0 ngu\u1ed3n th\u1ef1c ph\u1ea9m ch\u1ee9a flavonoid[2]\n<table>\n<tbody>\n<tr>\n<td>Lo\u1ea1i flavonoid<\/td>\n<td>C\u00e1c h\u1ee3p ch\u1ea5t th\u01b0\u1eddng g\u1eb7p<\/td>\n<td>Ngu\u1ed3n th\u1ef1c ph\u1ea9m<\/td>\n<\/tr>\n<tr>\n<td>Flavonol<\/td>\n<td>Kaempferol, quercetin, myricetin, tamarixetin<\/td>\n<td>H\u00e0nh t\u00e2y, r\u01b0\u1ee3u vang \u0111\u1ecf, c\u1ea3i xo\u0103n, d\u1ea7u \u00f4 liu, b\u00f4ng c\u1ea3i xanh, t\u00e1o, anh \u0111\u00e0o, qu\u1ea3 m\u1ecdng, v\u00e0 b\u01b0\u1edfi v\u00e0 tr\u00e0<\/td>\n<\/tr>\n<tr>\n<td>Flavones<\/td>\n<td>Chrysin, apigenin Rutin, luteolin, glucosidestangeretin<\/td>\n<td>V\u1ecf tr\u00e1i c\u00e2y, r\u01b0\u1ee3u vang \u0111\u1ecf, ki\u1ec1u m\u1ea1ch, \u1edbt \u0111\u1ecf, v\u1ecf c\u00e0 chua, rau m\u00f9i t\u00e2y, h\u00fang t\u00e2y<\/td>\n<\/tr>\n<tr>\n<td>Flavonones<\/td>\n<td>Naringin, naringenin, taxifolin, hesperidin<\/td>\n<td>Tr\u00e1i c\u00e2y h\u1ecd cam qu\u00fdt, b\u01b0\u1edfi, chanh v\u00e0 cam<\/td>\n<\/tr>\n<tr>\n<td>Flavanol<\/td>\n<td>Catechin, epicatechin, epigallocatechin, glausan-3-epicatechin, proanthocyanidins<\/td>\n<td>T\u00e1o v\u00e0 tr\u00e0<\/td>\n<\/tr>\n<tr>\n<td>Anthocyanidins<\/td>\n<td>Apigenidin, cyaniding, delphinidin, pelargonidin, malvidin<\/td>\n<td>Anh \u0111\u00e0o, qu\u1ea3 m\u00e2m x\u00f4i, d\u00e2u t\u00e2y v\u00e0 nho<\/td>\n<\/tr>\n<tr>\n<td>Isoflavones<\/td>\n<td>Genistein, daidzein<\/td>\n<td>\u0110\u1eadu n\u00e0nh, \u0111\u1eadu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><strong>C\u00e1c ho\u1ea1t t\u00ednh sinh h\u1ecdc c\u1ee7a flavonoid<\/strong><\/h2>\n<p>-Ch\u1ed1ng oxy h\u00f3a: l\u00e0 m\u1ed9t ho\u1ea1t t\u00ednh ch\u00ednh c\u1ee7a h\u1ea7u h\u1ebft c\u00e1c flavonoid, kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a t\u00f9y thu\u1ed9c v\u00e0o s\u1ef1 s\u1eafp x\u1ebfp c\u00e1c nh\u00f3m ch\u1ee9c trong c\u00f4ng th\u1ee9c c\u1ea5u t\u1ea1o n\u00ean c\u00e1c flavonoid.<\/p>\n<p>C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng oxy h\u00f3a c\u00f3 th\u1ec3 bao g\u1ed3m (1) \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c ch\u1ea5t ch\u1ee9a oxy ho\u1ea1t \u0111\u1ed9ng (Reactive Oxygen Species- ROS) ho\u1eb7c (2) k\u00edch ho\u1ea1t c\u00e1c enzyme ch\u1ed1ng oxy h\u00f3a hay gi\u1ea3m thi\u1ec3u stress oxy h\u00f3a tr\u00ean t\u1ebf b\u00e0o g\u00e2y ra b\u1edfi nitric oxit, (3) gi\u1ea3m c\u00e1c g\u1ed1c \u03b1-tocopheryl, \u1ee9c ch\u1ebf c\u00e1c oxydase v\u00e0 t\u0103ng \u0111\u1eb7c t\u00ednh ch\u1ed1ng oxy h\u00f3a c\u1ee7a c\u00e1c ch\u1ea5t ch\u1ed1ng oxy h\u00f3a ph\u00e2n t\u1eed th\u1ea5p[2, 3]\n<p>-Kh\u00e1ng khu\u1ea9n: C\u00e1c nghi\u00ean c\u1ee9u kh\u00e1c nhau cho th\u1ea5y c\u00e1c ch\u1ea5t chi\u1ebft xu\u1ea5t t\u1eeb th\u1ef1c v\u1eadt gi\u00e0u flavonoid c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n. Apigenin, galangin, flavone v\u00e0 flavonol glycoside, isoflavone, flavanones v\u00e0 chalcones \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n m\u1ea1nh m\u1ebd [2]\n<p>-Kh\u00e1ng vi\u00eam: Vi\u00eam l\u00e0 m\u1ed9t ph\u1ea3n \u1ee9ng sinh h\u1ecdc ph\u1ee9c t\u1ea1p c\u1ee7a c\u01a1 th\u1ec3 \u0111\u1ed1i v\u1edbi c\u00e1c k\u00edch th\u00edch c\u00f3 h\u1ea1i, ch\u1eb3ng h\u1ea1n nh\u01b0 nhi\u1ec5m m\u1ea7m b\u1ec7nh, t\u1ebf b\u00e0o b\u1ecb h\u01b0 h\u1ecfng, t\u1ed5n th\u01b0\u01a1ng m\u00f4 v\u00e0 k\u00edch \u1ee9ng h\u00f3a h\u1ecdc. Nhi\u1ec1u nghi\u00ean c\u1ee9u trong ph\u00f2ng th\u00ed nghi\u1ec7m (in vitro) cho th\u1ea5y nhi\u1ec1u lo\u1ea1i flavonoid c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng vi\u00eam. Qu\u00e1 tr\u00ecnh n\u00e0y \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1eb1ng c\u00e1ch thu h\u00fat c\u00e1c c\u00e1c t\u1ebf b\u00e0o \u0111\u00e1p \u1ee9ng vi\u00eam, gi\u1ea3i ph\u00f3ng ROS, RNS (Reactive Nitrogen Species \u2013 h\u1ee3p ch\u1ea5t mang nit\u01a1 ho\u1ea1t \u0111\u1ed9ng) v\u00e0 c\u00e1c cytokine ti\u1ec1n vi\u00eam \u0111\u1ec3 lo\u1ea1i b\u1ecf m\u1ea7m b\u1ec7nh ngo\u1ea1i lai v\u00e0 s\u1eeda ch\u1eefa c\u00e1c m\u00f4 b\u1ecb th\u01b0\u01a1ng. Hesperidin, Luteolin v\u00e0 Quercetin \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 c\u00f3 lo\u1ea1i \u0111\u1eb7c t\u00ednh ch\u1ed1ng vi\u00eam, ch\u1ee7 y\u1ebfu \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c h\u1ec7 th\u1ed1ng enzyme li\u00ean quan \u0111\u1ebfn vi\u1ec7c t\u1ea1o ra c\u00e1c qu\u00e1 tr\u00ecnh vi\u00eam[2]\n<h2>Flavonoid trong ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0:<\/h2>\n<p>Nhi\u1ec1u nghi\u00ean c\u1ee9u trong ph\u00f2ng th\u00ed nghi\u1ec7m (in vitro) cho th\u1ea5y c\u00e1c lo\u1ea1i flavonoid c\u00f3 kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf m\u1ed9t s\u1ed1 lo\u1ea1i t\u1ebf b\u00e0o ung th\u01b0 nh\u01b0 ung th\u01b0 v\u00fa, ung th\u01b0 ph\u1ed5i, ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t, ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, ung th\u01b0 m\u00e1u[2, 4]; m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u in vivo tr\u00ean chu\u1ed9t c\u0169ng cho th\u1ea5y m\u1ed9t v\u00e0i h\u1ee3p ch\u1ea5t flavonoid c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf kh\u1ed1i u[37]. (Tuy nhi\u00ean c\u1ea7n l\u01b0u \u00fd \u0111\u00e2y l\u00e0 nh\u1eefng k\u1ebft qu\u1ea3 trong nghi\u00ean c\u1ee9u in vitro, l\u00e0 c\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y, v\u00e0 m\u00f4 h\u00ecnh chu\u1ed9t ch\u1ee9 kh\u00f4ng ph\u1ea3i tr\u00ean c\u01a1 th\u1ec3 ng\u01b0\u1eddi)<\/p>\n<p>Nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u00e0 d\u1ecbch t\u1ec5 h\u1ecdc:<\/p>\n<p>Nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng:<\/p>\n<p>Hi\u1ec7n t\u1ea1i, c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng ung th\u01b0 v\u1ec1 c\u00e1c flavonoid v\u00e0 c\u00e1c ph\u00e2n l\u1edbp cho vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 c\u00f2n r\u1ea5t h\u1ea1n ch\u1ebf v\u00e0 nhi\u1ec1u nghi\u00ean c\u1ee9u ch\u01b0a c\u00f3 k\u1ebft qu\u1ea3 ch\u00ednh th\u1ee9c:<\/p>\n<p>Nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng pha 2 s\u1eed d\u1ee5ng flavone acetic acid kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, ung th\u01b0 v\u00fa, ung th\u01b0 da, ung th\u01b0 \u0111\u1ea7u v\u00e0 c\u1ed5.[5, 6]\n<p>Flavopiridol ( c\u00f2n g\u1ecdi l\u00e0 alvocidib) l\u00e0 flavonoid t\u1ed5ng h\u1ee3p thu\u1ed9c ph\u00e2n l\u1edbp flavone, l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf CDK, \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng pha I, II, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u01a1n l\u1ebb hay k\u1ebft h\u1ee3p v\u1edbi m\u1ed9t s\u1ed1 thu\u1ed1c h\u00f3a tr\u1ecb nh\u01b0 paclitaxel, docetaxel cho m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 nh\u01b0 ung th\u01b0 b\u1ea1ch c\u1ea7u c\u1ea5p t\u00ednh , ung th\u01b0 da melanoma, ung th\u01b0 tuy\u1ebfn ti\u1ec1n li\u1ec7t, ung th\u01b0 th\u1eadn v\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 kh\u00e1c, v\u00e0 v\u1eabn ch\u01b0a c\u00f3 k\u1ebft qu\u1ea3 ch\u00ednh th\u1ee9c [7, 8]\n<p>Nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng pha I\/II s\u1eed d\u1ee5ng genistein \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh giai \u0111o\u1ea1n \u0111\u1ea7u \u0111\u1ec3 ch\u1eefa ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, ung th\u01b0 t\u1ee5y, ung th\u01b0 b\u00e0ng quang. Trong c\u00e1c nghi\u00ean c\u1ee9u n\u00e0y, genistein c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u01a1n l\u1ebb hay k\u1ebft h\u1ee3p v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c nh\u01b0 gemcitabine, erlotinib,FOLFOX hayFOLFOX-Avastin. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng pha I v\u00e0 pha II s\u1eed d\u1ee5ng genistein \u0111\u00e3 ho\u00e0n th\u00e0nh nh\u01b0ng kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 r\u00f5 r\u1ec7t v\u00e0 kh\u00f4ng ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u (NCT00244933, NCT00376948) hay ch\u01b0a c\u00f3 c\u00f4ng b\u1ed1 k\u1ebft qu\u1ea3 ch\u00ednh th\u1ee9c, m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c \u0111\u01b0a ra nh\u01b0ng b\u1ecb thu h\u1ed3i[9].<\/p>\n<p>Quercetin \u0111\u00e3 ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng b\u01b0\u1edbc \u0111\u1ea7u tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng v\u00e0 tuy\u1ebfn ti\u1ec1n li\u1ec7t tuy nhi\u00ean ch\u01b0a c\u00f3 k\u1ebft qu\u1ea3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 [10, 11]. Quercetin \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u1ed9t c\u00e1ch an to\u00e0n v\u1edbi s\u1ed1 l\u01b0\u1ee3ng 500 mg hai l\u1ea7n m\u1ed7i ng\u00e0y trong 12 tu\u1ea7n. Tuy nhi\u00ean n\u1ebfu s\u1eed d\u1ee5ng l\u00e2u d\u00e0i ho\u1eb7c li\u1ec1u cao h\u01a1n th\u00ec \u0111\u1ed9 an to\u00e0n ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh. Khi u\u1ed1ng, quercetin c\u00f3 th\u1ec3 g\u00e2y \u0111au \u0111\u1ea7u v\u00e0 ng\u1ee9a \u1edf tay, ch\u00e2n. Li\u1ec1u cao c\u00f3 th\u1ec3 g\u00e2y t\u1ed5n th\u01b0\u01a1ng th\u1eadn[12].<\/p>\n<p>V\u00e0 tr\u00ean c\u01a1 s\u1edf d\u1eef li\u1ec7u thu\u1ed1c Drugbank ch\u01b0a c\u00f3 h\u1ee3p ch\u1ea5t flavonoid n\u00e0o \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m thu\u1ed1c ch\u1eefa ung th\u01b0 \u0111\u01b0\u1ee3c FDA c\u1ea5p ph\u00e9p [13]\n<p>Nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5 tr\u00ean s\u1ed1 l\u01b0\u1ee3ng l\u1edbn:<\/p>\n<p>T\u1ed5ng h\u1ee3p c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 ti\u00eau th\u1ee5 flavonoid v\u00e0 nguy c\u01a1 m\u1ed9t s\u1ed1 ung th\u01b0:<\/p>\n<table>\n<tbody>\n<tr>\n<td>Lo\u1ea1i ung th\u01b0<\/td>\n<td>Nghi\u00ean c\u1ee9u<\/td>\n<td>K\u1ebft qu\u1ea3<\/td>\n<td>T\u00e1c gi\u1ea3<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\">Ung th\u01b0 v\u00fa<\/td>\n<td>Nghi\u00ean c\u1ee9u \u00a0\u0111o\u00e0n h\u1ec7 ti\u1ec1n c\u1ee9u tr\u00ean10713 ph\u1ee5 n\u1eef t\u1ea1i T\u00e2y Ban Nha (Nghi\u00ean c\u1ee9u \u00a0\u0111o\u00e0n h\u1ec7 ti\u1ec1n c\u1ee9u-Prospective Cohort Study \u2013 s\u1ebd vi\u1ebft t\u1eaft l\u00e0 PCS \u1edf c\u00e1c ph\u1ea7n sau)<\/td>\n<td>Kh\u00f4ng c\u00f3 s\u1ef1 li\u00ean quan r\u00f5 r\u00e0ng gi\u1eefa vi\u1ec7c ti\u00eau th\u1ee5 flavonoid t\u1ed5ng v\u00e0 gi\u1ea3m nguy c\u01a1 ung th\u01b0 v\u00fa<\/td>\n<td>Itziar Gardeazabal, 2013[14]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u PCS EPIC tr\u00ean 334850 ph\u1ee5 n\u1eef t\u1ea1i c\u00e1c n\u01b0\u1edbc ch\u00e2u \u00c2u t\u1eeb 35-70 tu\u1ed5i trong kho\u1ea3ng 11,5 n\u0103m<\/td>\n<td>Trong 11,5 n\u0103m c\u00f3 11576 ca m\u1eafc m\u1edbi ung th\u01b0 v\u00fa \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n. v\u00e0 k\u1ebft qu\u1ea3 cho th\u1ea5y Kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa vi\u1ec7c ti\u00eau th\u1ee5 flavonoid t\u1ed5ng v\u00e0 isoflavonoid v\u00e0 l\u00e0m gi\u1ea3m nguy c\u01a1 ung th\u01b0 v\u00fa<\/td>\n<td>Raul Zamora-Ros, 2013[15]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u b\u1ec7nh ch\u1ee9ng (case-control) v\u1edbi 353 ng\u01b0\u1eddi b\u1ec7nh v\u00e0 701 \u0111\u1ed1i ch\u1ee9ng, 40-70 \u00a0tu\u1ed5i<\/td>\n<td>Cho th\u1ea5y \u00a0ti\u00eau th\u1ee5 epicatechin c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 ung th\u01b0 v\u00fa v\u00e0. Tuy nhi\u00ean t\u00e1c gi\u1ea3 kh\u1eb3ng \u0111\u1ecbnh k\u1ebft qu\u1ea3 v\u1eabn c\u00f2n ph\u1ea3i x\u00e1c nh\u1eadn th\u00eam<\/td>\n<td>Luo JF, 2010[16]<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Ung th\u01b0 ph\u1ed5i<\/td>\n<td>Nghi\u00ean c\u1ee9u tr\u00ean 34708 ph\u1ee5 n\u1eef sau m\u00e3n kinh.<\/td>\n<td>ti\u00eau th\u1ee5 li\u1ec1u cao flavanones, proanthocyanidins l\u00e0m gi\u1ea3m t\u1ec9 l\u1ec7 m\u1eafc m\u1edbi ung th\u01b0 ph\u1ed5i, tuy nhi\u00ean ch\u1ec9 c\u00f3 hi\u1ec7u qu\u1ea3 v\u1edbi ng\u01b0\u1eddi \u0111ang v\u00e0 \u0111\u00e3 t\u1eebng h\u00fat thu\u1ed1c l\u00e1, kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 v\u1edbi ng\u01b0\u1eddi ch\u01b0a t\u1eebng h\u00fat thu\u1ed1c<\/td>\n<td>Cutler, 2008[17]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u b\u1ec7nh ch\u1ee9ng: 1061 ng\u01b0\u1eddi b\u1ec7nh v \u00e0 1425 \u0111\u1ed1i ch\u1ee9ng<\/td>\n<td>Ti\u00eau th\u1ee5 m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf flavonoid cho th\u1ea5y t\u0103ng nguy c\u01a1 ung th\u01b0 ph\u1ed5i<\/td>\n<td>Christensen KY, 2012[18]<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"5\">Ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng[19]<\/td>\n<td>Nghi\u00ean c\u1ee9u PCS tr\u00ean 42478 nam v\u00e0 76364 n\u1eef trong 26 n\u0103m<\/td>\n<td>Kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa vi\u1ec7c ti\u00eau th\u1ee5 c\u00e1c lo\u1ea1i flavonoid (anthocyanin, flavan-3-ol, flavanone, flavone, flavonol) v\u00e0 l\u00e0m gi\u1ea3m nguy c\u01a1 ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng<\/td>\n<td>Nimptsch K, 2016[20]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u PCS tr\u00ean 62573 n\u1eef v\u00e0 58279 nam tu\u1ed5i t\u1eeb 55-69 t\u1ea1i H\u00e0 Lan<\/td>\n<td>Kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa vi\u1ec7c ti\u00eau th\u1ee5 flavone, flavonol, catechin v\u00e0 gi\u1ea3m nguy c\u01a1 ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng<\/td>\n<td>Simons, 2009[21]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u tr\u00ean 3234 b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng<\/td>\n<td>5 lo\u1ea1i flavone v\u00e0 flavonol th\u01b0\u1eddng g\u1eb7p :quercetin, kaempferol, myricetin apigenin v\u00e0 luteolin kh\u00f4ng c\u00f3 vai tr\u00f2 ng\u0103n ng\u1eeba ung th\u01b0<\/td>\n<td>L. Wang, 2009 [22]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u b\u1ec7nh ch\u1ee9ng v\u1edbi 523 ng\u01b0\u1eddi tham gia<\/td>\n<td>Ti\u00eau th\u1ee5 flavonoid kh\u00f4ng c\u00f3 li\u00ean h\u1ec7 v\u1edbi vi\u1ec7c gi\u1ea3m nguy c\u01a1 ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, v\u1ec1 c\u1ea3 t\u1ec9 l\u1ec7 s\u1ed1ng c\u0169ng nh\u01b0 t\u00e1i ph\u00e1t ung th\u01b0<\/td>\n<td>Zamora Ros, 2015[23]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u b\u1ec7nh ch\u1ee9ng v\u1edbi 424 ng\u01b0\u1eddi b\u1ec7nh v\u00e0 401 \u0111\u1ed1i ch\u1ee9ng t\u1ea1i T\u00e2y Ban nha<\/td>\n<td>C\u00f3 s\u1ef1 gi\u1ea3m nguy c\u01a1 ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng v\u00e0 vi\u1ec7c ti\u00eau th\u1ee5 flavonoid t\u1ed5ng v\u00e0 m\u1ed9t s\u1ed1 ph\u00e2n nh\u00f3m nh\u01b0 proanthocyanidins and flavones<\/td>\n<td>Zamora Ros, 2013[24]<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Ung \u00a0th \u01b0 d \u1ea1 d \u00e0y<\/td>\n<td>Nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec3 t\u1ea1i Hoa K\u1ef3 ng\u01b0\u1eddi t\u1eeb 30-79 tu\u1ed5i v\u1edbi 1027 b\u1ec7nh nh\u00e2n m\u1eafc c\u00e1c lo\u1ea1i ung th\u01b0 d\u1ea1 d\u00e0y v\u00e0 th\u1ef1c qu\u1ea3n, 662 ng\u01b0\u1eddi \u0111\u1ed1i ch\u1ee9ng<\/td>\n<td>kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa ti\u00eau th\u1ee5 flavonoid t\u1ed5ng v\u00e0 t\u1ec9 l\u1ec7 m\u1eafc m\u1edbi c\u0169ng nh\u01b0 t\u1ec9 l\u1ec7 s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n ung th\u1ef1c qu\u1ea3n v\u00e0 ung th\u01b0 d\u1ea1 d\u00e0y<\/td>\n<td>J L Petrick, 2015[25]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u b\u1ec7nh ch\u1ee9ng v\u1edbi 334 ng\u01b0\u1eddi b\u1ec7nh v\u00e0 334 \u0111\u1ed1i ch\u1ee9ng tu\u1ed5i t\u1eeb 35-70 t\u1ea1i H\u00e0n Qu\u1ed1c<\/td>\n<td>Ti\u00eau th\u1ee5 flavonoid t\u1ed5ng gi\u1ea3m nguy c\u01a1 ung th\u01b0 d\u1ea1 d\u00e0y \u1edf n\u1eef<\/td>\n<td>Hae Donw Woo, 2014[26]<\/td>\n<\/tr>\n<tr>\n<td>Ung th\u01b0 b\u00e0ng quang<\/td>\n<td>Nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec3 European Prospective Investigation into Cancer and Nutrition (EPIC) tr\u00ean 477312 ng\u01b0\u1eddi tu\u1ed5i t\u1eeb 35-70 t\u1ea1i 10 n\u01b0\u1edbc ch\u00e2u \u00c2u, sau 11 n\u0103m<\/td>\n<td>c\u00f3 1575 ca m\u1eafc ung th\u01b0 b\u00e0ng quang \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n, k\u1ebft qu\u1ea3 cho th\u1ea5y kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa vi\u1ec7c ti\u00eau th\u1ee5 flavonoid v\u00e0 nguy c\u01a1 ung th\u01b0 b\u00e0ng quang, tuy nhi\u00ean subclass flavonol th\u00ec cho th\u1ea5y t\u1ec9 l\u1ec7 ngh\u1ecbch v\u1edbi nguy c\u01a1 m\u1eafc ung th\u01b0<\/td>\n<td>Zamora-Ros R, 2014[27]<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Ung th\u01b0 t\u1ee5y<\/td>\n<td>Nghi\u00ean c\u1ee9u PCS EPIC v\u1edbi 477309 ng\u01b0\u1eddi tham gia trong 11 n\u0103m t\u1ea1i Ch\u00e2u \u00c2u<\/td>\n<td>Kh\u00f4ng c\u00f3 m\u1ed1i li\u00ean h\u1ec7 cho th\u1ea5y gi\u1ea3m nguy c\u01a1 ung th\u01b0 t\u1ee5y v\u00e0 vi\u1ec7c ti\u00eau th\u1ee5 flavonoid v\u00e0 c\u00e1c ph\u00e2n l\u1edbp flavonoid<\/td>\n<td>Molina-Montes E, 2016[28]<\/td>\n<\/tr>\n<tr>\n<td>Nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec3 National Institutes of Health (NIH)-AARP Diet and Health cohort, 537104 ng\u01b0\u1eddi \u0111\u01b0\u1ee3c kh\u1ea3o s\u00e1t, trong 10 n\u0103m<\/td>\n<td>Sau 10 n\u0103m c\u00f3 2379 b\u1ec7nh nh\u00e2n ung th\u01b0 t\u1ee5y \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n. kh\u00f4ng c\u00f3 b\u1ea5t k\u00ec s\u1ef1 li\u00ean quan gi\u1eefa nguy c\u01a1 ung th\u01b0 t\u1ee5y v\u00e0 ti\u00eau th\u1ee5 flavonoid t\u1ed5ng hay b\u1ea5t k\u00ec subtype flavonoid n\u00e0o \u00a0(6 subtypes flavonoid g\u1ed3m c\u00f3 : flavan-3-ols, flavanones, flavonols, anthocyanidins, flavones v\u00e0 isoflavones)<\/td>\n<td>Arem H, 2013[29]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u d\u1ecbch t\u1ec5 tr\u00ean s\u1ed1 l\u01b0\u1ee3ng l\u1edbn cho th\u1ea5y hi\u1ec7u qu\u1ea3 ng\u0103n ng\u1eeba ung th\u01b0 c\u1ee7a flavonoid t\u1ed5ng hay c\u1ea3 nh\u1eefng ph\u00e2n l\u1edbp flavonoid ch\u01b0a th\u1ef1c s\u1ef1 r\u00f5 r\u00e0ng, tuy c\u00f3 nh\u1eefng k\u1ebft qu\u1ea3 cho th\u1ea5y c\u00f3 kh\u1ea3 n\u0103ng gi\u1ea3m nguy c\u01a1 m\u1eafc m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 nh\u01b0ng nhi\u1ec1u nghi\u00ean c\u1ee9u l\u1ea1i cho th\u1ea5y vi\u1ec7c ti\u00eau th\u1ee5 c\u00e1c flavonoid kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng. V\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c flavonoid kh\u00e1 kh\u00e1c bi\u1ec7t v\u00e0 bi\u1ebfn \u0111\u1ed9ng t\u00f9y thu\u1ed9c v\u00e0o r\u1ea5t nhi\u1ec1u y\u1ebfu t\u1ed1 nh\u01b0 lo\u1ea1i flavonoid ti\u00eau th\u1ee5, ngu\u1ed3n g\u1ed1c thu nh\u1eadn, c\u1ea3 v\u1ecb tr\u00ed \u0111\u1ecba l\u00fd v\u00e0 ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng.[1]\n<p>T\u00f3m l\u1ea1i, th\u1ef1c s\u1ef1 Flavonoid ch\u1ee9a nhi\u1ec1u h\u1ee3p ch\u1ea5t ti\u1ec1m n\u0103ng c\u00f3 t\u00e1c d\u1ee5ng l\u00ean t\u1ebf b\u00e0o ung th\u01b0 nh\u01b0ng \u0111a s\u1ed1 c\u00e1c ho\u1ea1t ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong ph\u00f2ng th\u00ed nghi\u1ec7m. T\u1eeb \u0111\u00f3 cho th\u1ea5y \u0111\u1ec3 c\u00f3 th\u1ec3 kh\u1eb3ng \u0111\u1ecbnh t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c flavonoid trong ng\u0103n ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tr\u00ean ng\u01b0\u1eddi v\u1eabn c\u1ea7n qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u v\u00e0 x\u00e1c \u0111\u1ecbnh r\u00f5 r\u00e0ng h\u01a1n. V\u00e0 \u0111\u1eb7c bi\u1ec7t ch\u01b0a c\u00f3 s\u1ef1 cho ph\u00e9p s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t flavonoid cho \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u1edf th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i.<\/p>\n<p>Tuy nhi\u00ean nh\u01b0 \u0111\u00e3 n\u00f3i \u1edf tr\u00ean, c\u00e1c lo\u1ea1i rau c\u1ee7 qu\u1ea3 ch\u1ee9a nhi\u1ec1u flavonoid l\u00e0 c\u00e1c ch\u1ea5t ch\u1ed1ng oxy h\u00f3a, n\u00ean s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i rau c\u1ee7 qu\u1ea3 trong th\u00e0nh ph\u1ea7n b\u1eefa \u0103n nh\u1eb1m \u0111\u1ea3m b\u1ea3o vi\u1ec7c cung c\u1ea5p c\u00e1c vitamin v\u00e0 ch\u1ea5t x\u01a1 cho c\u01a1 th\u1ec3.<\/p>\n<h2>Th\u1ef1c h\u01b0 th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng ch\u1ee9a c\u00e1c ch\u1ea5t Flavonoid ch\u1eefa ung th\u01b0?<\/h2>\n<p>G\u1ea7n \u0111\u00e2y tr\u00ean m\u1ea1ng c\u00f3 lan truy\u1ec1n th\u00f4ng tin th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng c\u1ee7a c\u00f4ng ty Navita \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng c\u00f3 ch\u1ee9a c\u00e1c h\u1ee3p ch\u1ea5t Flavonoid s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb, h\u1ed7 tr\u1ee3 ung th\u01b0: \u201cH\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0, k\u1ec3 c\u1ea3 giai \u0111o\u1ea1n cu\u1ed1i: \u1ee9c ch\u1ebf t\u1ebf b\u00e0o ung th\u01b0 theo 3 c\u00e1ch: \u1ee9c ch\u1ebf nh\u00e2n b\u00e0o, \u1ee9c ch\u1ebf h\u00ecnh th\u00e0nh m\u1ea1ch m\u00e1u v\u00e0 k\u00edch ho\u1ea1t c\u01a1 ch\u1ebf t\u1ef1 s\u00e1t c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0. T\u1ed1t cho ung th\u01b0: Ph\u1ed5i, gan, v\u00fa, \u0111\u1ea1i tr\u00e0ng, d\u1ea1 d\u00e0y, tuy\u1ebfn tuy\u1ec1n li\u1ec7t, th\u1eadn, m\u00e1u, v\u00f2m h\u1ecdng, tuy\u1ebfn gi\u00e1p, tuy\u1ebfn t\u1ee5y, x\u01b0\u01a1ng, c\u1ed5 t\u1eed cung; Gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb: ch\u1ed1ng s\u1ee5t c\u00e2n, n\u00f4n m\u1eeda, r\u1ee5ng t\u00f3c\u2026\u201d<\/p>\n<p>FLAVITA\u00ae LIFEMAX: S\u1ea3n ph\u1ea9m cao c\u1ea5p : gi\u00e1 20 tri\u1ec7u VND, ch\u1ee9a Flovonoids t\u1eeb 200 lo\u1ea1i hoa, qu\u1ea3, h\u1ea1t, th\u1ea3o d\u01b0\u1ee3c, c\u00e2y gia v\u1ecb<\/p>\n<p>FLAVITA 88\u00ae CYTO: Ph\u00f2ng ch\u1ed1ng ung th\u01b0 : gi\u00e1 2 tri\u1ec7u 500 ng\u00e0n VND ch\u1ee9a Flavonoids c\u1ee7a 88 lo\u1ea1i tr\u00e1i c\u00e2y, hoa, h\u1ea1t, th\u1ea3o m\u1ed9c, gia v\u1ecb.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11165 aligncenter\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/flavita.jpg\" alt=\"flavita\" width=\"600\" height=\"470\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/flavita.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/flavita-511x400.jpg 511w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/flavita-350x274.jpg 350w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11164 aligncenter\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/flavita_1.jpg\" alt=\"flavita\" width=\"600\" height=\"470\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/flavita_1.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/flavita_1-511x400.jpg 511w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/flavita_1-350x274.jpg 350w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>H\u00ecnh 2. M\u1ed9t s\u1ed1 s\u1ea3n ph\u1ea9m qu\u1ea3ng c\u00e1o c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb v\u00e0 ch\u1eefa ung th\u01b0 c\u1ee7a Navita ( Ngu\u1ed3n: website www.navita.life)<\/p>\n<h3>V\u1eady th\u1ef1c h\u01b0 n\u00ean hi\u1ec3u nh\u01b0 th\u1ebf n\u00e0o?<\/h3>\n<p>Ph\u1ea7n ph\u00e2n t\u00edch ph\u00eda d\u01b0\u1edbi s\u1ebd th\u00f4ng tin cho b\u1ea1n \u0111\u1ecdc v\u1ec1 th\u1ef1c ph\u00e2m ch\u1ee9c n\u0103ng n\u00f3i chung v\u00e0 c\u00e1c th\u00f4ng tin t\u1eeb s\u1ea3n ph\u1ea9m ch\u1eefa ung th\u01b0 ch\u1ee9a Flavonoid c\u1ee7a c\u00f4ng ty Navita:<\/p>\n<p>Theo c\u00e1c quy \u0111\u1ecbnh hi\u1ec7n t\u1ea1i, c\u00e1c lo\u1ea1i th\u00e0nh ph\u1ea7n b\u1ed5 sung- dietary supplement \u0111\u01b0\u1ee3c x\u1ebfp v\u00e0o th\u1ef1c ph\u1ea9m v\u00e0 th\u01b0\u1eddng hay \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 Th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng (TPCN), tuy nhi\u00ean kh\u00f4ng \u0111\u01b0\u1ee3c qu\u1ea3ng c\u00e1o l\u00e0 c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ea5t k\u00ec lo\u1ea1i b\u1ec7nh n\u00e0o, ch\u1ec9 c\u00f3 th\u1ec3 n\u00f3i t\u1ed1t cho s\u1ee9c kh\u1ecfe hay gi\u1ea3m nguy c\u01a1 b\u1ec7nh n\u00e0o \u0111\u00f3 khi s\u1eed d\u1ee5ng[30].<\/p>\n<p>Hi\u1ec7p h\u1ed9i ung th\u01b0 Hoa K\u1ef3 c\u00f3 nh\u1eadn \u0111\u1ecbnh kh\u00f4ng n\u00ean mua b\u1ea5t k\u1ef3 s\u1ea3n ph\u1ea9m TPCN n\u00e0o qu\u1ea3ng c\u00e1o c\u00f3 th\u1ec3 ch\u1eefa b\u1ea5t k\u00ec b\u1ec7nh n\u00e0o, c\u00f3 hi\u1ec7u qu\u1ea3 th\u1ea7n k\u00ec v\u00e0 kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5. V\u00e0 n\u1ebfu s\u1ea3n ph\u1ea9m c\u00f3 tuy\u00ean b\u1ed1 ch\u1eefa \u0111\u01b0\u1ee3c b\u1ec7nh hay nhi\u1ec1u lo\u1ea1i b\u1ec7nh, ch\u1eefa kh\u1ecfi ung th\u01b0, ng\u0103n ng\u1eeba ung th\u01b0 ph\u00e1t tri\u1ec3n th\u00ec s\u1ea3n ph\u1ea9m n\u00e0y \u0111ang \u0111\u01b0\u1ee3c b\u00e1n b\u1ea5t h\u1ee3p ph\u00e1p d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c. Vi\u1ec7c d\u00e1n nh\u00e3n dietary supplement \u0111\u1ec3 l\u00e1ch lu\u1eadt tr\u00e1nh s\u1ef1 ph\u00ea chu\u1ea9n c\u1ee7a c\u00e1c \u0111\u01a1n v\u1ecb qu\u1ea3n l\u00fd thu\u1ed1c v\u00ed d\u1ee5 nh\u01b0 FDA. Kh\u00f4ng n\u00ean ph\u1ee5 thu\u1ed9c v\u00e0o m\u1ed9t s\u1ea3n ph\u1ea9m kh\u00f4ng k\u00ea \u0111\u01a1n n\u00e0o \u0111\u1ec3 ch\u1eefa b\u1ec7nh, ch\u1eefa ung th\u01b0, v\u00e0 n\u1ebfu mu\u1ed1n s\u1eed d\u1ee5ng b\u1ea5t k\u00ec s\u1ea3n ph\u1ea9m TPCN n\u00e0o trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb ung th\u01b0 c\u1ea7n h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u0129 c\u00f3 chuy\u00ean m\u00f4n[31-33].<\/p>\n<p>Theo \u201cTH\u00d4NG T\u01af Quy \u0111\u1ecbnh v\u1ec1 qu\u1ea3n l\u00fd th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng\u201d c\u1ee7a B\u1ed9 Y t\u1ebf \u2013 43\/2014\/TT-BYT ban h\u00e0nh n\u0103m 2014, Dietary Supplement l\u00e0 th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng thu\u1ed9c nh\u00f3m \u201cTh\u1ef1c ph\u1ea9m b\u1ea3o v\u1ec7 s\u1ee9c kho\u1ebb\u201d. Theo \u0111i\u1ec1u 4 trong th\u00f4ng t\u01b0 n\u00e0y, TPCN n\u1ebfu c\u00f4ng b\u1ed1 l\u00e0 c\u00f3 c\u00f4ng d\u1ee5ng \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi c\u1ea7n ph\u1ea3i c\u00f3 b\u00e1o c\u00e1o th\u1eed nghi\u1ec7m hi\u1ec7u qu\u1ea3 c\u00f4ng d\u1ee5ng, c\u00f3 t\u00e1c d\u1ee5ng h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh th\u00ec s\u1ea3n ph\u1ea9m ph\u1ea3i th\u1eed nghi\u1ec7m hi\u1ec7u qu\u1ea3 v\u1ec1 c\u00f4ng d\u1ee5ng \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi<\/p>\n<p>\u201cVi\u1ec7c th\u1eed nghi\u1ec7m hi\u1ec7u qu\u1ea3 v\u1ec1 c\u00f4ng d\u1ee5ng \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1ea1i c\u00e1c t\u1ed5 ch\u1ee9c c\u00f3 ch\u1ee9c n\u0103ng nghi\u00ean c\u1ee9u khoa h\u1ecdc v\u1ec1 y h\u1ecdc. Ri\u00eang \u0111\u1ed1i v\u1edbi s\u1ea3n ph\u1ea9m c\u00f4ng b\u1ed1 khuy\u1ebfn c\u00e1o c\u00f3 t\u00e1c d\u1ee5ng h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1ea1i c\u00e1c b\u1ec7nh vi\u1ec7n c\u00f3 ch\u1ee9c n\u0103ng nghi\u00ean c\u1ee9u khoa h\u1ecdc t\u1eeb tuy\u1ebfn t\u1ec9nh tr\u1edf l\u00ean.<\/p>\n<p>Trong tr\u01b0\u1eddng h\u1ee3p \u0111\u00e1nh gi\u00e1 th\u1eed nghi\u1ec7m hi\u1ec7u qu\u1ea3 v\u1ec1 c\u00f4ng d\u1ee5ng \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1ea1i n\u01b0\u1edbc ngo\u00e0i, vi\u1ec7c th\u1eed nghi\u1ec7m ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u1edf \u0111\u01a1n v\u1ecb \u0111\u01b0\u1ee3c c\u01a1 quan th\u1ea9m quy\u1ec1n n\u01b0\u1edbc s\u1edf t\u1ea1i th\u1eeba nh\u1eadn, c\u00f4ng nh\u1eadn ho\u1eb7c k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m \u0111\u01b0\u1ee3c \u0111\u0103ng t\u1ea3i tr\u00ean c\u00e1c t\u1ea1p ch\u00ed khoa h\u1ecdc.<\/p>\n<p>C\u1ee5c An to\u00e0n th\u1ef1c ph\u1ea9m (B\u1ed9 Y t\u1ebf) th\u00e0nh l\u1eadp H\u1ed9i \u0111\u1ed3ng khoa h\u1ecdc g\u1ed3m c\u00e1c chuy\u00ean gia thu\u1ed9c l\u0129nh v\u1ef1c ph\u00f9 h\u1ee3p \u0111\u1ec3 tham gia th\u1ea9m \u0111\u1ecbnh b\u00e1o c\u00e1o th\u1eed nghi\u1ec7m hi\u1ec7u qu\u1ea3 v\u1ec1 c\u00f4ng d\u1ee5ng s\u1ea3n ph\u1ea9m v\u00e0 c\u00e1c b\u1eb1ng ch\u1ee9ng khoa h\u1ecdc \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1\u201d. [34]\n<p>Quay l\u1ea1i 2 s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c qu\u1ea3ng c\u00e1o l\u00e0 c\u00f3 kh\u1ea3 n\u0103ng ch\u1eefa ung th\u01b0 k\u1ec3 tr\u00ean, b\u1eb1ng ch\u1ee9ng khoa h\u1ecdc \u0111\u01b0\u1ee3c nh\u00e0 s\u1ea3n xu\u1ea5t \u0111\u01b0a ra qua b\u00e0i b\u00e1o khoa h\u1ecdc: \u201cSynthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters, Dank\u00f3 B, et al. ChemMedChem. 2017\u201d. Trong nghi\u00ean c\u1ee9u n\u00e0y, m\u1ed9t s\u1ed1 h\u1ee3p ch\u1ea5t flavone \u201ctinh khi\u1ebft\u201d \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p v\u00e0 th\u1eed nghi\u1ec7m tr\u00ean m\u1ed9t s\u1ed1 d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 \u201cin vitro\u201d (trong ph\u00f2ng th\u00ed nghi\u1ec7m). B\u00ean c\u1ea1nh \u0111\u00f3, do c\u00e1c s\u1ea3n ph\u1ea9m n\u00e0y s\u1eed d\u1ee5ng theo \u0111\u01b0\u1eddng u\u1ed1ng, qu\u00e1 tr\u00ecnh h\u1ea5p th\u1ee5 th\u1ebf n\u00e0o v\u00e0 c\u00f3 \u0111\u1ebfn \u0111\u01b0\u1ee3c t\u1ebf b\u00e0o ung th\u01b0 trong c\u01a1 th\u1ec3 hay kh\u00f4ng c\u00f2n ch\u01b0a \u0111\u01b0\u1ee3c ch\u1ee9ng minh v\u00e0 trong nghi\u00ean c\u1ee9u ho\u00e0n to\u00e0n ch\u01b0a th\u1eed nghi\u1ec7m tr\u00ean m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt v\u00e0 ch\u01b0a c\u00f3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n<p>H\u01a1n n\u1eefa, c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u n\u00e0y ho\u00e0n to\u00e0n \u0111\u1ed9c l\u1eadp v\u00e0 kh\u00f4ng li\u00ean quan \u0111\u1ebfn s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c \u0111\u01b0a ra.<\/p>\n<p>Do \u0111\u00f3, d\u1ef1a tr\u00ean k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u n\u00e0y \u0111\u1ec3 kh\u1eb3ng \u0111\u1ecbnh s\u1ea3n ph\u1ea9m c\u00f3 kh\u1ea3 n\u0103ng ch\u1eefa ho\u1eb7c h\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 l\u00e0 ho\u00e0n to\u00e0n v\u00f4 c\u0103n c\u1ee9.<\/p>\n<p>B\u00ean c\u1ea1nh c\u00e1c s\u1ea3n ph\u1ea9m ch\u1ee9a Flavonoid c\u00f3 kh\u1ea3 n\u0103ng ch\u1eefa ung th\u01b0, c\u00f4ng ty n\u00e0y c\u00f2n c\u00f3 m\u1ed9t s\u1ea3n ph\u1ea9m ch\u1eefa ung th\u01b0 kh\u00e1c l\u00e0 Navita ARFeMAX\u00ae \u2013 H\u1ed7 tr\u1ee3 \u0111i\u1ec1u tr\u1ecb v\u00e0 ph\u00f2ng ch\u1ed1ng ung th\u01b0?<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11166 aligncenter\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/arfemax.jpg\" alt=\"arfemax\" width=\"600\" height=\"574\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/arfemax.jpg 600w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/arfemax-418x400.jpg 418w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/arfemax-350x335.jpg 350w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>Theo th\u00f4ng tin c\u00f4ng ty \u0111\u01b0a ra Navita ARFeMAX c\u00f3 ch\u1ee9a Artemisinin. V\u1eady Artemisinin l\u00e0 g\u00ec v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ch\u1eefa ung th\u01b0 hay ch\u01b0a?<\/p>\n<p>Artemisinin l\u00e0 m\u1ed9t lo\u1ea1i h\u1ee3p ch\u1ea5t c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb c\u00e2y Artemisia annua (Thanh hao hoa v\u00e0ng) ch\u00e2u \u00c1<\/p>\n<p>Hi\u1ec7n t\u1ea1i artemisinin cho th\u1ea5y c\u00f3 hi\u1ec7u qu\u1ea3 \u1ee9c ch\u1ebf m\u1ed9t s\u1ed1 d\u00f2ng t\u1ebf b\u00e0o ung th\u01b0 trong ph\u00f2ng th\u00ed nghi\u1ec7m ( in vitro)[35]. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng s\u1eed d\u1ee5ng artesunate, l\u00e0 h\u1ee3p ch\u1ea5t b\u00e1n t\u1ed5ng h\u1ee3p t\u1eeb artemisinin. Nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng pha I tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng ung th\u01b0 v\u00fa di c\u0103n (NCT00764036) v\u00e0 pha 2 tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng (NCT03093129, NCT02633098) . Tuy nhi\u00ean c\u00e1c nghi\u00ean c\u1ee9u n\u00e0y ch\u01b0a c\u00f3 k\u1ebft qu\u1ea3 x\u00e1c \u0111\u1ecbnh. V\u00e0 ch\u01b0a c\u00f3 thu\u1ed1c n\u00e0o hay h\u1ee3p ch\u1ea5t n\u00e0o c\u00f3 ngu\u1ed3n g\u1ed1c artemisinin d\u00f9ng \u0111\u1ec3 ch\u1eefa ung th\u01b0. Hi\u1ec7n t\u1ea1i thu\u1ed1c Coartem l\u00e0 li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p artemether-lumefantrine d\u1ef1a tr\u00ean Artemisinin v\u00e0 IV artesunate c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb artemisinin ch\u1ec9 s\u1eed d\u1ee5ng trong ch\u1eefa b\u1ec7nh s\u1ed1t r\u00e9t[36].<\/p>\n<p>Do \u0111\u00f3 vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c s\u1ea3n ph\u1ea9m TPCN nh\u01b0 tr\u00ean nh\u01b0 thu\u1ed1c ch\u1eefa ung th\u01b0 l\u00e0 ho\u00e0n to\u00e0n ch\u01b0a c\u00f3 c\u01a1 s\u1edf!<\/p>\n<p>T\u00f3m t\u1ea1i, ng\u01b0\u1eddi ti\u00eau d\u00f9ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng b\u1ec7nh nh\u00e2n ung th\u01b0 n\u00ean tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 chuy\u00ean m\u00f4n v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng b\u1ea5t k\u00ec s\u1ea3n ph\u1ea9m TPCN n\u00e0o trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb hay sau \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 tr\u00e1nh ti\u1ec1n m\u1ea5t t\u1eadt mang v\u00e0 tr\u00e1nh nh\u1eefng h\u1eadu qu\u1ea3 \u0111\u00e1ng ti\u1ebfc.<\/p>\n<p>Ch\u1ecbu tr\u00e1ch nhi\u1ec7m n\u1ed9i dung: Th.S Tr\u1ecbnh V\u1ea1n Ng\u1eef, Vi\u1ec7n nghi\u00ean c\u1ee9u Y sinh SoonChunHyang ( SoonChunHyang Institute of Medi-bio Science ), \u0110\u1ea1i h\u1ecdc SoonChunHyang, H\u00e0n Qu\u1ed1c<\/p>\n<h2>C\u1ed1 v\u1ea5n Khoa h\u1ecdc:<\/h2>\n<p>Ti\u1ebfn s\u0129 Nguy\u1ec5n H\u1ed3ng V\u0169, Vi\u1ec7n nghi\u00ean c\u1ee9u City of Hope, California, Hoa K\u1ef3<\/p>\n<p>Ti\u1ebfn s\u0129 L\u00ea Anh Ph\u01b0\u01a1ng, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c Gia Singapore.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/h2>\n<ol>\n<li>Rodriguez-Garcia, C., C. Sanchez-Quesada, and J.G. J, Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies. Antioxidants (Basel), 2019. 8(5). Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31109072\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31109072<\/a><\/li>\n<li>Karak, P., BIOLOGICAL ACTIVITIES OF FLAVONOIDS: AN OVERVIEW. International Journal of Pharmaceutical Sciences and Research, 2019. 10(4). Link:\u00a0<a href=\"http:\/\/ijpsr.com\/bft-article\/biological-activities-of-flavonoids-an-overview\/?view=fulltext\" rel=\"noopener\">http:\/\/ijpsr.com\/bft-article\/biological-activities-of-flavonoids-an-overview\/?view=fulltext<\/a><\/li>\n<li>Kumar, S. and A.K. Pandey, Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal, 2013. 2013: p. 162750.Link:\u00a0<a href=\"https:\/\/www.hindawi.com\/journals\/tswj\/2013\/162750\/\" rel=\"noopener\">https:\/\/www.hindawi.com\/journals\/tswj\/2013\/162750\/<\/a><\/li>\n<li>Robert, L. and S. Arvind, FLAVONOIDS NUTRACEUTICALS IN PREVENTION AND TREATMENT OF CANCER: A REVIEW. Asian Journal of Pharmaceutical and Clinical Research, 2018. 11(1). Link:\u00a0<a href=\"https:\/\/www.researchgate.net\/publication\/322205791_FLAVONOIDS_NUTRACEUTICALS_IN_PREVENTION_AND_TREATMENT_OF_CANCER_A_REVIEW\" rel=\"noopener\">https:\/\/www.researchgate.net\/publication\/322205791_FLAVONOIDS_NUTRACEUTICALS_IN_PREVENTION_AND_TREATMENT_OF_CANCER_A_REVIEW<\/a><\/li>\n<li>Kerr, D.J., et al., Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma. Br J Cancer, 1989. 60(1): p. 104-6. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2803908\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2803908<\/a><\/li>\n<li>Kaye, S.B., et al., Phase II trials with flavone acetic acid (NCS. 347512, LM975) in patients with advanced carcinoma of the breast, colon, head and neck and melanoma. Invest New Drugs, 1990. 8 Suppl 1: p. S95-9. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2380021\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2380021<\/a><\/li>\n<li>Deep, A., et al., Flavopiridol as cyclin dependent kinase (CDK) inhibitor: a review. New Journal of Chemistry, 2018. 42(23): p. 18500-18507. Link:\u00a0<a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2018\/nj\/c8nj04306j#!divAbstract\" rel=\"noopener\">https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2018\/nj\/c8nj04306j#!divAbstract<\/a><\/li>\n<li>Awan, F.T., et al., A phase 1 clinical trial of flavopiridol consolidation in chronic lymphocytic leukemia patients following chemoimmunotherapy. Ann Hematol, 2016. 95(7): p. 1137-43. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4981588\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4981588\/<\/a><\/li>\n<li>Spagnuolo, C., et al., Genistein and cancer: current status, challenges, and future directions. Advances in nutrition (Bethesda, Md.), 2015. 6(4): p. 408-419. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4496735\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4496735\/<\/a><\/li>\n<li>Buonerba, C., et al., Isoquercetin as an Adjunct Therapy in Patients With Kidney Cancer Receiving First-Line Sunitinib (QUASAR): Results of a Phase I Trial. Frontiers in pharmacology, 2018. 9: p. 189-189.Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29615901\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29615901<\/a><\/li>\n<li>Clinicaltrial.gov. Quercetin. Available from: <a href=\"https:\/\/clinicaltrials.gov\/ct2\/results?cond=Cancer&amp;term=Quercetin&amp;cntry=&amp;state=&amp;city=&amp;dist\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/ct2\/results?cond=Cancer&amp;term=Quercetin&amp;cntry=&amp;state=&amp;city=&amp;dist<\/a>.<\/li>\n<li>WebMD. Quercetin. Available from: <a href=\"https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-294\/quercetin\" rel=\"noopener\">https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-294\/quercetin<\/a>.<\/li>\n<li>Flavonoid \u2013 Drug bank. Available from: <a href=\"https:\/\/www.drugbank.ca\/categories\/DBCAT001281#drugs\" rel=\"noopener\">https:\/\/www.drugbank.ca\/categories\/DBCAT001281#drugs<\/a>.<\/li>\n<li>Gardeazabal, I., et al., Total polyphenol intake and breast cancer risk in the SUN cohort. Br J Nutr, 2018: p. 1-23. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30588893\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30588893<\/a><\/li>\n<li>Zamora-Ros, R., et al., Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Breast Cancer Research and Treatment, 2013. 139(1): p. 163-176. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23572295\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23572295<\/a><\/li>\n<li>Luo, J., et al., Urinary polyphenols and breast cancer risk: results from the Shanghai Women\u2019s Health Study. Breast Cancer Res Treat, 2010. 120(3): p. 693-702. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2842475\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2842475\/<\/a><\/li>\n<li>Cutler, G.J., et al., Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women\u2019s Health Study. Int J Cancer, 2008. 123(3): p. 664-71. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18491403\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18491403<\/a><\/li>\n<li>Christensen, K.Y., et al., The risk of lung cancer related to dietary intake of flavonoids. Nutr Cancer, 2012. 64(7): p. 964-74. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23061904\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23061904<\/a><\/li>\n<li>Afshari, K., et al., Natural flavonoids for the prevention of colon cancer: A comprehensive review of preclinical and clinical studies. J Cell Physiol, 2019. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31087338\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31087338<\/a><\/li>\n<li>Nimptsch, K., et al., Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts. Am J Clin Nutr, 2016. 103(1): p. 184-91. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26537935\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26537935<\/a><\/li>\n<li>Simons, C.C.J.M., et al., Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort Study. International Journal of Cancer, 2009. 125(12): p. 2945-2952. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19530252\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19530252<\/a><\/li>\n<li>Wang, L., et al., Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women. Am J Clin Nutr, 2009. 89(3): p. 905-12. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19158208\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19158208<\/a><\/li>\n<li>Zamora-Ros, R., et al., Dietary flavonoids, lignans and colorectal cancer prognosis. Scientific Reports, 2015. 5: p. 14148. Link:\u00a0<a href=\"https:\/\/www.nature.com\/articles\/srep14148\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/srep14148<\/a><\/li>\n<li>Zamora-Ros, R., et al., Association between habitual dietary flavonoid and lignan intake and colorectal cancer in a Spanish case-control study (the Bellvitge Colorectal Cancer Study). Cancer Causes Control, 2013. 24(3): p. 549-57. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22588680\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22588680<\/a><\/li>\n<li>Petrick, J.L., et al., Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). Br J Cancer, 2015. 112(7): p. 1291-300. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4385952\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4385952\/<\/a><\/li>\n<li>Woo, H.D., et al., Dietary flavonoids and gastric cancer risk in a Korean population. Nutrients, 2014. 6(11): p. 4961-4973. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4245574\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4245574\/<\/a><\/li>\n<li>Zamora-Ros, R., et al., Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Cancer, 2014. 111(9): p. 1870-80. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25121955\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25121955<\/a><\/li>\n<li>Molina-Montes, E., et al., Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort. Int J Cancer, 2016. 139(7): p. 1480-92. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27184434\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27184434<\/a><\/li>\n<li>Arem, H., et al., Flavonoid intake and risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study Cohort. Br J Cancer, 2013. 108(5): p. 1168-72. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3619057\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3619057\/<\/a><\/li>\n<li>Konstat-Korzenny, E., et al., Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer. Medical sciences (Basel, Switzerland), 2018. 6(1): p. 19. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5872176\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5872176\/<\/a><\/li>\n<li>Society, A.C. Choosing and using dietary supplements safely. Available from: <a href=\"https:\/\/www.cancer.org\/treatment\/treatments-and-side-effects\/complementary-and-alternative-medicine\/dietary-supplements\/choosing-safely.html\" rel=\"noopener\">https:\/\/www.cancer.org\/treatment\/treatments-and-side-effects\/complementary-and-alternative-medicine\/dietary-supplements\/choosing-safely.html<\/a>.<\/li>\n<li>Society, A.C. FDA regulation of drugs versus dietary supplements. Available from: <a href=\"https:\/\/www.cancer.org\/treatment\/treatments-and-side-effects\/complementary-and-alternative-medicine\/dietary-supplements\/fda-regulations.html\" rel=\"noopener\">https:\/\/www.cancer.org\/treatment\/treatments-and-side-effects\/complementary-and-alternative-medicine\/dietary-supplements\/fda-regulations.html<\/a>.<\/li>\n<li>Hua, X., et al., Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis. PLoS One, 2016. 11(3): p. e0151134. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26960146\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26960146<\/a><\/li>\n<li>Th\u00f4ng t\u01b0 s\u1ed1 43\/2014\/TT-BYT c\u1ee7a B\u1ed9 Y t\u1ebf : Quy \u0111\u1ecbnh v\u1ec1 qu\u1ea3n l\u00fd th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng2014. <a href=\"http:\/\/vfa.gov.vn\/van-ban\/thong-tu-quy-dinh-ve-quan-ly-thuc-pham-chuc-nang.html\" rel=\"noopener\">http:\/\/vfa.gov.vn\/van-ban\/thong-tu-quy-dinh-ve-quan-ly-thuc-pham-chuc-nang.html<\/a><\/li>\n<li>Konstat-Korzenny, E., et al., Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer. Medical sciences (Basel, Switzerland), 2018. 6(1): p. 19. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5872176\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5872176\/<\/a><\/li>\n<li>Raffetin, A., et al., Use of artesunate in non-malarial indications. Med Mal Infect, 2018. 48(4): p. 238-249. Link:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29422423\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29422423<\/a><\/li>\n<li>Farombi, E.O., Anti-cancer Foods: Flavonoids. Module in Food Science, 2018. Link:\u00a0<a href=\"https:\/\/www.researchgate.net\/publication\/326014769_Anti-cancer_Foods_Flavonoids\" rel=\"noopener\">https:\/\/www.researchgate.net\/publication\/326014769_Anti-cancer_Foods_Flavonoids<\/a><\/li>\n<\/ol>\n<h2>T\u00e1c gi\u1ea3:<\/h2>\n<p>Th\u1ea1c s\u0129 Tr\u1ecbnh V\u1ea1n Ng\u1eef<br \/>\nTh\u00e0nh vi\u00ean Ban Khoa h\u1ecdc<br \/>\nNghi\u00ean c\u1ee9u sinh, Vi\u1ec7n nghi\u00ean c\u1ee9u Y sinh SoonChunHyang (SoonChunHyang Institute of Medi-Bio Science &#8211; SIMS), \u0110\u1ea1i h\u1ecdc SoonChunHyang, H\u00e0n Qu\u1ed1c<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gi\u1edbi thi\u1ec7u Tr\u00ean th\u1ecb tr\u01b0\u1eddng hi\u1ec7n nay c\u00f3 nhi\u1ec1u s\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c qu\u1ea3ng c\u00e1o v\u1edbi nh\u1eefng c\u00f4ng d\u1ee5ng th\u1ea7n k\u00ec trong ph\u00f2ng ng\u1eeba ung th\u01b0, h\u1ed7 tr\u1ee3 v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0, k\u1ec3 c\u1ea3 ung th\u01b0 giai \u0111o\u1ea1n cu\u1ed1i v\u00e0 c\u00f3 th\u1ec3 \u00e1p d\u1ee5ng cho r\u1ea5t nhi\u1ec1u lo\u1ea1i ung th\u01b0 nh\u01b0 ung th\u01b0 ph\u1ed5i, gan, [&#8230;]\n","protected":false},"author":1,"featured_media":11163,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11162","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/11162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=11162"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/11162\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/11163"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=11162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=11162"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=11162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}