{"id":10741,"date":"2019-06-08T23:00:21","date_gmt":"2019-06-08T16:00:21","guid":{"rendered":"https:\/\/www.vnras.com\/drug\/?p=10741"},"modified":"2019-06-10T23:16:24","modified_gmt":"2019-06-10T16:16:24","slug":"oncolytic-virus-them-lua-chon-dieu-tri-cho-benh-nhan-ung-thu","status":"publish","type":"post","link":"https:\/\/vnras.com\/drug\/oncolytic-virus-them-lua-chon-dieu-tri-cho-benh-nhan-ung-thu\/","title":{"rendered":"Oncolytic virus \u2013 th\u00eam l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n ung th\u01b0"},"content":{"rendered":"<p>06\/2019, t\u00ecm ki\u1ebfm v\u1edbi t\u1eeb kho\u00e1 \u201c<strong>oncolytic virus<\/strong>\u201d tr\u00ean trang clinicaltrials.gov mang l\u1ea1i 92 k\u1ebft qu\u1ea3 hi\u1ec3n th\u1ecb. Sau khi s\u00e0ng l\u1ecdc th\u00ec c\u00f3 kho\u1ea3ng 10 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u1edf tr\u1ea1ng th\u00e1i ng\u1eebng (suspended), hu\u1ef7 (terminated), r\u00fat l\u1ea1i (withdraw) v\u00e0 t\u1ea1m th\u1eddi ch\u01b0a c\u1eadp nh\u1eadt tr\u1ea1ng th\u00e1i (unknown).<\/p>\n<h2>\u0110i\u1ec1u \u0111\u00f3 c\u00f3 \u00fd ngh\u0129a g\u00ec ?<\/h2>\n<p>V\u1eabn c\u00f2n \u0111\u1ebfn 82 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1ec1 \u1ee9ng d\u1ee5ng virus trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u1eabn c\u00f2n \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n. Trong \u0111\u00f3, 33 nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u01b0\u1ee3c ho\u00e0n th\u00e0nh v\u00e0 5 trong s\u1ed1 \u0111\u00f3 \u0111\u00e3 c\u00f4ng b\u1ed1 k\u1ebft qu\u1ea3. C\u1ea7n l\u1eb7p l\u1ea1i, \u0111\u00f3 l\u00e0 t\u00ecm ki\u1ebfm v\u1edbi ch\u1ec9 ri\u00eang t\u1eeb kho\u00e1 \u201concolytic virus\u201d, m\u1ed9t s\u1ed1 c\u1ee5m t\u1eeb kh\u00e1c nh\u01b0 \u201cTalimogene Laherparepvec\u201d, ho\u1eb7c \u201cT-VEC\u201d ho\u1eb7c \u201cImlygic\u201d \u0111\u00e3 c\u00f3 \u0111\u1ebfn 6 nghi\u00ean c\u1ee9u ho\u00e0n th\u00e0nh trong t\u1ed5ng s\u1ed1 46 nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y.<\/p>\n<p>&nbsp;<\/p>\n<h2>D\u00f9ng virus \u0111\u1ec3 di\u1ec7t t\u1ebf b\u00e0o Ung th\u01b0, m\u1ed9t \u00fd t\u01b0\u1edfng \u0111i\u00ean r\u1ed3 ?<\/h2>\n<p><strong>S\u1eed d\u1ee5ng virus bi\u1ebfn \u0111\u1ed5i gen \u0111\u1ec3 t\u1ea5n c\u00f4ng t\u1ebf b\u00e0o ung th\u01b0<\/strong> nh\u1eefng t\u01b0\u1edfng s\u1ebd m\u00e3i ch\u1ec9 l\u00e0 m\u1ed9ng t\u01b0\u1edfng d\u1eebng l\u1ea1i v\u1edbi c\u00e1c th\u00ed nghi\u1ec7m nh\u1ecf l\u1ebb trong ph\u00f2ng lab. Trong h\u01a1n nhi\u1ec1u th\u1eadp k\u1ec9 qua, h\u01b0\u1edbng nghi\u00ean c\u1ee9u n\u00e0y h\u1ea7u nh\u01b0 ch\u1ec9 d\u1eadm ch\u00e2n t\u1ea1i ch\u1ed7 v\u00e0 kh\u00f4ng h\u1ec1 c\u00f3 d\u1ea5u hi\u1ec7n ti\u1ebfn tri\u1ec3n th\u00eam. Th\u1eadm ch\u00ed, nhi\u1ec1u ng\u01b0\u1eddi c\u00f2n ch\u1ec9 tr\u00edch vi\u1ec7c d\u00e0nh th\u1eddi gian nghi\u00ean c\u1ee9u theo c\u00e1ch ti\u1ebfp c\u1eadn vi\u1ec3n v\u00f4ng n\u00e0y g\u00e2y hao t\u1ed5n kinh ph\u00ed v\u00e0 ngu\u1ed3n l\u1ef1c nh\u00e2n s\u1ef1.<\/p>\n<p>V\u00ec th\u1ebf, T-VEC (talimogene laherparevec) \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 da v\u00e0o n\u0103m 2015, th\u1eadt s\u1ef1 l\u00e0 m\u1ed9t b\u01b0\u1edbc ngo\u1eb7c quan tr\u1ecdng \u0111\u1ec3 \u0111\u00e1nh d\u1ea5u v\u00e0 ghi nh\u1eadn nh\u1eefng ti\u1ebfn tri\u1ec3n c\u1ee7a khoa h\u1ecdc trong t\u1ed1i \u01b0u ho\u00e1 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00e0 m\u1edf r\u1ed9ng c\u00e1nh c\u1eeda \u1ee9ng d\u1ee5ng li\u1ec7u ph\u00e1p virus bi\u1ebfn \u0111\u1ed5i gen. T-VEC hi\u1ec7n t\u1ea1i c\u00f3 hai nghi\u00ean c\u1ee9u pha III tr\u00ean ung th\u01b0 da \u0111\u00e3 \u0111\u01b0\u1ee3c ho\u00e0n th\u00e0nh, trong khi \u0111\u00f3 c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean ung th\u01b0 tu\u1ef5 c\u0169ng \u0111\u00e3 v\u1eeba xong pha I. C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a T-VEC vs m\u1ed9t s\u1ed1 virus bi\u1ebfn \u0111\u1ed5i gen kh\u00e1c l\u00ean t\u1ebf b\u00e0o ung th\u01b0 s\u1ebd \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch trong c\u00e1c ph\u1ea7n k\u1ebf ti\u1ebfp c\u1ee7a chu\u1ed7i b\u00e0i vi\u1ebft n\u00e0y.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-10744 aligncenter\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_1.jpg\" alt=\"Oncolytic virus\" width=\"450\" height=\"450\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_1.jpg 450w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_1-280x280.jpg 280w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_1-400x400.jpg 400w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_1-350x350.jpg 350w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_1-100x100.jpg 100w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/p>\n<p>\u1ede \u0111\u00e2y, c\u00e2u h\u1ecfi \u0111\u1eb7t ra l\u00e0: \u00fd t\u01b0\u1edfng s\u1eed d\u1ee5ng virus \u0111\u1ec3 t\u1ea5n c\u00f4ng c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 xu\u1ea5t hi\u1ec7n t\u1eeb khi n\u00e0o, v\u00e0 t\u1ea1i sao \u0111i qua bao giai \u0111o\u1ea1n th\u0103ng tr\u1ea7m, h\u01b0\u1edbng ti\u1ebfp c\u1eadn n\u00e0y v\u1eabn c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c duy tr\u00ec v\u00e0 ph\u00e1t tri\u1ec3n?<\/p>\n<h2>Ng\u01b0\u1ee3c d\u00f2ng l\u1ecbch s\u1eed<\/h2>\n<p>Nh\u00ecn l\u1ea1i m\u1ed9t ch\u00fat v\u1ec1 ch\u1eb7ng \u0111\u01b0\u1eddng ph\u00e1t tri\u1ec3n c\u1ee7a oncolytic virus. M\u1ed9t trong nh\u1eefng ph\u00e1t hi\u1ec7n s\u1edbm nh\u1ea5t v\u1ec1 kh\u1ea3 n\u0103ng t\u1ea5n c\u00f4ng t\u1ebf b\u00e0o ung th\u01b0 c\u1ee7a virus l\u00e0 t\u1eeb b\u00e1o c\u00e1o v\u1ec1 m\u1ed9t tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng \u0111i\u1ec3n h\u00ecnh c\u1ee7a BS. Georgia Dock v\u00e0o n\u0103m 1904 t\u1ea1i Michigan. Theo \u0111\u00f3, m\u1ed9t BN ung th\u01b0 b\u1ea1ch c\u1ea7u m\u1ea1n t\u00ednh do tu\u1ef7 x\u01b0\u01a1ng t\u1ea1o ra (CML-chronic myelogenous leukemia) \u0111\u00e3 gi\u1ea3m l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trong m\u00e1u t\u1eeb 367,070 xu\u1ed1ng c\u00f2n 7,500 trong v\u00f2ng 2 tu\u1ea7n k\u1ec3 t\u1eeb khi tr\u1ea3i qua m\u1ed9t \u0111\u1ee3t c\u00fam (flu-like)! G\u1ea7n nh\u01b0 gi\u1ea3m 50 l\u1ea7n so v\u1edbi ban \u0111\u1ea7u. Gan v\u00e0 l\u00e1 l\u00e1ch c\u1ee7a b\u1ec7nh nh\u00e2n c\u0169ng tr\u1edf v\u1ec1 k\u00edch th\u01b0\u1edbc b\u00ecnh th\u01b0\u1eddng. \u0110\u00e2y m\u1ed9t trong nh\u1eefng b\u00e0i b\u00e1o nh\u1eadn \u0111\u01b0\u1ee3c nhi\u1ec1u tr\u00edch d\u1eabn nh\u1ea5t trong h\u1ea7u h\u1ebft c\u00e1c b\u00e0i vi\u1ebft v\u1ec1 l\u1ecbch s\u1eed ph\u00e1t tri\u1ec3n c\u1ee7a li\u1ec7u ph\u00e1p s\u1eed d\u1ee5ng virus trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/p>\n<p>Ti\u1ebfp sau \u0111\u00f3 v\u00e0o n\u0103m 1939, hai nh\u00e0 khoa h\u1ecdc Wintrobe v\u00e0 Hasenbush ti\u1ebfp t\u1ee5c ghi nh\u1eadn 29 tr\u01b0\u1eddng h\u1ee3p ung th\u01b0 m\u00e1u kh\u00f4ng ti\u1ebfn tri\u1ec3n sau \u0111\u1ee3t nhi\u1ec5m virus c\u1ea5p t\u00ednh. M\u1ed9t tr\u01b0\u1eddng h\u1ee3p kh\u00e1c \u0111\u01b0\u1ee3c ghi nh\u1eadn tr\u00ean b\u00e9 trai 4 tu\u1ed5i m\u1eafc ung th\u01b0 b\u1ea1ch c\u1ea7u lympho (Lymphatic Leukemia). C\u1eadu b\u00e9 kh\u00f4ng h\u1ec1 nh\u1eadn \u0111\u01b0\u1ee3c b\u1ea5t k\u1ef3 \u0111i\u1ec1u tr\u1ecb n\u00e0o tr\u01b0\u1edbc khi nhi\u1ec5m thu\u1ef7 \u0111\u1eadu, gan v\u00e0 l\u00e1 l\u00e1ch to v\u00e0 l\u01b0\u1ee3ng t\u1ebf b\u00e0o lympho l\u00e0 200\/microlit m\u00e1u.<\/p>\n<p>Sau khi nhi\u1ec5m virus v\u00e0i ng\u00e0y, gan v\u00e0 l\u00e1 l\u00e1ch tr\u1edf l\u1ea1i k\u00edch th\u01b0\u1edbc c\u0169, l\u01b0\u1ee3ng lympho \u0111o \u0111\u01b0\u1ee3c l\u00e0 4.3 t\u1ebf b\u00e0o\/microlit m\u00e1u \u2013 \u0111\u1ea1t ng\u01b0\u1ee1ng b\u00ecnh th\u01b0\u1eddng. L\u01b0\u1ee3ng h\u1ed3ng c\u1ea7u v\u00e0 ti\u1ec3u c\u1ea7u t\u0103ng tr\u1edf l\u1ea1i, sau khi xem x\u00e9t tu\u1ef7 s\u1ed1ng c\u1ee7a c\u1eadu b\u00e9, c\u00e1c b\u00e1c s\u0129 kh\u1eb3ng \u0111\u1ecbnh t\u00ecnh tr\u1ea1ng \u201cremission\u201d. R\u1ea5t ti\u1ebfc, vi\u1ec7c n\u00e0y ch\u1ec9 k\u00e9o d\u00e0i trong v\u00f2ng 30 ng\u00e0y v\u00e0 ung th\u01b0 c\u1ee7a c\u00e2u b\u00e9 \u1ea5y ti\u1ebfn tri\u1ec3n nhanh sau \u0111\u00f3 cho \u0111\u1ebfn khi t\u1eed vong.<\/p>\n<p>Sau \u0111\u00f3, c\u00e0ng ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u b\u00e1o c\u00e1o v\u1ec1 ung th\u01b0 kh\u00f4ng ti\u1ebfn tri\u1ec3n \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n v\u00f4 t\u00ecnh m\u1eafc ph\u1ea3i c\u00e1c \u0111\u1ee3t nhi\u1ec5m virus kh\u00e1c nhau.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-10746\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_5-1.jpg\" alt=\"Oncolytic virus\" width=\"1247\" height=\"416\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_5-1.jpg 1247w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_5-1-800x267.jpg 800w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_5-1-768x256.jpg 768w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_5-1-350x117.jpg 350w\" sizes=\"auto, (max-width: 1247px) 100vw, 1247px\" \/><\/p>\n<p>M\u1ed9t ph\u00e1t hi\u1ec7n kh\u00e1 th\u00fa v\u1ecb kh\u00e1c v\u1ec1 c\u1ea3i thi\u1ec7n t\u00ecnh tr\u1ea1ng ung th\u01b0 c\u1ed5 \u00e1c t\u00ednh (maglinant cervical carcinoma) tr\u00ean m\u1ed9t ph\u1ee5 n\u1eef ng\u01b0\u1eddi \u00dd \u0111\u01b0\u1ee3c ghi nh\u1eadn v\u00e0o n\u0103m 1912 \u2013 8 n\u0103m sau b\u00e1o c\u00e1o c\u1ee7a BS. Dock. Kh\u00e1c v\u1edbi c\u00e1c tr\u01b0\u1eddng h\u1ee3p v\u00f4 t\u00ecnh nhi\u1ec5m virus c\u1ea5p n\u00eau tr\u00ean, ng\u01b0\u1eddi ph\u1ee5 n\u1eef n\u00e0y ti\u1ebfp x\u00fac v\u1edbi virus th\u00f4ng qua ti\u00eam ng\u1eeba v\u1eafc xin b\u1ec7nh d\u1ea1i. M\u1eb7c d\u00f9 kh\u00f4ng c\u00f3 b\u1ea5t c\u1ee9 m\u1ed9t tr\u01b0\u1eddng h\u1ee3p n\u00e0o \u0111\u01b0\u1ee3c ghi nh\u1eadn l\u00e0 ch\u1eefa kh\u1ecfi ung th\u01b0 ho\u00e0n to\u00e0n sau c\u00e1c \u0111\u1ee3t t\u1ea5n c\u00f4ng c\u1ee7a virus, \u0111\u00e2y v\u1eabn \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t trong nh\u1eefng l\u1ef1a ch\u1ecdn thay th\u1ebf tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n \u201ckh\u00f4ng c\u00f2n b\u1ea5t c\u1ee9 hi v\u1ecdng n\u00e0o v\u1edbi c\u00e1c li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng\u201d. \u0110\u1ebfn th\u1eddi \u0111i\u1ec3m \u0111\u00f3, s\u1eed d\u1ee5ng virus \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u1eabn ch\u01b0a c\u00f3 m\u1ed9t h\u1ec7 th\u1ed1ng nghi\u00ean c\u1ee9u b\u00e0i b\u1ea3n t\u1eeb ti\u1ec1n l\u00e2m s\u00e0ng \u0111\u1ebfn l\u00e2m s\u00e0ng, m\u00e0 t\u1ea5t c\u1ea3 ch\u1ec9 d\u1eebng l\u1ea1i \u1edf nh\u1eefng quan s\u00e1t v\u1ec1 c\u00e1c tr\u01b0\u1eddng h\u1ee3p ung th\u01b0 kh\u00f4ng ti\u1ebfn tri\u1ec3n sau m\u1ed9t \u0111\u1ee3t nhi\u1ec5m virus.<\/p>\n<p>C\u00e1c nh\u00e0 khoa h\u1ecdc ph\u00e2n t\u00edch m\u1ed9t s\u1ed1 \u0111\u1eb7c \u0111i\u1ec3m chung v\u1ec1 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 c\u1ee7a virus:<\/p>\n<p>Hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y \u0111a ph\u1ea7n ch\u1ec9 quan s\u00e1t th\u1ea5y tr\u00ean ng\u01b0\u1eddi tr\u1ebb, khi h\u1ec7 mi\u1ec5n d\u1ecbch c\u00f2n \u0111ang kho\u1ebb m\u1ea1nh.<br \/>\nTrong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p nh\u1ea5t \u0111\u1ecbnh, m\u1ed9t s\u1ed1 d\u1ea1ng virus c\u00f3 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 m\u00e0 kh\u00f4ng g\u00e2y \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c ph\u1ea7n kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3.<br \/>\nHi\u1ec7u qu\u1ea3 n\u00e0y ch\u1ec9 quan s\u00e1t \u0111\u01b0\u1ee3c trong m\u1ed9t th\u1eddi gian ng\u1eafn v\u00e0 kh\u00f4ng \u0111\u1ea3m b\u1ea3o b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u01b0\u1ee3c ch\u1eefa kh\u1ecfi.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-10745 aligncenter\" src=\"https:\/\/www.vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_3.jpg\" alt=\"Oncolytic virus\" width=\"450\" height=\"275\" title=\"\" srcset=\"https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_3.jpg 450w, https:\/\/vnras.com\/drug\/wp-content\/uploads\/2019\/06\/Oncolytic_virus_3-350x214.jpg 350w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/p>\n<p>Trong h\u01a1n m\u1ed9t th\u1ebf k\u1ef7 d\u00e0i \u0111\u1eb1ng \u0111\u1eb5ng, s\u1eed d\u1ee5ng virus \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 tr\u1ea3i qua nhi\u1ec1u giai \u0111o\u1ea1n th\u0103ng tr\u1ea7m: r\u1ea7m r\u1ed9 v\u00e0o nh\u1eefng n\u0103m 1950 \u2013 1960, g\u1ea7n nh\u01b0 b\u1ecb xo\u00e1 s\u1ed5 v\u00e0o th\u1eadp ni\u00ean 70, 80 v\u00e0 sau \u0111\u00f3 tr\u1edf l\u1ea1i v\u1edbi nhi\u1ec1u nghi\u00ean c\u1ee9u h\u01a1n v\u00e0o c\u00e1c th\u1eadp k\u1ec9 g\u1ea7n \u0111\u00e2y.<\/p>\n<p>Th\u1eddi k\u00ec h\u01b0ng th\u1ecbnh c\u1ee7a li\u1ec7u ph\u00e1p n\u00e0y \u0111i c\u00f9ng v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ti\u1ebfn b\u1ed9 v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p nu\u00f4i c\u1ea5y t\u1ebf b\u00e0o v\u00e0 m\u00f4 trong ph\u00f2ng th\u00ed nghi\u1ec7m c\u0169ng nh\u01b0 \u1ee9ng d\u1ee5ng c\u1ee7a c\u00f4ng ngh\u1ec7 bi\u1ebfn \u0111\u1ed5i gen tr\u00ean virus. Nh\u1eefng hi\u1ec3u bi\u1ebft v\u1ec1 b\u1ed9 gen c\u1ee7a virus v\u00e0 c\u01a1 ch\u1ebf sinh h\u1ecdc g\u00e2y b\u1ec7nh v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a virus gi\u00fap c\u00e1c nh\u00e0 khoa h\u1ecdc h\u1ec7 th\u1ed1ng l\u1ea1i kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng virus, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c ch\u1ee7ng k\u1ecb kh\u00ed trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/p>\n<p>\u0110\u1ec9nh \u0111i\u1ec3m quan tr\u1ecdng nh\u1ea5t c\u00f3 th\u1ec3 g\u1ecdi t\u00ean l\u00e0 ph\u00ea duy\u1ec7t ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng Adenovirus H101 v\u00e0o th\u00e1ng 11 n\u0103m 2005 t\u1ea1i Trung Qu\u1ed1c. Kelly v\u00e0 c\u1ed9ng s\u1ef1 (2007) \u0111\u00e3 c\u00f3 m\u1ed9t b\u00e0i t\u1ed5ng quan kh\u00e1 th\u00fa v\u1ecb v\u1ec1 h\u01a1n 150 n\u0103m l\u1ecbch s\u1eed ph\u00e1t tri\u1ec3n ung th\u01b0 v\u00e0 virus h\u1ecdc. T\u00e1c gi\u1ea3 c\u0169ng h\u1ec7 th\u1ed1ng l\u1ea1i b\u1ed1n nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng nh\u1ea5t trong giai \u0111o\u1ea1n 1949-1974 v\u1ec1 hi\u1ec7u qu\u1ea3 c\u1ee7a b\u1ed1n lo\u1ea1i virus trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0:<\/p>\n<p>Hepatitis B virus<br \/>\nEgypt 101 virus<br \/>\nAdenovirus adenoidal-pharyngeal-conjuctival virus (APC)<br \/>\nMumps virus<br \/>\nHai l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u khi giao thoa v\u1edbi nhau \u0111\u00e3 mang l\u1ea1i m\u1ed9t h\u01b0\u1edbng ti\u1ebfp c\u1eadn \u0111i\u1ec1u tr\u1ecb m\u1edbi v\u00e0 th\u1eafp s\u00e1ng th\u00eam ni\u1ec1m hi v\u1ecdng cho b\u1ec7nh nh\u00e2n ung th\u01b0.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/h2>\n<ol>\n<li>Clinical Trials link\u00a0<a href=\"https:\/\/clinicaltrials.gov\/ct2\/results\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/ct2\/results<\/a><\/li>\n<li>G Docket al; Am J Med Sci, 127 (1904), pp. 563-592\u00a0<a href=\"https:\/\/patents.justia.com\/patent\/9320787\" rel=\"noopener\">https:\/\/patents.justia.com\/patent\/9320787<\/a><\/li>\n<li>HR Bierman et al.Cancer, 6 (1953), pp. 591-605\u00a0<a href=\"https:\/\/www.cell.com\/molecular-therapy-family\/oncolytics\/fulltext\/S2372-7705(16)30023-7\" rel=\"noopener\">https:\/\/www.cell.com\/molecular-therapy-family\/oncolytics\/fulltext\/S2372-7705(16)30023-7<\/a><\/li>\n<li>Kelly E et al; Molecular Therapy; Volume 15, issue 4, April 2007, 651-659\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1525001616313314\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1525001616313314<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>06\/2019, t\u00ecm ki\u1ebfm v\u1edbi t\u1eeb kho\u00e1 \u201concolytic virus\u201d tr\u00ean trang clinicaltrials.gov mang l\u1ea1i 92 k\u1ebft qu\u1ea3 hi\u1ec3n th\u1ecb. Sau khi s\u00e0ng l\u1ecdc th\u00ec c\u00f3 kho\u1ea3ng 10 nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u1edf tr\u1ea1ng th\u00e1i ng\u1eebng (suspended), hu\u1ef7 (terminated), r\u00fat l\u1ea1i (withdraw) v\u00e0 t\u1ea1m th\u1eddi ch\u01b0a c\u1eadp nh\u1eadt tr\u1ea1ng th\u00e1i (unknown). \u0110i\u1ec1u \u0111\u00f3 c\u00f3 \u00fd ngh\u0129a g\u00ec [&#8230;]\n","protected":false},"author":1,"featured_media":10742,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-y-te-suc-khoe"],"acf":[],"_links":{"self":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/10741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/comments?post=10741"}],"version-history":[{"count":0,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/posts\/10741\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media\/10742"}],"wp:attachment":[{"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/media?parent=10741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/categories?post=10741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vnras.com\/drug\/wp-json\/wp\/v2\/tags?post=10741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}