Deepak Bhatt \u0111\u00e3 tr\u00ecnh b\u00e0y k\u1ebft qu\u1ea3 c\u1ee7a cu\u1ed9c th\u1eed nghi\u1ec7m v\u1ec1 icosapent ethyl \u2013 m\u1ed9t th\u00e0nh ph\u1ea7n c\u1ee7a d\u1ea7u c\u00e1<\/strong> \u2013 \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe tim m\u1ea1ch t\u1ea1i cu\u1ed9c h\u1ecdp c\u1ee7a Hi\u1ec7p h\u1ed9i Tim m\u1ea1ch Hoa K\u1ef3 di\u1ec5n ra \u1edf Chicago, Illnois, th\u00e1ng 11 n\u0103m 2018. Sau khi xem qua nh\u1eefng d\u1eef li\u1ec7u \u0111\u01b0\u1ee3c thu th\u1eadp trong qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u c\u1ee7a \u00f4ng, kh\u00e1n gi\u1ea3 \u0111\u00e3 l\u1eadp t\u1ee9c v\u1ee1 o\u00e0 trong tr\u00e0ng ph\u00e1o tay, ngay c\u1ea3 khi ph\u1ea7n tr\u00ecnh b\u00e0y c\u00f2n ch\u01b0a k\u1ebft th\u00fac.<\/p>\n B\u00e1c s\u0129 Deepak Bhatt, m\u1ed9t gi\u00e1o s\u01b0 chuy\u00ean khoa tim m\u1ea1ch t\u1ea1i B\u1ec7nh vi\u1ec7n Brigham And Women v\u00e0 Trung t\u00e2m Y t\u1ebf Harvard \u1edf Boston, Massachusetts, ng\u01b0\u1eddi d\u1eabn d\u1eaft nghi\u00ean c\u1ee9u REDUCE-IT, \u0111\u00e3 ch\u1ec9 ra icosapent ethyl, m\u1ed9t th\u00e0nh ph\u1ea7n c\u1ee7a d\u1ea7u c\u00e1, gi\u1ea3m thi\u1ec3u nguy c\u01a1 v\u1ec1 tim m\u1ea1ch v\u1edbi nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 d\u00f9ng thu\u1ed1c statin.<\/p>\n Bhatt hi\u1ec7n l\u00e0 m\u1ed9t gi\u00e1o s\u01b0 chuy\u00ean khoa tim m\u1ea1ch t\u1ea1i B\u1ec7nh vi\u1ec7n Brigham And Women v\u00e0 Trung t\u00e2m Y t\u1ebf Harvard \u1edf Boston, Massachusetts, \u00f4ng \u0111\u1ed3ng th\u1eddi c\u0169ng l\u00e0 ng\u01b0\u1eddi \u0111\u00e3 ph\u1ee5 tr\u00e1ch nghi\u00ean c\u1ee9u \u201cGi\u1ea3m thi\u1ec3u bi\u1ebfn c\u1ed1 tim m\u1ea1ch v\u1edbi th\u1eed nghi\u1ec7m can thi\u1ec7p b\u1eb1ng icosapent ethyl (REDUCE-IT)\u201d t\u1ea1i 11 qu\u1ed1c gia. \u00d4ng chia s\u1ebb r\u1eb1ng, \u201cT\u00f4i \u0111\u00e3 kh\u00f4ng \u0111\u01b0\u1ee3c th\u1ea5y n\u00f3 trong m\u1ed9t v\u00e0i th\u1eadp k\u1ec9 qua, nh\u01b0ng m\u1ed9t \u0111i\u1ec1u hi\u1ebfm th\u1ea5y l\u00e0 th\u00ed nghi\u1ec7m n\u00e0y v\u1eabn gi\u1eef \u0111\u01b0\u1ee3c \u0111\u1ed9 ch\u00ednh x\u00e1c nh\u01b0 l\u00fac tr\u01b0\u1edbc.\u201d<\/p>\n K\u1ebft qu\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y r\u1ea5t r\u00f5 r\u00e0ng, nh\u1eefng b\u1ec7nh nh\u00e2n s\u1eed d\u1ee5ng icosapent ethyl \u2013 m\u1ed9t lo\u1ea1i axit b\u00e9o omega 3; b\u00e1n tr\u00ean th\u1ecb tr\u01b0\u1eddng d\u01b0\u1edbi d\u1ea1ng thu\u1ed1c Vascepa v\u00e0 \u0111\u01b0\u1ee3c cung c\u1ea5p b\u1edfi c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m sinh h\u1ecdc Amarin t\u1ea1i ti\u1ec3u bang New Jersey \u2013 gi\u1ea3m \u0111\u01b0\u1ee3c 25% t\u1ec9 l\u1ec7 nguy c\u01a1 c\u00e1c b\u1ec7nh v\u1ec1 tim m\u1ea1ch nh\u01b0 nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5 v\u00e0 th\u1eadm ch\u00ed l\u00e0 t\u1eed vong, khi \u0111\u01b0\u1ee3c so s\u00e1nh v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng. K\u1ebft qu\u1ea3 tr\u00ean \u0111\u00e3 l\u00e0m rung chuy\u1ec3n c\u1ea3 m\u1ed9t l\u0129nh v\u1ef1c, b\u1edfi n\u00f3 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 sau h\u00e0ng lo\u1ea1t nh\u1eefng ph\u00e1t hi\u1ec7n kh\u00f4ng hi\u1ec7u qu\u1ea3 v\u1ec1 \u1ea3nh h\u01b0\u1edfng c\u1ee7a c\u00e1c s\u1ea3n ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb d\u1ea7u c\u00e1 \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe tim m\u1ea1ch n\u0103m 2018. H\u00e3y c\u00f9ng \u0111i\u1ec3m qua m\u1ed9t s\u1ed1 b\u00e0i nghi\u00ean c\u1ee9u cho nh\u1eefng k\u1ebft lu\u1eadn kh\u00f4ng m\u1ea5y kh\u1ea3 quan: \u201cM\u1ed9t nghi\u00ean c\u1ee9u v\u1ec1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch trong b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng (ASCEND)\u201d, nghi\u00ean c\u1ee9u tr\u00ean \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i 2 kh\u00f4ng nh\u1eadn \u0111\u01b0\u1ee3c b\u1ea5t k\u1ef3 m\u1ed9t l\u1ee3i \u00edch n\u00e0o t\u1eeb d\u1ea7u c\u00e1; \u201cTh\u1eed nghi\u1ec7m v\u1ec1 vitamin D v\u00e0 omega 3 (VITAL)\u201d, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng kh\u00f4ng th\u1ec3 t\u00ecm th\u1ea5y t\u00e1c d\u1ee5ng n\u00e0o c\u1ee7a d\u1ea7u c\u00e1 trong t\u1ed5ng s\u1ed1 26,000 ng\u01b0\u1eddi tham gia; m\u1ed9t b\u00e0i \u0111\u00e1nh gi\u00e1 t\u1ed5ng quan c\u1ee7a Cochrane v\u1ec1 79 cu\u1ed9c th\u1eed nghi\u1ec7m v\u1edbi h\u01a1n 112,000 ng\u01b0\u1eddi; m\u1ed9t b\u00e0i ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p v\u1ec1 10 cu\u1ed9c th\u1eed nghi\u1ec7m v\u1edbi h\u01a1n 77,000 ng\u01b0\u1eddi.<\/p>\n Bhatt cho bi\u1ebft, \u201cT\u00f4i ngh\u0129 r\u1eb1ng, c\u00f3 r\u1ea5t nhi\u1ec1u ng\u01b0\u1eddi ch\u1eb3ng bao gi\u1edd d\u00e0nh s\u1ef1 quan t\u00e2m cho v\u1ea5n \u0111\u1ec1 n\u00e0y, b\u1edfi h\u1ecd ch\u1ec9 nh\u00ecn v\u00e0o nh\u1eefng b\u00e0i ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p v\u00e0 h\u00ecnh dung l\u0129nh v\u1ef1c n\u00e0y \u0111\u00e3 kh\u00f4ng th\u1ec3 ph\u00e1t tri\u1ec3n \u0111\u01b0\u1ee3c n\u1eefa\u201d.<\/p>\n \u0110\u1ea7u ti\u00ean, t\u1eeb nh\u1eefng ghi nh\u1eadn d\u1ecbch t\u1ec5 h\u1ecdc cho th\u1ea5y t\u1ea1i v\u00f9ng ven bi\u1ec3n c\u00f3 t\u1ef7 l\u1ec7 th\u1ea5p m\u1eafc b\u1ec7nh tim m\u1ea1ch th\u1ea5p, c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 d\u1ea7u c\u00e1 c\u0169ng nh\u01b0 c\u00e1c th\u00e0nh ph\u1ea7n kh\u00e1c c\u1ee7a n\u00f3 \u0111\u00e3 t\u1ea1o n\u00ean nh\u1eefng k\u1ebft qu\u1ea3 h\u1ebft s\u1ee9c ph\u1ee9c t\u1ea1p. M\u1eb7c d\u00f9 v\u1eabn c\u00f2n t\u1ed3n t\u1ea1i nhi\u1ec1u s\u1ef1 \u201cm\u01a1 h\u1ed3\u201d, nh\u01b0ng s\u1ef1 h\u1ee9ng th\u00fa \u0111\u1ed1i v\u1edbi th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng l\u00e0m t\u1eeb d\u1ea7u c\u00e1 v\u1eabn t\u0103ng v\u1ee5t c\u00f9ng v\u1edbi l\u01b0\u1ee3ng kh\u00e1ch h\u00e0ng tr\u00ean to\u00e0n c\u1ea7u \u2013 nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 chi nhi\u1ec1u h\u01a1n 1 t\u1ef7 b\u1ea3ng Anh m\u1ed9t n\u0103m \u0111\u1ec3 s\u1eed d\u1ee5ng cho nhi\u1ec1u b\u1ec7nh kh\u00e1c nhau. Hi\u1ec7n nay, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u v\u1eabn \u0111ang c\u1ed1 g\u1eafng \u0111\u1ec3 ph\u00e2n bi\u1ec7t \u0111\u01b0\u1ee3c nh\u1eefng t\u00e1c d\u1ee5ng th\u1ef1c s\u1ef1 c\u1ee7a d\u1ea7u c\u00e1 v\u00e0 nh\u1eefng t\u00e1c d\u1ee5ng \u201ct\u01b0\u1edfng t\u01b0\u1ee3ng\u201d c\u1ee7a n\u00f3, m\u00e0 \u0111\u1ed1i v\u1edbi nh\u1eefng c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m, \u0111i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 s\u1ef1 t\u00e1ch bi\u1ec7t c\u00e1c th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a d\u1ea7u c\u00e1.<\/p>\n H\u01a1n m\u1ed9t th\u1eadp k\u1ec9 nay, nh\u1eefng c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m n\u00e0y \u0111\u00e3 ph\u00e1t tri\u1ec3n nh\u1eefng s\u1ea3n ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb d\u1ea7u c\u00e1, kh\u00f4ng gi\u1ed1ng nh\u01b0 nh\u1eefng lo\u1ea1i th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng th\u00f4ng th\u01b0\u1eddng, n\u00f3 c\u00f3 ch\u1ee9a axit b\u00e9o omega-3 nguy\u00ean ch\u1ea5t v\u1edbi nh\u1eefng c\u00f4ng th\u1ee9c c\u1ed1 \u0111\u1ecbnh v\u00e0 li\u1ec1u l\u01b0\u1ee3ng ph\u00f9 h\u1ee3p. S\u1eed d\u1ee5ng nh\u1eefng h\u1ee3p ch\u1ea5t n\u00e0y, m\u1ed9t lo\u1ea1t c\u00e1c th\u1eed nghi\u1ec7m (k\u1ec3 c\u1ea3 c\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y hi\u1ec7u qu\u1ea3 hay kh\u00f4ng hi\u1ec7u qu\u1ea3) \u0111\u00e3 gi\u00fap c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u thu h\u1eb9p \u0111\u01b0\u1ee3c nh\u1eefng th\u00e0nh ph\u1ea7n ch\u00ednh, li\u1ec1u l\u01b0\u1ee3ng, th\u1eddi gian \u0111i\u1ec1u tr\u1ecb v\u00e0 \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n \u2013 c\u00f3 \u00fd ngh\u0129a quan tr\u1ecdng trong vi\u1ec7c t\u00ecm ra \u0111\u01b0\u1ee3c nh\u1eefng l\u1ee3i \u00edch v\u1ec1 m\u1eb7t tim m\u1ea1ch.<\/p>\n \u201cC\u00f3 r\u1ea5t nhi\u1ec1u s\u1ef1 h\u01b0\u1edfng \u1ee9ng d\u00e0nh cho vi\u1ec7c s\u1eed d\u1ee5ng lo\u1ea1i th\u1ef1c ph\u1ea9m b\u1ed5 sung n\u00e0y, v\u1eady n\u00ean vi\u1ec7c \u0111\u01b0a ra nh\u1eefng l\u1eddi khuy\u1ebfn ngh\u1ecb v\u1ec1 y t\u1ebf l\u00e0 r\u1ea5t quan tr\u1ecdng.\u201d \u2013 ph\u00e1t bi\u1ec3u c\u1ee7a Louise Bowman, m\u1ed9t gi\u00e1o s\u01b0 v\u1ec1 y khoa v\u00e0 th\u00ed nghi\u1ec7m l\u00e2m s\u00e0ng t\u1ea1i tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Oxford \u1edf Anh, v\u00e0 c\u0169ng l\u00e0 ng\u01b0\u1eddi \u0111\u1ee9ng \u0111\u1ea7u cu\u1ed9c th\u1eed nghi\u1ec7m ASCEND.<\/p>\n \u0110\u1ed1i v\u1edbi Bowman, vi\u1ec7c \u0111\u01b0a ra k\u1ebft qu\u1ea3 ti\u00eau c\u1ef1c t\u1eeb ASCEND, sau \u0111\u00f3 l\u1ea1i l\u00e0 k\u1ebft qu\u1ea3 t\u00edch c\u1ef1c t\u1eeb REDUCE-IT ho\u00e0n to\u00e0n l\u00e0 m\u1ed9t s\u1ef1 t\u00ecnh c\u1edd, c\u00f4 cho r\u1eb1ng \u201cT\u00f4i ngh\u0129 r\u1eb1ng \u0111i\u1ec1u n\u00e0y \u0111\u00e3 t\u1ea1o n\u00ean m\u1ed9t b\u1ea7u kh\u00f4ng kh\u00ed tranh lu\u1eadn r\u1ea5t s\u00f4i \u0111\u1ed9ng v\u00e0 \u0111i\u1ec1u \u0111\u00f3 lu\u00f4n t\u1ed1t cho c\u00e1c c\u00e1c nghi\u00ean c\u1ee9u y h\u1ecdc\u201d.<\/p>\n M\u1eb7c d\u00f9 khoa h\u1ecdc v\u1eabn c\u00f2n nh\u1eefng \u0111i\u1ec1u ch\u01b0a l\u00fd gi\u1ea3i \u0111\u01b0\u1ee3c, nh\u01b0ng nhi\u1ec1u ng\u01b0\u1eddi v\u1eabn s\u1eb5n s\u00e0ng s\u1eed d\u1ee5ng th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng t\u1eeb d\u1ea7u c\u00e1 \u0111\u1ec3 ch\u1eefa b\u1ec7nh, kh\u00f4ng ch\u1ec9 \u0111\u1ec3 ng\u0103n ng\u1eeba c\u00e1c b\u1ec7nh v\u1ec1 tim m\u1ea1ch m\u00e0 c\u00f2n \u0111\u1ec3 \u0111\u1ec1 ph\u00f2ng b\u1ec7nh ung th\u01b0, h\u1ed7 tr\u1ee3 ch\u1eefa tr\u1ecb b\u1ec7nh t\u0103ng huy\u1ebft \u00e1p, \u0111au kh\u1edbp, s\u1ee9c kh\u1ecfe tinh th\u1ea7n, v\u00e0 th\u1eadm ch\u00ed l\u00e0 c\u1ea3i thi\u1ec7n ngo\u1ea1i h\u00ecnh. Nh\u1eefng vi\u00ean nang n\u00e0y ch\u1ee9a h\u1ed7n h\u1ee3p c\u00e1c ph\u00e2n t\u1eed \u0111\u01b0\u1ee3c t\u00e1ch chi\u1ebft t\u1eeb d\u1ea7u c\u00e1, nh\u01b0 c\u00e1 h\u1ed3i, c\u00e1 thu v\u00e0 c\u00e1 m\u00f2i, bao g\u1ed3m axit b\u00e9o omega-3, nh\u01b0 axit eicosapentaenoic (EPA) v\u00e0 axit docosahexaenoic (DHA), v\u00e0 v\u00f4 s\u1ed1 nh\u1eefng lo\u1ea1i axit b\u00e9o kh\u00e1c k\u1ec3 c\u1ea3 nh\u1eefng lo\u1ea1i axit b\u00e9o b\u00e3o h\u00f2a kh\u00f4ng l\u00e0nh m\u1ea1nh. H\u00e0m l\u01b0\u1ee3ng v\u00e0 li\u1ec1u l\u01b0\u1ee3ng c\u1ee7a nh\u1eefng lo\u1ea1i axit b\u00e9o \u0111\u01b0\u1ee3c ghi tr\u00ean nh\u00e3n m\u00e1c kh\u00f4ng th\u1ef1c s\u1ef1 gi\u1ed1ng v\u1edbi nh\u1eefng g\u00ec c\u00f3 trong m\u1ed7i vi\u00ean d\u1ea7u c\u00e1, \u0111i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn h\u1ec7 qu\u1ea3 t\u1ea5t y\u1ebfu l\u00e0 s\u1ef1 thi\u1ebfu s\u00f3t nh\u1eefng quy \u0111\u1ecbnh \u0111\u1ed1i v\u1edbi th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng.<\/p>\n M\u1eb7c d\u00f9 s\u1eed d\u1ee5ng nh\u1eefng th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng nh\u01b0 th\u1ebf n\u00e0y tr\u00f4ng c\u00f3 v\u1ebb kh\u00f4ng c\u00f3 h\u1ea1i \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe c\u1ee7a con ng\u01b0\u1eddi, nh\u01b0ng th\u1ef1c t\u1ebf v\u1eabn c\u00f3 m\u1eb7t ti\u00eau c\u1ef1c n\u1ebfu ng\u01b0\u1eddi d\u00f9ng b\u1ecf thu\u1ed1c, nh\u01b0 nh\u00f3m thu\u1ed1c statin l\u00e0m h\u1ea1 lipid. \u00d4ng Bhatt cho r\u1eb1ng \u201cNh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y th\u00ec r\u1ea5t \u0111\u1eaft ti\u1ec1n, v\u00e0 \u0111\u00e3 c\u00f3 r\u1ea5t nhi\u1ec1u b\u1eb1ng ch\u1ee9ng cho r\u1eb1ng ch\u00fang th\u1ef1c s\u1ef1 kh\u00f4ng mang l\u1ea1i nh\u1eefng l\u1ee3i \u00edch t\u1ed1t cho tim m\u1ea1ch\u201d.<\/p>\n Hi\u1ec7n nay, nh\u1eefng hi\u1ec7p h\u1ed9i v\u1ec1 y t\u1ebf v\u1eabn \u0111ang r\u1ea5t b\u0103n kho\u0103n v\u1ec1 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa d\u1ea7u c\u00e1 v\u00e0 s\u1ee9c kh\u1ecfe tim m\u1ea1ch. Hi\u1ec7p h\u1ed9i Tim m\u1ea1ch Hoa K\u1ef3 khuy\u00ean m\u1ecdi ng\u01b0\u1eddi n\u00ean \u0103n c\u00e1 2 tu\u1ea7n m\u1ed7i tu\u1ea7n, v\u00e0 trong m\u1ed9t v\u00e0i tr\u01b0\u1eddng h\u1ee3p n\u00ean t\u00ecm \u0111\u1ebfn b\u00e1c s\u0129 \u0111\u1ec3 l\u1ea5y l\u1eddi khuy\u00ean v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng t\u1eeb d\u1ea7u c\u00e1. Tuy nhi\u00ean, Qu\u1ef9 Tim m\u1ea1ch Anh ch\u1ec9 nh\u1eafc \u0111\u1ebfn c\u00e1 nh\u01b0 m\u1ed9t ph\u1ea7n c\u1ee7a ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang. V\u00e0o n\u0103m 2017, NHS England c\u0169ng \u0111\u00e3 khuy\u1ebfn c\u00e1o r\u1eb1ng c\u00e1c b\u00e1c s\u0129 gia \u0111\u00ecnh kh\u00f4ng n\u00ean k\u00ea c\u00e1c h\u1ee3p ch\u1ea5t axit b\u00e9o omega-3 cho nhi\u1ec1u lo\u1ea1i t\u00ecnh tr\u1ea1ng kh\u00e1c nhau, nh\u01b0 b\u1ec7nh gan nhi\u1ec5m m\u1ee1 kh\u00f4ng do r\u01b0\u1ee3u, sau c\u01a1n \u0111au tim, ch\u1ee9ng \u0111a x\u01a1 c\u1ee9ng, v\u00e0 nh\u1eefng r\u1ed1i lo\u1ea1n v\u1ec1 gi\u1ea5c ng\u1ee7 do t\u1ef1 k\u1ef7. NHS England c\u0169ng n\u00eau r\u00f5, d\u1eebng nh\u1eefng toa thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng th\u1ea5p n\u00e0y c\u00f3 th\u1ec3 gi\u00fap ti\u1ebft ki\u1ec7m \u0111\u1ebfn 6 tri\u1ec7u b\u1ea3ng Anh m\u1ed7i n\u0103m.<\/p>\n Sau \u0111\u00f3, l\u0129nh v\u1ef1c n\u00e0y v\u1eabn kh\u00f4ng b\u1ecf qua nh\u1eefng ti\u1ec1m n\u0103ng thu \u0111\u01b0\u1ee3c t\u1eeb d\u1ea7u c\u00e1. K\u1ec3 t\u1eeb n\u0103m 2004, C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 \u0111\u00e3 ph\u00ea duy\u1ec7t b\u1ed1n s\u1ea3n ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb d\u1ea7u c\u00e1 \u0111\u1ec3 l\u00e0m gi\u1ea3m ch\u1ec9 s\u1ed1 triglyceride (\u2265500mg\/dL), m\u1ed9t y\u1ebfu t\u1ed1 c\u00f3 vai tr\u00f2 trong s\u1ef1 ph\u00e1t tri\u1ec3n m\u1ea3ng x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch v\u00e0 c\u00e1c b\u1ec7nh v\u1ec1 tim m\u1ea1ch. Ch\u1ebf ph\u1ea9m Lovaza c\u1ee7a GSK (t\u1ea1i Anh c\u00f3 t\u00ean l\u00e0 Omacor) \u2013 m\u1ed9t h\u1ed7n h\u1ee3p g\u1ed3m EPA v\u00e0 DHA \u1edf d\u1ea1ng este \u2013 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u0111\u1ea7u ti\u00ean, theo sau l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 t\u00ean Omtryg (Trygg Pharma) ra m\u1eaft v\u00e0o n\u0103m 2014; hai phi\u00ean b\u1ea3n generic kh\u00e1c c\u0169ng xu\u1ea5t hi\u1ec7n sau \u0111\u00f3. V\u00e0o n\u0103m 2014, ch\u1ebf ph\u1ea9m Epanova c\u1ee7a Astra Zeneca c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p, ch\u1ee9a c\u1ea3 EPA v\u00e0 DHA d\u1ea1ng axit b\u00e9o t\u1ef1 do ch\u1ee9 kh\u00f4ng ph\u1ea3i d\u1ea1ng ethyl este, gi\u00fap t\u0103ng c\u01b0\u1eddng sinh kh\u1ea3 d\u1ee5ng c\u1ee7a ch\u1ebf ph\u1ea9m. Ch\u1ebf ph\u1ea9m Vascepa c\u1ee7a Amarin, lo\u1ea1i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c d\u00f9ng trong th\u1eed nghi\u1ec7m REDUCE-IT, \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn v\u00e0o n\u0103m 2012, kh\u00f4ng gi\u1ed1ng v\u1edbi nh\u1eefng lo\u1ea1i kh\u00e1c, n\u00f3 ch\u1ec9 ch\u1ee9a icosapent ethyl, m\u1ed9t lo\u1ea1i EPA.<\/p>\n D\u00f9 s\u1eed d\u1ee5ng c\u00e1c thu\u1ed1c \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t ch\u1eb7t ch\u1ebd nh\u01b0 v\u1eady th\u00ec v\u1eabn kh\u00f3 \u0111\u1ec3 th\u1ea5y l\u1ee3i \u00edch trong c\u1ed9ng \u0111\u1ed3ng ngo\u00e0i hi\u1ec7u qu\u1ea3 \u1edf tr\u01b0\u1eddng h\u1ee3p t\u0103ng triglyceride. Nghi\u00ean c\u1ee9u VITAL g\u1ea7n \u0111\u00e2y \u0111\u00e3 th\u1eed nghi\u1ec7m 1g Omacor m\u1ed7i ng\u00e0y \u1edf m\u1ed9t nh\u00f3m d\u00e2n c\u01b0 t\u01b0\u01a1ng \u0111\u1ed1i kh\u1ecfe m\u1ea1nh, t\u1eeb 50 tu\u1ed5i tr\u1edf l\u00ean, sau th\u1eddi gian theo d\u00f5i trung b\u00ecnh kho\u1ea3ng n\u0103m n\u0103m, nh\u1eefng ng\u01b0\u1eddi d\u00f9ng Omacor v\u00e0 nh\u1eefng ng\u01b0\u1eddi d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c c\u00f3 t\u1ec9 l\u1ec7 m\u1eafc bi\u1ebfn c\u1ed1 tim m\u1ea1ch v\u00e0 t\u1ec9 l\u1ec7 ch\u1ea9n \u0111o\u00e1n ung th\u01b0 l\u00e0 nh\u01b0 nhau. T\u01b0\u01a1ng t\u1ef1 nh\u01b0 v\u1eady, th\u1eed nghi\u1ec7m ASCEND \u0111\u00e3 theo d\u00f5i nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng \u2013 m\u1ed9t nguy\u00ean nh\u00e2n l\u00e0m t\u0103ng cao nguy c\u01a1 m\u1eafc b\u1ec7nh tim m\u1ea1ch. M\u1ed9t li\u1ec1u Omacor th\u1ea5p, kho\u1ea3ng 1g m\u1ed7i ng\u00e0y, trong kho\u1ea3ng 7 n\u0103m (t\u00ednh trung b\u00ecnh), c\u0169ng kh\u00f4ng l\u00e0m gi\u1ea3m s\u1ed1 bi\u1ebfn c\u1ed1 tim m\u1ea1ch, ch\u1eb3ng h\u1ea1n nh\u01b0 \u0111au tim ho\u1eb7c \u0111\u1ed9t qu\u1ef5, so v\u1edbi nh\u00f3m ch\u1ee9ng s\u1eed d\u1ee5ng gi\u1ea3 d\u01b0\u1ee3c.<\/p>\n K\u1ebft qu\u1ea3 tr\u00ean kh\u00f4ng h\u1ec1 l\u00e0m Bowman ng\u1ea1c nhi\u00ean b\u1edfi li\u1ec1u s\u1eed d\u1ee5ng qu\u00e1 th\u1ea5p. \u201cB\u1ea1n h\u00e3y nh\u1edb r\u1eb1ng ch\u00fang t\u00f4i \u0111\u00e3 thi\u1ebft k\u1ebf th\u1eed nghi\u1ec7m v\u00e0o n\u0103m 2003. K\u1ec3 t\u1eeb \u0111\u00f3, c\u00e1c b\u1eb1ng ch\u1ee9ng \u0111\u01b0\u1ee3c t\u00edch l\u0169y \u0111\u00e3 cho th\u1ea5y c\u00f3 l\u1ebd li\u1ec1u th\u1ea5p kh\u00f4ng c\u00f3 hi\u1ec7u qu\u1ea3 nh\u01b0 ch\u00fang t\u00f4i t\u1eebng ngh\u0129 khi d\u1ef1a tr\u00ean nh\u1eefng nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00f3\u201d.<\/p>\n REDUCE-IT t\u1eadp trung v\u00e0o nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh tim m\u1ea1ch v\u1edbi trigliceride t\u0103ng \u1edf m\u1ee9c \u0111\u1ed9 trung b\u00ecnh (135-149 ml\/dL) v\u00e0 \u0111\u00e3 s\u1eed d\u1ee5ng statin. C\u00e1c b\u1ec7nh nh\u00e2n \u1edf giai \u0111o\u1ea1n n\u00e0y s\u1ebd th\u01b0\u1eddng d\u00f9ng statin \u0111\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 \u0111\u1ebfn 25-35%. Bhatt v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 th\u00ed nghi\u1ec7m \u0111\u1ec3 ki\u1ec3m tra li\u1ec7u icosapent ethyl c\u00f3 th\u1ec3 gi\u1ea3m nguy c\u01a1 t\u1ed3n d\u01b0 hay kh\u00f4ng khi nh\u1eefng ng\u01b0\u1eddi tham gia u\u1ed1ng hai vi\u00ean hai l\u1ea7n m\u1ed9t ng\u00e0y, v\u1edbi li\u1ec1u cao 4g m\u1ed7i ng\u00e0y.<\/p>\n Ph\u1ea7n l\u1edbn ng\u01b0\u1eddi tham gia th\u1eed nghi\u1ec7m \u0111\u00e3 m\u1eafc b\u1ec7nh tim m\u1ea1ch, trong khi nh\u1eefng ng\u01b0\u1eddi kh\u00e1c b\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng c\u1ed9ng th\u00eam m\u1ed9t y\u1ebfu t\u1ed1 nguy c\u01a1; t\u1ed5ng c\u1ed9ng l\u1ea1i c\u00f3 8,179 ng\u01b0\u1eddi trong cu\u1ed9c th\u1eed nghi\u1ec7m, ph\u1ea7n l\u1edbn \u0111\u1ebfn t\u1eeb c\u00e1c qu\u1ed1c gia c\u00f3 ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng ph\u01b0\u01a1ng T\u00e2y. Trong su\u1ed1t 5 n\u0103m theo d\u00f5i, 17% th\u00e0nh vi\u00ean trong nh\u00f3m s\u1eed d\u1ee5ng icosapent ethyl c\u00f3 \u00edt nh\u1ea5t m\u1ed9t bi\u1ebfn c\u1ed1 tim m\u1ea1ch, bao g\u1ed3m t\u1eed vong li\u00ean quan \u0111\u1ebfn tim m\u1ea1ch, nh\u1ed3i m\u00e1u c\u01a1 tim, \u0111\u1ed9t qu\u1ef5 kh\u00f4ng g\u00e2y t\u1eed vong, c\u1ea7n th\u1ef1c hi\u1ec7n th\u1ee7 thu\u1eadt t\u00e1i th\u00f4ng m\u1ea1ch (v\u00ed d\u1ee5 nh\u01b0 stent v\u00e0 ph\u1eabu thu\u1eadt b\u1eafc c\u1ea7u ch\u1ee7 v\u00e0nh) v\u00e0 ch\u1ee9ng \u0111au th\u1eaft ng\u1ef1c; trong khi 22% trong s\u1ed1 s\u1eed d\u1ee5ng placebo d\u1ea7u kho\u00e1ng c\u0169ng tr\u1ea3i qua bi\u1ebfn c\u1ed1 t\u01b0\u01a1ng t\u1ef1. S\u1ef1 kh\u00e1c bi\u1ec7t n\u00e0y kh\u00f4ng ch\u1ec9 gi\u00fap gi\u1ea3m 25% r\u1ee7i ro t\u01b0\u01a1ng \u0111\u1ed1i, m\u00e0 s\u1ef1 gi\u1ea3m thi\u1ec3u c\u00f2n \u0111\u01b0\u1ee3c nh\u00ecn th\u1ea5y trong t\u1eebng bi\u1ebfn c\u1ed1 ri\u00eang l\u1ebb. D\u1ef1a v\u00e0o nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y Amarin s\u1ebd t\u00ecm ki\u1ebfm s\u1ef1 ch\u1ea5p thu\u1eadn theo quy \u0111\u1ecbnh cho m\u1ed9t ch\u1ec9 \u0111\u1ecbnh m\u1edbi c\u1ee7a Vascepa v\u00e0o n\u0103m 2019.<\/p>\n John Kalestine, gi\u00e1o s\u01b0 y khoa c\u1ee7a tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Amsterdam \u0111\u1ec1 c\u1eadp cu\u1ed9c th\u1eed nghi\u1ec7m REDUCE-IT l\u00e0 l\u1ea7n \u0111\u1ea7u ti\u00ean m\u1ed9t lo\u1ea1i axit b\u00e9o omega-3 tinh khi\u1ebft, \u0111\u01b0\u1ee3c tinh ch\u1ebf m\u1ee9c \u0111\u1ed9 cao \u0111\u01b0\u1ee3c cung c\u1ea5p v\u1edbi li\u1ec1u l\u01b0\u1ee3ng th\u00edch h\u1ee3p trong m\u1ed9t kho\u1ea3ng th\u1eddi gian th\u00edch h\u1ee3p cho m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi th\u00edch h\u1ee3p D\u1ea7u kho\u00e1ng c\u00f3 m\u1eb7t v\u1edbi s\u1ed1 l\u01b0\u1ee3ng \u00edt (d\u1ea1ng v\u1ebft) trong m\u1ecdi th\u1ee9, v\u00e0 \u0111\u00f3 c\u00f3 th\u1ec3 l\u00e0 l\u1eddi gi\u1ea3i th\u00edch duy nh\u1ea5t cho v\u00e0i ph\u1ea7n tr\u0103m t\u00e1c d\u1ee5ng.<\/p>\n M\u1ed9t s\u1ed1 ng\u01b0\u1eddi \u0111\u00e3 ch\u1ec9 ra m\u1ed9t h\u1ea1n ch\u1ebf trong REDUCE-IT: trong qu\u00e1 tr\u00ecnh th\u1eed nghi\u1ec7m, nh\u00f3m \u0111\u1ed1i ch\u1ee9ng c\u00f3 m\u1ee9c t\u0103ng kh\u00f4ng k\u1ef3 v\u1ecdng \u1edf l\u01b0\u1ee3ng lipoprotein, \u0111\u1eb7c bi\u1ec7t lipoprotein t\u1ec9 tr\u1ecdng th\u1ea5p v\u1eadn chuy\u1ec3n cholesterol (LDL-c)<\/p>\n . \u0110i\u1ec1u n\u00e0y g\u1ee3i \u00fd r\u1eb1ng placebo d\u1ea7u kho\u00e1ng b\u1eb1ng m\u1ed9t c\u00e1ch n\u00e0o \u0111\u00f3 li\u00ean quan \u0111\u1ebfn h\u1ea5p th\u1ee5 statin. D\u1ea7u kho\u00e1ng \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng nhu\u1eadn tr\u00e0ng, v\u00e0 35% nh\u00f3m \u0111\u1ed1i ch\u1ee9ng \u0111\u00e3 b\u00e1o c\u00e1o c\u00f3 bi\u1ec3u hi\u1ec7n tri\u1ec7u ch\u1ee9ng v\u1ec1 \u0111\u01b0\u1eddng ru\u1ed9t trong cu\u1ed9c th\u1eed nghi\u1ec7m, trong khi m\u1ed9t t\u1ec9 l\u1ec7 \u00edt h\u01a1n \u2013 c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea \u2013 trong nh\u00f3m icosapent ethyl b\u00e1o c\u00e1o v\u1ec1 tri\u1ec7u ch\u1ee9ng t\u01b0\u01a1ng t\u1ef1 (33%).<\/p>\n N\u1ebfu \u0111\u00fang nh\u01b0 v\u1eady, \u0111i\u1ec1u n\u00e0y c\u0169ng kh\u00f4ng l\u00e0m gi\u1ea3m gi\u00e1 tr\u1ecb k\u1ebft qu\u1ea3 ch\u00ednh c\u1ee7a REDUCE-IT, Kalestine n\u00f3i r\u1eb1ng: \u201cD\u1ea7u kho\u00e1ng c\u00f3 m\u1eb7t v\u1edbi s\u1ed1 l\u01b0\u1ee3ng \u00edt (d\u1ea1ng v\u1ebft) trong m\u1ecdi th\u1ee9, v\u00e0 \u0111\u00f3 c\u00f3 th m\u1eb7t v\u1edbi s\u1ed1 l\u01b0\u1ee3ng \u00edt (d\u1ea1ng v\u1ebftho v\u00e0i ph\u1ea7n tr\u0103m t\u00e1c d\u1ee5ng\u201d. Kalestine c\u0169ng l\u01b0u \u00fd d\u1ea7u ng\u00f4 \u0111\u00e3 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t placebo t\u1ed1t h\u01a1n.<\/p>\n Bhatt \u00e1m ch\u1ec9 b\u00e0i ph\u00ea b\u00ecnh n\u00e0y nh\u01b0 \u201cs\u1ef1 \u0111i\u00ean lo\u1ea1n v\u1ec1 d\u1ea7u kho\u00e1ng\u201d, cho r\u1eb1ng d\u1ea7u kho\u00e1ng th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ch\u01b0a c\u00f3 b\u1ea5t k\u1ef3 c\u1ea3nh b\u00e1o n\u00e0o tr\u01b0\u1edbc \u0111\u00f3 v\u1ec1 \u0111\u1ed9c t\u00ednh ho\u1eb7c \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 thu thu\u1ed1c. Th\u00eam v\u00e0o \u0111\u00f3, m\u1ed9t ph\u00e2n t\u00edch d\u01b0\u1edbi nh\u00f3m \u0111\u00e3 cho th\u1ea5y hi\u1ec7u qu\u1ea3 c\u1ee7a icosapent ethyl t\u01b0\u01a1ng t\u1ef1 d\u00f9 so s\u00e1nh v\u1edbi nh\u00f3m ch\u1ee9ng c\u00f3 t\u0103ng LDL-c hay so s\u00e1nh v\u1edbi nh\u00f3m ch\u1ee9ng kh\u00f4ng c\u00f3 t\u0103ng LDL-c.<\/p>\n \u201cM\u1ecdi ng\u01b0\u1eddi s\u1eed d\u1ee5ng d\u1ea7u kho\u00e1ng v\u1edbi l\u01b0\u1ee3ng l\u1edbn h\u01a1n r\u1ea5t nhi\u1ec1u l\u1ea7n so v\u1edbi ch\u00fang ta d\u00f9ng \u1edf \u0111\u00e2y, v\u1eady n\u00ean n\u1ebfu \u0111i\u1ec1u n\u00e0y th\u1ef1c s\u1ef1 t\u1ec7, ch\u00fang ta s\u1ebd c\u00f3 v\u1ea5n \u0111\u1ec1 l\u1edbn h\u01a1n v\u00e0 ta c\u1ea7n ph\u1ea3i \u0111\u01b0a d\u1ea7u kho\u00e1ng ra kh\u1ecfi th\u1ecb tr\u01b0\u1eddng\u201d, Bhatt n\u00f3i. \u201cT\u00f4i kh\u00f4ng ngh\u0129 c\u00f3 \u0111i\u1ec1u g\u00ec v\u1ec1 [cu\u1ed9c tranh lu\u1eadn n\u00e0y]. T\u00f4i ngh\u0129 \u0111\u00e2y ch\u1ec9 l\u00e0 m\u1ed9t cu\u1ed9c th\u1eed nghi\u1ec7m kh\u1ea3 quan v\u00e0 \u0111\u00f4i khi v\u00e0i vi\u1ec7c x\u1ea3y ra, m\u1ecdi ng\u01b0\u1eddi th\u01b0\u1eddng hay b\u1eaft b\u1ebb nh\u1eefng \u0111i\u1ec1u nh\u1ecf nh\u1eb7t\u201d.<\/p>\n B\u1eb1ng c\u00e1ch n\u00e0o m\u00e0 icosapent ethyl gi\u1ea3m thi\u1ec3u nguy c\u01a1 tim m\u1ea1ch v\u1eabn ch\u01b0a s\u00e1ng t\u1ecf (Xem b\u1ea3ng)<\/p>\n Icosapent ethyl ho\u1ea1t \u0111\u1ed9ng nh\u01b0 th\u1ebf n\u00e0o?<\/p>\n Icosapent ethyl ho\u1ea1t \u0111\u1ed9ng ch\u00ednh x\u00e1c ra sao v\u1eabn \u0111ang \u0111\u01b0\u1ee3c t\u00ecm hi\u1ec3u. Nh\u01b0 d\u1ef1 \u0111o\u00e1n, n\u00f3 l\u00e0m gi\u1ea3m triglyceride, nh\u01b0ng \u0111i\u1ec1u n\u00e0y kh\u00f4ng li\u00ean quan \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 gi\u1ea3m thi\u1ec3u r\u1ee7i ro nh\u00ecn th\u1ea5y trong nghi\u00ean c\u1ee9u \u2018Gi\u1ea3m thi\u1ec3u bi\u1ebfn c\u1ed1 tim m\u1ea1ch v\u1edbi th\u1eed nghi\u1ec7m can thi\u1ec7p b\u1eb1ng icosapent ethyl\u2019, \u0111\u1ec1 xu\u1ea5t c\u00e1c c\u01a1 ch\u1ebf kh\u00e1c \u0111ang di\u1ec5n ra. Axit eicosapentaenoic c\u00f3 ho\u1ea1t t\u00ednh ch\u1ed1ng vi\u00eam v\u00e0 ch\u1ed1ng oxi ho\u00e1 c\u0169ng nh\u01b0 ho\u1ea1t \u0111\u1ed9ng \u1ed5n \u0111\u1ecbnh m\u1ea3ng b\u00e1m v\u00e0 m\u00e0ng. M\u1ed9t \u00fd t\u01b0\u1edfng cho r\u1eb1ng icosapent ethyl c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf t\u00ecnh tr\u1ea1ng vi\u00eam \u1edf \u0111\u1ed9ng m\u1ea1ch, m\u1ed9t t\u00ecnh tr\u1ea1ng nguy hi\u1ec3m c\u00f3 th\u1ec3 l\u00e0m v\u1ee1 c\u00e1c m\u1ea3ng b\u00e1m v\u00e0 d\u1eabn \u0111\u1ebfn \u0111au tim. M\u1ed9t th\u1eed nghi\u1ec7m kh\u00e1c, s\u1ebd ho\u00e0n th\u00e0nh n\u0103m 2019, t\u00ecm c\u00e1ch tr\u1ef1c ti\u1ebfp h\u00ecnh dung hi\u1ec7u \u1ee9ng c\u1ee7a icosapent ethyl tr\u00ean c\u00e1c m\u1ea3ng x\u01a1 v\u1eefa \u1edf m\u1ea1ch v\u00e0nh.<\/p>\n C\u00e2u h\u1ecfi kh\u00e1c \u0111\u01b0\u1ee3c \u0111\u1eb7t ra l\u00e0 t\u1ea1i sao REDUCE-IT th\u00e0nh c\u00f4ng trong vi\u1ec7c t\u00ecm ra l\u1ee3i \u00edch v\u1ec1 tim m\u1ea1ch trong khi nh\u1eefng th\u1eed nghi\u1ec7m kh\u00e1c kh\u00f4ng l\u00e0m \u0111\u01b0\u1ee3c: c\u00f3 ph\u1ea3i \u0111i\u1ec1u quan tr\u1ecdng n\u1eb1m \u1edf li\u1ec1u l\u01b0\u1ee3ng acid b\u00e9o omega-3 cao, hay l\u00e0 do c\u00f4ng th\u1ee9c ch\u1ec9 c\u00f3 icosapent ethyl? T\u1ea5t c\u1ea3 c\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb d\u1ea7u c\u00e1 kh\u00e1c \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u, nh\u01b0 l\u00e0 Omacor, ch\u1ee9a m\u1ed9t h\u1ed7n h\u1ee3p g\u1ed3m EPA c\u00f9ng v\u1edbi DHA. DHA n\u00e2ng cao m\u1ee9c \u0111\u1ed9 LDL-c, c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng c\u1ee7a EPA.<\/p>\n V\u00e0i ng\u01b0\u1eddi thi\u00ean v\u1ec1 h\u01b0\u1edbng li\u1ec1u l\u01b0\u1ee3ng acid b\u00e9o omega-3 cao l\u00e0 y\u1ebfu t\u1ed1 ch\u1ee7 y\u1ebfu, v\u00ec ch\u00fang c\u1ea7n thi\u1ebft \u0111\u1ec3 l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 triglyceride c\u1ef1c k\u1ef3 cao. Nh\u01b0ng EPA c\u0169ng c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng c\u1ee7a ri\u00eang n\u00f3.<\/p>\n \u201c\u0110\u00e2y l\u00e0 m\u1ed9t suy ngh\u0129 th\u00fa v\u1ecb r\u1eb1ng \u0111\u00f3 l\u00e0 t\u00e1c \u0111\u1ed9ng c\u1ee7a EPA v\u00e0 b\u1ea1n c\u1ea7n r\u1ea5t nhi\u1ec1u EPA \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c \u0111i\u1ec1u m\u00ecnh mu\u1ed1n,\u201d Kalestine cho hay.<\/p>\n \u00dd t\u01b0\u1edfng n\u00e0y s\u1ebd s\u1ebd \u0111\u01b0\u1ee3c ki\u1ec3m tra trong m\u1ed9t th\u1eed nghi\u1ec7m \u0111ang di\u1ec5n ra \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u201cGi\u1ea3m nguy c\u01a1 t\u1ed3n d\u01b0 sau d\u00f9ng statin v\u1edbi Epanova \u1edf b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 tim m\u1ea1ch cao c\u00f3 t\u0103ng triglyceride m\u00e1u\u201d (STRENGTH), m\u00e0 Kalestine \u0111ang ph\u1ee5 tr\u00e1ch. STRENGTH s\u1ebd \u0111\u00e1nh gi\u00e1 li\u1ec7u m\u1ed9t li\u1ec1u 4g Epanova \u2013 m\u1ed9t h\u1ed7n h\u1ee3p g\u1ed3m EPA v\u00e0 DHA \u2013 m\u1ed7i ng\u00e0y c\u00f3 th\u1ec3 \u0111em \u0111\u1ebfn l\u1ee3i \u00edch v\u1ec1 tim m\u1ea1ch cho nh\u1eefng ng\u01b0\u1eddi m\u1eafc nguy c\u01a1 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u1edf REDUCE-IT. Li\u1ec1u Epanova n\u00e0y s\u1ebd gi\u00fap \u0111\u1ea1t \u0111\u01b0\u1ee3c n\u1ed3ng \u0111\u1ed9 EPA trong m\u00e1u g\u1ea7n gi\u1ed1ng nh\u01b0 trong REDUCE-IT hay JELIS. N\u1ebfu hi\u1ec7u qu\u1ea3 v\u1ec1 tim m\u1ea1ch t\u01b0\u01a1ng t\u1ef1 nh\u01b0 REDUCE-IT \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y, th\u00ec n\u1ed3ng \u0111\u1ed9 EPA trong m\u00e1u c\u00f3 th\u1ec3 l\u00e0 nguy\u00ean nh\u00e2n ch\u00ednh \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3.<\/p>\n \u0110i\u1ec1u n\u00e0y ch\u1eafc ch\u1eafn khi\u1ebfn ch\u00fang ta ph\u1ea3i suy ngh\u0129 nhi\u1ec1u, nh\u01b0ng t\u00f4i kh\u00f4ng ngh\u0129 m\u1ecdi ng\u01b0\u1eddi s\u1ebd thay \u0111\u1ed5i th\u1ef1c h\u00e0nh ng\u00e0y m\u1ed9t ng\u00e0y hai c\u0103n c\u1ee9 v\u00e0o \u0111i\u1ec1u n\u00e0y.<\/p>\n C\u00e1c d\u01b0\u1ee3c s\u0129 \u0111\u00e3 ch\u00fa \u00fd \u0111\u1ebfn th\u1eed nghi\u1ec7m REDUCE-IT, m\u1eb7c d\u00f9 th\u1ef1c h\u00e0nh k\u00ea \u0111\u01a1n ho\u1eb7c c\u00e1c c\u00f4ng th\u1ee9c b\u00e0o ch\u1ebf thu\u1ed1c s\u1eed d\u1ee5ng trong b\u1ec7nh vi\u1ec7n v\u1eabn kh\u00f4ng thay \u0111\u1ed5i.<\/p>\n \u201c\u0110i\u1ec1u n\u00e0y ch\u1eafc ch\u1eafn khi\u1ebfn ch\u00fang ta ph\u1ea3i suy ngh\u0129 nhi\u1ec1u, nh\u01b0ng t\u00f4i kh\u00f4ng ngh\u0129 m\u1ecdi ng\u01b0\u1eddi s\u1ebd thay \u0111\u1ed5i th\u1ef1c h\u00e0nh ng\u00e0y m\u1ed9t ng\u00e0y hai c\u0103n c\u1ee9 v\u00e0o \u0111i\u1ec1u n\u00e0y,\u201d theo Alison Warren, d\u01b0\u1ee3c s\u0129 chuy\u00ean khoa tim m\u1ea1ch t\u1ea1i \u0110\u1ea1i H\u1ecdc Brighton v\u00e0 Sussex B\u1ec7nh vi\u1ec7n NHS Trust. C\u00f4 \u1ea5y l\u01b0u \u00fd r\u1eb1ng c\u00e1c k\u1ebft qu\u1ea3 c\u1ee7a REDUCE-IT \u0111\u01b0\u1ee3c suy ra t\u1eeb m\u1ed9t qu\u1ea7n th\u1ec3 \u0111\u1eb7c tr\u01b0ng v\u1edbi l\u01b0\u1ee3ng triglyceride t\u0103ng; v\u1eabn c\u00f2n ph\u1ea3i xem li\u1ec7u icosapent ethyl c\u00f3 t\u00e1c d\u1ee5ng t\u01b0\u01a1ng t\u1ef1 trong vi\u1ec7c gi\u1ea3m nguy c\u01a1 \u1edf m\u1ed9t nh\u00f3m b\u1ec7nh nh\u00e2n r\u1ed9ng h\u01a1n hay kh\u00f4ng.<\/p>\n \u201cCh\u1eafc ch\u1eafn [REDUCE-IT] \u0111ang \u0111i ng\u01b0\u1ee3c l\u1ea1i xu h\u01b0\u1edbng,\u201d c\u00f4 \u1ea5y n\u00f3i. \u201cC\u00f3 th\u1ec3 nguy\u00ean nh\u00e2n l\u00e0 c\u00f4ng th\u1ee9c, c\u00f3 th\u1ec3 l\u00e0 do li\u1ec1u l\u01b0\u1ee3ng s\u1eed d\u1ee5ng, c\u00f3 th\u1ec3 ph\u01b0\u01a1ng ph\u00e1p nghi\u00ean c\u1ee9u \u2013 c\u00f2n nhi\u1ec1u \u0111i\u1ec1u th\u00fa v\u1ecb \u0111\u00e1ng xem \u1edf ph\u00eda tr\u01b0\u1edbc.\u201d<\/p>\n Alison Warren, d\u01b0\u1ee3c s\u0129 chuy\u00ean khoa tim m\u1ea1ch t\u1ea1i \u0110\u1ea1i h\u1ecdc Brighton v\u00e0 Sussex B\u1ec7nh vi\u1ec7n NHS Trust, n\u00f3i r\u1eb1ng cu\u1ed9c th\u1eed nghi\u1ec7m REDUCE-IT khi\u1ebfn ch\u00fang ta suy ngh\u0129 nhi\u1ec1u, nh\u01b0ng c\u00f4 \u1ea5y kh\u00f4ng tin r\u1eb1ng \u0111i\u1ec1u n\u00e0y s\u1ebd khi\u1ebfn d\u1eabn \u0111\u1ebfn s\u1ef1 thay \u0111\u1ed5i v\u1ec1 c\u00e1ch th\u1ef1c h\u00e0nh trong ch\u1ed1c l\u00e1t.<\/p>\n Ng\u01b0\u1eddi d\u1ecbch : Sinh vi\u00ean d\u01b0\u1ee3c Nguy\u1ec5n Ng\u1ecdc Anh Th\u01b0, L\u1ee5c Ng\u1ecdc B\u1ea3o Kh\u00e1nh \u2013 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Y khoa Ph\u1ea1m Ng\u1ecdc Th\u1ea1ch.<\/p>\n Ng\u01b0\u1eddi hi\u1ec7u \u0111\u00ednh : \u0110\u1eb7ng Th\u1ecb Ng\u1ecdc Mai, Trung t\u00e2m D\u01b0\u1ee3c l\u00fd l\u00e2m s\u00e0ng \u0110\u1ea1i h\u1ecdc Y H\u00e0 N\u1ed9i<\/p>\n![\"B\u00e1c](\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Deepak-Bhatt.jpg\" "\\"\\"")
![\"d\u1ea7u](\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/dau_ca-1.jpg\" "\\"\\"")
<\/p>\nS\u1ef1 khoa tr\u01b0\u01a1ng \u0111\u00e1ng ng\u1edd<\/h2>\n
Nghi\u00ean c\u1ee9u n\u1ed5i b\u1eadt<\/h2>\n
![\"d\u1ea7u](\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/dau_ca-2.jpg\" "\\"\\"")
<\/p>\n![\"Gi\u00e1o](\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/John-Kalestine.jpg\" "\\"\\"")
\n\u201c\u0110\u00e2y l\u00e0 l\u1ea7n \u0111\u1ea7u ti\u00ean m\u1ed9t lo\u1ea1i axit b\u00e9o omega-3 tinh khi\u1ebft, tinh ch\u1ebf m\u1ee9c \u0111\u1ed9 cao \u0111\u01b0\u1ee3c cung c\u1ea5p v\u1edbi li\u1ec1u l\u01b0\u1ee3ng th\u00edch h\u1ee3p trong m\u1ed9t kho\u1ea3ng th\u1eddi gian th\u00edch h\u1ee3p cho m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi th\u00edch h\u1ee3p,\u201d theo John Kalestine, gi\u00e1o s\u01b0 y khoa c\u1ee7a tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Amsterdam, ng\u01b0\u1eddi \u0111\u00e3 vi\u1ebft b\u00e0i b\u00ecnh lu\u1eadn \u0111i k\u00e8m v\u1edbi s\u1ef1 c\u00f4ng b\u1ed1 REDUCE-IT. \u201cBa \u0111i\u1ec1u t\u00f4i \u0111\u1ec1 c\u1eadp tr\u00ean ho\u00e0n to\u00e0n c\u1ea7n thi\u1ebft \u0111\u1ec3 th\u1ea5y m\u1ed9t t\u00e1c d\u1ee5ng, \u0111\u1ed1i v\u1edbi b\u1ea5t k\u1ef3 lo\u1ea1i thu\u1ed1c th\u1ef1c s\u1ef1 n\u00e0o, n\u00ean m\u1ecdi ng\u01b0\u1eddi th\u01b0\u1eddng t\u00ecm ra \u0111\u01b0\u1ee3c gi\u00e1 tr\u1ecb v\u1edbi ph\u01b0\u01a1ng ph\u00e1p n\u00e0y\u201d. Kalestine, t\u00e1c gi\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u t\u1eadp trung v\u1ec1 b\u1ec7nh nguy\u00ean c\u1ee7a x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch v\u00e0 \u0111i\u1ec1u tr\u1ecb t\u0103ng nguy c\u01a1 tim m\u1ea1ch.<\/p>\nS\u1ef1 th\u1eadt<\/h2>\n
![\"D\u01b0\u1ee3c](\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Alison-Warren.jpg\" "\\"\\"")
T\u00e1c gi\u1ea3<\/h2>\n