{"id":109591,"date":"2025-02-11T13:51:37","date_gmt":"2025-02-11T06:51:37","guid":{"rendered":"https:\/\/vnras.com\/drug\/?p=109591"},"modified":"2025-02-11T16:59:43","modified_gmt":"2025-02-11T09:59:43","slug":"su-ket-hop-2-thuoc-doi-khang-nhau-trong-cung-mot-san-pham","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/su-ket-hop-2-thuoc-doi-khang-nhau-trong-cung-mot-san-pham\/","title":{"rendered":"S\u1ef1 k\u1ebft h\u1ee3p 2 thu\u1ed1c \u0111\u1ed1i kh\u00e1ng nhau trong c\u00f9ng m\u1ed9t s\u1ea3n ph\u1ea9m"},"content":{"rendered":"

Ph\u1ed1i h\u1ee3p hai thu\u1ed1c \u0111\u1ed1i kh\u00e1ng t\u00e1c d\u1ee5ng v\u1edbi nhau?<\/h2>\n
\u201cHai ta nh\u01b0 ng\u00e0y n\u1eafng tr\u00e1nh ng\u00e0y m\u01b0a
\nNh\u01b0 m\u1eb7t tr\u0103ng m\u1eb7t tr\u1eddi c\u00e1ch tr\u1edf
\nNh\u01b0 sao H\u00f4m sao Mai kh\u00f4ng c\u00f9ng \u1edf
\nC\u00f3 bao gi\u1edd c\u00f9ng tr\u1edf l\u1ea1i v\u01b0\u1eddn x\u01b0a?\u201d
\n(\u201cV\u01b0\u1eddn x\u01b0a\u201d \u2013 T\u1ebf Hanh)<\/p>\n
Th\u00e1ng 09\/2024, C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m M\u1ef9 (FDA) ph\u00ea duy\u1ec7t thu\u1ed1c Cobenfy (ph\u1ed1i h\u1ee3p xanomeline v\u00e0 trospium chloride) c\u1ee7a h\u00e3ng d\u01b0\u1ee3c ph\u1ea9m Bristol Myers Squibb \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh [1], [2]. Vi\u1ec7c ph\u00ea duy\u1ec7t Cobenfy c\u00f3 2 \u0111i\u1ec3m th\u00fa v\u1ecb:<\/p>\n
M\u1ed9t l\u00e0, Cobenfy l\u00e0 thu\u1ed1c \u0111\u1ea7u ti\u00ean trong m\u1ed9t nh\u00f3m d\u01b0\u1ee3c l\u00fd m\u1edbi (first-in-class) sau h\u01a1n 30 n\u0103m (k\u1ec3 t\u1eeb khi clozapine, thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n kh\u00f4ng \u0111i\u1ec3n h\u00ecnh \u0111\u1ea7u ti\u00ean, \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn v\u00e0o n\u0103m 1989) \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t v\u1edbi c\u01a1 ch\u1ebf c\u1ee7a xanomeline l\u00e0 \u0111\u1ed3ng v\u1eadn th\u1ee5 th\u1ec3 muscarinic M1 v\u00e0 M4 c\u1ee7a h\u1ec7 cholinergic, thay v\u00ec t\u00e1c \u0111\u1ed9ng l\u00ean c\u00e1c th\u1ee5 th\u1ec3 c\u1ee7a dopamin v\u00e0 serotonin nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng lo\u1ea1n th\u1ea7n c\u1ed5 \u0111i\u1ec3n, \u0111\u00e3 m\u1edf ra m\u1ed9t k\u1ef7 nguy\u00ean m\u1edbi trong \u0111i\u1ec1u tr\u1ecb t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t v\u00e0 gi\u00fap cung c\u1ea5p th\u00eam l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh l\u00fd n\u00e0y.<\/p>\n
Hai l\u00e0, Cobenfy l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p \u0111\u1ed9c \u0111\u00e1o c\u1ee7a 2 ho\u1ea1t ch\u1ea5t c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng<\/strong> nhau (xanomeline v\u00e0 trospium) trong c\u00f9ng m\u1ed9t ch\u1ebf ph\u1ea9m. B\u00e0i vi\u1ebft n\u00e0y t\u1eadp trung v\u00e0o \u0111i\u1ec3m th\u00fa v\u1ecb th\u1ee9 hai n\u00e0y.<\/p>\n

Gi\u1ea3i th\u00edch cho s\u1ef1 k\u1ebft h\u1ee3p thu\u1ed1c \u0111\u1ed1i kh\u00e1ng<\/h2>\n
V\u1ec1 m\u1eb7t truy\u1ec1n th\u1ed1ng, thu\u1ed1c \u0111\u1ed1i kh\u00e1ng th\u01b0\u1eddng ch\u1ec9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng khi c\u00f3 d\u1ea5u hi\u1ec7u qu\u00e1 li\u1ec1u c\u1ee7a m\u1ed9t thu\u1ed1c n\u00e0o \u0111\u00f3. Trong \u0111i\u1ec1u tr\u1ecb, khi ph\u1ed1i h\u1ee3p 2 hay nhi\u1ec1u thu\u1ed1c, ch\u00fang ta mong \u0111\u1ee3i ch\u00fang s\u1ebd cho t\u00e1c d\u1ee5ng hi\u1ec7p \u0111\u1ed3ng (synergistic) th\u1ec3 hi\u1ec7n qua m\u1ed9t s\u1ed1 h\u00ecnh th\u1ee9c:<\/p>\n
+ (1) T\u00e1c \u0111\u1ed9ng \u0111\u1ed3ng th\u1eddi tr\u00ean c\u00e1c c\u01a1 ch\u1ebf kh\u00e1c nhau li\u00ean quan \u0111\u1ebfn b\u1ec7nh l\u00fd \u0111\u1ec3 t\u0103ng t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb (v\u00ed d\u1ee5: k\u1ebft h\u1ee3p c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb t\u0103ng huy\u1ebft \u00e1p, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng,\u2026)
\n+ (2) M\u1edf r\u1ed9ng ph\u1ed5 t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c cho nhi\u1ec1u b\u1ec7nh nguy\u00ean kh\u00e1c nhau (v\u00ed d\u1ee5: k\u1ebft h\u1ee3p c\u00e1c thu\u1ed1c kh\u00e1ng sinh trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh l\u00fd nhi\u1ec5m tr\u00f9ng\u2026)
\n+ (3) M\u1ed9t thu\u1ed1c \u0111\u00f3ng vai tr\u00f2 \u201cb\u1ea3o v\u1ec7\u201d thu\u1ed1c kia kh\u1ecfi s\u1ef1 ph\u00e2n h\u1ee7y do enzyme ho\u1eb7c t\u00e1c nh\u00e2n m\u00f4i tr\u01b0\u1eddng (v\u00ed d\u1ee5: ph\u1ed1i h\u1ee3p kh\u00e1ng sinh beta-lactam v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf beta-lactamase; ho\u1eb7c ph\u1ed1i h\u1ee3p imipenem v\u1edbi cilastatin \u2013 ch\u1ea5t \u1ee9c ch\u1ebf dehydropeptidase \u1edf th\u1eadn, gi\u00fap b\u1ea3o v\u1ec7 imipenem kh\u1ecfi b\u1ecb ph\u00e2n h\u1ee7y\u2026)
\n+ (4) M\u1ed9t thu\u1ed1c \u0111\u00f3ng vai tr\u00f2 \u201ch\u1ed7 tr\u1ee3\u201d, t\u1ea1o ra t\u01b0\u01a1ng t\u00e1c d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc \u0111\u1ec3 l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 v\u00e0 t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c kia (v\u00ed d\u1ee5: ph\u1ed1i h\u1ee3p lopinavir\/ritonavir, 2 thu\u1ed1c \u1ee9c ch\u1ebf protease s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb HIV, trong \u0111\u00f3 lopinavir \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a ch\u1ee7 y\u1ebfu b\u1edfi CYP3A4, trong khi ritonavir l\u00e0 m\u1ed9t trong nh\u1eefng ch\u1ea5t \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh nh\u1ea5t t\u1eebng \u0111\u01b0\u1ee3c bi\u1ebft, do \u0111\u00f3 ph\u1ed1i h\u1ee3p gi\u00fap l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 t\u00e1c d\u1ee5ng kh\u00e1ng virus c\u1ee7a lopinavir; ho\u1eb7c ph\u1ed1i h\u1ee3p probenecid v\u1edbi m\u1ed9t s\u1ed1 kh\u00e1ng sinh nh\u00f3m beta-lactam l\u00e0m \u1ee9c ch\u1ebf s\u1ef1 th\u1ea3i tr\u1eeb kh\u00e1ng sinh qua th\u1eadn, gi\u00fap t\u0103ng n\u1ed3ng \u0111\u1ed9 kh\u00e1ng sinh trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m khu\u1ea9n ti\u1ebft ni\u1ec7u\u2026)<\/p>\n
S\u1ef1 \u0111\u1ed9c \u0111\u00e1o c\u1ee7a Cobenfy n\u1eb1m ngo\u00e0i c\u00e1c h\u00ecnh th\u1ee9c quen thu\u1ed9c tr\u00ean, l\u00e0 s\u1ef1 ph\u1ed1i h\u1ee3p c\u1ee7a 2 ho\u1ea1t ch\u1ea5t c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng nhau tr\u00ean c\u00f9ng th\u1ee5 th\u1ec3 muscarinic (ch\u1ec9 kh\u00e1c nhau \u1edf v\u1ecb tr\u00ed t\u00e1c \u0111\u1ed9ng), trong khi xanomeline l\u00e0 thu\u1ed1c \u0111\u1ed3ng v\u1eadn muscarinic, c\u00f2n trospium l\u00e0 thu\u1ed1c \u0111\u1ed1i kh\u00e1ng muscarinic.<\/p>\n
\u0110\u1ea7u nh\u1eefng n\u0103m 1990, xanomeline ra \u0111\u1eddi v\u1edbi s\u1ef1 h\u1ee3p t\u00e1c c\u1ee7a Eli Lilly v\u00e0 Novo Nordisk nh\u1eb1m m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Alzheimer. Tuy nhi\u00ean, th\u1eed nghi\u1ec7m xanomeline trong \u0111i\u1ec1u tr\u1ecb Alzheimer \u0111\u00e3 d\u1eebng l\u1ea1i t\u1eeb n\u0103m 1998 do c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1ed3ng v\u1eadn cholinergic ngo\u1ea1i bi\u00ean qu\u00e1 m\u1ee9c (v\u00ed d\u1ee5, ti\u00eau ch\u1ea3y, \u0111\u1ed5 m\u1ed3 h\u00f4i, t\u0103ng ti\u1ebft n\u01b0\u1edbc b\u1ecdt). Nghi\u00ean c\u1ee9u c\u1ee7a Neil C. Bodick v\u00e0 c\u1ed9ng s\u1ef1 (1997) th\u1eed nghi\u1ec7m xanomeline \u1edf 343 b\u1ec7nh nh\u00e2n Alzheimer cho th\u1ea5y thu\u1ed1c c\u00f3 hi\u1ec7u qu\u1ea3, tuy nhi\u00ean, \u1edf nh\u00f3m s\u1eed d\u1ee5ng thu\u1ed1c li\u1ec1u cao (225 mg\/ng\u00e0y), c\u00f3 \u0111\u1ebfn 52% b\u1ec7nh nh\u00e2n ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb v\u00ec c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5, v\u00e0 ng\u1ea5t x\u1ec9u (syncope) x\u1ea3y ra \u1edf 12,6% b\u1ec7nh nh\u00e2n trong nh\u00f3m d\u00f9ng li\u1ec1u cao [3].<\/p>\n
N\u0103m 1993, GS Brian Dean c\u1ee7a tr\u01b0\u1eddng Florey ph\u00e1t hi\u1ec7n ra r\u1eb1ng c\u00e1c th\u1ee5 th\u1ec3 muscarinic M1 v\u00e0 M4, v\u1ed1n l\u00e0 th\u00e0nh ph\u1ea7n kh\u00f4ng th\u1ec3 thi\u1ebfu c\u1ee7a h\u1ec7 th\u1ed1ng cholinergic trong n\u00e3o, th\u1ea5p h\u01a1n \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi m\u1eafc b\u1ec7nh t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t; nh\u1eefng thay \u0111\u1ed5i nh\u01b0 v\u1eady s\u1ebd \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng t\u01b0\u01a1ng t\u00e1c v\u1edbi ng\u01b0\u1eddi kh\u00e1c v\u00e0 nh\u1eadn th\u1ee9c c\u1ee7a h\u1ecd, \u0111\u00e2y l\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh l\u00fd n\u00e0y.<\/p>\n
N\u0103m 2009, m\u1ed9t s\u1ed1 nh\u00e0 khoa h\u1ecdc \u0111\u00e3 r\u1eddi Eli Lilly v\u00e0 th\u00e0nh l\u1eadp Karuna Therapeutics (c\u00f4ng ty n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c Bristol Myers Squibb mua l\u1ea1i v\u1edbi gi\u00e1 14 t\u1ef7 USD v\u00e0o \u0111\u1ea7u n\u0103m 2024) ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u xanomeline trong \u0111i\u1ec1u tr\u1ecb t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t, nh\u01b0ng l\u1ea7n n\u00e0y, h\u1ecd t\u1eadp trung t\u00ecm c\u00e1ch kh\u1eafc ph\u1ee5c c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n m\u00e0 h\u1ecd \u0111\u00e3 th\u1ea5y trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ban \u0111\u1ea7u. Ch\u00eca kh\u00f3a \u1edf \u0111\u00e2y l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p th\u00eam trospium v\u1edbi xanomeline. H\u1ecd b\u1eaft \u0111\u1ea7u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p n\u00e0y v\u00e0 KarXT (xanomeline-trospium) \u0111\u00e3 ra \u0111\u1eddi.<\/p>\n
M\u1ed9t s\u1ed1 th\u1eed nghi\u1ec7m tr\u00ean l\u00e2m s\u00e0ng v\u1ec1 s\u1ef1 k\u1ebft h\u1ee3p n\u00e0y<\/h2>\n
Trospium chloride, m\u1ed9t ch\u1ea5t \u0111\u1ed1i kh\u00e1ng muscarinic kh\u00f4ng ch\u1ecdn l\u1ecdc (\u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t n\u0103m 2004 v\u1edbi t\u00ean th\u01b0\u01a1ng m\u1ea1i Sanctura) \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng tr\u01b0\u1edbc \u0111\u00e2y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh b\u00e0ng quang t\u0103ng ho\u1ea1t trong nhi\u1ec1u n\u0103m. Trospium l\u00e0 m\u1ed9t ph\u00e2n t\u1eed amin b\u1eadc b\u1ed1n l\u1edbn, ph\u00e2n c\u1ef1c cao, n\u00ean thu\u1ed1c \u00edt th\u1ea5m qua qua \u0111\u01b0\u1ee3c h\u00e0ng r\u00e0o m\u00e1u n\u00e3o \u0111\u1ec3 v\u00e0o h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng; do \u0111\u00f3, \u00edt g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 b\u1ea5t l\u1ee3i l\u00ean h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 h\u1ea7u nh\u01b0 ch\u1ec9 c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng muscarinic \u1edf ngo\u1ea1i bi\u00ean. \u0110i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn \u00fd t\u01b0\u1edfng d\u00f9ng \u0111\u1ed3ng th\u1eddi trospium v\u00e0 xanomeline \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 do \u0111\u1ed3ng v\u1eadn cholinergic ngo\u1ea1i bi\u00ean c\u1ee7a xanomeline (h\u00ecnh minh h\u1ecda). \u00dd t\u01b0\u1edfng n\u00e0y sau \u0111\u00f3 \u0111\u01b0\u1ee3c c\u1ee7ng c\u1ed1 th\u00f4ng qua c\u00e1c k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, cho th\u1ea5y ph\u1ed1i h\u1ee3p 2 thu\u1ed1c l\u00e0m gi\u1ea3m \u0111\u1ebfn 50% c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 do ch\u1ee7 v\u1eadn cholinergic \u1edf nh\u1eefng ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n kh\u1ecfe m\u1ea1nh.<\/p>\n
M\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ng\u1eabu nhi\u00ean, m\u00f9 \u0111\u00f4i (phase 1) c\u1ee7a Kavoussi v\u00e0 c\u1ed9ng s\u1ef1 (2016) nh\u1eb1m \u0111\u00e1nh gi\u00e1 kh\u1ea3 n\u0103ng dung n\u1ea1p c\u1ee7a s\u1ef1 k\u1ebft h\u1ee3p xanomeline (225mg\/ng\u00e0y) + trospium (40 mg\/ng\u00e0y), so v\u1edbi xanomeline + placebo. S\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a xanomeline + trospium \u0111\u00e3 cho th\u1ea5y l\u00e0 c\u00f3 \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 do ch\u1ee7 v\u1eadn cholinergic h\u01a1n \u0111\u00e1ng k\u1ec3 (p = 0,016), so v\u1edbi xanomeline + placebo (34,3% so v\u1edbi 63,6%). C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ri\u00eang l\u1ebb do ch\u1ee7 v\u1eadn cholinergic \u1edf nh\u00f3m xanomeline + trospium \u0111\u1ec1u th\u1ea5p h\u01a1n nh\u00f3m xanomeline + placebo, bao g\u1ed3m: bu\u1ed3n n\u00f4n (17,1% so v\u1edbi 24,2%), n\u00f4n (5,7% so v\u1edbi 15,2%), ti\u00eau ch\u1ea3y (5,7% so v\u1edbi 21,2%), \u0111\u1ed5 m\u1ed3 h\u00f4i qu\u00e1 m\u1ee9c (20,0% so v\u1edbi 48,5%) v\u00e0 ti\u1ebft n\u01b0\u1edbc b\u1ecdt qu\u00e1 m\u1ee9c (25,7% so v\u1edbi 36,4%) [4].<\/p>\n
Vi\u1ec7c ph\u1ed1i h\u1ee3p 2 ho\u1ea1t ch\u1ea5t c\u0169 c\u00f3 t\u00e1c d\u1ee5ng \u0111\u1ed1i kh\u00e1ng nhau trong m\u1ed9t ch\u1ebf ph\u1ea9m \u0111\u1ec3 v\u1eeba cho t\u00e1c d\u1ee5ng \u0111i\u1ec1u tr\u1ecb, v\u1eeba gi\u1ea3i quy\u1ebft t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n c\u1ee7a nhau, \u0111\u00fang l\u00e0 m\u1ed9t \u00fd t\u01b0\u1edfng th\u00fa v\u1ecb c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc. S\u1ef1 ph\u00ea duy\u1ec7t c\u1ee7a FDA ch\u00ednh l\u00e0 th\u00e0nh c\u00f4ng b\u01b0\u1edbc \u0111\u1ea7u, h\u1ee9a h\u1eb9n mang v\u1ec1 cho Bristol Myers Squibb doanh s\u1ed1 \u0111\u1ebfn 6 t\u1ef7 USD\/n\u0103m v\u00e0 s\u1ebd th\u00fac \u0111\u1ea9y nhi\u1ec1u nghi\u00ean c\u1ee9u m\u1edbi trong l\u0129nh v\u1ef1c n\u00e0y.
\n* Bi\u00ean d\u1ecbch, t\u1ed5ng h\u1ee3p: Ds. Ph\u1ea1m C\u00f4ng Khanh<\/p>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n
\n
FDA Approves Drug with New Mechanism of Action for Treatment of Schizophrenia
\nhttps:\/\/www.fda.gov\/…\/fda-approves-drug-new-mechanism…<\/a><\/li>\n
U.S. Food and Drug Administration Approves Bristol Myers Squibb\u2019s COBENFY\u2122 (xanomeline and trospium chloride), a First-In-Class Muscarinic Agonist for the Treatment of Schizophrenia in Adults
\n https:\/\/news.bms.com\/…\/U.S.-Food-and-Drug…\/default.aspx<\/a><\/li>\n
Bodick NC, Offen WW, Levey AI, et al. Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease. Arch Neurol. 1997;54(4):465\u2013473.<\/li>\n
Kavoussi R, Miller A, Breier A. Results of a double-blind, placebo-controlled, tolerability study of KarXT: a novel combination targeting muscarinic acetylcholine receptors using xanomeline with trospium chloride to mitigate cholinergic side effects. Poster presented at: American Society of Clinical Psychopharmacology Annual Meeting; May 29\u2013June 2, 2017. Miami Beach, FL.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
Ph\u1ed1i h\u1ee3p hai thu\u1ed1c \u0111\u1ed1i kh\u00e1ng t\u00e1c d\u1ee5ng v\u1edbi nhau? \u201cHai ta nh\u01b0 ng\u00e0y n\u1eafng tr\u00e1nh ng\u00e0y m\u01b0a Nh\u01b0 m\u1eb7t tr\u0103ng m\u1eb7t tr\u1eddi c\u00e1ch tr\u1edf Nh\u01b0 sao H\u00f4m sao Mai kh\u00f4ng c\u00f9ng \u1edf C\u00f3 bao gi\u1edd c\u00f9ng tr\u1edf l\u1ea1i v\u01b0\u1eddn x\u01b0a?\u201d (\u201cV\u01b0\u1eddn x\u01b0a\u201d \u2013 T\u1ebf Hanh) Th\u00e1ng 09\/2024, C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c […]\n","protected":false},"author":1,"featured_media":109593,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-109591","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/109591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=109591"}],"version-history":[{"count":4,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/109591\/revisions"}],"predecessor-version":[{"id":109599,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/109591\/revisions\/109599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/109593"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=109591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=109591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=109591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}